The effect of active immunization with gonadotropin releasing hormone conjugate (GnRH-BSA) on gonadosomatic indices (GSI) and sperm parameters in mice

Iranian Journal of Reproductive Medicine

Volumn 6, Issue 3, 2008, Pages 119-123

  Ganaie, Javid Ahmad ^a   Shrivastava, Vinoy K ^a  

^a BARKATULLAH UNIVERSITY   (India)

Author keywords

Active immunization; GnRH; GSI; Infertility; Mus musculus; Sperm quality

Indexed keywords

ANTIBODY; BOVINE SERUM ALBUMIN; FREUND ADJUVANT; GONADORELIN;

ACTIVE IMMUNIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; IMMUNOCONTRACEPTION; MALE; MALE INFERTILITY; MOUSE; NONHUMAN; SEXUAL MATURATION; SPERMATOGENESIS; SPERMATOZOON; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TREATMENT OUTCOME;

EID: 70249111549     PISSN: 16806433     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Garner LL, Campbell GT, Blake CA. Luteinizing hormone (LH)-releasing hormone; Chronic effects on LH and Follicle Stimulating Hormone cells and secretion in adult male rats. Endocrinology 1990; 126: 992-1000.
2. Ladd A, Tsong YY, Prabhu G, Thau R. Effects of long - term immunization against GnRH and androgen treatment on gonadal function. J Reprod Immunol 1989; 15: 85-101.
3. Ladd A, Tsong YY, Walfield AM, Thau R. Development of antifertility vaccine for pets based on active immunization against luteinizing hormone - releasing hormone. Biol Reprod 1994; 51: 1076-1083.
4. Prevendiville DJ. Immunization of Heifers against gonadotropin releasing hormone: Antibody titers, Ovarian function, Body growth and Carcass characteristics. J Anim Sci 1995; 73: 2382-2389.
5. Upadhyay SN, Alam A, Talwar GP. Functional morphology of testis and its excurrent ducts in rats immunized with synthetic luteinizing hormone-releasing hormone conjugated to tetanus toxoid. J Reprod Immunol 1989; 16: 151-163.
6. Fromme B, ftekhari P, Van Regenmortel M, Hoebeke J, Katz A, Millar R. A novel retro-inverso gonadotropin - releasing hormone (GnRH) immunogen elicits antibodies that neutralize the activity of native GnRH. Endocrinology 2003; 144: 3262-3269.
7. Parkinson RJ, Simms MS, Broome P, Humphreys JE, Bishop MC. A vaccination strategy for the long - term suppression of androgens in advanced prostate cancer. Eur Urol 2004; 45:171-175.
8. Jinshu X, Jingjing L, Duan P, Zheng Z, Ding M, Jie W, et al. The immunogenicity of recombinant and dimeric gonadotrophin- releasing hormone vaccines incorporating a T-helper epitope and GnRH or repeated GnRH units. J Immunol Methods 2004; 289: 111-122.
9. Miller LA, Johns BE, Killian GJ. Immunocontraception of white-tailed deer with GnRH vaccine. Am J Reprod Immunol 2000; 44: 266-274.
10. Curtis PD, Pooler RL, Richmond ME, Miller LA, Mattfeld GF, Quimby FW. Comparative effects of GnRH and porcine zona pellucida (PZP) immunocontraceptive vaccines for controlling reproduction in white-tailed deer (Odocoileus virginianus). Reproduction 2002; 60:131-141.
11. Highland HN, Rao MV, Chinoy NJ, Shah VC. Analysis of the functional and nuclear integrity of human spermatozoa. Int J Fertil 1991; 36: 43-47.
12. Arimura A, Sato H, Kumasaka T, Wordrobe RB, Debeljuk L, Dunn J, et al. Production of antiserum to LH-releasing hormone (LHRH) associated with gonadal atrophy in rabbits; Development of radioimmunoassay for LHRH. Endocrinology 1973; 93: 1092-1103.
13. Fraser HM, Gunn A, Jeffcoate SL, Holland DT. Effect of active immunization to luteinizing hormone releasing hormone on serum and pituitary gonadotropins, testes and accessory sex organs in the male rat. J Endocrino 1974; 63: 399-406.
14. Giri DK, Chaudhuri MK, Jayashankar R, Neelaram GS, Jayaraman S, Talwar GP. Histopathological changes in reproductive organs of male Wistar rats following active immunization against GnRH. Exp Mol Pathol 1990; 52:54-62.
15. Kumar N, Sarage T, Dejesus W, Tsong YY, Didolkar A, Sundara K. Chronic Toxicity and reversibility of antifertility effect of immunization against gonadotropin releasing hormone in male rats and rabbits. Toxicological Sciences 2000; 53: 92-109.
16. Malmgren L, Andersen O, Dalin AM. Effect of GnRH immunization on hormonal levels, Sexual behavior, semen quality and testicular morphology in mature stallions. Equine Vet J 2001; 33: 75-83.
17. Hannesdottir SG, Han X, Lund T, Singh M, Van Der Zee R, Roitt IM, et al. Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70. Reproduction 2004; 128: 365-371.
18. Talwar GP, Raina K, Gupta JC, Ray R, Wadhwa S, Ali MM. A recombinant luteinizing - hormone - releasing - hormone immunogen bioeffective in causing prostatic atrophy. Vaccine 2004; 22: 3713-3721.
19. Turkstra JA. Active immunization against gonadotropin releasing hormone, an active tool to block the fertility in mammals. PhD thesis, Utrecht University, Netherlands 2005; 13-50.
20. Benagiano G, Bastianelli C, Farris M. Contraception today. Ann N Y Acad Sci 2006; 1092: 1-32.
21. Page ST, Amory JK, Bremner WJ. Advances in male contraception. Endocr Rev 2008; 29:465-493.