Detection of low levels of human immunodeficiency virus (HIV) may be critical for early diagnosis of pediatric HIV infection by use of dried blood spots

Journal of Clinical Microbiology

Volumn 47, Issue 9, 2009, Pages 2989-2991

  Walter, Jan ^a,h   Kuhn, Louise ^b   Semrau, Katherine ^c   Decker, Don W ^a   Sinkala, Moses ^d,i   Kankasa, Chipepo ^e   Thea, Donald M ^c   Bulterys, Marc ^f   Ou, Chin Yih ^f   Aldrovandi, Grace M ^a,g  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Mailman School of Public Health   (United States)

^c BOSTON UNIVERSITY   (United States)

^d Lusaka District Health Management Team   (Zambia)

^e UNIVERSITY TEACHING HOSPITAL   (Zambia)

^f CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^g CHILDREN S HOSPITAL LOS ANGELES   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ Catholic Medical Mission Board   (Zambia)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACID; VIRUS DNA; VIRUS RNA;

ARTICLE; ASSAY; BLOOD; CHILDHOOD DISEASE; DNA DETERMINATION; EARLY DIAGNOSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; NONHUMAN; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; VIRUS DETECTION;

BLOOD; DESICCATION; DNA, VIRAL; EARLY DIAGNOSIS; HIV; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; SPECIMEN HANDLING;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 69949108670     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.02453-08     Document Type: Article

References (18)

1. Creek, T. L., G. G. Sherman, J. Nkengasong, L. Lu, T. Finkbeiner, M. G. Fowler, E. Rivadeneira, and N. Shaffer. 2007. Infant human immunodeficiency virus diagnosis in resource-limited settings: issues, technologies, and country experiences. Am. J. Obstet. Gynecol. 197:S64-S71.
2. Cunningham, C. K., T. T. Charbonneau, K. Song, D. Patterson, T. Sullivan, T. Cummins, and B. Poiesz. 1999. Comparison of human immunodeficiency virus 1 DNA polymerase chain reaction and qualitative and quantitative RNA polymerase chain reaction in human immunodeficiency virus 1-exposed infants. Pediatr. Infect. Dis. J. 18:30-35.
3. De Rossi, A., S. Masiero, C. Giaquinto, E. Ruga, M. Comar, M. Giacca, and L. Chieco-Bianchi. 1996. Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection. J. Clin. Investig. 97:323-330.
4. Kourtis, A. P., F. K. Lee, E. J. Abrams, D. J. Jamieson, and M. Bulterys. 2006. Mother-to-child transmission of HIV-1: timing and implications for prevention. Lancet Infect. Dis. 6:726-732.
5. Kuhn, L., G. M. Aldrovandi, M. Sinkala, C. Kankasa, K. Semrau, M. Mwiya, P. Kasonde, N. Scott, C. Vwalika, J. Walter, M. Bulterys, W. Y. Tsai, and D. M. Thea. 2008. Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N. Engl. J. Med. 359:130-141.
6. Kuhn, L., M. Sinkala, C. Kankasa, K. Semrau, P. Kasonde, N. Scott, M. Mwiya, C. Vwalika, J. Walter, W. Y. Tsai, G. M. Aldrovandi, and D. M. Thea. 2007. High uptake of exclusive breastfeeding and reduced early post-natal HIV transmission. PLoS ONE 2:e1363.
7. Lambert, J. S., D. R. Harris, E. R. Stiehm, J. Moye, Jr., M. G. Fowler, W. A. Meyer III, J. Bethel, and L. M. Mofenson. 2003. Performance characteristics of HIV-1 culture and HIV-1 DNA and RNA amplification assays for early diagnosis of perinatal HIV-1 infection. J. Acquir. Immune Defic. Syndr. 34:512-519.
8. Li, C. C., I. A. Beck, K. D. Seidel, and L. M. Frenkel. 2004. Persistence of human immunodeficiency virus type 1 subtype B DNA in dried-blood samples on FTA filter paper. J. Clin. Microbiol. 42:3847-3849.
9. McNulty, A., C. Jennings, D. Bennett, J. Fitzgibbon, J. W. Bremer, M. Ussery, M. L. Kalish, W. Heneine, and J. G. Garcia-Lerma. 2007. Evaluation of dried blood spots for human immunodeficiency virus type 1 drug resistance testing. J. Clin. Microbiol. 45:517-521.
10. Mitchell, C., C. Jennings, D. Brambilla, G. Aldrovandi, A. M. Amedee, I. Beck, J. W. Bremer, R. Coombs, D. Decker, S. Fiscus, J. Fitzgibbon, K. Luzuriaga, J. Moye, P. Palumbo, P. Reichelderfer, M. Somasundaran, W. Stevens, and L. Frenkel. 2008. Diminished human immunodeficiency virus type 1 DNA yield from dried blood spots after storage in a humid incubator at 37 degrees C compared to -20 degrees C. J. Clin. Microbiol. 46:2945-2949.
11. Ou, C. Y., H. Yang, S. Balinandi, S. Sawadogo, V. Shanmugam, P. M. Tih, C. Adje-Toure, S. Tancho, L. K. Ya, M. Bulterys, R. Downing, and J. N. Nkengasong. 2007. Identification of HIV-1 infected infants and young children using real-time RT PCR and dried blood spots from Uganda and Cameroon. J. Virol. Methods 144:109-114.
12. Read, J. S. 2007. Diagnosis of HIV-1 infection in children younger than 18 months in the United States. Pediatrics 120:e1547-e1562.
13. Simonds, R. J., T. M. Brown, D. M. Thea, S. L. Orloff, R. W. Steketee, F. K. Lee, P. E. Palumbo, M. L. Kalish, and the Perinatal AIDS Collaborative Transmission Study. 1998. Sensitivity and specificity of a qualitative RNA detection assay to diagnose HIV infection in young infants. AIDS 12:1545-1549.
14. Steketee, R. W., E. J. Abrams, D. M. Thea, T. M. Brown, G. Lambert, S. Orloff, J. Weedon, M. Bamji, E. E. Schoenbaum, J. Rapier, M. L. Kalish, and the New York City Perinatal HIV Transmission Collaborative Study. 1997. Early detection of perinatal human immunodeficiency virus (HIV) type 1 infection using HIV RNA amplification and detection. J. Infect. Dis. 175:707-711.
15. Stevens, W., G. Sherman, R. Downing, L. M. Parsons, C. Y. Ou, S. Crowley, G. M. Gershy-Damet, K. Fransen, M. Bulterys, J. Homsy, L. Lu, T. Finkbeiner, and J. N. Nkengasong. 2008. Role of the laboratory in ensuring global access to ARV treatment for HIV-infected children: consensus statement on the performance of laboratory assays for early infant diagnosis. Open AIDS J. 2:17-25.
16. Violari, A., M. F. Cotton, D. M. Gibb, A. G. Babiker, J. Steyn, S. A. Madhi, P. Jean-Philippe, and J. A. McIntyre. 2008. Early antiretroviral therapy and mortality among HIV-infected infants. N. Engl. J. Med. 359:2233-2244.
17. Yun, Z., E. Fredriksson, and A. Sonnerborg. 2002. Quantification of human immunodeficiency virus type 1 proviral DNA by the TaqMan real-time PCR assay. J. Clin. Microbiol. 40:3883-3884.
18. Zhang, Q., L. Wang, Y. Jiang, L. Fang, P. Pan, S. Gong, J. Yao, Y. W. Tang, S. H. Vermund, and Y. Jia. 2008. Early infant human immunodeficiency virus type 1 detection suitable for resource-limited settings with multiple circulating subtypes by use of nested three-monoplex DNA PCR and dried blood spots. J. Clin. Microbiol. 46:721-726.