-
1
-
-
40249111478
-
Concomitant treatment with nebulized formoterol and tiotropium in subjects with COPD: A placebo-controlled trial
-
Tashkin DP, Littner M, Andrews CP, Tomlinson L, Rinehart M, Denis-Mize K. Concomitant treatment with nebulized formoterol and tiotropium in subjects with COPD: a placebo-controlled trial. Respir. Med. 102, 479-487 (2008).
-
(2008)
Respir. Med
, vol.102
, pp. 479-487
-
-
Tashkin, D.P.1
Littner, M.2
Andrews, C.P.3
Tomlinson, L.4
Rinehart, M.5
Denis-Mize, K.6
-
2
-
-
33745218112
-
Muscarinic receptor signaling in the pathophysiology of asthma and COPD
-
Gosens R, Zaagsma J, Meurs H, Halayko AJ. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir. Res. 7, 73 (2006).
-
(2006)
Respir. Res
, vol.7
, pp. 73
-
-
Gosens, R.1
Zaagsma, J.2
Meurs, H.3
Halayko, A.J.4
-
3
-
-
0034982763
-
Function of pulmonary neuronal M(2) muscarinic receptors in sBox chronic obstructive pulmonary disease
-
On LS, Boonyongsunchai P, Webb S, Davies L, Calverley PM, Costello RW. Function of pulmonary neuronal M(2) muscarinic receptors in sBox chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 163, 1320-1325 (2001).
-
(2001)
Am. J. Respir. Crit. Care Med
, vol.163
, pp. 1320-1325
-
-
On, L.S.1
Boonyongsunchai, P.2
Webb, S.3
Davies, L.4
Calverley, P.M.5
Costello, R.W.6
-
4
-
-
0027446311
-
Ba 679 BR, a novel long-acting anticholinergic bronchodilator
-
Disse B, Reichl R, Speck G, Traunecker W, Ludwig Rominger KL, Hammer R. Ba 679 BR, a novel long-acting anticholinergic bronchodilator. Life Sci. 52, 537-544 (1993).
-
(1993)
Life Sci
, vol.52
, pp. 537-544
-
-
Disse, B.1
Reichl, R.2
Speck, G.3
Traunecker, W.4
Ludwig Rominger, K.L.5
Hammer, R.6
-
5
-
-
0035126934
-
Motor control of airway goblet cells and glands
-
Rogers DF. Motor control of airway goblet cells and glands. Respir. Physiol. 125, 129-144 (2001).
-
(2001)
Respir. Physiol
, vol.125
, pp. 129-144
-
-
Rogers, D.F.1
-
6
-
-
0035683136
-
The nonneuronal cholinergic system: An emerging drug target in the airways
-
Wessler IK, Kirkpatrick CJ. The nonneuronal cholinergic system: an emerging drug target in the airways. Pulm. Pharmacol. Ther. 14, 423-434 (2001).
-
(2001)
Pulm. Pharmacol. Ther
, vol.14
, pp. 423-434
-
-
Wessler, I.K.1
Kirkpatrick, C.J.2
-
7
-
-
0034099036
-
Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in sBox chronic obstructive pulmonary disease
-
Littner MR, Ilowite JS, Tashkin DP et al. Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in sBox chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 161, 1136-1142 (2000).
-
(2000)
Am. J. Respir. Crit. Care Med
, vol.161
, pp. 1136-1142
-
-
Littner, M.R.1
Ilowite, J.S.2
Tashkin, D.P.3
-
8
-
-
0036181956
-
A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
-
Casaburi R, Mahler DA, Jones PW et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur. Respir. J. 19, 217-224 (2002).
-
(2002)
Eur. Respir. J
, vol.19
, pp. 217-224
-
-
Casaburi, R.1
Mahler, D.A.2
Jones, P.W.3
-
9
-
-
33845938174
-
Pooled clinical trial analysis of tiotropium safety
-
Kesten S, Jara M, Wentworth C, Lanes S. Pooled clinical trial analysis of tiotropium safety. Chest 130, 1695-1703 (2006).
-
(2006)
Chest
, vol.130
, pp. 1695-1703
-
-
Kesten, S.1
Jara, M.2
Wentworth, C.3
Lanes, S.4
-
10
-
-
0034055236
-
A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease. The Dutch Tiotropium Study Group
-
van Noord JA, Bantje TA, Eland ME, Korducki L, Cornelissen PJ. A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease. The Dutch Tiotropium Study Group. Thorax55, 289-294 (2000).
-
(2000)
Thorax
, vol.55
, pp. 289-294
-
-
van Noord, J.A.1
Bantje, T.A.2
Eland, M.E.3
Korducki, L.4
Cornelissen, P.J.5
-
11
-
-
1042292620
-
One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease
-
Oostenbrink JB, Rutten-van Molken MP, Al MJ, Van Noord JA, Vincken W. One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease. Eur. Respir. J. 23, 241-249 (2004).
-
(2004)
Eur. Respir. J
, vol.23
, pp. 241-249
-
-
Oostenbrink, J.B.1
Rutten-van Molken MP, A.M.2
Van Noord, J.A.3
Vincken, W.4
-
12
-
-
0037879081
-
Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses
-
Tashkin D, Kesten S. Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses. Chest 123, 1441-1449 (2003).
-
(2003)
Chest
, vol.123
, pp. 1441-1449
-
-
Tashkin, D.1
Kesten, S.2
-
13
-
-
24644492301
-
Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: A randomized trial
-
Niewoehner DE, Rice K, Cote C et al. Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial. Ann. Intern. Med. 143, 317-326 (2005).
-
(2005)
Ann. Intern. Med
, vol.143
, pp. 317-326
-
-
Niewoehner, D.E.1
Rice, K.2
Cote, C.3
-
14
-
-
33644859913
-
The effect of tiotropium on exacerbations and airflow in patients with COPD
-
Dusser D, Bravo ML, Iacono P. The effect of tiotropium on exacerbations and airflow in patients with COPD. Eur. Respir. J. 27, 547-555 (2006).
-
(2006)
Eur. Respir. J
, vol.27
, pp. 547-555
-
-
Dusser, D.1
Bravo, M.L.2
Iacono, P.3
-
15
-
-
0017402583
-
The natural history of chronic airflow obstruction
-
Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br. Med. J. 1, 1645-1648 (1977).
-
(1977)
Br. Med. J
, vol.1
, pp. 1645-1648
-
-
Fletcher, C.1
Peto, R.2
-
16
-
-
0027962628
-
Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study
-
Anthonisen NR, Connett JE, Kiley JP et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA 272, 1497-1505 (1994).
-
(1994)
JAMA
, vol.272
, pp. 1497-1505
-
-
Anthonisen, N.R.1
Connett, J.E.2
Kiley, J.P.3
-
17
-
-
0036683267
-
Lung Health Study Research Group. Hospitalizations and mortality in the Lung Health Study
-
Anthonisen NR, Connett JE, Enright PL, Manfreda J; Lung Health Study Research Group. Hospitalizations and mortality in the Lung Health Study. Am. J. Respir. Crit. Care Med. 166, 333-339 (2002).
-
(2002)
Am. J. Respir. Crit. Care Med
, vol.166
, pp. 333-339
-
-
Anthonisen, N.R.1
Connett, J.E.2
Enright, P.L.3
Manfreda, J.4
-
18
-
-
15844429415
-
Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD
-
Casaburi R, Kukafka D, Cooper CB, Witek TJ Jr, Kesten S. Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest 127, 809-817 (2005).
-
(2005)
Chest
, vol.127
, pp. 809-817
-
-
Casaburi, R.1
Kukafka, D.2
Cooper, C.B.3
Witek Jr, T.J.4
Kesten, S.5
-
19
-
-
11844265905
-
One-year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropium
-
Anzueto A, Tashkin D, Menjoge S, Kesten S. One-year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropium. Pulm. Pharmacol. Ther. 18, 75-81 (2005).
-
(2005)
Pulm. Pharmacol. Ther
, vol.18
, pp. 75-81
-
-
Anzueto, A.1
Tashkin, D.2
Menjoge, S.3
Kesten, S.4
-
20
-
-
0038366897
-
Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
-
Brusasco V, Hodder R, Miravitlles M, Korducki L, Towse L, Kesten S. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 58, 399-404 (2003).
-
(2003)
Thorax
, vol.58
, pp. 399-404
-
-
Brusasco, V.1
Hodder, R.2
Miravitlles, M.3
Korducki, L.4
Towse, L.5
Kesten, S.6
-
21
-
-
23144457098
-
Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD
-
van Noord JA, Aumann JL, Janssens E et al. Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD. Eur. Respir. J. 26, 214-222 (2005).
-
(2005)
Eur. Respir. J
, vol.26
, pp. 214-222
-
-
van Noord, J.A.1
Aumann, J.L.2
Janssens, E.3
-
22
-
-
34247561439
-
Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: A randomized trial
-
Aaron SD, Vandemheen KL, Fergusson D et al.; Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann. Intern. Med. 146, 545-555 (2007).
-
(2007)
Ann. Intern. Med
, vol.146
, pp. 545-555
-
-
Aaron, S.D.1
Vandemheen, K.L.2
Fergusson, D.3
-
23
-
-
37849011194
-
INSPIRE Investigators. The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide
-
Wedzicha JA, Calverley PM, Seemungal TA, Hagan G, Ansari Z, Stockley RA; INSPIRE Investigators. The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. Am. J. Respir. Crit. Care Med. 177, 19-26 (2008).
-
(2008)
Am. J. Respir. Crit. Care Med
, vol.177
, pp. 19-26
-
-
Wedzicha, J.A.1
Calverley, P.M.2
Seemungal, T.A.3
Hagan, G.4
Ansari, Z.5
Stockley, R.A.6
-
24
-
-
0029993821
-
Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma
-
O'Connor BJ, Towse LJ, Barnes PJ. Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma. Am. J. Respir. Crit. Care Med. 154, 876-880 (1996).
-
(1996)
Am. J. Respir. Crit. Care Med
, vol.154
, pp. 876-880
-
-
O'Connor, B.J.1
Towse, L.J.2
Barnes, P.J.3
-
25
-
-
37849014833
-
Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD
-
Powrie DJ, Wilkinson TM, Donaldson GC et al. Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD. Eur. Respir. J. 30, 472-478 (2007).
-
(2007)
Eur. Respir. J
, vol.30
, pp. 472-478
-
-
Powrie, D.J.1
Wilkinson, T.M.2
Donaldson, G.C.3
-
26
-
-
58149376396
-
Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts
-
Haag S, Matthiesen S, Juergens UR, Racke K. Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts. Eur. Respir. J. 32, 555-562 (2008).
-
(2008)
Eur. Respir. J
, vol.32
, pp. 555-562
-
-
Haag, S.1
Matthiesen, S.2
Juergens, U.R.3
Racke, K.4
-
27
-
-
38449113726
-
Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: A comparison
-
Bos IS, Gosens R, Zuidhof AB et al. Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison. Eur. Respir. J. 30, 653-661 (2007).
-
(2007)
Eur. Respir. J
, vol.30
, pp. 653-661
-
-
Bos, I.S.1
Gosens, R.2
Zuidhof, A.B.3
-
28
-
-
18644380685
-
Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling
-
Gosens R, Bos IS, Zaagsma J, Meurs H. Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling. Am. J. Respir. Crit. Care Med. 171, 1096-1102 (2005).
-
(2005)
Am. J. Respir. Crit. Care Med
, vol.171
, pp. 1096-1102
-
-
Gosens, R.1
Bos, I.S.2
Zaagsma, J.3
Meurs, H.4
-
29
-
-
0034047010
-
First-line therapy for adult patients with acute asthma receiving a multiple-dose protocol of ipratropium bromide plus albuterol in the emergency department
-
Rodrigo GJ, Rodrigo C. First-line therapy for adult patients with acute asthma receiving a multiple-dose protocol of ipratropium bromide plus albuterol in the emergency department. Am. J. Respir. Crit. Care Med. 161, 1862-1868 (2000).
-
(2000)
Am. J. Respir. Crit. Care Med
, vol.161
, pp. 1862-1868
-
-
Rodrigo, G.J.1
Rodrigo, C.2
-
30
-
-
49649102385
-
Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype
-
Iwamoto H, Yokoyama A, Shiota N et al. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype. Eur. Respir. J. 31, 1379-1380 (2008).
-
(2008)
Eur. Respir. J
, vol.31
, pp. 1379-1380
-
-
Iwamoto, H.1
Yokoyama, A.2
Shiota, N.3
-
31
-
-
3042549235
-
Tiotropium Sleep Study in COPD Investigators. Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD
-
McNicholas WT, Calverley PM, Lee A, Edwards JC; Tiotropium Sleep Study in COPD Investigators. Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD. Eur. Respir. J. 23, 825-831 (2004).
-
(2004)
Eur. Respir. J
, vol.23
, pp. 825-831
-
-
McNicholas, W.T.1
Calverley, P.M.2
Lee, A.3
Edwards, J.C.4
-
32
-
-
0036683267
-
Lung Health Study Research Group. Hospitalizations and mortality in the Lung Health Study
-
Anthonisen NR, Connett JE, Enright PL, Manfreda J; Lung Health Study Research Group. Hospitalizations and mortality in the Lung Health Study. Am. J. Respir. Crit. Care Med. 166, 333-339 (2002).
-
(2002)
Am. J. Respir. Crit. Care Med
, vol.166
, pp. 333-339
-
-
Anthonisen, N.R.1
Connett, J.E.2
Enright, P.L.3
Manfreda, J.4
-
33
-
-
0037362716
-
-
Lanes S, Golisch W, Mikl J. Ipratropium and lung health study. Am. J. Respir. Crit. Care Med. 167, 801; author reply 801-802 (2003).
-
Lanes S, Golisch W, Mikl J. Ipratropium and lung health study. Am. J. Respir. Crit. Care Med. 167, 801; author reply 801-802 (2003).
-
-
-
-
34
-
-
52449106502
-
Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
-
Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA 300, 1439-1450 (2008).
-
(2008)
JAMA
, vol.300
, pp. 1439-1450
-
-
Singh, S.1
Loke, Y.K.2
Furberg, C.D.3
-
35
-
-
53749102775
-
UPLIFT Study Investigators. A 4-year trial of tiotropium in chronic obstructive pulmonary disease
-
Tashkin DP, Celli B, Senn S et al.; UPLIFT Study Investigators. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N. Engl. J. Med. 359, 1543-1554 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1543-1554
-
-
Tashkin, D.P.1
Celli, B.2
Senn, S.3
|