Assays for the quantification of melphalan and its hydrolysis products in human plasma by liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 27, 2009, Pages 3089-3096

  Mirkou, Asmae ^a   Vignal, Bruno ^a   Cohen, Sabine ^a   Guillaumont, Marc ^a   Glehen, Olivier ^a   Guitton, Jérôme ^a,b  

^a CENTRE HOSPITALIER LYON SUD   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Hydrolysis products; Mass spectrometry; Melphalan

Indexed keywords

ASSAYS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; HYDROPHILICITY; MASS SPECTROMETRY; PATIENT MONITORING; PHASE SEPARATION; PLASMA (HUMAN);

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRIES; HYDROLYSIS PRODUCTS; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MELPHALAN; PHARMACOKINETIC STUDIES; SELECTED REACTION MONITORING; THERAPEUTIC DRUG MONITORING;

EXTRACTION;

DIHYDROXYMELPHALAN; DRUG METABOLITE; ETHANOLAMINE DERIVATIVE; HYDROXYMELPHALAN; MELPHALAN; METHANOL; UNCLASSIFIED DRUG;

AGED; ARTICLE; CASE REPORT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROPHILICITY; MALE; MOLECULAR INTERACTION; PRECIPITATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 69949100965     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.07.033     Document Type: Article

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