Epidemiological, clinical and therapeutic aspects of Bothrops asper bites

Toxicon

Volumn 54, Issue 7, 2009, Pages 998-1011

  Otero Patiño, Rafael ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

Ancillary treatment; Antivenom; Bothrops asper; Clinical features; Envenoming; Epidemiology; Therapy

Indexed keywords

ADRENALIN; ANTIHISTAMINIC AGENT; CEFTRIAXONE; CIPROFLOXACIN; CLINDAMYCIN; DOPAMINE; ELECTROLYTE; FUROSEMIDE; GLUCOSE; HYDROCORTISONE; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; OXYGEN; PARACETAMOL; PETHIDINE; SNAKE VENOM; SNAKE VENOM ANTISERUM; SULTAMICILLIN; TRAMADOL;

ABORTION; ACUTE KIDNEY FAILURE; AGRICULTURAL WORKER; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ANURIA; ARTICLE; BLEEDING DISORDER; BLISTER; BRAZIL; BRONCHOSPASM; CENTRAL AMERICA; CENTRAL NERVOUS SYSTEM DISEASE; CHILL; CLINICAL FEATURE; CLINICAL TRIAL; COLOMBIA; CONTINUOUS INFUSION; COSTA RICA; DRUG ERUPTION; DRUG FEVER; DRUG HYPERSENSITIVITY; ECCHYMOSIS; EDEMA; ENVENOMATION; FETUS WASTAGE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL SYMPTOM; HEART ARREST; HUMAN; HYPOTENSION; HYPOVOLEMIA; INJECTION SITE BLEEDING; KIDNEY DISEASE; LIVER DISEASE; MEXICO; MUSCLE NECROSIS; NONHUMAN; PAIN; PRIORITY JOURNAL; RURAL AREA; SHOCK; SIDE EFFECT; SKIN NECROSIS; SNAKEBITE; SOFT TISSUE INFECTION; SOLUTIO PLACENTAE; SOUTH AMERICA; SYSTEMIC DISEASE; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTOPENIA; VENOUS RETURN;

ANIMALS; BOTHROPS; CENTRAL AMERICA; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; SNAKE BITES; SOUTH AMERICA;

BOTHROPS ASPER;

EID: 70149120945     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.07.001     Document Type: Article

References (123)

1. Alape-Girón A., Sanz L., Escolano J., Flores-Díaz M., Madrigal M., Sasa M., and Calvete J.J. Snake venomics of the lancehead viper Bothrops asper: geographic, individual and ontogenetic variations. J. Proteom. Res. 7 (2008) 3556-3571
2. Amaral C.F.S., Rezende N.A.D., Silva O.A.D., Ribeiro M.M.F., Magalhães R.A., Reis R.J.D., Carneiro J.G., and Castro J.R.S. Insuficiencia renal aguda secundaria a acidentes ofídicos bothrópico e crotálico. Análise de 63 casos. Rev. Inst. Med. Trop. São Paulo 28 (1986) 220-227
3. a Reimpressão, Ministério da Saúde, Fundação Nacional de Saúde, Brasília. 53 p (1991)
4. Ameratunga B. Middle cerebral occlusion following Russel's viper bite (1972), Ross Institute of Tropical Hygiene, London pp. 95-97
5. Andrade J.G.D., Pinto R.N.L., Andrade A.L.S.S.D., Martelli C.M.T., and Zicker F. Estudo bacteriológico de abscesos causados por picada de serpentes do genero Bothrops. Rev. Inst. Med. Trop. São Paulo 31 (1989) 363-367
6. Arroyo O., Bolaños R., and Muñoz G. The bacterial flora of venoms and mouth cavities of Costa Rican snakes. Bull. Pan. Am. Health Organ. 14 (1980) 280-285
7. Ayerbe S. Ofidismo en Colombia. Enfoque, diagnóstico y tratamiento. In: Ordóñez C.A., Ferrada R., and Buitrago R. (Eds). Cuidado Intensivo y Trauma. 2a. Edición. (2009), Editorial Distribuna, Bogotá 1143-1167 Ofidismo en Colombia
8. Belluomini H.E., De Biasi P., Puorto G., Fernandes W., and Domínguez A.L. Amostras de população de Bothrops atrox (Linneaus 1758) apreciadas nas quantidades de veneno obtidas e dados ecológicos (Serpentes: Viperidae: Crotalinae). Bol. Mus. Para. Emilio Goeldi, sér. Zool. 7 (1991) 53-69
9. Blaylock R.S. Antibiotic use and infection in snakebite victims. S. Afr. Med. J. 89 (1999) 874-876
10. Bolaños R. Serpientes, Venenos y Ofidismo en Centroamérica. Editorial Universidad de Costa Rica, San José. 136p (1984)
11. Bon C. The serum-therapie was discovered 100 years ago. Toxicon 34 (1996) 142-143
12. Broder J., Jerrard D., Olshaker J., and Witting M. Low risk of infection in selected human bites treated without antibiotics. Am. J. Emerg. Med. 22 (2004) 10-13
13. Busch S.P., Hegewald K.G., Green S.M., Cardwell M.D., and Hayes W.K. Effects of a negative pressure venom extraction device (Extractor) on local tissue injury after artificial rattlesnake envenomation in a porcine model. Wilderness Environ. Med. 11 (2000) 180-188
14. Campbell J.A., and Lamar W.W. The Venomous Reptiles of the Western Hemisphere (2004), Cornell University Press, Ithaca, New York
15. Cardoso J.L.C., Fan H.W., França F.O.S., Jorge M.T., Leite R.P., Nishioka S.A., Avila A., Sano-Martins I.S., Tomy S.C., Santoro M.L., Chudzinski A.M., Castro S.C.B., Kamiguti A.S., Kelen E.M.A., Hirata M.H., Mirandola R.M.S., Theakston R.D.G., and Warrell D.A. Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in São Paulo, Brazil. QJM 86 (1993) 315-325
16. Chippaux J.P. Snake Venoms and Envenomations (2006), Krieger Publishing Company, Malabar (FLA) 287p
17. Chippaux J.P., Ramos-Cerrillo B., and Stock R.P. Study of the efficacy of the black stone on envenomation by snakebite in the murine model. Toxicon 49 (2007) 717-720
18. Clark R.F., Selden B.S., and Furbee B. The incidence of wound infection following crotalid envenomation. J. Emerg. Med. 11 (1993) 583-586
19. Cuesta J., Peña L.M., and Zuluaga A.F. Es necesaria la profilaxis antibiótica en la ofidiotoxicosis?. Infectio 12 (2008) 280-289
20. Cupo P., Azevedo- Marques M.M., de Menezes J.B., and Hering S.E. Reaçoes de hipersensibilidade imediatas apos uso intravenoso de soros antivenenos: valor prognostico dos testes de sensibilidade intradermicos. Rev. Inst. Med. Trop. Sao Paulo 33 (1991) 115-122
21. Dao L. Emponzoñamiento ofídico en el estado Lara. Gac. Med. Caracas 79 (1971) 383-410
22. Dart R.C. Can steel heal a compartment syndrome caused by rattlesnake venom?. Ann. Emerg. Med. 44 (2004) 105-107
23. Fan H.W., and França F.O.S. Soroterapia. In: Schvartsman S. (Ed). Plantas Venenosas e Animais Peçonhentos (1992), Sarvier, São Paulo 176-181
24. Fan H.W., and Cardoso J.L. Clinical toxicology of snake bites in South America. In: Meier J., and White J. (Eds). Handbook of Clinical Toxicology of Animal, Venoms and Poisons (1995), CRC Press, Boca Raton 667-688
25. Fan, H.W., Santalucia, M., Oliveira, R.C., 2004. Epidemiology of snakebites in Brazil 18 years after the implementation of the national program for snakebites control. In: VIII Symposium of the Pan American Section of the International Society on Toxinology. Angra dos Reis, RJ-Brazil, p. 171.
26. Fernández P., and Gutiérrez J.M. Mortality due to snakebite envenomation in Costa Rica. Toxicon 52 (2008) 530-533
27. França F.O.S., and Málaque C.M.S.A. Acidente botrópico. In: Cardoso J.L.C., França F.O.S., Fan H.W., Málaque C.M.S.A., and Hadad Jr. V. (Eds). Animais Peçonhentos no Brasil. Biología, Clínica e Terapéutica dos Acidentes (2003), Sarvier/FAPESP, Sao Paulo 72-86
28. França F.O.S., Bárbaro K.C., Fan H.W., Cardoso J.L.C., Sano-Martins I.S., Tomy S.C., Lopes M.H., Warrell D.A., and Theakston R.D.G. Envenoming by Bothrops jararaca in Brazil: association between venom antigenaemia and severity at admission to hospital. Trans. R. Soc. Trop. Med. Hyg. 97 (2003) 312-317
29. Furtado M.F.D., Travaglia-Cardoso S.R., and Rocha M.M. Sexual dimorphism in venom of Bothrops jararaca (Serpentes: Viperidae). Toxicon 48 (2006) 401-410
30. García M., Monge M., León G., Lizano S., Segura E., Solano G., Rojas G., and Gutiérrez J.M. Effect of preservatives on IgG aggregation, complement-activating effect and hypotensive activity of horse polyvalent antivenom used in snakebite envenomation. Biologicals 30 (2002) 143-151
31. Garfin S.R., Mubarak S.J., and Davidson T.M. Rattlesnake bites. Current concepts. Clin. Orthop. 140 (1979) 50-57
32. Goldstein E.J. Bite wounds and infection. Clin. Infect. Dis. 14 (1992) 633-638
33. Gómez H.F., and Dart R.C. Clinical toxicology of snakebite in North America. In: Meier J., and White J. (Eds). Handbook of Clinical Toxicology of Animal,Venoms and Poisons (1995), CRC Press, Boca Raton 619-644
34. Gutiérrez J.M. Clinical toxicology of snakebite in Central America. In: Meier J., and White J. (Eds). Handbook of Clinical Toxicology of Animal, Venoms and Poisons (1995), CRC Press, Boca Raton 645-665
35. Gutiérrez J.M., and Lomonte B. Efectos locales en el envenenamiento ofídico en América Latina. In: Cardoso J.L.C., França F.O.S., Fan H.W., Málaque C.M.S.A., and Hadad Jr. V. (Eds). Animais Peçonhentos no Brasil. Biología, Clínica e Terapéutica dos Acidentes (2003), Sarvier/FAPESP, Sao Paulo 310-323
36. Gutiérrez J.M., Chaves F., and Bolaños R. Estudio comparativo de venenos de ejemplares recién nacidos y adultos de Bothrops asper. Rev. Biol. Trop. 28 (1980) 341-351
37. Gutiérrez J.M., Theakston R.D.G., and Warrell D.A. Confronting the neglected problem of snake bite envenoming: The need for a global partnership. PLoS Med 3 (2006) e150 10.1371/journal.pmed.0030150
38. Gutiérrez J.M., Rojas G., and Aymerich R. El envenenamiento por mordedura de serpiente en Centroamérica (2006), Universidad de Costa Rica, Facultad de Microbiología, Instituto Clodomiro Picado
39. Hardman J.G., Limbird L.E., and Goodman Gilman A. Goodman & Gilman's. The Pharmacological Basis of Therapeutics. 10th ed. (2001), McGraw-Hill, USA
40. Hardy D.L. Bothrops asper (Viperidae) snakebite and field researchers in Middle America. Biotropica 26 (1994) 198-207
41. Hardy D.L. Alternatives in the field management of venomous snakebite. In: Cardoso J.L.C., França F.O.S., Fan H.W., Málaque C.M.S.A., and Hadad Jr. V. (Eds). Alternatives in the field management of venomous snakebite (2003), Animais peçonhentos no Brasil. Biología, Clínica e Terapéutica dos Acidentes. Sarvier/FAPESP, Sao Paulo 402-416
42. Hayden J.W. Compartment syndromes. Early recognition and treatment. Postgrad. Med. 74 (1983) 191-202
43. Jorge M.T., Mendonça J.S., Ribeiro L.A., Silva M.L.R., Kusano E.J.U., and Cordeiro C.L.S. Flora bacteriana da cavidade oral, presas e veneno de Bothrops jararaca: possível fonte de infecção no local da picada. Rev. Inst. Med. Trop. São Paulo 32 (1990) 6-10
44. Jorge M.T., Ribeiro L.A., Silva M.L.R., Kusano E.J.U., and Mendonça J.S. Bacteriology of abscesses complicating Bothrops snake bites in humans: a prospective study. Toxicon 32 (1994) 743-748
45. Jorge M.T., and Ribeiro L.A. Infections in the bite site after envenoming by snakes of the Bothrops genus. J. Venom. Anim. Toxins 3 (1997) 264-272
46. Jorge M.T., Nishioka S.D.A., Oliveira R.B.D., Ribeiro L.A., and Silveira P.V.P. Aeromonas hydrophila soft-tissue infection as a complication of snake bite: report of three cases. Ann. Trop. Med. Parasitol. 92 (1998) 213-217
47. Jorge M.T., Málaque C., Ribeiro L.A., Fan H.W., Cardoso J.L.C., Nishioka S.A., Sano-Martins I.S., França F.O.S., Kamiguti A.S., Theakston R.D.G., and Warrell D.A. Failure of chloramphenicol prophylaxis to reduce the frequency of abscess formation as a complication of envenoming by Bothrops snakes in Brazil: a double-blind randomized controlled trial. Trans. R. Soc. Trop. Med. Hyg. 98 (2004) 529-534
48. Kamiguti A.S., and Cardoso J.L.C. Haemostatic changes caused by venoms of South American snakes. Toxicon 27 (1989) 955-963
49. Kamiguti A.S., Hay C.R.M., Theakston R.D.G., and Zuzel M. Insights into the mechanism of haemorrhage caused by snake venom metalloproteinases. Toxicon 34 (1996) 627-642
50. Kasturiratne A., Wickremasinghe A.R., de Silva N., Gunawardena N.K., Pathmeswaran A., Premaratna R., SAvioli L., Lalloo D.G., and da Silva H.J. The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths. PLoS Med 5 (2008) e218 10.1371/journal.pmed.0050218
51. Kerrigan K.R. Venomous snake bite in Eastern Ecuador. Am. J. Trop. Med. Hyg. 44 (1991) 93-99
52. Kerrigan K.R., Mertz B.L., Nelson S.J., and Dye J.D. Antibiotic prophylaxis for pit viper envenomation: prospective, controlled trial. World J. Surg. 21 (1997) 369-373
53. Kornalik F., and Vorlová Z. Non-specific therapy of a hemorrhagic diathesis after a bite by a young Bothrops asper (barba amarilla): a case report. Toxicon 28 (1990) 1497-1501
54. Kouyoumdjian J.A., Polizelli C., Lobo S.M.A., and Guimares S.M. Fatal extradural haematoma after snake bite (Bothrops moojeni). Trans. R. Soc. Trop. Med. Hyg. 85 (1991) 552
55. Lalloo D.G., and Theakston R.D.G. Snake antivenoms. Clin. Toxicol. 41 (2003) 277-290
56. Lee R.I., and White P.D. A clinical study of the coagulation time of blood. Am. J. Med. Sci. 145 (1913) 495-505
57. LoVecchio F., Klemens J., Welch S., and Rodriguez R. Antibiotics after rattlesnake envenomation. J. Emerg. Med 23 (2002) 327-328
58. LoVecchio F., Klemens J., Roundy E.B., and Klemens A. Serum sickness following administration of Antivenin (Crotalidae) Polyvalent in 181 cases of presumed rattlesnake envenomation. Wild. Env. Med 14 (2003) 220-221
59. Malasit P., Warrell D.A., Chantavanich P., Viravan C., Mongkilsapaya J., Singhthong B., and Sulpich C. Prediction, prevention and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites. Br. Med. J. 292 (1986) 17-20
60. Meier J., and White J. Handbook of Clinical Toxicology of Animal Venoms and Poisons (1995), CRC Press, Boca Raton
61. Mekbel S., and Céspedes R. Las lesiones renales en el ofidismo. Acta Med. Costarricense 6 (1963) 111-118
62. Miller D.R., Pearson H.A., Baehner R.L., and McMillan C.W. Smith's Blood Diseases of Infancy and Childhood (1978), C.V. Mosby Company, St. Louis
63. Mycek M.J., Harvey R.A., Champe P.C., Fisher B.D., and Cooper M. Pharmacology. Second ed. (2000), Lippincott Williams & Wilkins, Philadelphia
64. Olivo R., Teixeira C.F.P., Wallace J.L., Gutiérrez J.M., and Zamuner S.R. Role of cyclooxygenases in oedema-forming activity of bothropic venoms. Toxicon 49 (2007) 670-677
65. Otero R. Manual de Diagnóstico y Tratamiento del Accidente Ofídico, Editorial Universidad de Antioquia, Medellín (1994)
66. Otero R. Accidente Ofídico. In: Correa J.A., Gómez J.F., and Posada R. (Eds). Fundamentos de Pediatría (1995), Editorial CIB, Medellín 2412-2425
67. Otero R. Seroterapia y tratamiento del accidente ofídico en Antioquia y Chocó. In: Otero R., Ángel R., and García M. (Eds). Memorias del I Simposio Colombiano de Toxinología (1998), Ecográficas Ltda., Medellín 157-168
68. 2 o Fab en picaduras de escorpiones y mordeduras de serpientes. Pediatría 37 (2002) 8-16
69. Otero R. Adivina adivinador por quién doblan las campanas?. Alma Mater 524 (2004) 26-27
70. Otero R. Envenenamiento ofídico. In: Correa J.A., Gómez J.F., and Posada R. (Eds). Fundamentos de Pediatría (Tomo V) (2007), Corporación para Investigaciones Biológicas, Medellín
71. Otero R., and Mesa M.B. Mordeduras graves por serpientes. In: Quevedo A., Martínez Y., Duque J.I., and Mejía J.A. (Eds). El niño en Estado Crítico (2001), Editorial CIB, Medellín 571-578
72. Otero R., and Mesa M.B. Accidentes por animales venenosos. In: Correa J.C. (Ed). Manual de Urgencias en Pediatría (2005), Corporación de Amor al Niño, Medellín
73. Otero R., Tobón G.S., Gómez L.F., Osorio R., Valderrama R., Hoyos D., Urreta J.E., Molina S., and Arboleda J.J. Accidente ofídico en Antioquia y Chocó. Aspectos clínicos y epidemiológicos (marzo de 1989- febrero de 1990). Acta Med. Colomb. 17 (1992) 229-249
74. Otero R., Osorio R.G., Valderrama R., and Giraldo C.A. Efectos farmacológicos y enzimáticos de los venenos de serpientes de Antioquia y Chocó (Colombia). Toxicon 30 (1992) 611-620
75. Otero R., Valderrama R., Osorio R.G., and Posada L.L. Programa de atencion primaria del accidente ofidico. Una propuesta para Colombia. Iatreia 5 (1992) 96-102
76. Otero R., Núñez V., Osorio R.G., Gutiérrez J.M., Giraldo C.A., and Posada L.E. Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia). Toxicon 33 (1995) 809-815
77. Otero R., Gutiérrez J.M., Núñez V., Robles A., Estrada R., Segura E., Toro M.F., García M.E., Díaz A., Ramírez E.C., Gómez G., Castañeda J., Moreno M.E., and The Regional Group on Antivenom Therapy Research (REGATHER). A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia. Trans. R. Soc. Trop. Med. Hyg. 90 (1996) 696-700
78. Otero R., Núñez V., Gutiérrez J.M., Robles A., Estrada R., Osorio R.G., Del-Valle G., Valderrama R., and Giraldo C.A. Neutralizing capacity of a new monovalent anti- Bothrops atrox antivenom: comparison with two comercial antivenoms. Braz. J. Med. Biol. Res. 30 (1997) 375-379
79. Otero R., Gutiérrez J.M., Rojas G., Núñez V., Díaz A., Miranda E., Uribe A.F., Silva J.F., Ospina J.G., Medina J., Toro M.F., García M.E., León G., García M., Lizano S., De La Torre J., Márquez J., Mena Y., González N., Arenas L.C., Puzón A., Blanco N., Sierra A., Espinal M.E., Arboleda M., Jiménez J.C., Ramírez P., Díaz M., Guzmán M.C., Barros J., Henao S., Ramírez A., Macea U., and Lozano R. A randomized blind clinical trial of two antivenoms prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia. Correlation between safety and biochemical characteristics of antivenoms. Toxicon 37 (1999) 895-908
80. Otero R., Fonnegra R., and Jiménez S.L. Plantas Utilizadas Contra Mordeduras de Serpientes en Antioquia y Chocó, Colombia (2000), Grandacolor, Medellín
81. Otero R., Fonnegra R., Jiménez S., Núñez V., Evans N., Alzate S.A., García M.E., Saldarriaga M., del Valle G., Osorio R.G., Díaz A., Valderrama R., Duque A., and Vélez H.N. Snakebites and ethnobotany in the northwest region of Colombia. Part I: traditional use of plants. J. Ethnopharmacol. 71 (2000) 493-504
82. Otero R., Gutiérrez J., Rodríguez O., Cárdenas S.J., Rodríguez L., and Caro E. Aspectos actuales de las mordeduras de serpientes en Colombia. Propuesta de intervención para un problema grave de salud en Antioquia y Chocó. Revista Epidemiológica de Antioquia 26 (2001) 43-48
83. Otero R., Callejas M.E., Gutiérrez J., Lotero G.J., Rodríguez O., and Villa N.H. Necesidades reales de antivenenos en Colombia. Características de los productos y del mercado. Revista Epidemiológica de Antioquia 26 (2001) 49-59
84. Otero R., Gutiérrez J., Mesa M.B., Duque E., Rodríguez O., Arango J.L., Gómez F., Toro A., Cano F., Rodríguez M.L., Caro E., Martínez J., Cornejo W., Gómez M.L., Uribe L.F., Cárdenas S., Núñez V., and Díaz A. Complications of Bothrops, Porthidium and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital. Toxicon 40 (2002) 1107-1114
85. Otero R., Núñez V., Barona J., Díaz A., and Saldarriaga M. Características bioquímicas y capacidad neutralizante de cuatro antivenenos polivalentes frente a los efectos farmacológicos y enzimáticos del veneno de Bothrops asper y Porthidium nasutum de Antioquia y Chocó. Iatreia 15 (2002) 5-15
86. Otero R., León G., Gutiérrez J.M., Rojas G., Toro M.F., Barona J., Rodríguez V., Díaz A., Núñez V., Quintana J.C., Ayala S., Mosquera D., Conrado L.L., Fernández D., Arroyo Y., Paniagua C.A., López M., Ospina C.E., Alzate C., Fernández J., Meza J.J., Silva J.F., Ramírez P., Fabra P.E., Ramírez E., Córdoba E., Arrieta A.B., Warrell D.A., and Theakston R.D.G. Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia. Trans. R. Soc. Trop. Med. Hyg. 100 (2006) 1173-1182
87. Otero-Patiño R., Cardoso J.L.C., Higashi H.G., Núñez V., Díaz A., Toro M.F., García M.E., Sierra A., García L.F., Moreno A.M., Medina M.C., Castañeda N., Silva-Díaz J.F., Murcia M., Cárdenas S.Y., Dias Da Silva W.D., and The Regional Group on Antivenom Therapy Research (REGATHER). A randomized, blinded, comparative trial of one pepsin-digested and two whole IgG antivenoms for Bothrops snake bites in Urabá, Colombia. Am. J. Trop. Med. Hyg. 58 (1998) 183-189
88. ®, un antiveneno polivalente producido en México. Iatreia 20 (2007) 244-262
89. Otero-Patiño, R., 2008. El accidente ofídico: realidades y perspectivas. In: Memorias VIII Congreso de APANAC, Panamá.
90. Pantanowitz L., and Guidozzi F. Management of snake and spider bite in pregnancy. Obstet. Gynecol. Surg. 51 (1996) 615-620
91. Pinho F.M.O., Zanetta D.M.T., and Burdmann E.A. Acute renal failure after Crotalus durissus snakebite: A prospective survey on 100 patients. Kidney Int. 67 (2005) 659-667
92. Reid H.A., Thean P.C., Chan K.E., and Baharom A.R. Clinical effects of bites by Malayan viper (Ancistrodon rhodostoma). Lancet ii (1963) 617-621
93. Reid H.A., Chan K.E., and Thean P.C. Prolonged coagulation defect (Defibrination syndrome) in Malayan viper bite. Lancet ii (1963) 621-626
94. Ribeiro L.A., and Jorge M.T. Alteração do tempo de coagulaçao sanguínea em pacientes picados por serpente Bothrops jararaca adulta e filhote. Revista do Hospital de Clínicas da Facultad de Medicina de São Paulo 44 (1989) 143-145
95. Ribeiro L.A., and Jorge M.T. Epidemiologia e quadro clinico dos acidentes por serpentes Bothrops jararaca adultas e filhotes. Rev. Inst. Med. Trop. Sao Paulo 32 (1990) 436-442
96. Ribeiro L.A., Jorge M.T., and Lebrão M.L. Prognostic factors for local necrosis in Bothrops jararaca (Brazilian pit viper) bites. Trans. R. Soc. Trop. Med. Hyg. 95 (2001) 630-634
97. Roitt I., Brostoff J., and Male D. Immunology (2001), Mosby, London 480p
98. Rosenfeld G. Symptomatology, pathology and treatment of snake bites in South America. In: Bücherl W., and Buckley E.E. (Eds). Venomous Animals and their Venoms (1971), Academic Press, New York 345-384
99. Russell F.E., Carlson R.W., Wainschel J., and Osborne A.H. Snake venom poisoning in the United States. Experience with 550 cases. J. Am. Med. Assoc. 233 (1975) 341-344
100. Saldarriaga, M., Otero, R., 1995. Morbilidad y mortalidad por enfermedades infecciosas en serpientes venenosas mantenidas en cautiverio. Tesis de Grado, Facultad de Medicina Veterinaria y de Zootecnia, Universidad de Antioquia, Medellín, 78p.
101. Saldarriaga M.M., Otero R., Núñez V., Toro M.F., Díaz A., and Gutiérrez J.M. Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia. Toxicon 42 (2003) 405-411
102. Sano-Martins I.S., Fan H.W., Castro S.C.B., Tomy S.C., Franca F.O.S., Jorge M.T., Kamiguti A.S., Warrell D.A., and Theakston R.D.G. Reliability of the simple 20 minute whole blood clotting test (WBCT20) as an indicator of low plasma fibrinogen concentration in patients envenomed by Bothrops snakes. Toxicon 32 (1994) 1045-1050
103. Saravia-Otten P., Gutiérrez J.M., Arvidson S., Thelestam M., and Flock J.I. Increased infectivity of Staphylococcus aureus in an experimental model of snake venom-induced tissue damage. J. Infect. Dis. 196 (2007) 748-754
104. Sasa M., and Vázquez S. Snakebite envenomation in Costa Rica: a revision of incidence in the decade 1990-2000. Toxicon 41 (2003) 19-22
105. Sasa, M., Wasko, D.K., Lamar, W.W., 2009. Natural history of the terciopelo Bothrops asper (Serpentes: Viperidae) in Costa Rica. Toxicon 54, 904-922.
106. Silva-Haad J.J. Las serpientes del género Bothrops en la Amazonia Colombiana. Aspectos biomédicos (epidemiología, clínica y biología del ofidismo). Acta Med. Colomb. 14 (1989) 148-165
107. Smalligan R., Cole J., Brito N., Laing G., Mertz B.L., Manock S., Maudlin J., Quist B., Holland G., Nelson S., Lalloo D.G., Rivadeneira G., Barragan M.E., Dolley D., Eddleston M., Warrell D.A., and Theakston R.D.G. Crotaline snake bite in the Ecuadorian Amazon: randomized double blind comparative trial of three South American polyspecific antivenoms. Br. Med. J 329 (2004) 1129-1135
108. Soe S., Than T., and Han K.E. The nephrotoxic action of Russell's viper (Vipera russelli) venom. Toxicon 28 (1990) 461-467
109. Stewart R.M., Page C.P., Schwesinger W.H., McCarter R., Martínez J., and Aust J.B. Antivenin and fasciotomy/debridement in the treatment of the severe rattlesnake bite. Am. J. Surg. 158 (1989) 543-547
110. Tanen D.A., Danish D.C., and Clark R.F. Crotalidae polyvalent immune Fab antivenom limits the decrease in perfusion pressure of the anterior leg compartment in a porcine Crotaline envenomation model. Ann. Emerg. Med. 41 (2003) 384-390
111. Tanen D.A., Danish D.C., Grice G.A., Riffenburgh R.H., and Clark R.F. Fasciotomy worsens the amount of myonecrosis in a porcine model of crotaline envenomation. Ann. Emerg. Med. 44 (2004) 99-104
112. Teixeira, C., Cury, Y., Moreira, V., Picolo, G., Chaves, F., 2009. Inflammation induced by Bothrops asper. Toxicon 54, 67-76.
113. Theakston R.D.G., Phillips R.E., Looareesuwan S., Echeverría P., Makin T., and Warrell D.A. Bacteriological studies of the venom and mouth cavities of wild Malayan pit vipers (Calloselasma rhodostoma) in southern Thailand. Trans. R. Soc. Trop. Med. Hyg. 84 (1990) 875-879
114. Theakston R.D.G., Fan H.W., Warrell D.A., Dias da Silva W.D., Ward S.A., Higashi H.G., and The Butantan Institute Antivenom Study Group (BIASG). Use of enzyme immunoassays to compare the effect and assess the dosage regimens of three Brazilian Bothrops antivenoms. Am. J. Trop. Med. Hyg. 47 (1992) 593-604
115. Theakston R.D.G., Warrell D.A., and Griffiths E. Report of a WHO workshop on the standardization and control of antivenoms. Toxicon 41 (2003) 541-557
116. Thomas L., Tyburn B., Bucher B., Pecout B., Ketterle D., Rieux D., Smadja D., Garnier D., and Plumelle Y. Prevention of thromboses in human patients with Bothrops lanceolatus envenoming in Martinique: failure of anticoagulants and efficacy of a monospecific antivenom. Am. J. Trop. Med. Hyg. 52 (1995) 419-426
117. Vargas-Baldares M. Renal lesions in snake bite in Costa Rica. In: Rosenberg P. (Ed). Toxins: Animal, Plant and Microbial (1978), Pergamon Press, Oxford 497
118. Warrell D.A. Clinical toxicology of snakebite in Asia. In: Meier J., and White J. (Eds). Handbook of Clinical Toxicology of Animal, Venoms and Poisons (1995), CRC Press, Boca Raton 493-594
119. Warrell D.A. Epidemiology, clinical features and management of snake bites in Central and South America. In: Campbell J., and Lamar W.W. (Eds). Venomous Reptiles of the Western Hemisphere (2004), Cornell University Press, Ithaca 709-761
120. Weed H.G. Nonvenomous snakebite in Massachusetts: prophylactic antibiotics are unnecessary. Ann. Emerg. Med 22 (1993) 220-224
121. Wingert W.A., and Wainschel J. Diagnosis and management of envenomation by poisonous snakes. South. Med. J. 68 (1975) 1015-1026
122. World Health Organization. Progress in the Characterization of Venoms and Standardization of Antivenoms vol. 58 (1981), WHO Offset Publication 1-44
123. Zugaib M., Barros A.C.S.D., Bittar R.E., Burdmann E.D.A., and Neme B. Abruptio placentae following snake bite. Am. J. Obstet. Gynecol. 151 (1985) 754-755