Dysregulation of the vitamin D nuclear receptor may contribute to the higher prevalence of some autoimmune diseases in women

Annals of the New York Academy of Sciences

Volumn 1173, Issue , 2009, Pages 252-259

  Proal, Amy D ^a,d   Albert, Paul J ^b   Marshall, Trevor G ^c  

^a GEORGETOWN UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c MURDOCH UNIVERSITY   (Australia)

^d NONE   (United States)

Author keywords

1,25 dihydroxyvitamin D; Antimicrobial peptides; Autoimmune disease; Hashimoto's thyroiditis; Metagenomic microbiota; Olmesartan; Pregnancy; Vitamin D; Vitamin D receptor; Women

Indexed keywords

ANDROGEN RECEPTOR; BETA DEFENSIN; BIOLOGICAL MARKER; CALCITRIOL; CATHELICIDIN; CELL NUCLEUS RECEPTOR; GLUCOCORTICOID RECEPTOR; LIOTHYRONINE; VITAMIN D RECEPTOR;

AUTOIMMUNE DISEASE; BACTERIAL GENOME; BINDING AFFINITY; COMPUTER MODEL; CONFERENCE PAPER; DISEASE EXACERBATION; ENDOCRINE DISEASE; ENDOMETRIUM; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HASHIMOTO DISEASE; HUMAN; IDIOPATHIC DISEASE; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; INNATE IMMUNITY; KERATINOCYTE; MACROPHAGE; MENSTRUAL CYCLE; METAGENOMICS; MICROBIAL COMMUNITY; MICROBIOME; PREGNANCY; PREVALENCE; PROTEIN EXPRESSION; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY; VITAMIN D DEFICIENCY;

BACTERIA (MICROORGANISMS);

EID: 70049093889     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04672.x     Document Type: Conference Paper

References (39)

1. Whitacre, C.C. 2001. Sex differences in autoimmune disease. Nat. Immunol. 2: 777-780.
2. Rose, N.R. 1998. The role of infection in the pathogenesis of autoimmune disease. Semin Immunol. 10: 5-13.
3. Beeson, P.B. 1994. Age and sex associations of 40 autoimmune diseases. Am. J. Med. 96: 457-462.
4. Da Silva, J.A. 1995. Sex hormones, glucocorticoids and autoimmunity: facts and hypotheses. Ann. Rheum. Dis. 54: 6-16.
5. Beagley, K.W. & C.M. Gockel. 2003. Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone. FEMS Immunol. Med. Microbiol. 38: 13-22.
6. Bouman, A., M.J. Heineman & M.M. Faas. 2005. Sex hormones and the immune response in humans. Hum. Reprod. Update 11: 411-423.
7. Olefsky, J.M. 2001. Nuclear receptor minireview series. J. Biol. Chem. 276: 36863-36864.
8. Holick, M.F. 2007. Vitamin D deficiency. N. Engl. J. Med. 357: 266-281.
9. Vigano, P. et al. 2006. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol. 36: 415-424.
10. Wang, T.T. et al. 2004. Cutting edge: 1, 25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J. Immunol. 173: 2909-2912.
11. Wang, T.T. et al. 2005. Large-scale in silico and microarray-based identification of direct 1, 25-dihydroxyvitamin D3 target genes. Mol. Endocrinol. 19: 2685-2695.
12. O'Connor, S.M., C.E. Taylor & J.M. Hughes. 2006. Emerging infectious determinants of chronic diseases. Emerg. Infect. Dis. 12: 1051-1057.
13. Rook, G.A. & J.L. Stanford. 1992. Slow bacterial infections or autoimmunity? Immunol. Today 13: 160-164.
14. Relman, D.A. 1998. Detection and identification of previously unrecognized microbial pathogens. Emerg. Infect Dis. 4: 382-389.
15. Wirostko, E., L. Johnson & B. Wirostko. 1987. Crohn's disease. Rifampin treatment of the ocular and gut disease. Hepatogastroenterology 34: 90-93.
16. Wirostko E., L. Johnson & B. Wirostko. 1989. Sar-coidosis associated uveitis. Parasitization of vitreous leucocytes by mollicute-like organisms. Acta. Ophthal-mol. (Copenh.) 67: 415-424. (Pubitemid 19241442)
17. Wirostko E., L. Johnson & W. Wirostko. 1989. Juvenile rheumatoid arthritis inflammatory eye disease. Parasitization of ocular leukocytes by mollicute-like organisms. J. Rheumatol. 16: 1446-1453.
18. Prummel, M.F., T. Strieder & W.M. Wiersinga. 2004. The environment and autoimmune thyroid diseases. Eur. J. Endocrinol. 150: 605-618.
19. Tomer, Y. & T.F. Davies. 1993. Infection, thyroid disease, and autoimmunity. Endocr. Rev. 14: 107-120.
20. Waterhouse, J.C. et al. In press. Reversing bacteria-induced vitamin d receptor dysfunction is key to autoimmune disease. Ann. N.Y. Acad. Sci.
21. Turnbaugh, P.J. et al. 2007. The human microbiome project. Nature 449: 804-810.
22. Marcy, Y. et al. 2007. Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth. Proc. Natl. Acad. Sci. USA 104: 11889-11894.
23. Singh, P.K. et al. 2002. A component of innate immunity prevents bacterial biofilm development. Nature 417: 552-525.
24. von Herrath, M.G., R.S. Fujinami & J.L. Whitton. 2003. Microorganisms and autoimmunity: making the barren field fertile? Nat. Rev. Microbiol. 1: 151-157.
25. DiGiulio, D.B. et al. 2008. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS ONE 3: e3056.
26. Machin, G.A. et al. 1992. Perinatally acquired neonatal tuberculosis: report of two cases. Pediatr. Pathol. 12: 707-716.
27. Gu J. et al. 2007. H5N1 infection of the respiratory tract and beyond: a molecular pathology study. Lancet 370: 1137-1145.
28. Kodati, V.L. et al. 2008. Role of Shigella infection in endometriosis: a novel hypothesis. Med. Hypotheses 70: 239-243.
29. Romero, R., J. Espinoza & M. Mazor. 2004. Can en-dometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil. Steril. 82: 799-804.
30. Marshall, T.G. 2008. Vitamin D discovery outpaces FDA decision making. Bioessays 30: 173-182.
31. Brahmachary, M. et al. 2006. Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. BMC Bioinformatics 7(Suppl 5): S8.
32. Bazzichi, L. et al. 2007. Association between thyroid autoimmunity and fibromyalgic disease severity. Clin. Rheumatol. 26: 2115-2120.
33. Jenkins, R.C. & A.P. Weetman. 2002. Disease associations with autoimmune thyroid disease. Thyroid 12: 977-988.
34. Sloka, J.S. et al. 2005. Co-occurrence of autoimmune thyroid disease in a multiple sclerosis cohort. J. A u-toimmune Dis. 2: 9.
35. Zych-Twardowska, E. & A. Wajgt. 2001. Blood levels of selected hormones in patients with multiple sclerosis. Med. Sci. Monit. 7: 1005-1012.
36. Waterhouse, J. et al. 2006. High levels of active 1, 25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor-implications of dys-regulated vitamin D for diagnosis and treatment of chronic disease. In Vitamin D: New Research: 1-23.
37. Blaney, G. et al. In press. Vitamin D metabolites as clinical markers in autoimmune and chronic illness. Ann. N.Y. Acad. Sci.
38. Confav reux, C. et al. 1998. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in multiple sclerosis group. N. Engl. J. Med. 339: 285-291.
39. Ostensen, M. & P.M. Villiger. 2002. Immunology of pregnancy-pregnancy as a remission inducing agent in rheumatoid arthritis. Transpl. Immunol. 9: 155-160.