Blood concentration of food-derived peptides following oral intake of chicken collagen hydrolysate and its angiotensin-converting enzyme inhibitory activity in healthy volunteers

Nippon Shokuhin Kagaku Kogaku Kaishi

Volumn 56, Issue 6, 2009, Pages 326-330

  Iwais, Koji ^a   Zhang, Youzuo ^a   Kouguchi, Tomomi ^a   Saiga Egusa, Ai ^a   Shimizu, Muneshige ^a   Ohmori, Takashi ^a   Takahata, Yoshihisa ^a   Morimatsu, Fumiki ^a  

^a NIPPON MEAT PACKERS INC   (Japan)

Author keywords

Angiotensin converting enzyme inhibitory activity; Blood concentration; Chicken collagen octa peptides; Food derived peptide; Hydroxyproline

Indexed keywords

EID: 69949177556     PISSN: 1341027X     EISSN: None     Source Type: Journal    
DOI: 10.3136/nskkk.56.326     Document Type: Article

References (28)

1. Cushman, D.W., Cheung, H.S., Sabo, E.F. and Ondetti, M. A., Design of potent competitive inhibitors of angio-tensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids. Biochemistry, 16, 5484-5491 (1977).
2. Yang, H.Y., Erdos, E.G. and Levin, Y. J., Characterization of a dipeptid hydrolase (Kininase II : angiotensin Icon-verting enzyme). J. pharmacol. exp. ther., 177, 291-300 (1971).
3. Ondetti, M.A., Rubin, B. and Cushman, D.W., Design of specific inhibitors of angiotensin I-converting enzyme : new class of orally active antihypertensive agents. Science, 196, 441-444 (1977).
4. Miyoshi, S., Ishikawa, H., Kaneko, T., Fukui, F., Tanaka, H. and Maruyama, S., Structures and activity of angiotensin I-converting enzyme inhibitors in an alpha-zain hydrolysate. Agric. Biol. Chem., 55, 1313-1318 (1991).
5. Mateui, T., Li, C. and Osajima, Y., Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ. J. pept. sci., 5, 289-297 (1999).
6. Arihara, K., Nakashima, Y., Mukai, T., Ishikawa, S. and Itoh, M., Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins. Meat Scinece, 57, 319-324 (2001).
7. Yang, Y., Marczak, E., Yokoo, M., Usui, H. and Yoshi-kawa, M., Isolation and antihypertensive effect of agio-tensin I-converting enzyme (ACE) inhibitory peptides from spinach rubisco. J. Agric. Food Chem,, 51, 4897-4902 (2003).
8. Saiga, A., Okumura, T., Makihara, T., Katsuta, S., Shimizu, T., Yamada, R. and Nishimura T., Angiotensin I-converting enzyme in a hydrolyzed chicken breast muscle extract. J. Agric. Food Chem., 51, 1741-1745 (2003).
9. Hata, Y., Yamamoto, M., Ohni, M., Nakajima, K., Naka-mura, Y. and Takano T., A placebo-controlled study of the effects of sour milk on blood pressure in hypertensive subjects. Am. j. clin. nutr., 64, 767-771 (1996).
10. Saiga, A., Iwai, K., Hayakawa, T., Takahata, Y., Kita-mura, S., Nishimura, T. and Morimatsu, F., Angiotensin I-converting enzyme inhibitory peptides obtained from chicken collagen hydrolysate. J. Agric. Food Chem., 56, 9586-9591 (2008).
11. Saiga-Egusa, A., Iwai, K., Hayakawa, T., Takahata, Y. and Morimatsu, F., Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild hypertension. Biosci. Biotech. Biochem., 73, 422-424 (2009).
12. Iwai, K., Hasegawa, T., Taguchi, Y., Morimatsu, F., Sato, K., Nakamura, Y., Higashi, A., Kido, Y., Nakabo, Y. and Ohtsuki, K., Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J. Agric. Food Chem., 53, 6531-6536 (2005).
13. Aito-Inoue, M., Ohtsuki, k., Nakamura, Y., Park, E.Y., Iwai, K., Morimatsu, F. and Sato, K., Improvement in isolation and identification of food-derived peptides in human plasma based on precolumn derivatization of peptides with phenyl isothiocyanate. J. Agric. Food Chem., 54, 5261-5266 (2006).
14. Cheung, S., Wang, L., Ondetti, A., Sabo, F. and Cushman, W., Binding of peptide substrates and inhibitors of angio-tensfn-converting enzyme : Importance of the COOH-terminal dipeptide sequence. J. Biol. Chem., 255, 401-407 (1980).
15. Matsui, T., Tamaya, K., Seki, E., Osajima, K., Matsumoto, K. and Kawasaki, T., Absorption of Val - Tyr with in vitro angiotensin I - converting enzyme inhibitory activity into the circulating blood system of mild hypertensive subjects. Biol. Pharm. Bull, 25, 1228-1230 (2002).
16. Matsui, T., Imamura, M., Oka, H., Osajima, K., Kimoto, K., Kawasaki, T. and Matsumoto, K., Tissue distribution of antihypertensive dipeptide, Val-Tyr, after its single oral administration to spontaneously hypertensive rats. J. Pept. Sci., 10, 535-545 (2004).
17. Health Sciences, 20, 82-89 (2004).