Effects of the estrogen antagonist EM-652.HCl on energy balance and lipid metabolism in ovariectomized rats

International Journal of Obesity

Volumn 24, Issue 7, 2000, Pages 830-840

  Picard, F ^a   Deshaies, Y ^a   Lalonde, J ^a   Samson, P ^a   Labrie, C ^b   Belanger A ^b   Labrie, F ^b   Richard, D ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Adipose tissue; Antiestrogen; Cholesterol; EM 652.HCl; Energy balance; Food intake; Insulin; Lipoprotein lipase; Obesity; Ovariectomy; SCH57068.HCl; Triglycerides

Indexed keywords

ACOLBIFENE; ESTRADIOL; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ENERGY BALANCE; ENZYME ACTIVITY; FEMALE; HYPERCHOLESTEROLEMIA; HYPERINSULINEMIA; LIPID METABOLISM; LIVER LEVEL; NONHUMAN; OBESITY; OVARIECTOMY; PRIORITY JOURNAL; RAT; SOLEUS MUSCLE; WHITE ADIPOSE TISSUE;

EID: 0033936681     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801240     Document Type: Article

References (27)

1. 1 Després J-P. The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. Obes Res 1998; 6(Suppl 1): 8S-17S.
2. 2 Després J-P, Lemieux S, Lamarche B, Prudhomme D, Moorjani S, Brun LD, Gagné C, Lupien PJ. The insulin resistance dyslipidemic syndrome: contribution of visceral obesity and therapeutic implications. Int J Obes 1995; 19: S76-S86.
3. 3 Després J-P, Lamarche B, Mauriège P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952-957.
4. 4 Richard D. Effects of ovarian hormones on energy balance and brown adipose tissue thermogenesis. Am J Physiol 1986; 250: R245-R249.
5. 5 Wade GN, Gray JM, Bartness TJ. Gonadal influences on adiposity. Int J Obes 1985; 9: 83-92.
6. 6 Deshaies Y, Dagnault A, Lalonde J, Richard D. Interaction of corticosterone and gonadal steroids on lipid deposition in the female rat. Am J Physiol 1997; 273: E355-E362.
7. 7 Dagnault A, Deshaies Y, Richard D. Involvement of type I corticosteroid receptor in the effects of ovariectomy on energy balance. Am J Physiol 1996; 270: R199-R206.
8. 8 Wade GN, Gray JM. Gonadal effects on food intake and adiposity: a metabolic hypothesis. Physiol Behav 1979; 22: 583-593.
9. 9 Labrie F, Labrie C, Bélanger A, Simard J, Gauthier S, Luu-The V, Mérand Y, Giguère V, Candas B, Luo S, Martel C, Singh SM, Fournier M, Coquet A, Richard V, Charbonneau R, Charpenet G, Tremblay A, Tremblay G, Cusan L, Veilleux R. EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium. J Steroid Biochem Mol Biol 1999; 69: 51-84.
10. 10 Tremblay A, Tremblay GB, Labrie C, Labrie F, Giguère V. EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta. Endocrinology 1998; 139: 111-118.
11. 11 Luo S, Sourla A, Labrie C, Bélanger A, Labrie F. Combined effects of dehydroepiandrosterone and EM-800 on bone mass, serum lipids, and the development of dimethylbenz(A)anthracene-induced mammary carcinoma in the rat. Endocrinology 1997; 138: 4435-4444.
12. 12 Luo S, Labrie C, Bélanger A, Candas B, Labrie F. Prevention of development of dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in the rat by the new nonsteroidal antiestrogen EM-800 (SCH57050). Breast Cancer Res Treat 1998; 49: 1-11.
13. 13 Webster AJF. Energetics of maintenance and growth. In: Girardier L, Stock M (eds). Mammalian Thermogenesis. Chapman and Hall: London, 1983. pp 178-207.
14. 14 Murphy BEP. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab 1967; 27: 973-990.
15. 15 Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957; 226: 497-509.
16. 16 Deshaies Y, Géloën A, Paulin A, Bukowiecki LJ. Restoration of lipoprotein lipase activity in insulin-deficient rats by insulin infusion is tissue-specific. Can J Physiol Pharmac 1991; 69: 746-751.
17. 17 Belfrage P, Vaughan M. Simple liquid - liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res 1969; 10: 341-344.
18. 18 Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-275.
19. 19 Dagnault A, Deshaies Y, Richard D. The effects of RU38486 and RU28318 on energy balance of ovariectomized rats. Ann NY Acad Sci 1994; 746: 418-420.
20. 20 Ouerghi D, Rivest S, Richard D. Adrenalectomy attenuates the effect of chemical castration on energy balance in rats. J Nutr 1992; 122: 369-373.
21. (9 41) prevents the anorectic effect of 17-β-estradiol. Brain Res Bull 1993; 32: 689-692.
22. 22 Krauss RM, Burkman RT. The metabolic impact of oral contraceptives. Am J Obstet Gynecol 1992; 167: 1177-1184.
23. 23 Gray JM, Schrock S, Bishop M. Estrogens and antiestrogens: actions and interactions with fluphenazine on food intake and body weight in rats. Am J Physiol 1993; 264: R1214-R1218.
24. 24 Sato M, Rippy MK, Bryant HU. Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J 1996; 10: 905-912.
25. 25 Wade GN, Blaustein JD, Gray JM, Meredith JM. ICI-182,780: a pure antiestrogen that affects behaviors and energy balance in rats without acting in the brain. Am J Physiol 1993; 265: R1392-R1398.
26. 26 Wade GN, Heller HW. Tamoxifen mimics the effects of estradiol on food intake, body weight, and body composition in rats. Am J Physiol 1993; 264: R1219-R1223.
27. 27 Ke HZ, Paralkar VM, Grasser WA, Crawford DT, Qi H, Simmons HA, Pirie cm, Chidsey-Frink KL, Owen TA, Smock SL, Chen HK, Jee WS, Cameron KO, Rosati RL, Brown TA, Dasilva-Jardine P, Thompson DD. Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models. Endocrinology 1998; 139: 2068-2076.