Paclitaxel inhibits radiation induced VEGF secretion and enhances radiosensitizing effects in human colon cancer cell HT29

Cancer Therapy

Volumn 7, Issue ISSUE A, 2009, Pages 123-132

  Toiyama, Yuji ^a   Inoue, Yasuhiro ^a   Hiro, Junichiro ^a   Ojima, Eiki ^a   Watanabe, Hideki ^a   Narita, Youhei ^a   Okigami, Masato ^a   Hosono, Atuko ^a   Miki, Chikao ^a   Kusunoki, Masato ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

5 fluorouracil; Colon cancer; Paclitaxel; Radio enhancement; VEGF

Indexed keywords

FLUOROURACIL; PACLITAXEL; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELLULAR DISTRIBUTION; COLON CANCER; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PROTEIN SECRETION; RADIOSENSITIZATION;

EID: 69949142907     PISSN: 15439135     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Ahmad NR, Nagle D (1997) Long-term results of preoperative radiation therapy alone for stage T3 and T4 rectal cancer. Br J Surg 84, 1445-1448.
2. Belotti D, Vergani V, Drudis T Borsotti P, Pitelli MR, Viale G, Giavazzi R, Taraboletti G (1996) The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res 2, 1843-1849.
3. Camma C, Giunta M, Fiorica F, Pangliaro L, Craxi A, Cottone M (2000) Preoperative radiotherapy for respectable rectal cancer: A meta-analysis. JAMA 284, 1008-1015.
4. Cascinu S, Graziano F, Catalano V, Staccioli MP, Rossi MC, Baldelli AM, Barni S, Brenna A, Secondino S, Muretto P, Catalano G (2002) An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. Br J Cancer 86, 744-749.
5. Choy H, Rodriguez FF, Koester S, Hilsenbeck S, Von Hoff DD (1993) Investigation of Taxol as a potential radiation sensitizer. Cancer 71, 3774-3778.
6. Colorectal Cancer Collaborative Group (2001) Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials. Lancet 358, 1291-304.
7. Einzig AI, Neuberg D, Wiernik PH, Grochow LB, Ramirez G, O'Dwyer PJ, Petrelli NJ (1996) Phase II Trial of Paclitaxel in Patients with Advanced Colon Cancer Previously Untreated with Cytotoxic Chemotherapy: An Eastern Cooperative Oncology Group Trial (PA286). Am J Ther 3, 750-754.
8. Fan YF, Huang ZH, Nie J (2002) Inhibitory effects of TNP-470 in combination with 5-fluorouracil on growth of human colon cancer Ai Zheng 21, 1319-1323.
9. Geard CR, Jones JM, Schiff PB (1993) Taxol and radiation. J Natl Cancer Inst 15, 89-94.
10. Gorski DH, Beckett MA, Jaskowiak Nt, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW, Weichselbaum RR (1999) Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of irradiation. Cancer Res 59, 3374-3378.
11. Gridley DS, Loredo LN, Slater JD, Archambeau JO, Bedros AA, Andres ML, Slater JM (1998) Pilot evaluation of cytokine levels in patients undergoing radiotherapy for brain tumor. Cancer Detect Pre 22, 20-29.
12. Gupta N, Hu LJ, Deen DF (1997) Cytotoxicity and cell-cycle effects of paclitaxel when used as a single agent in combination with ionizing radiation. Int J Radiat Oncol Biol Phys 37, 885-895.
13. Horwitz SB (1992) Mechanism of action of taxol. Trends Pharmacol Sci 13, 134-136.
14. Klauber N, Parangi S, Flynn E, Hamel E, D'Amato RJ (1997) Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and Taxol. Cancer Res 57, 81-86.
15. Liebmann J, Cook JA, Fisher J, Teague D, Mitchell JB (1994) In vitro studies of Taxol as a radiation sensitizer in human tumor cells. J Natl Cancer Inst 86, 441-446.
16. Manfredi JJ, Parness J, Horwitz SB (1982) Taxol binds to cellular microtubules. J Cell Biol 94, 688-696.
17. Milas L, Hunter NR, Mason KA, Milross CG, Saito Y, Peters LJ (1995) Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel. Cancer Res 55, 3564-3568.
18. Milross CG, Mason KA, Hunter NR, Terry NH, Patel N, Harada S, Jibu T, Seong J, Milas L (1997) Enhanced radioresponse of paclitaxel-sensitive and -resistant tumors in vivo. Eur J Cancer 33, 1299-1308.
19. Moeller BJ, Cao Y, Li CY, Dewhirst MW (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5, 429-441.
20. Myoung H, Hong SD, Kim YY, Hong SP, Kim MJ (2001) Evaluation of the anti-tumor and anti-angiogenic effect of paclitaxel and thalidomide on the xenotransplanted oral squamous cell carcinoma. Cancer Lett 163, 191-200.
21. NIH Consensus Conference (1990) Adjuvant therapy for patients with colon and rectal cancer. JAMA 264, 1444-1450.
22. Nozue M, Isaka N, Fukao K (2001) Over-expression of vascular endothelial growth factor after preoperative radiation therapy for rectal cancer. Oncol Rep 8, 1247-1249.
23. Riedel F, Gotte K, Goessler U, Sadick H, Hormann K (2004) Targeting chemotherapy-induced VEGF up-regulation by VEGF antisense oligonucleotides in HNSCC cell lines. Anticancer Res 24, 2179-2183.
24. Rodriguez M, Sevin BU, Perras J, Nguyen HN, Pham C, Steren AJ, Koechli OR, Averette HE (1995) Paclitaxel: a radiation sensitizer of human cervical cancer cells. Gynecol Oncol 57, 165-169.
25. Rowinsky EK, Cazenave LA, Donehower RC (1990) Taxol: a novel investigational antimicrotubule agent. J Natl Cancer Inst 82, 1247-1259.
26. Rowinsky EK, Donehower RC (1995) Paclitaxel (Taxol). New Engl J Med 332, 1004-1008.
27. Schiff PB, Horwitz SB (1980) Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci USA 77, 1561-1565.
28. Shaheen RM, Davis DW, Liu W Zebrowski BK, Wilson MR, Bucana CD, McConkey DJ, McMahon G, Ellis LM (1999) Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res 59, 5412-5416.
29. Sinclair WK (1968) Cyclic X-ray response in mammalian cells in vitro. Radiat Res 33, 620-643.
30. Steren A, Sevin BU, Perras J, Ramos R, Angioli R, Nguyen H, Koechli O, Averette HE (1993) Taxol as a radiation sensitizer: a flow cytometric study. Gynecol Oncol 50, 89-93.
31. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM (1995) Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55, 3964-3968.
32. Tishler RB, Schiff PB, Geard CR, Hall EJ (1992) Taxol: a novel radiation sensitizer. Int J Radiat Oncol Biol Phys 22, 613-617.
33. Trial SRC (1997) Improved survival with preoperative radiotherapy in respectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med 336, 980-987.
34. Yamamura T, Tsukikawa S, Yamada K, Yamaguchi S (2001) Morphologic analysis of microvessels in colorectal tumors with respect to the formation of liver metastases. J Surg Oncol 78, 259-264.
35. Zhou X, Li J, Kucik DF (2001) The microtubule cytoskeleton participates in control of beta2 integrin avidity. J Biol Chem 276, 44762-44769.
36. Zhu AX, Willett CG (2003) chemotherapeutic and biologic agencys as radiosensitizers in rectal cancer. Semin Radiat Oncol 13, 454-468.
37. Steren A, Sevin BU, Perras J, Ramos R, Angioli R, Nguyen H, Koechli O, Averette HE. (1993) Taxol as a radiation sensitizer: a Xow cytometric study. Gynecol Oncol 50, 89-93.