Failure of chloramphenicol prophylaxis to reduce the frequency of abscess formation as a complication of envenoming by Bothrops snakes in Brazil: Q double-blind randomized controlled trial

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 98, Issue 9, 2004, Pages 529-534

  Jorge, M T ^a   Malaque, C ^b   Ribeiro, L A ^a   Fan, H W ^b   Cardoso, J L C ^b   Nishioka, S A ^a   Sano Martins, I S ^b   Franca F O S ^b   Kamiguti, A S ^c   Theakston, R D G ^d   Warrell, David A ^d,e  

^a FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Abscesses; Bothrops; Brazil; Chloramphenicol; Prophylaxis; Snake bite

Indexed keywords

CHLORAMPHENICOL; PLACEBO; SNAKE VENOM ANTISERUM;

ABSCESS; ADOLESCENT; ADULT; ARTICLE; BRAZIL; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; ENVENOMATION; FEMALE; HOSPITAL ADMISSION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; NECROSIS; RANDOMIZED CONTROLLED TRIAL; SNAKE; SNAKEBITE; STATISTICAL SIGNIFICANCE; TREATMENT FAILURE; VICTIM;

ABSCESS; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; BOTHROPS; BRAZIL; CHILD; CHILD, PRESCHOOL; CHLORAMPHENICOL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; NECROSIS; SNAKE BITES; TREATMENT OUTCOME;

BOTHROPS; SERPENTES;

EID: 3342881974     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2003.12.009     Document Type: Article

References (32)

1. Bartlett J.G. Chloramphenicol Med. Clin. North America 66 1982 91-102
2. Davidson T.M. Shafer S.F. Rattlesnake bites. Guidelines for aggressive treatment Postgrad. Med. 96 1994 107-114
3. De Andrade J.G. Pinto R.N.L. Andrade A.L.S.S. Martelli C.M.T. Zicker F. Estudo bacteriológico de abscessos causados por picada de serpente do gênero Bothrops Rev. Inst. Med. Trop. São Paulo 31 1989 363-367
4. Forks T.P. Evaluation and treatment of poisonous snakebites Am. Fam. Physician 50 1994 123-130
5. Fullen W.D. Hunt J. Altemeier W.A. Prophylactic antibiotics in penetrating wounds of the abdomen Journal of Trauma 12 1972 282-289
6. Goldstein E.J.C. Citron D.M. Gonzalez H. Russell F.E. Bacteriology of rattlesnake venom and implications for therapy J. Infect. Dis. 140 1979 818-821
7. Instituto Butantan, 1993. Manual para o diagnóstico e tratamento de acidentes por animais peçonhentos São Paulo. Coordenadoria de Serviços Técnicos Especializados. Instituto Butantan, São Paulo.
8. Joiner K.A. Lowe B.R. Dzink J.L. Bartlett J.G. Antibiotic levels in infected and sterile subcutaneous abscesses in mice J. Infect. Dis. 143 1981 487-494
9. Jorge, M.T., Ribeiro, L.A., 1989. Acidentes por animais peçonhentos. In: Doenças Transmissíveis, Amato Neto, V., Baldy, J.L.S. (Eds.), Sarvier, São Paulo, pp. 133-141.
10. Jorge M.T. Ribeiro L.A. Acidentes por serpentes peçonhentas do Brasil Rev. Associação Méd. Bras. 36 1990 66-77
11. Jorge M.T. Ribeiro L.A. Infections in the bite site after envenoming by snakes of the Bothrops genus J. Ven. Animals Toxins 2 1997 264-272
12. Jorge M.T. Mendonça J.S. Ribeiro L.A. Silva M.L.R. Kusano E.J.U. Cordeiro C.L.S. Flora bacteriana da cavidade oral, presas e veneno de Bothrops jararaca: possível fonte de infecção no local da picada Rev. Inst. Med. Trop. São Paulo 32 1990 6-10
13. Jorge M.T. Ribeiro L.A. Silva M.L.R. Kusano E.J.U. Mendonça J.S. Microbiological studies of abscesses complicating Bothrops snakebite in humans: a prospective study Toxicon. 32 1994 743-748
14. Jorge M.T. Nishioka S.A. Ribeiro L.A. Oliveira R.B. Silveira P.V.P. Aeromonas hydrophila soft-tissue infection as a complication of snake bite: report of three cases Ann. Trop. Med. Parasitol. 92 1998 213-217
15. Kerrigan K.R. Bacteriology of snakebite abscess Trop. Doct. 22 1992 158-160
16. Kerrigan K.R. Mertz B.L. Nelson S.J. Dye J.D. Antibiotic prophylaxis for pit viper envenomation: prospective, controlled trial World J. Surg. 21 1997 369-373
17. Kouyoumdjian J.A. Polizelli C. Acidentes ofídicos causados por Bothrops moojeni; correlação do quadro clínico com o tamanho da serpente Rev. Inst. Med. Trop. São Paulo 30 1989 424-432
18. Milani R.Jr. Jorge M.T. de Campos F.P.F. Martins F.P. Bousso A. Cardoso J.L.C. Ribeiro L.A. Fan H.W. França F.O.S. Sano-Martins I.S. Cardoso D. Fernandez I.C.O.F. Fernandes J.C. Aldred V.L. Sandoval M.P. Puorto G. Theakston R.D.G. Warrell D.A. Snake bites by the jararacu (Bothropsu̧u jararacussu): clinicopathological studies of 29 proven cases in São Paulo State, Brazil QJM 90 1997 323-334
19. Ministério da Saúde, Brasil, 1998. Manual de diagnóstico e tratamento de acidentes por animais peçonhentos. Gerência Técnica de Editoração da Coordenação de Comunicação, Educação e Documentação do Ministério da Saúde, Brasília.
20. Nishioka S.A. Silveira P.V.P. Bacteriology of abscesses complicating bites of the lance-headed vipers Ann. Trop. Med. Parasitol. 86 1992a 89-91
21. Nishioka S.A. Silveira P.V.P. A clinical and epidemiologic study of 292 cases of lance-headed viper bite in a Brazilian teaching hospital Am. J. Trop. Med. Hyg. 47 1992b 805-810
22. Pantanowit L. Routine antibiotics for snake bite East Afr. Med. J. 75 1998 60
23. Ribeiro L.A. Jorge M.T. Epidemiologia e quadro clínico dos acidentes por serpentes Bothrops jararaca adultas e filhotes Rev. Inst. Med. Trop. São Paulo 32 1990 436-442
24. Ribeiro L.A. Jorge M.T. Acidente por serpente do gênero Bothrops: série de 3.139 casos Rev. Soc. Bras. Med. Trop. 30 1997 475-480
25. Ribeiro L.A. Albuquerque M.J. Pires de Campos V.A. Katz G. Takaoka N.Y. Lebrão M.L. Jorge M.T. Óbitos por serpentes peçonhentas no Estado de São Paulo: avaliação de 43 casos, 1988/93 Rev. Assoc. Méd. Bras. 44 1998 312-318
26. Ribeiro L.A. Jorge M.T. Lebrão M.L. Prognostic factors for local necrosis in Bothrops jararaca (Brazilian pit viper) bites Trans. R. Soc. Trop. Med. Hyg. 95 2001 630-634
27. Sarma P.S. Aeromonas jandaei cellulitis and bacteremia in a man with diabetes Am. J. Med. 112 2002 325
28. Summersgill J.T. Schupp L.G. Raff M.J. Comparative penetration of metronidazole, clindamycin, chloramphenicol, cefoxitin, ticarcillin, and moxalactam into bone Antimicrob. Agents Chemother. 21 1982 601-603
29. Theakston R.D.G. Warrell D.A. Antivenoms: a list of hyperimmune sera currently available for the treatment of envenoming by bites and stings Toxicon 29 1991 1419-1470
30. Theakston R.D.G. Phillips R.E. Looareesuwan S. Echeverria P. Makin T. Warrell D.A. Bacteriological studies of the venom and mouth cavities of wild Malayan pit vipers (Calloselasma rhodostoma) in southern Thailand Trans. R. Soc. Trop. Med. Hyg. 84 1990 875-879
31. Watson A.D. McDonald P.J. Distribution of chloramphenicol in some tissues and extravascular fluids of dogs after oral administration Am. J. Vet. Res. 37 1976 557-559
32. Ziv G. Wanner M. Nicolet J. Distribution of penicillin G, dihydrostreptomycin, oxytetracycline, and chloramphenicol in serum and subcutaneous chamber fluid J. Vet. Pharmacol. Ther. 5 1982 59-69