Evidence of association of Vitamin D receptor Apa I gene polymorphism with bone mineral density in postmenopausal women with osteoporosis

Clinical Rheumatology

Volumn 28, Issue 10, 2009, Pages 1187-1191

  Dundar, Umit ^a   Solak, Mustafa ^b   Kavuncu, Vural ^a   Ozdemir, Mujgan ^b   Cakir, Tuncay ^a   Yildiz, Handan ^b   Evcik, Deniz ^c  

^a AFYON KOCATEPE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b AFYON KOCATEPE UNIVERSITY   (Turkey)

^c UFUK UNIVERSITY   (Turkey)

Author keywords

Bone mineral density; Osteoporosis; Vitamin D receptor Apa I gene polymorphism

Indexed keywords

UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; VITAMIN D RECEPTOR APA I;

ADULT; ARTICLE; BONE DENSITY; BONE METABOLISM; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; DNA POLYMORPHISM; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GENOTYPE; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; OSTEOPENIA; POLYMERASE CHAIN REACTION; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VENOUS BLOOD;

ABSORPTIOMETRY, PHOTON; AGED; BONE DENSITY; CALCIUM; CASE-CONTROL STUDIES; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HIP JOINT; HUMANS; LUMBAR VERTEBRAE; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POLYMORPHISM, GENETIC; RECEPTORS, CALCITRIOL;

EID: 69949116381     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-009-1220-1     Document Type: Article

References (24)

1. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141
2. Prince RL, Dick I (1997) Oestrogen effects on calcium membrane transport: A new view of the inter-relationship between oestrogen deficiency and age-related osteoporosis. Osteoporos Int 7(suppl 3):S150-S154
3. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S (1987) Genetic determinants of bone mass in adults: A twin study. J Clin Invest 80:706-710
4. Christian JC, Yu PL, Slemenda CW, Johnston CC (1989) Heritability of bone mass: A longitudinal study in aging male twins. Am J Hum Genet 44:429-433
5. Slemenda CW, Christian JC, Williams CJ, Norton JA, Johnston CC (1991) Genetic determinants of bone mass in adult women: A reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. J Bone Miner Res 6:561-567
6. Flicker L, Hopper JL, Rodgers L, Kaymakci B, Green RM, Wark JD (1995) Bone density in elderly women: A twin study. J Bone Miner Res 10:1607-1613
7. Michaelsson K, Melhus H, Ferm H, Ahlbom A, Pedersen NL (2005) Genetic liability to fractures in the elderly. Arch Intern Med 165:1825-1830
8. Stewart TL, Ralston SH (2000) Role of genetic factors in the pathogenesis of osteoporosis. J Endocrinol 166:235-245
9. Ralston SH, de Crombrugghe B (2006) Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev 20:2492-2506
10. Kristjansson K, Rut AR, Hewison M, O'Riordan JL, Hughes MR (1993) Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3. J Clin Invest 92:12-16
11. Zmuda JM, Cauley JA, Danielson ME, Wolf RL, Ferrell RE (1997) Vitamin D receptor gene polymorphisms, bone turnover, and rates of bone loss in older African-American women. J Bone Miner Res 12:1446-1452
12. Zhang ZL, Zhao JX, Meng XW, Zhou XY, Xing XP, Xia WB (2003) Association of polymorphisms of vitamin D receptor gene start codon and 3′-end region with bone mineral density in postmenopausal women. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20(1):5-8
13. Qin YJ, Zhang ZL, Huang QR, He JM, Hu YQ, Zhao Q, Lu JH, Li M, Liu YJ (2004) Association of vitamin D receptor and estrogen receptor-alpha gene polymorphism with peak bone mass and bone size in Chinese women. Acta Pharmacol Sin 25(4):462-468
14. Gennari L, Becherini L, Masi L, Gonnelli S, Cepollaro C, Martini S, Mansani R, Brandi ML (1997) Vitamin D receptor genotypes and intestinal calcium absorption in postmenopausal women. Calcif Tissue Int 61:460-463
15. Zambrano-Morales M, Borjas L, Fernández E, Zabala W, de Romero P, Pineda L, Morales-Machín A (2008) Association of the vitamin D receptor gene BBAAtt haplotype with osteoporosis in post-menopausic women. Invest Clin 49(1):29-38
16. Huang QR, Zhang ZL, Qin YJ, He JW, Lu JH, Zhou Q, Hu YQ, Li M, Liu YJ (2003) Association of Apa I polymorphism of vitamin D receptor gene with bone mass in men. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25(3):254-257
17. Williams FMK, Spector TD (2007) The genetics of osteoporosis. Acta Reumatol Port 32:231-240
18. Yokoyama K, Shigematsu T, Tsukada T, Ogura Y, Takemoto F, Hara S, Yamada A, Kawaguchi Y, Hosoya T (1998) Apa I polymorphism in the vitamin D receptor gene may affect the parathyroid response in Japanese with end-stage renal disease. Kidney Int 53(2):454-458
19. Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K, Tonai T, Nishisho T, Mori S, Takeda E (1997) A vitamin D receptor gene polymorphism in the translation initiation codon: Effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 12:915-921
20. Zhang ZL, Qin YJ, Huang QR, He JW, Li M, Zhou Q, Hu YQ, Liu YJ (2004) Association of estrogen receptor-alpha and vitamin D receptor genotypes with therapeutic response to calcium in postmenopausal Chinese women. Acta Pharmacol Sin 25(12):1690-1697
21. Iki M, Saito Y, Dohi Y, Kajita E, Nishino H, Yonemasu K, Kusaka Y (2002) Greater trunk muscle torque reduces postmenopausal bone loss at the spine independently of age, body size and vitamin D receptor genotype in Japanese women. Calcif Tissue Int 71:300-307
22. Bid HK, Mishra DK, Mittal R (2005) Vitamin-D receptor (VDR) gene (Fok-I, Taq-I and Apa-I) polymorphisms in healthy individuals from north Indian population. Asian Pac J Cancer Prev 6(2):147-152
23. Fountas L, Moutsatsou P, Kastanias I, Tamouridis N, Tzanela M, Anapliotou M, Sekeris CE (1999) The contribution of vitamin D receptor gene polymorphisms in osteoporosis and familial osteoporosis. Osteoporos Int 10(5):392-398
24. Thakkinstian A, D'Este C, Eisman J, Nguyen T, Attia J (2004) Meta-analysis of molecular association studies: Vitamin D receptor gene polymorphisms and BMD as a case study. J Bone Miner Res 19:419-428