Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells

Differentiation

Volumn 78, Issue 2-3, 2009, Pages 108-115

  Boeuf, Stephane ^a   Börger, Maike ^a   Hennig, Thea ^a   Winter, Anja ^a   Kasten, Philip ^a   Richter, Wiltrud ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Chondrogenesis; Differentiation; Mesenchymal stem cells; Representational difference analysis

Indexed keywords

INTEGRAL MEMBRANE PROTEIN 2A; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ARTICLE; BONE MARROW; CARTILAGE; CELL DIFFERENTIATION; CELL POPULATION; CHONDROGENESIS; CONTROLLED STUDY; DATA ANALYSIS; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE ENGINEERING; TISSUE REGENERATION;

ADIPOSE TISSUE; ADULT; AGED; ANIMALS; BONE MARROW; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROGENESIS; HUMANS; IMMUNOBLOTTING; MEMBRANE PROTEINS; MESENCHYMAL STEM CELLS; MICE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; YOUNG ADULT;

EID: 69949165799     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1016/j.diff.2009.05.007     Document Type: Article

References (38)

1. Atsumi T., Miwa Y., Kimata K., and Ikawa Y. A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells. Cell Differ. Dev. 30 (1990) 109-116
2. Azizan A., Holaday N., and Neame P.J. Post-translational processing of bovine chondromodulin-I. J. Biol. Chem. 276 (2001) 23,632-23,638
3. Benz K., Breit S., Lukoschek M., Mau H., and Richter W. Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genes. Biochem. Biophys. Res. Commun. 293 (2002) 284-292
4. Boeuf S., Klingenspor M., Van Hal N.L., Schneider T., Keijer J., and Klaus S. Differential gene expression in white and brown preadipocytes. Physiol. Genomics 7 (2001) 15-25
5. Boeuf S., Steck E., Pelttari K., Hennig T., Buness A., Benz K., Witte D., Sultmann H., Poustka A., and Richter W. Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers. Osteoarthritis Cartilage 16 (2008) 48-60
6. De Ugarte D.A., Alfonso Z., Zuk P.A., Elbarbary A., Zhu M., Ashjian P., Benhaim P., Hedrick M.H., and Fraser J.K. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol. Lett. 89 (2003) 267-270
7. De Ugarte D.A., Morizono K., Elbarbary A., Alfonso Z., Zuk P.A., Zhu M., Dragoo J.L., Ashjian P., Thomas B., Benhaim P., Chen I., Fraser J., and Hedrick M.H. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 174 (2003) 101-109
8. Deleersnijder W., Hong G., Cortvrindt R., Poirier C., Tylzanowski P., Pittois K., Van Marck E., and Merregaert J. Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J. Biol. Chem. 271 (1996) 19,475-19,482
9. Friedenstein A.J., Chailakhyan R.K., and Gerasimov U.V. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet. 20 (1987) 263-272
10. Goessler U.R., Bugert P., Bieback K., Stern-Straeter J., Bran G., Hormann K., and Riedel F. Integrin expression in stem cells from bone marrow and adipose tissue during chondrogenic differentiation. Int. J. Mol. Med. 21 (2008) 271-279
11. Guilak F., Lott K.E., Awad H.A., Cao Q., Hicok K.C., Fermor B., and Gimble J.M. Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. J. Cell Physiol. 206 (2006) 229-237
12. Haynesworth S.E., Goshima J., Goldberg V.M., and Caplan A.I. Characterization of cells with osteogenic potential from human marrow. Bone 13 (1992) 81-88
13. Hennig T., Lorenz H., Thiel A., Goetzke K., Dickhut A., Geiger F., and Richter W. Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. J. Cell Physiol. 211 (2007) 682-691
14. Hubank M., and Schatz D.G. Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acids Res. 22 (1994) 5640-5648
15. Kasten P., Vogel J., Luginbuhl R., Niemeyer P., Tonak M., Lorenz H., Helbig L., Weiss S., Fellenberg J., Leo A., Simank H.G., and Richter W. Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier. Biomaterials 26 (2005) 5879-5889
16. Katz A.J., Tholpady A., Tholpady S.S., Shang H., and Ogle R.C. Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells. Stem Cells 23 (2005) 412-423
17. Kirchner J., and Bevan M.J. ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes. J. Exp. Med. 190 (1999) 217-228
18. Lee R.H., Kim B., Choi I., Kim H., Choi H.S., Suh K., Bae Y.C., and Jung J.S. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol. Biochem. 14 (2004) 311-324
19. Liu T.M., Martina M., Hutmacher D.W., Hui J.H., Lee E.H., and Lim B. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 25 (2007) 750-760
20. Mehlhorn A.T., Niemeyer P., Kaiser S., Finkenzeller G., Stark G.B., Sudkamp N.P., and Schmal H. Differential expression pattern of extracellular matrix molecules during chondrogenesis of mesenchymal stem cells from bone marrow and adipose tissue. Tissue Eng. 12 (2006) 2853-2862
21. Muraglia A., Cancedda R., and Quarto R. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J. Cell Sci. 113 Pt 7 (2000) 1161-1166
22. Musina R.A., Bekchanova E.S., and Sukhikh G.T. Comparison of mesenchymal stem cells obtained from different human tissues. Bull. Exp. Biol. Med. 139 (2005) 504-509
23. Pastorian K., Hawel III L., and Byus C.V. Optimization of cDNA representational difference analysis for the identification of differentially expressed mRNAs. Anal. Biochem. 283 (2000) 89-98
24. Pelttari K., Winter A., Steck E., Goetzke K., Hennig T., Ochs B.G., Aigner T., and Richter W. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum. 54 (2006) 3254-3266
25. Pittois K., Wauters J., Bossuyt P., Deleersnijder W., and Merregaert J. Genomic organization and chromosomal localization of the Itm2a gene. Mamm. Genome 10 (1999) 54-56
26. Reznikoff C.A., Brankow D.W., and Heidelberger C. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res. 33 (1973) 3231-3238
27. Sakaguchi Y., Sekiya I., Yagishita K., and Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum. 52 (2005) 2521-2529
28. Sanchez-Pulido L., Devos D., and Valencia A. BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem. Sci. 27 (2002) 329-332
29. Silva Jr. W.A., Covas D.T., Panepucci R.A., Proto-Siqueira R., Siufi J.L., Zanette D.L., Santos A.R., and Zago M.A. The profile of gene expression of human marrow mesenchymal stem cells. Stem Cells 21 (2003) 661-669
30. Steck E., Benz K., Lorenz H., Loew M., Gress T., and Richter W. Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes. Biochem. J. 353 (2001) 169-174
31. Tintut Y., Alfonso Z., Saini T., Radcliff K., Watson K., Bostrom K., and Demer L.L. Multilineage potential of cells from the artery wall. Circulation 108 (2003) 2505-2510
32. Tuckermann J.P., Pittois K., Partridge N.C., Merregaert J., and Angel P. Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. J. Bone Miner. Res. 15 (2000) 1257-1265
33. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98 (2001) 5116-5121
34. Van den Plas D., and Merregaert J. Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells. Cell Biol. Int. 28 (2004) 199-207
35. Van den Plas D., and Merregaert J. In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathway. Biol. Cell 96 (2004) 463-470
36. Winter A., Breit S., Parsch D., Benz K., Steck E., Hauner H., Weber R.M., Ewerbeck V., and Richter W. Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells. Arthritis Rheum. 48 (2003) 418-429
37. Young H.E., Steele T.A., Bray R.A., Hudson J., Floyd J.A., Hawkins K., Thomas K., Austin T., Edwards C., Cuzzourt J., Duenzl M., Lucas P.A., and Black Jr. A.C. Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat. Rec. 264 (2001) 51-62
38. Zuk P.A., Zhu M., Ashjian P., De Ugarte D.A., Huang J.I., Mizuno H., Alfonso Z.C., Fraser J.K., Benhaim P., and Hedrick M.H. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell 13 (2002) 4279-4295