Effect of GnRH immunisation on hormonal levels, sexual behaviour, semen quality and testicular morphology in mature stallions

Equine Veterinary Journal

Volumn 33, Issue 1, 2001, Pages 75-83

  Malmgren, L ^a   Andresen, O ^b   Dalin, A M ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

GnRh; Horse; Immunisation; Oestrone sulphate; Semen quality; Sexual behaviour; Stallion; Testosterone

Indexed keywords

ANIMALIA; EQUUS CABALLUS;

ANTIBODY; ESTRONE; GONADORELIN; TESTOSTERONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; CHEMOLUMINESCENCE; CYTOCHEMISTRY; ELECTRON MICROSCOPY; HISTOLOGY; HORSE; IMMUNIZATION; IMMUNOLOGY; LIBIDO; MALE; METHODOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RADIOIMMUNOASSAY; SCINTILLATION COUNTING; SEXUAL BEHAVIOR; SPERM; SPERMATOZOON MOTILITY; TESTIS; ULTRASTRUCTURE;

ANIMALS; ANTIBODIES; CHEMILUMINESCENT MEASUREMENTS; ESTRONE; GONADOTROPIN-RELEASING HORMONE; HISTOCYTOCHEMISTRY; HORSES; IMMUNIZATION; LIBIDO; MALE; MICROSCOPY, ELECTRON; RADIOIMMUNOASSAY; SCINTILLATION COUNTING; SEMEN; SEXUAL BEHAVIOR, ANIMAL; SPERM MOTILITY; TESTIS; TESTOSTERONE;

EID: 0035221003     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516401776767340     Document Type: Article

References (42)

1. Adams, T.E., Daley, C.A., Adams, B.M. and Sakuri, H. (1996) Testes function and feedlot performance of bulls actively immunized against gonodotropin-releasing hormone: Effect of age at immunization. J. anim. Sci. 74, 950-954.
2. Amann, R.P. (1993) Physiology and endocrinology. In: Equine Reproduction, Eds: A.O. McKinnon and J.L. Voss, Lea & Febiger, Philadelphia. pp 658-685.
3. Awonjyi, C.A., Chandrashekar, V. Arthur, R.D., Schanbacher, B.D. and Falvo, R.E. (1988) Changes in testicular morphology in boars actively immunized against gonadotropin hormone-releasing hormone. J. Androl. 9, 160-171.
4. Bambino, T.H., Schreiber, J.R. and Hsueh, A.J. (1980) Gonadotropin-releasing hormone and its agonist inhibit testicular luteinizing hormone receptor and steroidogenesis in immature and adult hypophysectomized rats. Endocrinology 107, 908-917.
5. Bane, A. (1961) Acrosomal abnormality associated with sterility in boars. In: Proceedings of the 4th International Congress on Animal Reproduction & AI. pp 810-817.
6. Bonneau, M. and Enright, W.J. (1995) Immunocastration in cattle and pigs. Livestock Prod. Sci. 42, 193-200.
7. Chappel, S.C., Ellinwood, W.E., Huckins, C., Herbert, D.C. and Spies, H.G. (1980) Active immunization of male Rhesus monkeys against luteinizing hormone releasing hormone. Biol. Reprod. 22, 333-342.
8. Colenbrander, B., Puyk, H., Zandee, A.R. and Parlevliet, J. (1992) Evaluation of the stallion for breeding. Acta vet. Scand. Suppl. 88, 29-37.
9. Darenius, K., Kindahl, H. and Madej, A. (1988) Clinical and endocrine study in mares with known history of repeated conceptus losses. Theriogenol. 29, 1215-1232.
10. Dorrington, J.H., Fritz, I.B. and Amstrong, D.T. (1978) Control of testicular oestrogens synthesis. Biol. Reprod. 18, 55-64.
11. Dowsett, K.F. and Knott, L.M. (1996) The influence on age and breed on stallion semen. Theriogenol. 46, 397-412.
12. Dowsett, K.F., Tshewang, U., Knott, L.M., Jackson, A.E. and Trigg, T.E. (1994) Immunocastration of colts with a watersoluble GnRH vaccine. In: 6th International Symposium on Equine Reproduction. pp 159-160.
13. Dowsett, K.F., Knott, L.M., Tshewang U., Jackson, A.E., Bodero, D.A.V. and Trigg, T.E. (1996) Suppression of testicular function using two dose rates of a reversible water soluble gonodotrophin releasing hormone (GnRH) vaccine in colts. Aust. vet. J. 74, 228-235.
14. Dowsett, K.F., Pattie, W.A., Knott, L.M., Jackson, A.E., Hoskinson, R.M., Rigby, R.P.G. and Moss, B.A. (1991) A preliminary study of immunological castration in colts. J. Reprod. Fert. Suppl. 44, 183-190.
15. English, H.F., Schanbacher, B.D., Gross, D., Walker, M.E. Falvo, R.E. and Santen, R.J. (1983) Animal model of isolated gonadotropin deficiency. II. Morphologic responses to LHRH immunoneutralization. J. Androl. 4, 240-247.
16. Falvo, R.E., Chandrashekar, V., Arthur, R.D., Kuenstler, A.R., Hasson, T., Awoniyi, C. and Schanbacher, B.D. (1986) Effect of immunization against LHRH in boars: Reproductive consequences and performance traits. J. anim. Sci. 63, 986-944.
17. Fraser, H.M., Gunn, A., Jeffcoate, S.L. and Holland, D.T. (1974a) Preparation of antisera to luteinizing hormone releasing hormone. J. Endocr. 61, IX-X.
18. Fraser, H.M., Gunn, A., Jeffcoate, S.L. and Holland, D.T. (1974b) Effect of active immunization to luteinizing hormone releasing hormone on serum and pituitary gonadotrophins, testes and accessory sex organs in the male rat. J. Endocr. 63, 399-406.
19. Garza, F. Jr., Thompson, D.L. Jr., French, D.D., Wiest, J.J., St. George, R.L., Ashley, K.B., Jones, L.S., Mitchell, P.S. and McNeill, D.R. (1986) Active immunization of intact mares against gonadotropin-releasing hormone: Differential effects on secretion of luteinizing hormone and follicle-stimulating hormone. Biol. Reprod. 35, 347-352.
20. Hagen, G., Andresen, Ø., Blichfeldt, T. and Berg, K.A. (1988) Effects of immunization of young boars against gonadotropin releasing hormone. In: Proceedings of the 11th International Congress on Animal Reproduction & AI. Vol. 1, 493.
21. Hancock, J. (1957) The morphology of boar spermatozoa. J. Roy. Micr. Soc. 76, 84-97.
22. Hart, B.L. and Barrett, R.E. (1973) Effects of castration on fighting, roaming, and urine spraying in adult male cats. J. Am. vet. med. Ass. 163, 290-292.
23. Hopkins, S.G., Schubert, T.A. and Hart, B.L. (1976) Castration of adult male dogs: effects on roaming, aggression, urine marking, and mounting. J. Am. vet. med. Ass. 168, 1108-1110.
24. Hoskinson, R.M., Rigby, R.D.G., Mattner, P.E., Huynh, V.L., D'Occhio, M., Neish, A., Trigg, T.E., Moss, B.A., Lindsey, M.J., Coleman, G.D. and Schwartzkoff, C.L. (1990) Vaxtrate®: An anti-reproductive vaccine for cattle. Austr. J. Biotech. 4, 166-70.
25. Jeffcoate, I.A., Lucas, J.M.S. and Crighton, D.B. (1982) Effects of active immunization of ram lambs and bull calves against synthetic luteinizing hormone releasing hormone. Theriogenol. 18, 65-77.
26. Kenney, R.M., Bergman, R.V., Cooper, W.L. and Morse, G.W. (1975) Minimal contamination techniques for breeding mares: techniques and preliminary findings. Proc. Am. Ass. equine Practnrs. 21, 327-336.
27. Line, S.W., Hart, B.L. and Sanders, L. (1985) Effect of prepubertal versus postpubertal castration on sexual and aggressive behavior in male horses. J. Am. vet. med. Ass. 186, 249-251.
28. Meloen, R.H., Turkstra, J.A., Lankhof, H., Puijk, W.C., Schaaper, W:M.M., Dijkstra, G., Wensing, C.J.G. and Oonk, R.B. (1994) Efficient immunocastration of male piglets by immunoneutralization of GnRH using a new GnRH-like peptide. Vaccine 12, 741-746.
29. Oltner, R., Lundström, K. and Edqvist, L-E. (1979) LH and testosterone in monozygous growing bulls. Repeatability and variation with and without GnRH stimulation. Swedish J. Agric. Res. 9, 151-61.
30. Papanicolaou, G.N. (1942) A new procedure for staining vaginal smears. Science 95, 438-439.
31. Pickett, B.W., Faulkner, L.C. and Sutherland, T.M. (1970) Effect of month and stallion on seminal characteristics and sexual behavior. J. anim. Sci. 31, 713-728.
32. Raeside, J.I. (1978/1979) Seasonal changes in the concentration of oestrogens and testosterone in the plasma of the stallion. Anim. Reprod. Sci. 1, 205-212.
33. Raeside, J.I. and Renaud, R.L. (1983) Oestrogens and androgen production by purified Leydig cells of mature boars. Biol. Reprod. 28, 727-733.
34. Roberts, S.J. and Beaver, B.V. (1987) The use of progestagen for aggressive and hypersexual horses. In: Current Therapy in Equine Medicine, Ed: N.E. Robinson, W.B. Saunders Co., London. pp 129-131.
35. Roser, J.F. and Hughes, J.P. (1992) Seasonal effects on seminal quality, plasma hormone concentration, and GnRH-induced LH response in fertile and subfertile stallion. J. Androl. 13, 214-223.
36. Saez, J.M., Sanchez, P., Berthelon, M.C. and Avallet. O. (1989) Regulation of pig Leydig cell aromatase activity by gonadotropins and Sertoli cells. Biol. Reprod. 41, 813-820.
37. Schanbacher, B.D. (1984) Active immunization against LH-RH in the male. In: Immunological Aspects of Reproduction in Mammals, Ed: D.B. Crighton. Butterworths, London. pp 345-362.
38. Swierstra, E.E., Gebauer, M.R. and Picket, B.W. (1974) Reproductive physiology of the stallion. I. Spermatogenesis and testis composition. J. Reprod. Fert. 40, 113-123.
39. Thompson Jr, D.L., Pickett, B.W., Berndtson, W.E., Voss, J.L. and Nett, T.M. (1977) Reproductive physiology of the stallion. VIII. Artificial photoperiod, collection interval and seminal characteristics, sexual behavior and concentrations of LH and testosterone in serum. J. anim. Sci. 44, 656-664.
40. Tshewang, U., Dowsett, K.F., Knott, L.M. and Trigg, T.E. (1997) Preliminary study of ovarian activity in fillies treated with a GnRH vaccine. Aust. vet. J. 75, 663-667.
41. Williams, W.W. (1920) Technique of collecting semen for laboratory examination with review of several diseased bulls. Cornell Vet. 10, 87-94.
42. Wright, K., Collins, D.C., Musey, P.I. and Preedy, J.R.K. (1978) A specific radioimmunoassay for oestrone sulfate in plasma and urine without hydrolysis. J. Clin. Endocrinol. Metab. 47, 1092-1098.