Prevention of aortic elastic lamina defects by losartan in apolipoprotein e-deficient mouse

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 9, 2009, Pages 919-924

  Chan, Elsa C ^a   Jones, Gregory T ^b   Dusting, Gregory J ^a   Datla, Srinivasa R ^a,c   Jiang, Fan ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin II; Aorta; Apolipoprotein E deficient mouse; Elastic lamina defect; Losartan

Indexed keywords

DRINKING WATER; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; LOSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ARCH; AORTA DISEASE; ARTICLE; BLOOD PRESSURE; BOWMAN MEMBRANE; CONTROLLED STUDY; DRUG MEGADOSE; HISTOLOGY; HYPERLIPOPROTEINEMIA TYPE 3; LIPID BLOOD LEVEL; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION;

AGE FACTORS; AGING; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; AORTA, THORACIC; AORTIC DISEASES; APOLIPOPROTEINS E; DISEASE MODELS, ANIMAL; ELASTIC TISSUE; GENE EXPRESSION REGULATION; HEMODYNAMICS; HYPERLIPIDEMIAS; INFLAMMATION MEDIATORS; LIPIDS; LOSARTAN; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 69949108854     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05169.x     Document Type: Article

References (29)

1. Sims FH. The initiation of intimal thickening in human arteries. Pathology 2000 32 : 171 175.
2. Moreno PR, Purushothaman KR, Fuster V, O'Connor WN. Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: Implications for plaque vulnerability. Circulation 2002 105 : 2504 2511.
3. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992 258 : 468 471.
4. Jones GT, Jiang F, McCormick SP, Dusting GJ. Elastic lamina defects are an early feature of aortic lesions in the apolipoprotein E knockout mouse. J. Vasc. Res. 2005 42 : 237 246.
5. Huang W, Alhenc Gelas F, Osborne-Pellegrin MJ. Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat. Circ. Res. 1998 82 : 879 890.
6. Tham DM, Martin-McNulty B, Wang YX et al. Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002 283 : R1442 9.
7. Katsuda S, Kaji T. Atherosclerosis and extracellular matrix. J. Atheroscler. Thromb. 2003 10 : 267 274.
8. Mori T, Hashimoto A. Direct positive chronotropic action by angiotensin II in the isolated mouse atrium. Life Sci. 2006 79 : 637 640.
9. Suganuma E, Babaev VR, Motojima M et al. Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques. J. Am. Soc. Nephrol. 2007 18 : 2311 2319.
10. Smith EB, Staples EM. Distribution of plasma proteins across the human aortic wall: Barrier functions of endothelium and internal elastic lamina. Atherosclerosis 1980 37 : 579 590.
11. Kwon GP, Schroeder JL, Amar MJ, Remaley AT, Balaban RS. Contribution of macromolecular structure to the retention of low-density lipoprotein at arterial branch points. Circulation 2008 117 : 2919 2927.
12. Lijnen HR, Van Hoef B, Vanlinthout I, Verstreken M, Rio MC, Collen D. Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivation. Arterioscler. Thromb. Vasc. Biol. 1999 19 : 2863 2870.
13. Eagleton MJ, Ballard N, Lynch E, Srivastava SD, Upchurch Jr GR, Stanley JC. Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during angiotensin II induced aneurysm formation. J. Surg. Res. 2006 135 : 345 351.
14. Fan J, Watanabe T. Inflammatory reactions in the pathogenesis of atherosclerosis. J. Atheroscler. Thromb. 2003 10 : 63 71.
15. Brasier AR, Recinos 3rd A, Eledrisi MS. Vascular inflammation and the renin-angiotensin system. Arterioscler. Thromb. Vasc. Biol. 2002 22 : 1257 1266.
16. Nikkari ST, Hoyhtya M, Isola J, Nikkari T. Macrophages contain 92-kd gelatinase (MMP-9) at the site of degenerated internal elastic lamina in temporal arteritis. Am. J. Pathol. 1996 149 : 1427 1433.
17. Ishii T, Asuwa N. Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection. Hum. Pathol. 2000 31 : 640 646.
18. Boyle JR, McDermott E, Crowther M, Wills AD, Bell PR, Thompson MM. Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease. J. Vasc. Surg. 1998 27 : 354 361. (Pubitemid 28136817)
19. Jiang F, Jones GT, Dusting GJ. Failure of antioxidants to protect against angiotensin II-induced aortic rupture in aged apolipoprotein (E)-deficient mice. Br. J. Pharmacol. 2007 152 : 880 890.
20. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J. Clin. Invest. 1996 98 : 2572 2579.
21. Dobrian AD, Schriver SD, Prewitt RL. Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension. Hypertension 2001 38 : 361 366.
22. 2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species. Atherosclerosis 2007 195 : 39 47.
23. 1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice. J. Hypertens. 2005 23 : 1383 1389.
24. Lijnen HR. Extracellular proteolysis in the development and progression of atherosclerosis. Biochem. Soc. Trans. 2002 30 : 163 167.
25. Lutgens E, Lutgens SP, Faber BC et al. Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation 2006 113 : 98 107.
26. Suganuma E, Zuo Y, Ayabe N et al. Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction. J. Am. Soc. Nephrol. 2006 17 : 433 441.
27. O'Rourke MF. Arterial aging: Pathophysiological principles. Vasc. Med. 2007 12 : 329 341.
28. Inserra F, Romano L, Ercole L, de Cavanagh EM, Ferder L. Cardiovascular changes by long-term inhibition of the renin-angiotensin system in aging. Hypertension 1995 25 : 437 442.
29. Maeso R, Rodrigo E, Munoz-Garcia R et al. Chronic treatment with losartan ameliorates vascular dysfunction induced by aging in spontaneously hypertensive rats. J. Hypertens. 1998 16 : 665 672.