Isolated limb infusion for in-transit malignant melanoma of the extremity: A well-tolerated but less effective alternative to hyperthermic isolated limb perfusion

Annals of Surgical Oncology

Volumn 15, Issue 8, 2008, Pages 2195-2205

  Beasley, Georgia M ^a   Petersen, Rebecca P ^a   Yoo, Jin ^a   McMahon, Nicole ^a   Aloia, Thomas ^b   Petros, William ^c   Sanders, Gretchen ^a   Cheng, Tsung Yen ^d   Pruitt, Scott K ^a   Seigler, Hilliard ^a   Tyler, Douglas S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Methodist Weill Cornell Hospital   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

^d KOO FOUNDATION SUN YAT SEN CANCER CENTER   (Taiwan)

Author keywords

Isolated limb infusion; Melanoma; Regional chemotherapy

Indexed keywords

CHLORAMBUCIL; DACTINOMYCIN; MELPHALAN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CREATINE KINASE BLOOD LEVEL; DERMATITIS; DOSE CALCULATION; DRUG TOLERABILITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERTHERMIC ISOLATED LIMB PERFUSION; IN TRANSIT MALIGNANT MELANOMA; INFUSION; ISOLATED LIMB INFUSION; LIMB PERFUSION; MAJOR CLINICAL STUDY; MALE; MELANOMA; MOTOR NEUROPATHY; MUSCULOSKELETAL PAIN; MYOSITIS; SENSORY NEUROPATHY; SIDE EFFECT; TEMPERATURE; ULCER;

ADULT; AGED; AGED, 80 AND OVER; ANTIBIOTICS, ANTINEOPLASTIC; CHEMOTHERAPY, CANCER, REGIONAL PERFUSION; DACTINOMYCIN; EXTREMITIES; FEMALE; HUMANS; HYPERTHERMIA, INDUCED; MALE; MELANOMA; MELPHALAN; MIDDLE AGED; NEOPLASM STAGING; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 48149092966     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-008-9988-9     Document Type: Article

References (31)

1. Balch CM, Houghton AN, Peters LJ. (1993) Cutaneous melanoma. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology, 4th edition. JB Lippincott, Philadelphia. p. 1612
2. TW Pawlik MI Ross MM Johnson 2004 Predictors and natural history of in-transit melanoma after sentinel lymphadenectomy Ann Surg Oncol 11 1612 61
3. DR Minor RE Allen D Alberts 1985 A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma Cancer 55 2638 44
4. F Di Filippo A Calabro D Giannarelli 1989 Prognostic variables in recurrent limb melanoma treated with hyperthermic aniblastic perfusion Cancer 63 2551 61
5. JM Klaase BBR Kroon AN van Geel 1994 Prognostic factors for tumor response and limb recurrence-free interval in patients with advanced melanoma of the limbs treated with regional isolated perfusion with melphalan Surgery 115 39 45
6. BR Kroon AN van Geel C Benckhuijsen 1987 Normothermic isolation perfusion with melphalan for advanced melanoma of the limbs Anticancer Res 7 4411 2
7. DL Fraker HR Alexader M Ross 2002 A phase III trial of isolated limb infusion perfusion for extremity melanoma comparing melphalan alone versus melphalan plus tumor necrosis factor (TNF-α) plus interferon-gamma (IFN) Ann Surg Oncol 9 S8
8. AL Skene AS Bulman TF Williams 1990 Hyperthermic isolated limb perfusion with melphalan in the treatment of advanced malignant melanoma of the lower limb Br J Surg 77 765 7
9. Fraker DL, Eggermont AMM. (2003) Hyperthermic regional perfusion for melanoma of the limbs. In: Balch H, Sober S, eds. Cutaneous Melanoma, 14th edition. Quality Medical, St. Louis, MO
10. A Sanki PCA Kam JF Thompson 2007 Long-term results of hyperthermic, isolated limb perfusion for melanoma Ann Surg 245 591 6
11. JF Thompson PC Kam RC Waugh 1998 Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion Semin Surg Oncol 14 238 47
12. JF Thompson RC Waugh RPM Saw 1994 Isolated limb infusion with melphalan for recurrent limb melanoma: a simple alternative to isolated limb perfusion Regional Cancer Treat 7 188 92
13. P Lindner A Doubrovsky PCA Kam 2002 Prognostic factors after isolated limb infusion with cytotoxic agents for melanoma Ann Surg Oncol 9 127 36
14. WR Cornett LM McCall RP Petersen 2006 Prospective randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone versus melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020 J Clin Oncol 24 4196 201
15. MS Brady K Brown A Patel 2006 A phase II trial of isolated limb infusion with melphalan and dactinomycin for regional melanoma and soft tissue sarcoma of the extremity Ann Surg Oncol 13 1123 9
16. TA Aloia E Grubbs M Onaitis 2005 Predictors of outcome after hyperthermic limb perfusion: role of tumor response Arch Surg 140 1115 20
17. H Ehrsson S Eksborg A Lindfors 1986 Quantitative determination of melphalan in plasma by liquid chromatography after derivatization with N-acetylcysteine J Chromatogr Biomed Appl 380 220
18. CM Balch AC Buzaid SJ Soong 2001 Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma J Clin Oncol 19 3635 48
19. T-Y Cheng E Grubbs O Abdul-Wahab 2003 Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion Am J Surg 186 460 7
20. Zager JS, Gershenwald JE, Aldrink J, et al. Isolated limb infusion for locally recurrent and in-transit extremity melanoma: combined institutional initial experience. Presented at Society of Surgical Oncology 59th annual cancer symposium. San Diego, CA March 23-26, 2006
21. Brady MS, Patel A, Brown K, et al. Isolated limb infusion for patients with advanced extremity melanoma and soft tissue sarcoma. Final report of a Phase II trial. Presented at Society of Surgical Oncology 60th annual cancer symposium. Washington, DC March 15-18, 2007
22. DW Siemann M Chapman A Beikrich 1991 Effects of oxygenation and pH on tumor cell response to aklylating chemotherapy Int J Radiat Oncol Biol Phys 20 287 9
23. JS Stehlin 1969 Hyperthermic perfusion with chemotherapy for cancers of the extremity Surg Gynecol Obstet 129 305
24. AL Skene AS Bulman TF Williams 1990 Hyperthermic isolated limb perfusion with melphalan in the treatment of advanced malignant melanoma of the lower limb Br J Surg 77 765 7
25. FK Storm DL Morton 1985 Value of therapeutic hyperthermic limb perfusion in advanced recurrent melanoma of the lower extremity Am J Surg 15 32 5
26. DR Minor RE Allen D Alberts 1985 A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma Cancer 55 2638 44
27. BB Kroon 1998 Regional isolated perfusion in melanoma of the limbs: accomplishments, unsolved problems, future Eur J Surg Oncol 14 101 10
28. OI Abdel-Wahab E Grubbs B Viglianti 2004 The role of hyperthermia in regional alkylating agent chemotherapy Clin Can Res 10 5919 29
29. B Hildebrandt P Wust O Ahlers 2002 The cellular and molecular basis of hyperthermia Crit Rev Oncol/Hematol 43 33 56
30. JF Thompson JA Hunt KF Shannon 1997 Frequency and duration of remission after isolated limb perfusion for melanoma Arch Surg 132 903 7
31. J Wieberdink C Benckhuijsen RP Braat 1982 Dosimetry in isolated perfusion of the limbs by assessment of perfused tissue and grading of toxic tissue reactions Eur J Cancer Clin Oncol 18 905 10