Cerebrospinal fluid amyloid β40 is decreased in cerebral amyloid angiopathy

Annals of Neurology

Volumn 66, Issue 2, 2009, Pages 245-249

  Verbeek, Marcel M ^a   Kremer, Berry P H ^a   Rikkert, Marcel Olde ^a   Van Domburg, Peter H M F ^b   Skehan, Maureen E ^c   Greenberg, Steven M ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Sittard Geleen Heerlen   (Netherlands)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD VESSEL; CEREBROSPINAL FLUID; CONTROLLED STUDY; DEMENTIA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPATHOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VASCULAR AMYLOIDOSIS;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AREA UNDER CURVE; BIOLOGICAL MARKERS; CEREBRAL AMYLOID ANGIOPATHY; DIAGNOSIS, DIFFERENTIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; PEPTIDE FRAGMENTS; PHOSPHORYLATION; ROC CURVE; TAU PROTEINS;

EID: 70149113950     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.21694     Document Type: Article

References (20)

1. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of Ab42(43) and Ab40 in senile plaques with end-specific monoclonals: evidence that an initially deposited species is Ab42(43). Neuron 1994;13:45-53.
2. 42 in cerebrovascular deposits. Amyloid 1995;2:234-240.
3. Miller DL, Papayannopoulos IA, Styles J, et al. Peptide composition of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch Biochem Biophys 1993;301:41-52. (Pubitemid 23227174)
4. Alonzo NC, Hyman BT, Rebeck GW, et al. Progression of cerebral amyloid angiopathy: accumulation of amyloid-beta40 in affected vessels. J Neuropathol Exp Neurol 1998;57:353-359.
5. de Jong D, Kremer BP, Olde Rikkert MG, et al. Current state and future directions of neurochemical biomarkers for Alzheimer's disease. Clin Chem Lab Med 2007;45:1421-1434. (Pubitemid 350036575)
6. Fagan AM, Roe CM, Xiong C, et al. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol 2007;64:343-349.
7. Knudsen KA, Rosand J, Karluk D, et al. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 2001;56:537-539. (Pubitemid 32172884)
8. Greenberg SM, Gurol ME, Rosand J, et al. Amyloid angiopathy-related vascular cognitive impairment. Stroke 2004;35:2616-2619. (Pubitemid 39458351)
9. Levy E, Carman MD, Fernandez-Madrid IJ, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990;248:1124-1126.
10. Grabowski TJ, Cho HS, Vonsattel JP, et al. Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol 2001;49:697-705.
11. Reijn TS, Olde Rikkert M, van Geel WJ, et al. Diagnostic accuracy of ELISA and xMAP technology for analysis of amyloid beta(42) and tau proteins. Clin Chem 2007;53:859-865.
12. Vinters HV, Wang ZZ, Secor DL. Brain parenchymal and microvascular amyloid in Alzheimer's disease. Brain Pathol 1996;6:179-195. (Pubitemid 26160505)
13. Weller RO, Subash M, Preston SD, et al. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 2008;18:253-266.
14. Davis J, Xu F, Deane R, et al. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem 2004;279:20296-20306. (Pubitemid 38623475)
15. Miners JS, Baig S, Palmer J, et al. Abeta-degrading enzymes in Alzheimer's disease. Brain Pathol 2008;18:240-252.
16. Mandybur TI. Cerebral amyloid angiopathy: the vascular pathology and complications. J Neuropathol Exp Neurol 1986;45:79-90. (Pubitemid 16189845)
17. Maat-Schieman MLC, Radder CM, van Duinen SG, et al. Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology. Acta Neuropathol 1994;88:371-378.
18. Pettersen JA, Sathiyamoorthy G, Gao FQ, et al. Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol 2008;65:790-795. (Pubitemid 351831457)
19. Johnson KA, Gregas M, Becker JA, et al. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 2007;62:229-234. (Pubitemid 47525398)
20. Smith EE, Vijayappa M, Lima F, et al. Impaired visual evoked flow response in cerebral amyloid angiopathy. Neurology 2008;71:1424-1430.