Impaired function of innate T lymphocytes and NK cells in the acute phase of ischemic stroke

Cerebrovascular Diseases

Volumn 28, Issue 5, 2009, Pages 490-498

  Peterfalvi, Agnes ^a   Molnar, Tihamer ^a   Banati, Miklos ^a   Pusch, Gabriella ^a   Miko, Eva ^a   Bogar, Lajos ^a   Pal, Jozsef ^a   Szereday, Laszlo ^a   Illes, Zsolt ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

T cells; Innate immunity; NK cells; NKT cells; Stroke

Indexed keywords

FAS LIGAND; GAMMA INTERFERON; PERFORIN;

ACUTE DISEASE; ADULT; AGED; ARTICLE; CD3+ T LYMPHOCYTE; CELL ACTIVATION; CELL FUNCTION; CELL ISOLATION; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; NATURAL KILLER T CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CELL SEPARATION; CYTOKINES; FAS LIGAND PROTEIN; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNITY, INNATE; INTERFERON-GAMMA; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; RISK FACTORS; STROKE; T-LYMPHOCYTES; TH1 CELLS;

EID: 70049098753     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000236527     Document Type: Article

References (56)

1. Davenport RJ, Dennis MS, Wellwood I, Warlow CP: Complications after acute stroke. Stroke 1996; 27: 415-420.
2. Johnston KC, Li JY, Lyden PD, Hanson SK, Feasby TE, Adams RJ, Faught RE, Haley EC: Medical and neurological complications of ischemic stroke: experience from the RANTTAS trial. RANTTAS Investigators. Stroke 1998; 29: 447-453.
3. Georgilis K, Plomaritoglou A, Dafni U, Bassiakos Y, Vemmos K: Aetiology of fever in patients with acute stroke. J Intern Med 1999; 246: 203-209.
4. Grau AJ, Buggle F, Schnitzler P, Spiel M, Lichy C, Hacke W: Fever and infection early after ischemic stroke. J Neurol Sci 1999; 171: 115-120.
5. Vargas M, Horcajada JP, Obach V, Revilla M, Cervera A, Torres F, Planas AM, Mensa J, Chamorro A: Clinical consequences of infection in patients with acute stroke: is it prime time for further antibiotic trials? Stroke 2006; 37: 461-465.
6. Sellars C, Bowie L, Bagg J, Sweeney MP, Miller H, Tilston J, Langhorne P, Stott DJ: Risk factors for chest infection in acute stroke: a prospective cohort study. Stroke 2007; 38: 2284-2291.
7. Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U: Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci 2005; 6: 775-786.
8. Chamorro A, Urra X, Planas AM: Infection after acute ischemic stroke: a manifestation of brain induced immunodepression. Stroke 2007; 38: 1097-1103.
9. Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, Ziemssen T, Prass K, Meisel A: Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke 2007; 38: 770-773.
10. Prass K, Meisel C, Höflich C, Braun J, Halle E, Wolf T, Ruscher K, Victorov IV, Priller J, Dirnagl U, Volk HD, Meisel A: Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 2003; 198: 725-736.
11. Offner H, Subramanian S, Parker SM, Wang C, Afentoulis ME, Lewis A, Vandenbark AA, Hurn PD: Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. J Immunol 2006; 176: 6523-6531.
12. Vogelgesang A, Grunwald U, Langner S, Jack R, Bröker BM, Kessler C, Dressel A: Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke. Stroke 2008; 39: 237-241.
13. Klehmet J, Harms H, Richter M, Prass K, Volk HD, Dirnagl U, Meisel A, Meisel C: Stroke-induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial. Neuroscience 2009; 158: 1184-1193. DOI: 10.1016/j.neuroscience.2008.07.044.
14. Urra X, Cervera A, Villamor N, Planas AM, Chamorro A: Harms and benefits of lymphocyte subpopulations in patients with acute stroke. Neuroscience 2009; 158: 1174-1183. DOI: 10.1016/j.neuroscience.2008.06.014.
15. Haeusler KG, Schmidt WU, Föhring F, Meisel C, Helms T, Jungehulsing GJ, Nolte CH, Schmolke K, Wegner B, Meisel A, Dirnagl U, Villringer A, Volk HD: Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovasc Dis 2008; 25: 50-58.
16. Lahn M: The role of gammadelta T cells in the airways. J Mol Med 2000,78: 409-425.
17. De Rosa SC, Andrus JP, Perfetto SP, Mantovani JJ, Herzenberg LA, Herzenberg LA, Roederer M: Ontogeny of T cells in humans. J Immunol 2004; 172: 1637-1645.
18. Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z: T cells provide an early source of interferon in tumor immunity. J Exp Med 2003; 198: 433-442.
19. Szekeres-Bartho J, Barakonyi A, Miko E, Polgar B, Palkovics T: The role of gamma/ delta T cells in the feto-maternal relationship. Semin Immunol 2001; 13: 229-233.
20. Kronenberg M, Gapin L: The unconventional lifestyle of NKT cells. Nat Rev Immunol 2002; 2: 557-568.
21. Tupin E, Kinjo Y, Kronenberg M: The unique role of natural killer T cells in the response to microorganisms. Nat Rev Microbiol 2007; 5: 405-417.
22. Lu PH, Negrin RS: A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J Immunol 1994; 153: 1687-1696.
23. Mehta BA, Schmidt-Wolf IG, Weissman IL, Negrin RS: Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+CD56+ killer cells. Blood 1995; 86: 3493-3499.
24. Hammond KJ, Godfrey DI: NKT cells: potential targets for autoimmune disease therapy? Tissue Antigens 2002; 59: 353-363.
25. Hammond KJ, Kronenberg M: Natural killer T cells: natural or unnatural regulators of autoimmunity? Curr Opin Immunol 2003; 15: 683-689. (Pubitemid 37434076)
26. Miyake S, Yamamura T: NKT cells and autoimmune diseases: unraveling the complexity. Curr Top Microbiol Immunol 2007; 314: 251-267.
27. Carnaud C, Lee D, Donnars O, Park SH, Beavis A, Koezuka Y, Bendelac A: Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol 1999; 163: 4647-4650.
28. Robertson MJ, Ritz J: Biology and clinical relevance of human natural killer cells. Blood 1990; 76: 2421-2438.
29. Cooper MA, Fehniger TA, Caligiuri MA: The biology of human natural killer-cell subsets. Trends Immunol 2001; 22: 633-640.
30. Strowig T, Brilot F, Münz C: Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 2008; 180: 7785-7791.
31. Kägi D, Vignaux F, Ledermann B, Bürki K, Depraetere V, Nagata S, Hengartner H, Golstein P: Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Scienc e 1994; 265: 528-530.
32. Lowin B, Hahne M, Mattmann C, Tschopp J: Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 1994; 370: 650-652.
33. Podack ER, Hengartner H, Lichtenheld MG: A central role of perforin in cytolysis? Annu Rev Immunol 1991; 9: 129-157.
34. Griffith GM, Mueller C: Expression of perforin and granzymes in vivo: potential markers for activated cytotoxic cells. Immunol Today 1991; 12: 415-419.
35. Suda T, Okazaki T, Naito Y, Yokota T, Arai N, Ozaki S, Nakao K, Nagata S: Expression of the Fas ligand in cells of T cell lineage. J Immunol 1995; 154: 3806-3813.
36. Jordán J, Segura T, Brea D, Galindo MF, Castillo J: Inflammation as therapeutic objective in stroke. Curr Pharm Des 2008; 14: 3549-3564.
37. Molnar T, Peterfalvi A, Szereday L, Pusch G, Szapary L, Komoly S, Bogar L, Illes Z: Deficient leukocyte antisedimentation is related to post-stroke infections and outcome. J Clin Pathol 2008; 61: 1209-1213.
38. Hauben E, Schwartz M: Therapeutic vaccination for spinal cord injury: helping the body to cure itself. Trends Pharmacol Sci 2003; 24: 7-12.
39. Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M: Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 1999; 5: 49-55.
40. Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A, Kuchroo V, Cohen IR, Weiner H, Schwartz M: Protective autoimmunity is a physiological response to CNS trauma. J Neurosci 2001; 21: 3740-3748. (Pubitemid 32466465)
41. Guth L, Zhang Z, DiProspero NA, Joubin K, Fitch MT: Spinal cord injury in the rat: treatment with bacterial lipopolysaccharide and indomethacin enhances cellular repair and locomotor function. Exp Neurol 1994; 126: 76-87.
42. Nishimura M, Mitsunaga S, Akaza T, Mitomi Y, Tadokoro K, Juji T: Protection against natural killer cells by interferon- treatment of K562 cells cannot be explained by augmented major histocompatibility complex class I expression. Immunology 1994; 83: 75-80.
43. Kubista B, Trieb K, Herbacek I, Micksche M: Effect of granulocyte-macrophage colonystimulating factor on natural-killer cell mediated cytotoxicity. Int J Biochem Cell Biol 2003; 35: 1056-1060.
44. Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA: Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199: 971-979.
45. Young HA, Bream JH: IFN-gamma: recent advances in understanding regulation of expression, biological functions, and clinical applications. Curr Top Microbiol Immunol 2007; 316: 97-117.
46. Young HA, Hardy KJ: Role of interferon- in immune cell regulation. J Leukoc Biol 1995; 58: 373-381.
47. Gardiner CM, Reen DJ: Differential cytokine regulation of natural killer cell-mediated necrotic and apoptotic cytotoxicity. Immunology 1998; 93: 511-517.
48. Prass K, Braun JS, Dirnagl U, Meisel C, Meisel A: Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia. Stroke 2006; 37: 2607-2612.
49. Kipnis J, Mizrahi T, Hauben E, Shaked I, Shevach E, Schwartz M: Neuroprotective autoimmunity: naturally occurring CD4+ CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc Natl Acad Sci USA 2002; 99: 15620-15625.
50. Schwartz M, Moalem G, Leibowitz-Amit R, Cohen IR: Innate and adaptive immune responses can be beneficial for CNS repair. Trends Neurosci 1999; 22: 295-299.
51. Butovsky O, Hauben E, Schwartz M: Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation. FASEB J 2001; 15: 1065-1067.
52. Barouch R, Schwartz M: Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: Implications for protective autoimmunity. FASEB J 2002; 16: 1304-1306.
53. Hammarberg H, Lidman O, Lundberg C, Eltayeb SY, Gielen AW, Muhallab S, Svenningsson A, Lindå H, van Der Meide PH, Cullheim S, Olsson T, Piehl F: Neuroprotection by encephalomyelitis: rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells. J Neurosci 2000; 20: 5283-5291.
54. Stadelmann C, Kerschensteiner M, Misgeld T, Brück W, Hohlfeld R, Lassmann H: BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain 2002; 125: 75-85.
55. Harms H, Prass K, Meisel C, Klehmet J, Rogge W, Drenckhahn C, Göhler J, Bereswill S, Göbel U, Werencke KD, Wolf T, Arnold G, Halle E, Volk H-D, Dirnagl U, Meisel A: Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PLoS One 2008; 3: 1-12.
56. Schwarz S, Al-Shajlawi F, Sick C, Meairs S, Hennerici MG: Effects of prophylactic antibiotic therapy with mezlocillin plus sulbactam on the incidence and height of fever after severe acute ischemic stroke. Stroke 2008; 39: 1220-1227.