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Volumn 2, Issue 5, 2002, Pages 309-317

Pharmacogenetic approaches to hypertension therapy: Design and rationale for the Genetics of Hypertension Associated Treatment (GenHAT) study

Author keywords

Amlodipine; Chlorthalldone; Doxazosin; Hypertension; Pharmacogenetics:Genetic polymorphism

Indexed keywords

ADDUCIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMLODIPINE; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ATENOLOL; BETA 2 ADRENERGIC RECEPTOR; CALCIUM CHANNEL BLOCKING AGENT; CAPTOPRIL; CHLORTALIDONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; DOXAZOSIN; ENALAPRIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCHLOROTHIAZIDE; LIPOPROTEIN LIPASE; LISINOPRIL; LOSARTAN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NIFEDIPINE; PLACEBO; PRAVASTATIN; TRIACYLGLYCEROL;

EID: 0036448441     PISSN: 1470269X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500113     Document Type: Article
Times cited : (52)

References (35)
  • 1
    • 0033848124 scopus 로고    scopus 로고
    • Genetic mapping and tailored antihypertensive therapy
    • Ferrari P, Bianchi G. Genetic mapping and tailored antihypertensive therapy. Cardiovasc Drugs Ther 2000; 14: 387-395.
    • (2000) Cardiovasc. Drugs Ther. , vol.14 , pp. 387-395
    • Ferrari, P.1    Bianchi, G.2
  • 2
    • 0031871488 scopus 로고    scopus 로고
    • Genetics of hypertension. Therapeutic implications
    • O'Byrne S, Caulfield M. Genetics of hypertension. Therapeutic implications. Drugs 1998; 56: 203-214.
    • (1998) Drugs , vol.56 , pp. 203-214
    • O'Byrne, S.1    Caulfield, M.2
  • 3
    • 0032616028 scopus 로고    scopus 로고
    • Genomics and hypertension: Concepts, potentials, and opportunities
    • Pratt RE, Dzau VJ. Genomics and hypertension: concepts, potentials, and opportunities. Hypertension 1999; 33: 238-247.
    • (1999) Hypertension , vol.33 , pp. 238-247
    • Pratt, R.E.1    Dzau, V.J.2
  • 4
    • 0030898258 scopus 로고    scopus 로고
    • Polymorphisms of α-adducin and salt sensitivity in patients with essential hypertension
    • Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M et al. Polymorphisms of α-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997; 349: 1353-1357.
    • (1997) Lancet , vol.349 , pp. 1353-1357
    • Cusi, D.1    Barlassina, C.2    Azzani, T.3    Casari, G.4    Citterio, L.5    Devoto, M.6
  • 5
    • 0034685403 scopus 로고    scopus 로고
    • The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone
    • ALLHAT Collaborative Research Group
    • ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone. JAMA 2000; 283: 1967-1975.
    • (2000) JAMA , vol.283 , pp. 1967-1975
  • 6
    • 0029918188 scopus 로고    scopus 로고
    • Rationale and design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • Davis BR, Cutler JA, Gordon DJ, Furberg CD, Wright JT Jr, Cushman WC et al. Rationale and design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Amer J Hypertens 1996; 9: 342-360.
    • (1996) Amer. J. Hypertens. , vol.9 , pp. 342-360
    • Davis, B.R.1    Cutler, J.A.2    Gordon, D.J.3    Furberg, C.D.4    Wright J.T., Jr.5    Cushman, W.C.6
  • 7
    • 0028216652 scopus 로고
    • Molecular cloning and characterization of the promoter for human type-1 angiotensin II receptor gene
    • Takayanagi R, Ohnaka K, Sakai Y, Ikuyama S, Nawata H. Molecular cloning and characterization of the promoter for human type-1 angiotensin II receptor gene. Biochem Biophys Res Commun 1994; 200: 1264-1270.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 1264-1270
    • Takayanagi, R.1    Ohnaka, K.2    Sakai, Y.3    Ikuyama, S.4    Nawata, H.5
  • 9
    • 15844419531 scopus 로고    scopus 로고
    • Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22
    • Wu D-A, Bu X, Warden CH, Shen DDC, Jeng C-Y, Sheu WHH et al. Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. J Clin Invest. 1996; 97: 2111-2118.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2111-2118
    • Wu, D.-A.1    Bu, X.2    Warden, C.H.3    Shen, D.D.C.4    Jeng, C.-Y.5    Sheu, W.H.H.6
  • 10
    • 0035202533 scopus 로고    scopus 로고
    • Influence of lipoprotein lipase serine 447 stop polymorphism on tracking triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: The Bogalusa heart study
    • Dec
    • Chen W, Srinivasan SR, Elkasabany A, Ellsworth DL, Boerwinkle E, Berenson GS. Influence of lipoprotein lipase serine 447 stop polymorphism on tracking triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: the Bogalusa heart study. Antherosclerosis 2001 Dec; 159(2): 367-73.
    • (2001) Antherosclerosis , vol.159 , Issue.2 , pp. 367-373
    • Chen, W.1    Srinivasan, S.R.2    Elkasabany, A.3    Ellsworth, D.L.4    Boerwinkle, E.5    Berenson, G.S.6
  • 11
    • 0027564307 scopus 로고
    • Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects
    • Reihsaus E, Innis M, MacIntyre N, Liggett SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993; 8: 334-339.
    • (1993) Am. J. Respir. Cell Mol. Biol. , vol.8 , pp. 334-339
    • Reihsaus, E.1    Innis, M.2    MacIntyre, N.3    Liggett, S.B.4
  • 12
    • 18344398465 scopus 로고
    • A biallelic DNA polymorphism of the human -adrenergic receptor detected by Ban 1-Adrbr-2
    • Lentes K, Berrettini W, Hoeche M, Chung F, Gershon E. A biallelic DNA polymorphism of the human -adrenergic receptor detected by Ban 1-Adrbr-2. Nucleic Acids Res 1988; 16: 2359.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 2359
    • Lentes, K.1    Berrettini, W.2    Hoeche, M.3    Chung, F.4    Gershon, E.5
  • 13
    • 0029834131 scopus 로고    scopus 로고
    • The American Society of Human Genetics ASHG Report-Statement on informed consent for genetic research
    • Anonymous
    • Anonymous. The American Society of Human Genetics ASHG Report-Statement on informed consent for genetic research. Am J Hum Genet 1996; 59: 471-474.
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 471-474
  • 14
    • 0027136747 scopus 로고
    • Sample size requirement and length of study for testing interaction in a 2 × 4 factorial design when time-to-failure is the outcome
    • Peterson B, George SL. Sample size requirement and length of study for testing interaction in a 2 × 4 factorial design when time-to-failure is the outcome. Cont Clin Trials 1993; 14: 511-522.
    • (1993) Cont. Clin. Trials , vol.14 , pp. 511-522
    • Peterson, B.1    George, S.L.2
  • 15
    • 0034530370 scopus 로고    scopus 로고
    • Practical guidelines for multiplicity adjustment in clinical trials
    • Proschan MA, Waclawiw MA. Practical guidelines for multiplicity adjustment in clinical trials. Cont Clin Trials 2000; 21: 527-539.
    • (2000) Cont. Clin. Trials , vol.21 , pp. 527-539
    • Proschan, M.A.1    Waclawiw, M.A.2
  • 16
    • 0034824306 scopus 로고    scopus 로고
    • Baseline characteristics of the diabetic participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • Barzilay JI, Jones CL, Davis BR, Basile JN, Goff DC Jr, Ciocon JO et al. Baseline characteristics of the diabetic participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Diabetes Care 2001; 24: 654-658.
    • (2001) Diabetes Care , vol.24 , pp. 654-658
    • Barzilay, J.I.1    Jones, C.L.2    Davis, B.R.3    Basile, J.N.4    Goff D.C., Jr.5    Ciocon, J.O.6
  • 17
    • 0035156493 scopus 로고    scopus 로고
    • Baseline characteristics of participants in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • Grimm RH, Margolis KL, Papademetriou V, Cushman WC, Ford CE, Bettencourt J et al. Baseline characteristics of participants in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Hypertension 2001; 37: 19-27.
    • (2001) Hypertension , vol.37 , pp. 19-27
    • Grimm, R.H.1    Margolis, K.L.2    Papademetriou, V.3    Cushman, W.C.4    Ford, C.E.5    Bettencourt, J.6
  • 19
    • 0035957262 scopus 로고    scopus 로고
    • Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    • McNamara DM, Holubkov R, Janosko K, Palmer A, Wang JJ, MacGowan GA et al. Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. Circulation 2001; 103: 1644-1648.
    • (2001) Circulation , vol.103 , pp. 1644-1648
    • McNamara, D.M.1    Holubkov, R.2    Janosko, K.3    Palmer, A.4    Wang, J.J.5    MacGowan, G.A.6
  • 22
    • 0025165779 scopus 로고
    • An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels
    • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1343-1346
    • Rigat, B.1    Hubert, C.2    Alhenc-Gelas, F.3    Cambien, F.4    Corvol, P.5    Soubrier, F.6
  • 23
    • 0029738658 scopus 로고    scopus 로고
    • A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction
    • Samani NJ, Thompson JR, O'Toole L, Channer K, Woods KL. A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction. Circulation 1996; 94: 708-712.
    • (1996) Circulation , vol.94 , pp. 708-712
    • Samani, N.J.1    Thompson, J.R.2    O'Toole, L.3    Channer, K.4    Woods, K.L.5
  • 24
    • 0030893575 scopus 로고    scopus 로고
    • A nucleotide substitution in the promotor of human angiotensinogen is associated with essential hypertension and affects basal transcription in vivo
    • Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M et al. A nucleotide substitution in the promotor of human angiotensinogen is associated with essential hypertension and affects basal transcription in vivo. J Clin Invest 1997; 99: 1786-1797.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1786-1797
    • Inoue, I.1    Nakajima, T.2    Williams, C.S.3    Quackenbush, J.4    Puryear, R.5    Powers, M.6
  • 25
    • 0028294357 scopus 로고
    • Renal and cardiovascular mechanisms of hypertension in obesity
    • Hall JE. Renal and cardiovascular mechanisms of hypertension in obesity. Hypertension 1994; 23: 381-394.
    • (1994) Hypertension , vol.23 , pp. 381-394
    • Hall, J.E.1
  • 28
    • 0029550501 scopus 로고
    • Association of angiotensin I-converting enzyme gene polymorphism with susceptibility to antiproteinuric effect of angiotensin I-converting enzyme inhibitors in patients with proteinuria
    • Moriyama T, Kitamura H, Ochi S, Izumi M, Yokoyama K, Yamauchi A et al. Association of angiotensin I-converting enzyme gene polymorphism with susceptibility to antiproteinuric effect of angiotensin I-converting enzyme inhibitors in patients with proteinuria. J Am Soc Nephrol 1995; 6: 1676-1678.
    • (1995) J. Am. Soc. Nephrol. , vol.6 , pp. 1676-1678
    • Moriyama, T.1    Kitamura, H.2    Ochi, S.3    Izumi, M.4    Yokoyama, K.5    Yamauchi, A.6
  • 29
    • 0030474233 scopus 로고    scopus 로고
    • Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies
    • Sasaki M, Oki T, Iuchi A, Tabata T, Yamada H, Manabe K et al. Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies. J Hypertens 1996; 14: 1403-1408.
    • (1996) J. Hypertens. , vol.14 , pp. 1403-1408
    • Sasaki, M.1    Oki, T.2    Iuchi, A.3    Tabata, T.4    Yamada, H.5    Manabe, K.6
  • 30
    • 0029880851 scopus 로고    scopus 로고
    • Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: Investigation of renin-angiotensin system genes
    • Dudley C, Keavney B, Casadei B, Conway J, Bird R, Ratcliffe P. Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes. J Hypertens 1996; 4: 259-262.
    • (1996) J. Hypertens. , vol.4 , pp. 259-262
    • Dudley, C.1    Keavney, B.2    Casadei, B.3    Conway, J.4    Bird, R.5    Ratcliffe, P.6
  • 31
    • 0028848097 scopus 로고
    • Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy
    • Yoshida H, Mitarai T, Kawamura T, Kitajima T, Miyazaki Y, Nagasawa R et al. Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy. J Clin Invest. 1995; 96: 2100-2102.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2100-2102
    • Yoshida, H.1    Mitarai, T.2    Kawamura, T.3    Kitajima, T.4    Miyazaki, Y.5    Nagasawa, R.6
  • 32
    • 0031673596 scopus 로고    scopus 로고
    • Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure
    • O'Toole L, Stewart M, Padfield P, Channer K. Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure. J Cardio Pharmacol 1998; 32: 988-994.
    • (1998) J. Cardio. Pharmacol. , vol.32 , pp. 988-994
    • O'Toole, L.1    Stewart, M.2    Padfield, P.3    Channer, K.4
  • 33
    • 0033134676 scopus 로고    scopus 로고
    • Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors
    • Kohno M, Yokokawa K, Minami M, Kano H, Yasunari K, Hanehira T et al. Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors. Am J Med 1999; 106: 544-549.
    • (1999) Am. J. Med. , vol.106 , pp. 544-549
    • Kohno, M.1    Yokokawa, K.2    Minami, M.3    Kano, H.4    Yasunari, K.5    Hanehira, T.6
  • 34
    • 0033858212 scopus 로고    scopus 로고
    • Regression of left ventricular hypertrophy by lisinopril after renal transplantation: Role of ACE gene polymorphism
    • Hernandez D, Lacalzada J, Salido E, Linares J, Barragan A, Lorenzo V et al. Regression of left ventricular hypertrophy by lisinopril after renal transplantation: role of ACE gene polymorphism. Kidney Int 2000; 58: 889-897.
    • (2000) Kidney Int. , vol.58 , pp. 889-897
    • Hernandez, D.1    Lacalzada, J.2    Salido, E.3    Linares, J.4    Barragan, A.5    Lorenzo, V.6
  • 35
    • 0035895320 scopus 로고    scopus 로고
    • Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: A randomized controlled trial with Losartan
    • Myerson SG, Montgomery HE, Whittingham M, Jubb M, World MJ, Humphries SE et al. Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: a randomized controlled trial with Losartan. Circulation 2001; 103: 226-230.
    • (2001) Circulation , vol.103 , pp. 226-230
    • Myerson, S.G.1    Montgomery, H.E.2    Whittingham, M.3    Jubb, M.4    World, M.J.5    Humphries, S.E.6


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