Infant human immunodeficiency virus diagnosis in resource-limited settings: issues, technologies, and country experiences

American Journal of Obstetrics and Gynecology

Volumn 197, Issue 3 SUPPL., 2007, Pages

  Creek, Tracy L ^a   Sherman, Gayle G ^b   Nkengasong, John ^a   Lu, Lydia ^a   Finkbeiner, Thomas ^c   Fowler, Mary Glenn ^d   Rivadeneira, Emilia ^a   Shaffer, Nathan ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

infant human immunodeficiency virus testing and diagnosis; mother to child transmission; pediatric antiretroviral treatment; polymerase chain reaction; rapid human immunodeficiency virus tests

Indexed keywords

DNA; RNA;

DISEASE TRANSMISSION; HEALTH CARE POLICY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LABORATORY TEST; MOTHER CHILD RELATION; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; REVIEW; SEROLOGY; SOCIAL PSYCHOLOGY; TECHNOLOGY;

AFRICA; DNA, VIRAL; HEALTH RESOURCES; HIV; HIV ANTIBODIES; HIV CORE PROTEIN P24; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; PRACTICE GUIDELINES; RNA, VIRAL; TIME FACTORS;

EID: 34548418967     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2007.03.002     Document Type: Review

References (43)

1. Nolan M.L., Greenberg A.E., and Fowler M.G. A review of clinical trials to prevent mother-to-child HIV-1 transmission in Africa and inform rational intervention strategies. AIDS 16 (2002) 1991-1999
2. Newell M.L., Coovadia H., Cortina-Borja M., Rollins N., Gaillard P., and Dabis F. Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet 364 (2004) 1236-1243
3. Jackson J.B., Musoke P., Fleming T., et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet 362 (2003) 859-868
4. Obimbo E.M., Mbori-Ngacha D.A., Ochieng J.O., et al. Predictors of early mortality in a cohort of human immunodeficiency virus type 1-infected African children. Pediatr Infect Dis J 23 (2004) 536-543
5. Jones S.A., Sherman G.G., and Coovadia A.H. Can clinical algorithms deliver an accurate diagnosis of HIV infection in infancy?. Bull World Health Organ 83 (2005) 559-560
6. Parekh B.S., Shaffer N., Coughlin R., et al. Human immunodeficiency virus 1-specific IgA capture enzyme immunoassay for early diagnosis of human immunodeficiency virus 1 infection in infants. NYC Perinatal HIV Transmission Study Group. Pediatr Infect Dis J 12 (1993) 908-913
7. Palasanthiran P., Robertson P., Ziegler J.B., and Graham G.G. Decay of transplacental human immunodeficiency virus type 1 antibodies in neonates and infants. J Infect Dis 170 (1994) 1593-1596
8. Moodley D., Bobat R.A., Coutsoudis A., and Coovadia H.M. Predicting perinatal human immunodeficiency virus infection by antibody patterns. Pediatr Infect Dis J 14 (1995) 850-852
9. Brambilla D., Jennings C., Aldrovandi G., et al. Multicenter evaluation of use of dried blood and plasma spot specimens in quantitative assays for human immunodeficiency virus RNA: measurement, precision, and RNA stability. J Clin Microbiol 41 (2003) 1888-1893
10. Varga C.A., Sherman G.G., Maphosa J., and Jones S.A. Psychosocial consequences of early diagnosis of HIV status in vertically exposed infants in Johannesburg, South Africa. Health Care Women Int 26 (2005) 387-397
11. Berk D.R., Falkovitz-Halpern M.S., Hill D.W., et al. Temporal trends in early clinical manifestations of perinatal HIV infection in a population-based cohort. JAMA 293 (2005) 2221-2231
12. Gichuhi C., Obimbo E., Mbori-Ngacha D., et al. Predictors of mortality in HIV-1 exposed uninfected post-neonatal infants at the Kenyatta National Hospital, Nairobi. East Afr Med J 82 (2005) 447-451
13. Stringer J.S., Sinkala M., Maclean C.C., et al. Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia. AIDS 19 (2005) 1309-1315
14. United Children's Fund, and World Health Organization. UNICEF/WHO technical consultation: improving access to appropriate paediatric ARV formulations (2004), World Health Organization, Geneva (Switzerland)
15. World Health Organization. Antiretroviral therapy of HIV infection in infants and children in resource-limited settings: towards universal access (2006), World Health Organization, Geneva (Switzerland)
16. Kankasa C., Katepa-Bwalya M., Bulterys M., et al. Routine and universal counseling and testing among hospitalized children at a University Teaching Hospital, Lusaka, Zambia. Presented at the 2006 HIV/AIDS Implementers' Meeting, Durban, South Africa. (2006)
17. Humphrey J., Marinda E., Moulton L., et al. Breastfeeding-associated HIV transmission among women who seroconvert during late pregnancy and during breastfeeding. Presented at the AIDS 2006-XVI International AIDS Conference, Toronto, Canada. (2006)
18. Otieno F.A., Mbori-Ngacha D.A., Wafula E.M., and Ndinya-Achola J.O. Evaluation of a proposed clinical case definition of paediatric acquired immune deficiency syndrome. East Afr Med J 79 (2002) 111-114
19. Jones S., and Sherman G. Death before diagnosis: IMCI clinical algorithm fails to identify HIV infected infants under the age of 12 months. Presented at the International Conference on AIDS, Bangkok, Thailand; July 11-16 (2004)
20. Blackburn L., Sherman G., Coovadia A., and Foromo R. HIV rapid tests can be used as a screening tool to reduce HIV DNA PCR assays in a resource-poor setting. Presented at the 2006 HIV/AIDS Implementers' Meeting, Durban, South Africa. (2006)
21. Sherman G.G., and Jones S.A. Oral fluid human immunodeficiency virus tests: improved access to diagnosis for infants in poorly resourced prevention of mother to child transmission programs. Pediatr Infect Dis J 24 (2005) 253-256
22. American Academy of Pediatrics. Red Book: 2006 Report of the Committee on Infectious Diseases. In: Pickering L., Baker C., Long S., and McMillan J. (Eds) (2006), American Academy of Pediatrics, Elk Grove Village (Illinois)
23. Bremer J.W., Lew J.F., Cooper E., et al. Diagnosis of infection with human immunodeficiency virus type 1 by a DNA polymerase chain reaction assay among infants enrolled in the Women and Infants' Transmission Study. J Pediatr 129 (1996) 198-207
24. Sherman G.G., Cooper P.A., Coovadia A.H., et al. Polymerase chain reaction for diagnosis of human immunodeficiency virus infection in infancy in low resource settings. Pediatr Infect Dis J 24 (2005) 993-997
25. Sherman G.G., Jones S.A., Coovadia A.H., Urban M.F., and Bolton K.D. PMTCT from research to reality-results from a routine service. S Afr Med J 94 (2004) 289-292
26. Lyamuya E., Olausson-Hansson E., Albert J., Mhalu F., and Biberfeld G. Evaluation of a prototype Amplicor PCR assay for detection of human immunodeficiency virus type 1 DNA in blood samples from Tanzanian adults infected with HIV-1 subtypes A, C and D. J Clin Virol 17 (2000) 57-63
27. Cassol S., Weniger B.G., Babu P.G., et al. Detection of HIV type 1 env subtypes A, B, C, and E in Asia using dried blood spots: a new surveillance tool for molecular epidemiology. AIDS Res Hum Retroviruses 12 (1996) 1435-1441
28. World Health Organization. Draft. Recommendations on the diagnosis of HIV infection in infants and children (2006), World Heath Organization, Geneva (Switzerland)
29. Cunningham C.K., Charbonneau T.T., Song K., et al. Comparison of human immunodeficiency virus 1 DNA polymerase chain reaction and qualitative and quantitative RNA polymerase chain reaction in human immunodeficiency virus 1-exposed infants. Pediatr Infect Dis J 18 (1999) 30-35
30. Zhao Y., Yu M., Miller J.W., et al. Quantification of human immunodeficiency virus type 1 proviral DNA by using TaqMan technology. J Clin Microbiol 40 (2002) 675-678
31. Katsoulidou A., Petrodaskalaki M., Sypsa V., et al. Evaluation of the clinical sensitivity for the quantification of human immunodeficiency virus type 1 RNA in plasma: comparison of the new COBAS TaqMan HIV-1 with three current HIV-RNA assays-LCx HIV RNA quantitative, VERSANT HIV-1 RNA 3.0 (bDNA) and COBAS AMPLICOR HIV-1 Monitor v1.5. J Virol Methods 131 (2006) 168-174
32. Sherman G.G., Stevens G., and Stevens W.S. Affordable diagnosis of human immunodeficiency virus infection in infants by p24 antigen detection. Pediatr Infect Dis J 23 (2004) 173-176
33. Patton J.C., Sherman G.G., Coovadia A.H., Stevens W.S., and Meyers T.M. Ultrasensitive human immunodeficiency virus type 1 p24 antigen assay modified for use on dried whole-blood spots as a reliable, affordable test for infant diagnosis. Clin Vaccine Immunol 13 (2006) 152-155
34. Benjamin Jr. D.K., Miller W.C., Fiscus S.A., et al. Rational testing of the HIV-exposed infant. Pediatrics 108 (2001) E3
35. Mrus J.M., Yi M.S., Eckman M.H., and Tsevat J. The impact of expected HIV transmission rates on the effectiveness and cost of ruling out HIV infection in infants. Med Decis Making 22 (2002) S38-S44
36. Miotti P.G., Taha T.E., Kumwenda N.I., et al. HIV transmission through breastfeeding: a study in Malawi. JAMA 282 (1999) 744-749
37. Iliff P.J., Piwoz E.G., Tavengwa N.V., et al. Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival. AIDS 19 (2005) 699-708
38. Coutsoudis A., Dabis F., Fawzi W., et al. Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis. J Infect Dis 189 (2004) 2154-2166
39. Ross J.S., and Labbok M.H. Modeling the effects of different infant feeding strategies on infant survival and mother-to-child transmission of HIV. Am J Public Health 94 (2004) 1174-1180
40. Piwoz E.G., and Ross J.S. Use of population-specific infant mortality rates to inform policy decisions regarding HIV and infant feeding. J Nutr 135 (2005) 1113-1119
41. Homsy J., Moore D., Barasa A., et al. Mother-to-child HIV transmission and infant mortality among women receiving highly active antiretroviral therapy (HAART) in rural Uganda. Presented at the AIDS 2006-XVI International AIDS Conference, Toronto, Canada. (2006)
42. World Health Organization. HIV and infant feeding: guidelines for decision-makers-a guide for health care managers and supervisors. In: World Health Organization, editors. Geneva (Switzerland): World Health Organization; 2003.
43. Chintu C., Bhat G.J., Walker A.S., et al. Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind, randomised, placebo-controlled trial. Lancet 364 (2004) 1865-1871