Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 6832-6840

  Kumar, Shailesh ^a   Deshpande, Shreekant ^a   Chandra, Vishal ^a   Kitchlu, Shakti ^a   Dwivedi, Anila ^a   Nayak, Vadithe Lakshma ^a   Konwar, Rituraj ^a   Prabhakar, Yenamandra S ^a   Sahu, Devi Prasad ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

2,3,4 Triarylsubstituted dihydrobenzopyran; 4 Acetoxy 2,3 diaryldihydrobenzopyran; Estradiol; SERMs; Therapeutic agent for breast cancer

Indexed keywords

2,4 DI (4 HYDROXYPHENYL) 3 PHENYLDIHYDROBENZO PYRAN; 3 PHENYL 2 [4 [2 PYRROLIDIN 1 YL ETHOXY] PHENYL] CHROMAN 4 OL; 3 PHENYL 2 [4 [2 PYRROLIDIN 1 YL)ETHOXY]PHENYL]CHROMAN 4 ONE; 4 [3 PHENYL 4 [4 (2 PIPERIDIN 1 YL ETHOXY)PHENYL] CHROMAN 2 YL]PHENOL; 4 [3 PHENYL 4 [4 (2 PYRROLIDIN 1 YL ETHOXY) PHENYL] CHROMAN 2 YL]PHENOL; 4 [4 [4 (2 AZEPAN 1 YL)ETHOXY]PHENYL] 3 PHENYLCHROMAN 2 YL]PHENYL ACETATE; 4 [4 [4 (2 DIISOPROPYLAMINO ETHOXY) PHENYL] 3 PHENYLCHROMAN 2 YL] PHENOL; ACETIC ACID 4 [3 PHENYL 4 [4 (2 PIPERIDIN 1 YL ETHOXY) PHENY] CHROMAN 2 YL] PHENYL ESTER; ACETIC ACID 4 [3 PHENYL 4 [4 (2 PYRROLIDIN 1 YL ETHOXY) PHENY]CHROMAN 2 YL] PHENYL ESTER; ACETIC ACID 4 [4 (4 HYDROXY PHENYL) 3 PHENYL CHROMAN 2 YL] PHENYL ESTER; ACETIC ACID 4 [4 [4 (2 DIETHYLAMINOETHOXY)PHENYL] 3 PHENYLCHROMAN 2 YL]PHENYL ESTER; ACETIC ACID 4 [4 [4 (2 DIISOPROPYLAMINOETHOXY) PHENYL] 3 PHENYLCHROMAN 2 YL]PHENYL ESTER; ACETIC ACID 4 [4 [4 (3 DIMETHYLAMINOPROPOXY) PHENYL] 3 PHENYLCHROMAN 2 YL]PHENYL ESTER; ACOLBIFENE; ANTIESTROGEN; ANTINEOPLASTIC AGENT; BENZOPYRAN DERIVATIVE; CENTCHROMAN; ESTROGEN RECEPTOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER THERAPY; CELL STRAIN HEK293; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; HUMAN CELL CULTURE; HYDROLYSIS; IC 50; NONHUMAN; RAT;

BENZOPYRANS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ESTROGEN ANTAGONISTS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; RECEPTORS, ESTROGEN; SELECTIVE ESTROGEN RECEPTOR MODULATORS;

EID: 69949177139     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.034     Document Type: Article

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