Cancer cell expressions of immunoglobulin heavy chains with unique carbohydrate-associated biomarker

Cancer Biomarkers

Volumn 5, Issue 4-5, 2009, Pages 177-188

  Lee, Gregory ^a   Ge, Bixia ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

CA215; Carbohydrate associated epitope; Immunoglobulins; Pan cancer biomarker; RP215 monoclonal antibod; RT PCR

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; BIOLOGICAL MARKER; CA 215 ANTIGEN; CARBOHYDRATE; EPITOPE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MESSENGER RNA; MONOCLONAL ANTIBODY; RAG1 PROTEIN; RAG2 PROTEIN; SERINE; THREONINE; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CANCER CELL CULTURE; CELL CLONE; CONTROLLED STUDY; DNA SEQUENCE; EPITOPE MAPPING; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; MALE; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; BASE SEQUENCE; CELL LINE, TUMOR; EPITOPES; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; MALE; OVARIAN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 70149086517     PISSN: 15740153     EISSN: None     Source Type: Journal    
DOI: 10.3233/CBM-2009-0102     Document Type: Article

References (21)

1. G. Babbage, C.H. Ottensmeier, J. Blaydes, F.K. Stevenson and S.S. Sahota, Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines, Cancer Res 66 (2006), 3996-4000.
2. Z. Chen and J. Gu, Immunoglobulin G expression in carcinomas and cancer cell lines, FASEB J 21 (2007), 2931-2938.
3. P. Felsner, W. Steinschifter, M. Fischer, R. Eferl, L. Kenner, K. Zatloukal, M. Lahousen, P.M. Liebmann, E. Schauenstein and K. Schauenstein, The tumor-associated shift in immunoglobulin G1/G2 is expressed at the messenger RNA level of peripheral blood B lymphocytes in patients with gynecologic malignancies, Cancer 88 (2000), 461-467.
4. F. Forconi, S.S. Sahota, D. Raspadori, C.I. Mockridge, F. Lauria and F.K. Stevenson, Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing, Blood 98 (2001), 1174-1181.
5. K.A. Freed, S.P. Brennecke and E.K. Moses, Gene expression of the constant region of the heavy chain of immunoglobulin G is down-regulated in human decidua in association with preeclampsia, J Reprod Immunol 68 (2005), 105-120.
6. Y. Kimoto, Expression of heavy-chain constant region of immunoglobulin and T-cell receptor gene transcripts in human non-hematopoietic tumor cell lines. Genes Chromos, Cancer 22 (1998), 83-86.
7. G. Lee, Monoclonal Antibodies Against an Antigen Associated with Ovarian Cervical and other Tumors, United States Patent 5650291, 1997 July 22.
8. C.Y.G. Lee, K.W. Chen, F.S. Sheu, A. Tsang, K.C. Chao and H.T. Ng, Studies of a tumor associated antigens, COX-1, recognized by a monoclonal antibody, Cancer Immunol Immunol Therapy 35 (1992), 19-26.
9. G. Lee, E. Laflamme, C.-H. Chien and H.H. Ting, Molecular identity of a pan cancer marker, CA215, Cancer Biology and Therapy 7 (2008), 91-98.
10. C.Y.G. Lee and H.T. Ng, Clinical evaluation of a new ovarian cancer marker, COX-1, Int J Gynecol Obstet 49 (1995), S27-S32.
11. G. Lee, Q. Wu, C.-H. Li, H.-H. Ting and C.H. Chien, Recent studies of a new carbohydrate-associated pan cancer marker, CA215, J Clin Ligand Assay 29 (2006), 47-51.
12. H.-D. Liu, H. Zheng, M. Li, D.-S. Hu, M. Tang and Y. Cao, Upregulated expression of kappa light chain by Epstein-barr virus encoded latent memebrane protein 1 in nasopharyngeal carcinoma cells via NF-κB and AP-1 pathways, Cellular Signalling 19 (2007), 419-427.
13. X. Qiu, X. Zhu, L. Zhang, Y. Mao, J. Zhang, P. Hao, G. Li, P. Lv, Z. Li, X. Sun, L. Wu, J. Zheng et al., Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells, Cancer Res 63 (2003), 6488-6495.
14. T. Reya and S.J. Morrison, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells, Nature 414 (2001), 105-111.
15. A. Stâhlberg, P. Åman, B. Ridell, P. Mostad and M. Kubista, Quantitative real-time PCR method for detection of B-lymphocyte monoclonality by comparison of κ and γ immunoglobulin light chain expression, Clin Chem 49 (2003), 51-59.
16. A.R. Thompsett, D.W. Ellison, F.K. Stevenson and D. Zhu, VH gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity, Blood 94 (1999), 1738-1746.
17. V.C. Thoree, S.J.C. Golby, L. Boursier, M. Hackett, D.K. Dunn-Walters, J.D. Sanderson and J. Spencer, Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis, Gut 51 (2002), 44-50.
18. B.M. Tyler, A.F. Cowman, S.D. Gerondakis, J.M. Adams and O. Bernard, mRNA for surface immunoglobulin γ chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain, Proc Natl Acad Sci USA 79 (1982), 2008-2012.
19. S.D. Xiang, E.M. Benson and I.S. Dunn, Tracking membrane and secretory immunoglobulin α heavy chain mRNA variation during B-cell differentiation by real-time quantitative polymerase chain reaction, Immunol Cell Biol 79 (2001), 472-481.
20. H. Zheng, M. Li, W. Ren, L. Zeng, H.-D. Liu, D. Hu, X. Deng, M. Tang, Y. Shi, J. Gong and Y. Cao, Expression and secretion of immunoglobulin alpha heavy chain with diverse VDJ recombinations by human epithelial cancer cells, Mol Immun 44 (2007), 2221-2227.
21. X. Zhu, C. Li, X. Sun et al., Immunoglobulin mRNA and protein expression in human oral epithelial tumor cells, Appl Immunohistochem Mol Morphol 16 (2008), 232-238.