Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 100, Issue 12, 2006, Pages 1173-1182

  Otero, Rafael ^a   León, Guillermo ^b   Gutiérrez, José María ^b   Rojas, Gustavo ^b   Toro, María Fabiola ^a   Barona, Jacqueline ^a   Rodríguez, Verónica ^a   Díaz, Abel ^a   Núñez, Vitelbina ^a   Quintana, Juan Carlos ^a   Ayala, Shirley ^c   Mosquera, Diana ^c   Conrado, Lesdy L ^c   Fernández, Diego ^d   Arroyo, Yobana ^d   Paniagua, Carlos A ^e   López, Mercedes ^e   Ospina, Carlos E ^f   Alzate, Claudia ^f   Fernández, Jorge ^g   Meza, Jazmín J ^g   Silva, Juan F ^g   Ramírez, Patricia ^g   Fabra, Patricia E ^g   Ramírez, Eugenio ^h   Córdoba, Elkin ^h   Arrieta, Ana B ^h   Warrell, David A ⁱ   Theakston, R David G ^j   more..

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c Hospital San Francisco de Asís   (Colombia)

^d Hospital San Sebastián   (Colombia)

^e Hospital Francisco Valderrama   (Colombia)

^f Hospital María Auxiliadora   (Colombia)

^g Hospital La Anunciacion   (Colombia)

^h Hospital César Uribe Piedrahita   (Colombia)

ⁱ UNIVERSITY OF OXFORD   (United Kingdom)

^j LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

more..

Author keywords

Propiolactone; Anticomplementary activity; Bothrops asper; Caprylic acid; Colombia; Envenomation; Serotherapy

Indexed keywords

FIBRINOGEN; IMMUNOGLOBULIN G POLYVALENT ANTIVENOM A; IMMUNOGLOBULIN G POLYVALENT ANTIVENOM B; OCTANOIC ACID; PROPIOLACTONE; SNAKE VENOM; SNAKE VENOM ANTISERUM; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CHILL; CLINICAL PROTOCOL; CLINICAL TRIAL; COLOMBIA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; ENVENOMATION; FEMALE; FIBRINOGEN BLOOD LEVEL; FRACTIONATION; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRECIPITATION; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SKIN MANIFESTATION; SNAKEBITE;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIVENINS; BLOOD COAGULATION DISORDERS; BOTHROPS; CHEMICAL FRACTIONATION; CHILD; CHILD, PRESCHOOL; CROTALID VENOMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRINOGEN; HUMANS; IMMUNOGLOBULIN G; MALE; MICE; MIDDLE AGED; OCTANOIC ACIDS; PROPIOLACTONE; RECURRENCE; SNAKE BITES; TREATMENT OUTCOME; WHOLE BLOOD COAGULATION TIME;

BOTHROPS ASPER;

EID: 33749063834     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2006.01.006     Document Type: Article

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