Identification of linear epitopes in bacillus anthracis protective antigen bound by neutralizing antibodies

Journal of Biological Chemistry

Volumn 284, Issue 37, 2009, Pages 25077-25086

  Abboud, Nareen ^a   De Jesus, Magdia ^a   Nakouzi, Antonio ^a   Cordero, Radames J B ^a   Pujato, Mario ^a   Fiser, András ^a   Rivera, Johanna ^a   Casadevall, Arturo ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXINS; ANTHRAX VACCINES; BACILLUS ANTHRACIS; CELL EPITOPES; CLEAVAGE SITES; CLOSE PROXIMITY; COMPLEX STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; LINEAR EPITOPES; MOLECULAR DOCKING; MONOCLONAL ANTIBODIES (MABS); NEUTRALIZING ANTIBODIES; NEUTRALIZING EPITOPE; PARATOPE; PROTECTIVE ANTIGENS;

AMINO ACIDS; ANTIGENS; BACTERIOLOGY; CELL MEMBRANES; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; PEPTIDES; POLYPEPTIDES;

AMINES;

ANTHRAX TOXIN; ANTHRAX VACCINE; ASPARAGINE; BACTERIAL ANTIGEN; EPITOPE; FURIN; ISOLEUCINE; LEUCINE; LEUCYLLYSYLGLUTAMYLLYSYLSERYLSERYLASPARAGINYLSERYLARGINYLLYSYLLYSYLARGINYLSERYLTHREONYLSERINE; NEUTRALIZING ANTIBODY; SERINE; UNCLASSIFIED DRUG; VALINE; VALYLLYSYLASPARAGINYLLYSYLARGINYLTHREONYLPHENYLALANYLLEUCYLSERYLPROLYLTRYPTOPHYLISOLEUCYLSERYLASPARAGYLISOLEUCINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; ANTIGEN STRUCTURE; ARTICLE; BACILLUS ANTHRACIS; BAGG ALBINO MOUSE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN SYNTHESIS;

ANIMALS; ANTIBODIES; ANTIGENS, BACTERIAL; B-LYMPHOCYTES; BACILLUS ANTHRACIS; BACTERIAL TOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; FEMALE; HYBRIDOMAS; MACROPHAGES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PROTEIN STRUCTURE, TERTIARY;

BACILLUS ANTHRACIS; MUS;

EID: 69949172313     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.022061     Document Type: Article

References (29)

1. Barth, H., Aktories, K., Popoff, M. R., and Stiles, B. G. (2004) Microbiol. Mol. Biol. Rev. 68, 373-402
2. Inglesby, T. V., O'Toole, T., Henderson, D. A., Bartlett, J. G., Ascher, M. S., Eitzen, E., Friedlander, A. M., Gerberding, J., Hauer, J., Hughes, J., Mc-Dade, J., Osterholm, M. T., Parker, G., Perl, T. M., Russell, P. K., and Tonat, K. (2002) J. Am. Med. Assoc. 287, 2236-2252
3. Abboud, N., and Casadevall, A. (2008) Clin. Vaccine Immunol. 15, 1115-1123
4. Flick-Smith, H. C., Walker, N. J., Gibson, P., Bullifent, H., Hayward, S., Miller, J., Titball, R. W., and Williamson, E. D. (2002) Infect. Immun. 70, 1653-1656
5. Gubbins, M. J., Berry, J. D., Corbett, C. R., Mogridge, J., Yuan, X. Y., Schmidt, L., Nicolas, B., Kabani, A., and Tsang, R. S. (2006) FEMS Immunol. Med. Microbiol. 47, 436-443
6. Reed, D. S., Smoll, J., Gibbs, P., and Little, S. F. (2002) Cytometry 49, 1-7
7. Rosovitz, M. J., Schuck, P., Varughese, M., Chopra, A. P., Mehra, V., Singh, Y., McGinnis, L. M., and Leppla, S. H. (2003) J. Biol. Chem. 278, 30936-30944
8. Zhang, J., Xu, J., Li, G., Dong, D., Song, X., Guo, Q., Zhao, J., Fu, L., and Chen, W. (2006) Biochem. Biophys. Res. Commun. 341, 1164-1171
9. Laffly, E., Danjou, L., Condemine, F., Vidal, D., Drouet, E., Lefranc, M. P., Bottex, C., and Thullier, P. (2005) Antimicrob. Agents Chemother. 49, 3414-3420
10. Peterson, J. W., Comer, J. E., Baze, W. B., Noffsinger, D. M., Wenglikowski, A., Walberg, K. G., Hardcastle, J., Pawlik, J., Bush, K., Taormina, J., Moen, S., Thomas, J., Chatuev, B. M., Sower, L., Chopra, A. K., Stanberry, L. R., Sawada, R., Scholz, W. W., and Sircar, J. (2007) Infect. Immun. 75, 3414-3424
11. Subramanian, G. M., Cronin, P. W., Poley, G., Weinstein, A., Stoughton, S. M., Zhong, J., Ou, Y., Zmuda, J. F., Osborn, B. L., and Freimuth, W. W. (2005) Clin. Infect. Dis. 41, 12-20
12. Baillie, L., Townend, T., Walker, N., Eriksson, U., and Williamson, D. (2004) FEMS Immunol. Med. Microbiol. 42, 267-270
13. Rivera, J., Nakouzi, A., Abboud, N., Revskaya, E., Goldman, D., Collier, R. J., Dadachova, E., and Casadevall, A. (2006) Infect. Immun. 74, 4149-4156
14. De Jesus, M., Nicola, A. M., Rodrigues, M. L., Janbon, G., and Casadevall, A. (2009) Eukaryot. Cell 8, 96-103
15. de StGroth, S. F., and Scheidegger, D. (1980) J. Immunol. Methods 35, 1-21
16. Laemmli, U. K. (1970) Nature 227, 680-685
17. Wellings, D. A., and Atherton, E. (1997) Methods Enzymol. 289, 44-67
18. Beavis, R. C., and Chait, B. T. (1996) Methods Enzymol. 270, 519-551
19. Casadevall, A., Mukherjee, J., and Scharff, M. D. (1992) J. Immunol. Methods 154, 27-35
20. Rai, B. K., and Fiser, A. (2006) Proteins 63, 644-661
21. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
22. Gabb, H. A., Jackson, R. M., and Sternberg, M. J. (1997) J. Mol. Biol. 272, 106-120
23. Baldari, C. T., Tonello, F., Paccani, S. R., and Montecucco, C. (2006) Trends Immunol. 27, 434-440
24. Brossier, F., Lévy, M., Landier, A., Lafaye, P., and Mock, M. (2004) Infect. Immun. 72, 6313-6317
25. Moayeri, M., Wiggins, J. F., and Leppla, S. H. (2007) Infect. Immun. 75, 5175-5184
26. Petosa, C., Collier, R. J., Klimpel, K. R., Leppla, S. H., and Liddington, R. C. (1997) Nature 385, 833-838
27. Benson, E. L., Huynh, P. D., Finkelstein, A., and Collier, R. J. (1998) Biochemistry 37, 3941-3948
28. Nassi, S., Collier, R. J., and Finkelstein, A. (2002) Biochemistry 41, 1445-1450
29. Santelli, E., Bankston, L. A., Leppla, S. H., and Liddington, R. C. (2004) Nature 430, 905-908