The tumor-associated shift in immunoglobulin G1/G2 is expressed at the messenger RNA level of peripheral blood B lymphocytes in patients with gynecologic malignancies

Cancer

Volumn 88, Issue 2, 2000, Pages 461-467

  Felsner, Peter ^a   Steinschifter, Waltraud ^a   Fischer, Michaela ^a   Eferi, Robert ^a   Kenner, Lukas ^a   Zatloukal, Kurt ^a   Lahousen, Manfred ^a   Liebmann, Peter M ^a   Schauenstein, Erwin ^a   Schauenstein, Konrad ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Immunoglobulin G sublasses; Immunoglobulin gene expression; Quantitative reverse transcriptase polymerase chain reaction; Tumor marker; Tumor immune system relations

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2;

ARTICLE; B LYMPHOCYTE; FEMALE; GENE EXPRESSION; GYNECOLOGIC CANCER; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; PRIORITY JOURNAL;

B-LYMPHOCYTES; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENITAL NEOPLASMS, FEMALE; HUMANS; IMMUNOGLOBULIN G; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0034650191     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(20000115)88:2<461::AID-CNCR29>3.0.CO;2-V     Document Type: Article

References (16)

1. Schauenstein E., Reiter M., Gombotz M., List W. Labile disulfide bonds and free thiol groups in human IgG. II. Characteristic changes in malignant diseases corresponding to shifts of IgG1 and IgG2 subclasses. Int Arch Allergy Immunol 1986;80:180-4.
2. Smola M, Estelberger W, Reiter M, Schauenstein K, Schauenstein E. ΣS, a measure of reactive sulfur groups of immunoglobulin G, is a sensitive tumor marker discriminating different stages of breast cancer. Cancer 1991;68:1026-30.
3. Kronberger L Jr, Weblacher M, Estelberger W, Hauser H, Schauenstein E, Schauenstein K. Pre-and postoperative analysis of serum IgG1 in patients with benign and malignant breast diseases. In: E. Kubista, Staffen A, Zielinski C, editors. Second European Congress Serology, Monduzzi Editore, 1994:47-85.
4. Schauenstein E, Lahousen M, Weblacher M, Steinschifter W, Estelberger W, Schauenstein K. Selective decrease in serum immunoglobulin G1: a tissue nonspecific tumor marker detecting early stages of gynecological malignant disease with high efficiency. Cancer 1996;78:511-6.
5. Schauenstein E, Rabl H, Steinschifter W, Hirschmann C, Estelberger W, Schauenstein K. Selective decrease in serum immunoglobulin G1: an indirect, tissue nonspecific tumor marker detecting colorectal carcinoma with high efficiency. Cancer 1996;79:1482-6.
6. Anderhuber W, Steinschifter W, Schauenstein E, Gotschuli A, Habermann W, Fischer M, et al. The IgG1/G2 subclass shift: a sensitive tissue nonspecific marker for malignancy. Diagnostic performance with squamous cell carcinoma of the head and neck. Br J Cancer 1999;79:1777-81.
7. 2-induced, noncovalent self-aggregation upon storage at room temperature. Free Radic Biol Med 1996;20:263-70.
8. Takahashi N, Ueda S, Obata M, Nikaido T, Nakai S, Honjo T. Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. Cell 1982;29:671-9.
9. Ellison JW, Berson BJ, Hood LE. The nucleotide sequence of a human immunoglobulin C-gamma-1 gene. Nucleic Acids Res 1982;10:4071-9.
10. Eferl R, Lehner M, Kenner L, Kapfer I, Gürtl B, Zatloukal K. Evaluation of different standard types for quantitative reverse transcription polymerase chain reaction: possible pitfalls and strategies for avoidance. Trends Genet Technical Tips Online, 1997:T01214.
11. Weblacher M, Leitsberger A, Tillian H, Maninger K, Estelberger W, Schauenstein K, et al. A decrease in reactive disulfide bonds of serum IgG signals a characteristic change in the IgG subclass pattern of rats bearing experimental tumors. Int Arch Allergy Immunol 1993;102:340-6.
12. Maninger K, Schauenstein K, Weblacher M, Tillian H, Schauenstein E. Shift in IgG subclasses: a sensitive early marker for malignant proliferation in tumor bearing rats as a representative model for human cancer. Cancer Mol Biol 1994;1:165-71.
13. Zimmermann K, Mannhalter W. Technical aspects of quantitative competitive PCR. Biotechniques 1996;21:268-79.
14. Sideras P, Nilsson L, Islam K.B, Ericsson H, Hammarstrom L, Smith C.I. Quantitative and qualitative analysis of human IgG subclass specific mRNA using solution hybridization. Scand J Immunol 1991;34:557-64.
15. Kitani A, Strober W. Regulation of Cγ subclass germ-line transcripts in human peripheral blood B-cells. J Immunol 1993;151:3478-88.
16. Kawano Y, Noma T, Yata J. Regulation of human IgG subclass production by cytokines. IFN-γ and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2. J Immunol 1994;153:4948-58.