Preliminary evaluation of phosphatidylethanol and alcohol consumption in patients with liver disease and hypertension

Alcohol and Alcoholism

Volumn 44, Issue 5, 2009, Pages 464-467

  Stewart, Scott H ^a,b,d   Reuben, Adrian ^a   Brzezinski, Walter A ^b   Koch, David G ^a   Basile, Jan ^c   Randall, Patrick K ^a   Miller, Peter M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^d Center for Drug and Alcohol Programs   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLETHANOLAMINE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERTENSION; LIVER DISEASE; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SELF REPORT;

ADULT; ALCOHOL DRINKING; FEMALE; GLYCEROPHOSPHOLIPIDS; HUMANS; HYPERTENSION; LIVER DISEASES; MALE; MIDDLE AGED; PREVALENCE; SEVERITY OF ILLNESS INDEX;

EID: 70249089999     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agp039     Document Type: Article

References (23)

1. Allen JP. (2003) Use of biomarkers of heavy drinking in health care practice. Mil Med 168:364-7.
2. Anton RF. (2001) Carbohydrate-deficient transferrin for detection and monitoring of sustained heavy drinking. What have we learned? Where do we go from here? Alcohol 25:185-8.
3. Aradottir S, Asanovska G, Gjerss S et al. (2006) Phosphatidylethanol (PEth) concentrations in blood are correlated to reported alcohol intake in alcohol-dependent patients. Alcohol Alcohol 41:431-7.
4. Austin PC, Escobar M, Kopec JA. (2000) The use of the Tobit model for analyzing measures of health status. Qual Life Res 9:901-10.
5. Babor TF, Steinberg K, Anton R et al. (2000) Talk is cheap:mEasuring drinking outcomes in clinical trials. J Stud Alcohol 61:55-63.
6. Butikofer P, Yee MC, Schott MA et al. (1993) Generation of phosphatidic acid during calcium-loading of human erythrocytes. Evidence for a phosphatidylcholine-hydrolyzing phospholipase D. Eur J Biochem 213:367-75.
7. Conigrave KM, Davies P, Haber P et al. (2003) Traditional markers of excessive alcohol use. Addiction 98(Suppl 2):31-43.
8. Del Boca FK, Darkes J. (2003) The validity of self-reports of alcohol consumption: State of the science and challenges for research. Addiction 98(Suppl 2):1-12.
9. DiMartini A, Day N, Lane T et al. (2001) Carbohydrate deficient transferrin in abstaining patients with end-stage liver disease. Alcohol Clin Exp Res 25:1729-33.
10. Gunnarsson T, Karlsson A, Hansson P et al. (1998) Determination of phosphatidylethanol in blood from alcoholic males using high-performance liquid chromatography and evaporative light scattering or electrospray mass spectrometric detection. J Chromatogr B Biomed Sci Appl 705:243-9.
11. Gustavsson L. (1995) Phosphatidylethanol formation: Specific effects of ethanol mediated via phospholipase D. Alcohol Alcohol 30 391-406.
12. Hansson P, Caron M, Johnson G et al. (1997) Blood phosphatidylethanol as a marker of alcohol abuse: Levels in alcoholic males during withdrawal. Alcohol Clin Exp Res 21:108-10.
13. Hartmann S, Aradottir S, Graf M et al. (2007) Phosphatidylethanol as a sensitive and specific biomarker: Comparison with gamma-glutamyl transpeptidase, mean corpuscular volume and carbohydrate-deficient transferrin. Addict Biol 12:81-4.
14. Heinemann A, Sterneck M, Kuhlencordt R et al. (1998) Carbohydrate-deficient transferrin: Diagnostic efficiency among patients with endstage liver disease before and after liver transplantation. Alcohol Clin Exp Res 22:1806-12.
15. Kamath PS, Wiesner RH, Malinchoc M et al. (2001) A model to predict survival in patients with end-stage liver disease. Hepatology 33:464-70.
16. Kip MJ, Spies CD, Neumann T et al. (2008) The usefulness of direct ethanol metabolites in assessing alcohol intake in nonintoxicated male patients in an emergency room setting. Alcohol Clin Exp Res 32 1284-91.
17. National Institute on Alcohol Abuse and Alcoholism. (2007) Helping Patients Who Drink Too Much: A Clinician's Guide. Bethesda, MD: US Department of Health and Human Services.
18. Nissinen AE, Makela SM, Vuoristo JT et al. (2008) Immunological detection of in vitro formed phosphatidylethanol - an alcohol biomarker - with monoclonal antibodies. Alcohol Clin Exp Res 32 921-8.
19. Palmer RB. (2009) A review of the use of ethyl glucuronide as a marker for ethanol consumption in forensic and clinical medicine. Semin Diagn Pathol 26:18-27.
20. Saitz R. (2003) Overview of medical and surgical complications. In Graham AW, Schultz TK, Mayo-Smith MF, Ries RK, Wilford BB (eds). Principles of Addiction Medicine. Chevy Chase, MD: American Society of Addiction Medicine, 1027-52.
21. Sobell L, Sobell M. (1992) Timeline follow-back: A technique for assessing self-reported ethanol consumption. In Litten RZ, Allen JP (eds). Measuring Alcohol Consumption: Psychological and Biological Methods. Totowa, NJ: Humana Press, 41-72.
22. Varga A, Alling C. (2002) Formation of phosphatidylethanol in vitro in red blood cells from healthy volunteers and chronic alcoholics. J Lab Clin Med 140:79-83.
23. Varga A, Hansson P, Johnson G et al. (2000) Normalization rate and cellular localization of phosphatidylethanol in whole blood from chronic alcoholics. Clin Chim Acta 299:141-50.