메뉴 건너뛰기




Volumn 7 1, Issue , 2009, Pages 59-69

Pharmacogenetics strategies: From candidate genes to whole-genome association analysis. Exploratory or confirmatory studies?

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADDUCIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSINOGEN; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; COUMARIN DERIVATIVE; CYTOCHROME P450 2C9; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLIBENCLAMIDE; GLIMEPIRIDE; GLYCINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RENIN; SALICYLIC ACID; TOLBUTAMIDE; TRYPTOPHAN; WARFARIN; COUMARIN;

EID: 70249083839     PISSN: 18756921     EISSN: 18756913     Source Type: Journal    
DOI: 10.2174/187569209787582367     Document Type: Review
Times cited : (4)

References (54)
  • 1
    • 0036448441 scopus 로고    scopus 로고
    • Pharmacogenetic approaches to hypertension therapy; design and rationale for the genetics of Hypertension Associate (GenHAT) study
    • Arnett, D. K.; Boerwinkle, E.; Davis, B. R.; Eckfeldt, J.; Ford, C. E. and Black, H. (2002) Pharmacogenetic approaches to hypertension therapy; design and rationale for the genetics of Hypertension Associate (GenHAT) study. Pharmacogenomics J. 2, 309-317.
    • (2002) Pharmacogenomics J , vol.2 , pp. 309-317
    • Arnett, D.K.1    Boerwinkle, E.2    Davis, B.R.3    Eckfeldt, J.4    Ford, C.E.5    Black, H.6
  • 2
    • 33748804424 scopus 로고    scopus 로고
    • A tutorial on statistical methods for population association studies
    • Balding, D. J. (2006) A tutorial on statistical methods for population association studies. Nat. Rev. 7, 781-791.
    • (2006) Nat. Rev , vol.7 , pp. 781-791
    • Balding, D.J.1
  • 3
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barret, J. C.; Fry, B.; Moller, J. and Daily, M. J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barret, J.C.1    Fry, B.2    Moller, J.3    Daily, M.J.4
  • 6
    • 22044433685 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants ofacenocoumarol sensitivity
    • Bodin, L.; Verstuyft, C.; Tregouet, D. A.; Robert, A.; Dubert, L. and Funck-Brentano, C. (2005) Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants ofacenocoumarol sensitivity. Blood 106, 135-140.
    • (2005) Blood , vol.106 , pp. 135-140
    • Bodin, L.1    Verstuyft, C.2    Tregouet, D.A.3    Robert, A.4    Dubert, L.5    Funck-Brentano, C.6
  • 7
    • 33845870419 scopus 로고    scopus 로고
    • Deconstructing schizophrenia; an overview of the use of endophenotypes in order to understand a complex disease
    • Braff, D. L.; Freedman, R.; Schork, N. J. and Gottesman, I. I. (2007) Deconstructing schizophrenia; an overview of the use of endophenotypes in order to understand a complex disease. Schizophrenia Bull. 33, 21-32.
    • (2007) Schizophrenia Bull , vol.33 , pp. 21-32
    • Braff, D.L.1    Freedman, R.2    Schork, N.J.3    Gottesman, I.I.4
  • 8
    • 79959524146 scopus 로고    scopus 로고
    • Consortium I. H. A. (2005) A haplotype map of the Human Genome. Nature 437, 1299-1320.
    • Consortium I. H. A. (2005) A haplotype map of the Human Genome. Nature 437, 1299-1320.
  • 9
    • 50249142263 scopus 로고    scopus 로고
    • A pharmacogenomics primer
    • Court, M. H. A. (2007) A pharmacogenomics primer. J. Clin. Pharmacol. 47, 1087-1113.
    • (2007) J. Clin. Pharmacol , vol.47 , pp. 1087-1113
    • Court, M.H.A.1
  • 10
    • 34547994995 scopus 로고    scopus 로고
    • Simultaneous genotyping of CYP2D6*3,*4,*5 and *6 polymorphisms in a Spanish population through multiplex long-PCR and minisequencing multiplex Single Base Extension (SBE) Analysis
    • Crescenti, A.; Mas, S.; Gasso, P.; Baiget, M.; Bernardo, M. and Lafuente, A. (2007) Simultaneous genotyping of CYP2D6*3,*4,*5 and *6 polymorphisms in a Spanish population through multiplex long-PCR and minisequencing multiplex Single Base Extension (SBE) Analysis. Clin. Exp. Pharmacol. Psysiol. 34, 992-997.
    • (2007) Clin. Exp. Pharmacol. Psysiol , vol.34 , pp. 992-997
    • Crescenti, A.1    Mas, S.2    Gasso, P.3    Baiget, M.4    Bernardo, M.5    Lafuente, A.6
  • 11
    • 0030858832 scopus 로고    scopus 로고
    • The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase
    • Crespi, C. L. and Miller, V. P. (1997) The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase. Pharmacogenetics. 7, 203-210.
    • (1997) Pharmacogenetics , vol.7 , pp. 203-210
    • Crespi, C.L.1    Miller, V.P.2
  • 14
    • 34547554358 scopus 로고    scopus 로고
    • UNPHASED user guide
    • Technical report 2006/5, MRC Biostatistics Unit, Cambridge, UK
    • Dudbridge, F. UNPHASED user guide. Technical report 2006/5, MRC Biostatistics Unit, Cambridge, UK.
    • Dudbridge, F.1
  • 15
    • 34447536645 scopus 로고    scopus 로고
    • Recent development in pharmacogenomics: From candidate genes to genome-wide association studies
    • Grant, S. F. and Hakonarson, H. (2007) Recent development in pharmacogenomics: from candidate genes to genome-wide association studies. Expert Rev. Mol. Diagn. 7, 371-393.
    • (2007) Expert Rev. Mol. Diagn , vol.7 , pp. 371-393
    • Grant, S.F.1    Hakonarson, H.2
  • 17
    • 0030587544 scopus 로고    scopus 로고
    • Allelic variants of human cytochrome P450 2C9: Baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms
    • Haining, R. L.; Hunter, A. P.; Veronese, M. E.; Trager, W. F. and Rettie, A. E. (1996) Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms. Arch. Biochem. Biophys. 333, 447-458.
    • (1996) Arch. Biochem. Biophys , vol.333 , pp. 447-458
    • Haining, R.L.1    Hunter, A.P.2    Veronese, M.E.3    Trager, W.F.4    Rettie, A.E.5
  • 18
    • 33846598002 scopus 로고    scopus 로고
    • Integrating large-scale genotype and phenotype data
    • Hernandez-Boussard, T.; Woom, M.; Klein, T. E. and Altman, R. B. (2006) Integrating large-scale genotype and phenotype data. OMICS 10, 545-550.
    • (2006) OMICS , vol.10 , pp. 545-550
    • Hernandez-Boussard, T.1    Woom, M.2    Klein, T.E.3    Altman, R.B.4
  • 20
    • 0025767240 scopus 로고
    • Determinants of disease and disability in the elderly; the Rotterdam elderly study
    • Hofman, A.; Grobbee, D. E.; de Jong, P. T. and van den Ouweland, F. A. (1991) Determinants of disease and disability in the elderly; the Rotterdam elderly study. Eur. J. Epidemiol. 7, 403-422.
    • (1991) Eur. J. Epidemiol , vol.7 , pp. 403-422
    • Hofman, A.1    Grobbee, D.E.2    de Jong, P.T.3    van den Ouweland, F.A.4
  • 22
    • 34248580622 scopus 로고    scopus 로고
    • Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients
    • Kimura, R.; Miyashida, K.; Kokubo, Y.; Akaiwa, Y.; Otsubo, R. and Nagatsuka, K. (2007) Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients. Thromb. Res. 120, 181-186
    • (2007) Thromb. Res , vol.120 , pp. 181-186
    • Kimura, R.1    Miyashida, K.2    Kokubo, Y.3    Akaiwa, Y.4    Otsubo, R.5    Nagatsuka, K.6
  • 23
    • 11244298063 scopus 로고    scopus 로고
    • High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumors
    • Koed, K.; Wiuf, C.; Christensen, L. L.; Wikman, F. P.; Zieger, K.; Møller, K.; von der Maase, H. and Orntoft, T. F. (2005) High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumors. Cancer Res. 65, 34-45.
    • (2005) Cancer Res , vol.65 , pp. 34-45
    • Koed, K.1    Wiuf, C.2    Christensen, L.L.3    Wikman, F.P.4    Zieger, K.5    Møller, K.6    von der Maase, H.7    Orntoft, T.F.8
  • 24
    • 33645466595 scopus 로고    scopus 로고
    • Bayesian toolkit for genetic association studies
    • Lumm, D. J.; Whittaker, J. C. and Best, N. (2006) Bayesian toolkit for genetic association studies. Genet. Epidemiol. 30, 231-247.
    • (2006) Genet. Epidemiol , vol.30 , pp. 231-247
    • Lumm, D.J.1    Whittaker, J.C.2    Best, N.3
  • 25
    • 34447639823 scopus 로고    scopus 로고
    • DNA cards: Determinants of DNA yield and quality in collecting genetic samples for pharmacogenetic studies
    • Mas, S.; Crescenti, A.; Gassó, P.; Vidal-Taboada, J. M. and Lafuente, A. (2007) DNA cards: Determinants of DNA yield and quality in collecting genetic samples for pharmacogenetic studies. Basic Clin. Pharmacol. Toxicol. 101, 132-137.
    • (2007) Basic Clin. Pharmacol. Toxicol , vol.101 , pp. 132-137
    • Mas, S.1    Crescenti, A.2    Gassó, P.3    Vidal-Taboada, J.M.4    Lafuente, A.5
  • 26
    • 33745071279 scopus 로고    scopus 로고
    • Simultaneous genotyping of CYP2C9*2, *3, and 5′ flanking region (C-1189T) polymorphisms in a Spanish population through a new minisequencing multiplex single-base extension analysis
    • Mas, S.; Crescenti, A.; Vidal-Taboada, J. M.; Bergonon, S.; Cuevillas, F.; Laso, N. and Lafuente, A. (2005) Simultaneous genotyping of CYP2C9*2, *3, and 5′ flanking region (C-1189T) polymorphisms in a Spanish population through a new minisequencing multiplex single-base extension analysis. Eur. J. Clin. Pharmacol. 61, 635-641.
    • (2005) Eur. J. Clin. Pharmacol , vol.61 , pp. 635-641
    • Mas, S.1    Crescenti, A.2    Vidal-Taboada, J.M.3    Bergonon, S.4    Cuevillas, F.5    Laso, N.6    Lafuente, A.7
  • 27
    • 43049122356 scopus 로고    scopus 로고
    • From human genetics and genomics to pharmacogenetics and pharmacogenomics: Past lessons, future directions
    • Nebert, D. W.; Zhang, G. and Vesell, E. S. (2008) From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions. Drug Metab. Rev. 40, 187-224.
    • (2008) Drug Metab. Rev , vol.40 , pp. 187-224
    • Nebert, D.W.1    Zhang, G.2    Vesell, E.S.3
  • 28
    • 20044375763 scopus 로고    scopus 로고
    • Array comparative genomic hybridization and its application in cancer
    • Pinkel, D. and Albertson, D. G. (2005) Array comparative genomic hybridization and its application in cancer. Nat. Genet. 37, 11-17.
    • (2005) Nat. Genet , vol.37 , pp. 11-17
    • Pinkel, D.1    Albertson, D.G.2
  • 29
    • 27644481779 scopus 로고    scopus 로고
    • A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk
    • Reitsma, P. H.; van der Heijden, J. F.; Groot, A. P.; Rosendaal, F. R. and Buller, H. R. (2005) A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk. PLoS Med. 2, e312.
    • (2005) PLoS Med , vol.2
    • Reitsma, P.H.1    van der Heijden, J.F.2    Groot, A.P.3    Rosendaal, F.R.4    Buller, H.R.5
  • 32
    • 10744228888 scopus 로고    scopus 로고
    • Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
    • Rost, S.; Fregin, A.; Ivaskevicius, V.; Conzelmann, E.; Hortnagel, K. and Pelz, H. J. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 427, 537-541.
    • (2004) Nature , vol.427 , pp. 537-541
    • Rost, S.1    Fregin, A.2    Ivaskevicius, V.3    Conzelmann, E.4    Hortnagel, K.5    Pelz, H.J.6
  • 34
    • 36549032598 scopus 로고    scopus 로고
    • Avoiding false discoveries in association studies
    • Sabbati, C. (2007) Avoiding false discoveries in association studies. Methods Mol. Biol. 376, 195-211.
    • (2007) Methods Mol. Biol , vol.376 , pp. 195-211
    • Sabbati, C.1
  • 35
    • 13844315559 scopus 로고    scopus 로고
    • CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: A HuGEnet systematic review and meta-analysis
    • Sanderson, S.; Emery, J. and Higgins, J. (2005) CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis. Genet. Med. 7, 97-104.
    • (2005) Genet. Med , vol.7 , pp. 97-104
    • Sanderson, S.1    Emery, J.2    Higgins, J.3
  • 38
    • 23044440450 scopus 로고    scopus 로고
    • The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: Proposal for a new dosing regimen
    • Sconce, E. A.; Khan, T. I.; Wynne, H. A.; Avery, P.; Monkhouse, L. and King, B. P. (2005) The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen. Blood 106, 2329-2333.
    • (2005) Blood , vol.106 , pp. 2329-2333
    • Sconce, E.A.1    Khan, T.I.2    Wynne, H.A.3    Avery, P.4    Monkhouse, L.5    King, B.P.6
  • 39
    • 20044388557 scopus 로고    scopus 로고
    • From signatures to models: Understanding cancer with microarrays
    • Segal, E.; Friedman, N.; Kaminski, N.; Reger, A. and Koller, D. (2005) From signatures to models: understanding cancer with microarrays. Nat. Genet. 37, 38-45.
    • (2005) Nat. Genet , vol.37 , pp. 38-45
    • Segal, E.1    Friedman, N.2    Kaminski, N.3    Reger, A.4    Koller, D.5
  • 40
    • 13844292408 scopus 로고    scopus 로고
    • Sigurdsson, S.; Nordmark, G.; Göring, H. H.; Lindroos, K.; Wiman, A. C.; Sturfelt, G.; Jönsen, A.; Rantapää-Dahlqvist, S.; Möller, B.; Kere, J.; Koskenmies, S.; Widén, E.; Eloranta, M. L.; Julkunen, H.; Kristjansdottir, H.; Steinsson, K.; Alm, G.; Rönnblom, L. and Syvänen, A. C. (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am. J. Hum. Genet. 76, 528-537.
    • Sigurdsson, S.; Nordmark, G.; Göring, H. H.; Lindroos, K.; Wiman, A. C.; Sturfelt, G.; Jönsen, A.; Rantapää-Dahlqvist, S.; Möller, B.; Kere, J.; Koskenmies, S.; Widén, E.; Eloranta, M. L.; Julkunen, H.; Kristjansdottir, H.; Steinsson, K.; Alm, G.; Rönnblom, L. and Syvänen, A. C. (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am. J. Hum. Genet. 76, 528-537.
  • 41
    • 70249084113 scopus 로고    scopus 로고
    • Toward genome-wide genotyping
    • Syvänen, A. C. (2005) Toward genome-wide genotyping. Nat. Genet. 37, 555-510.
    • (2005) Nat. Genet , vol.37 , pp. 555-510
    • Syvänen, A.C.1
  • 42
    • 0031030620 scopus 로고    scopus 로고
    • The effect of aggressive lowering low-density lipoprotein cholesterol levels and low-dose anticuagulation on obstructive changes in saphenous vein coronary artery bypass graft
    • The Post Coronary Artery Bypass Graft Trial Investigators
    • The Post Coronary Artery Bypass Graft Trial Investigators. (1997) The effect of aggressive lowering low-density lipoprotein cholesterol levels and low-dose anticuagulation on obstructive changes in saphenous vein coronary artery bypass graft. N. Engl. J. Med. 336, 153-162.
    • (1997) N. Engl. J. Med , vol.336 , pp. 153-162
  • 45
    • 25144502325 scopus 로고    scopus 로고
    • Association of vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population
    • Veenstra, D. L.; You, J. H.; Rieder, M. J.; Farin, F. M.; Wilkerson, H. W. and Blough, D. K. (2005) Association of vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population. Pharmacogenet. Genomics 15, 687-691.
    • (2005) Pharmacogenet. Genomics , vol.15 , pp. 687-691
    • Veenstra, D.L.1    You, J.H.2    Rieder, M.J.3    Farin, F.M.4    Wilkerson, H.W.5    Blough, D.K.6
  • 46
    • 33745071571 scopus 로고    scopus 로고
    • Satisfaction survey with DNA cards method to collect genetic sample for pharmacogenetic studies
    • Vidal-Taboada, J. M.; Cucala, M.; Mas, S.; Lafuente, A. and Cobos, A. (2006) Satisfaction survey with DNA cards method to collect genetic sample for pharmacogenetic studies. BMC Med. Genet. 7, 45.
    • (2006) BMC Med. Genet , vol.7 , pp. 45
    • Vidal-Taboada, J.M.1    Cucala, M.2    Mas, S.3    Lafuente, A.4    Cobos, A.5
  • 50
    • 34147162376 scopus 로고    scopus 로고
    • Pharmacogenetics of warfarin; current status and future challenges
    • Wadelius, M. and Pirmohamed, M. (2007) Pharmacogenetics of warfarin; current status and future challenges. Pharmacogenomics J. 7, 99-111.
    • (2007) Pharmacogenomics J , vol.7 , pp. 99-111
    • Wadelius, M.1    Pirmohamed, M.2
  • 51
    • 34247141066 scopus 로고    scopus 로고
    • Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1-rationale and perspectives
    • Yin, T. and Miyata, T. (2007) Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1-rationale and perspectives. Thromb. Res. 120, 1-10.
    • (2007) Thromb. Res , vol.120 , pp. 1-10
    • Yin, T.1    Miyata, T.2
  • 52
    • 24944503322 scopus 로고    scopus 로고
    • A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity
    • Yuan, H. Y.; Chen, J. J.; Lee, M. T.; Wung, J. C.; Chen, Y. F. and Charng, M. J. (2005) A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. Hum. Mol. Genet. 14, 1745-1751.
    • (2005) Hum. Mol. Genet , vol.14 , pp. 1745-1751
    • Yuan, H.Y.1    Chen, J.J.2    Lee, M.T.3    Wung, J.C.4    Chen, Y.F.5    Charng, M.J.6
  • 53
    • 32044468293 scopus 로고    scopus 로고
    • Integrated analysis of genetic data with R
    • Zhao, J. H. and Tan, Q. (2006) Integrated analysis of genetic data with R. Hum. Genomics 2, 258-265.
    • (2006) Hum. Genomics , vol.2 , pp. 258-265
    • Zhao, J.H.1    Tan, Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.