Differential contributions of Glu96, Asp102 and Asp111 to coagulation Factor V/Va metal ion binding and subunit stability

Biochemical Journal

Volumn 422, Issue 2, 2009, Pages 257-264

  Song, Jina ^a   Talbot, Kimberley ^a   Hewitt, Jeffrey ^a   MacGillivray, Ross T A ^a   Pryzdial, Edward L G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

B domain; Calcium; Coagulation; Copper; Factor V; Subunit

Indexed keywords

ACTIVATED PLATELETS; B DOMAIN; BLOOD COAGULATION; COAGULATION FACTOR; DIFFERENTIAL CONTRIBUTION; FACTOR V; HETERODIMERS; INDIRECT EFFECTS; METAL ION BINDING; NORMAL METALS; SUBUNIT; SUBUNIT DISSOCIATION; SUBUNIT INTERFACES; WILD TYPES;

AMINES; AMINO ACIDS; CALCIUM; CALCIUM ALLOYS; CHELATION; COAGULATION; DISSOCIATION; METAL IONS; METALS; ORGANIC ACIDS; PLATELETS;

METAL REFINING;

ALANINE; AMINO ACID DERIVATIVE; ASPARTIC ACID; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5A; CALCIUM ION; COPPER ION; GLUTAMIC ACID; METAL ION; THROMBIN; CALCIUM; COPPER; PROTEIN SUBUNIT;

ARTICLE; CONTROLLED STUDY; METAL BINDING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN VARIANT; THROMBOCYTE ACTIVATION; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; HUMAN; METABOLISM;

ASPARTIC ACID; BINDING SITES; CALCIUM; COPPER; FACTOR V; FACTOR VA; GLUTAMIC ACID; HUMANS; PROTEIN STABILITY; PROTEIN SUBUNITS;

EID: 70149084537     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090405     Document Type: Article

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