Free radical scavenging and radioprotective effects of carnosine and anserine

Radiation Physics and Chemistry

Volumn 78, Issue 12, 2009, Pages 1192-1197

  Fu, Haiying ^a   Katsumura, Yosuke ^a,b   Lin, Mingzhang ^b   Muroya, Yusa ^a   Hata, Kuniki ^a   Fujii, Kentaro ^b   Yokoya, Akinari ^b   Hatano, Yoshihiko ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN ATOMIC ENERGY AGENCY   (Japan)

Author keywords

Anserine; Carnosine; DNA; Free radicals; Scavenging activity

Indexed keywords

AGAROSE GEL ELECTROPHORESIS; ANSERINE; ANTIOXIDANT SYSTEMS; ANTIOXIDATIVE PROPERTY; AQUEOUS SOLUTIONS; CARNOSINE; DI-PEPTIDES; EXPERIMENTAL CONDITIONS; FREE RADICAL SCAVENGING; L-HISTIDINE; NEUTRAL PH; OH RADICAL; PROTECTIVE EFFICIENCY; PULSE RADIOLYSIS STUDY; SCAVENGING ACTIVITY; STRAND BREAKS; X RAY RADIATION;

DNA; ELECTROPHORESIS; FREE RADICAL REACTIONS; FREE RADICALS; GENES; NUCLEIC ACIDS; RADIATION CHEMISTRY; RADIOLYSIS; RATE CONSTANTS;

BIOMARKERS;

ANSERINE; CARNOSINE; HYDROXIDE; PLASMID DNA;

AGAR GEL ELECTROPHORESIS; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; DNA STRAND BREAKAGE; DRUG STRUCTURE; PH MEASUREMENT; PLASMID; PROTEIN FUNCTION; PULSE RADIOLYSIS; RADIATION PROTECTION; SCAVENGING SYSTEM; STRUCTURE ANALYSIS;

EID: 69949095694     PISSN: 0969806X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radphyschem.2009.07.023     Document Type: Article

References (32)

1. Abe H. Role of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscle. Biochem. (Moscow) 65 (2000) 757-765
2. Aldini G., Facino R.M., Beretta G., and Carini M. Carnosine and related dipeptides as quenchers of reactive carbonyl species: From structural studies to therapeutic perspectives. Biofactors 24 (2005) 77-87
3. Babizhayev M.A., Courbebaisse Y., Nicolay J.F., and Semiletov Y.A. Design and biological activity of imidazole-containing peptidomimetics with a broad-spectrum antioxidant activity. Lett. Pept. Sci. 5 (1998) 163-169
4. Babizhayev M.A., Seguin M.C., Gueyne J., Evstigneeva R.P., Ageyeva E.A., and Zheltukhina G.A. l-carnosine (β-alanyl-l-histidine) and carcinine (β-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. Biochem. J. 304 (1994) 509-516
5. Babizhayev M.A. Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C(TM) N-acetylcarnosine prodrug lubricant eye drops for cataract prevention. Drugs R & D 6 (2005) 345-369
6. Bansal K.M., and Sellers R.M. Polarographic and optical pulse radiolysis study of the radicals formed by OH attack on the imidazole and related compounds in aqueous solutions. J. Phys. Chem. 79 (1975) 1275-1280
7. Boldyrev A., Koudinov A., Berezov T., and Carpenter D.O. Amyloid-β induced cell death is independent of free radicals. J. Alzheimer′s Dis. 6 (2004) 633-638 (discussion 673-681)
8. Boldyrev A., and Severin S. The Histidine-containing dipeptides, carnosine and anserine: distribution, properties and biological significance. Adv. Enzyme Regul. 30 (1990) 175-193
9. Buxton G.V., and Stuart C.R. Re-evaluation of the thiocyanate dosimeter for pulse radiolysis. J. Chem. Soc., Faraday Trans. 91 (1995) 279-281
10. Choi S.Y., Kwon H.Y., Kwon O.B., and Kang J.H. Hydrogen peroxidemediated Cu, Zn-superoxide dismutase fragmentation: protection by carnosine, homocarnosine and anserine. Biochem. Biophys. Acta 1472 (1999) 651-657
11. Cuzzocrea S., Genovese T., Failla M., Vecchio G., Fruciano M., Mazzon E., Di Paola R., La Rosa C., Crimi N., Rizzarelli E., and Vancheri C. Protective effect of orally administered carnosine on bleomycin-induced lung injury. Am. J. Physiol. 292 (2007) L1095-L1104
12. Decker E.A., Crum A.D., and Calvert J.T. Differences in the antioxidant mechanism of carnosine in the presence of copper and iron. J. Agric. Food Chem. 40 (1992) 756-759
13. Fulford, J., 2000. Quantification of complex DNA damage by ionizing radiation: an experimental and theoretical approach. Ph.D, thesis, University of Burnel, UK.
14. Gariballa S.E., and Sinclair A.J. Carnosine: physiological properties and therapeutic potential. Age Ageing 29 (2000) 207-210
15. Guiotto A., Calderan A., Ruzza P., and Borin G. Carnosine and carnosine-related antioxidants: a review. Curr. Med. Chem. 12 (2005) 2293-2315
16. Guiotto A., Calderan A., Ruzza P., Osier A., Rubini C., Jo D.G., Mattson M.P., and Borin G. Synthesis and evaluation of neuroprotective alpha, beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine. J. Med. Chem. 48 (2005) 6156-6161
17. Hipkiss A.R., Brownson C., Bertani M.F., Ruiz E., and Ferro A. Reaction of carnosine with aged proteins: another protective process?. Ann. N. Y. Acad. Sci. 959 (2002) 285-294
18. Kang J.H., Kim K.S., Choi S.Y., Kwon H.Y., Won M.H., and Kang T.-C. Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification. Mol. Cells 13 (2002) 498-502
19. Kang J.H. Protection by carnosine and homocarnosine against l-DOPA-Fe(III)-mediated DNA cleavage. Bull. Korean Chem. Soc. 26 (2005) 1251-1254
20. Lavery R., and Pullman B. The molecular electrostatic potential, steric accessibility and hydration of Dickerson's B-DNA dodecamerd (CpGpCpGpApApTpTpCpGpCpG). Nucleic Acids Res. 9 (1981) 3765-3777
21. Lee Y.T., Hsu C.C., Lin M.H., Liu K.S., and Yin M.C. Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. Eur. J. Pharmacol. 513 (2005) 145-150
22. Leinsoo T.A., Abe H., and Boldyrev A.A. Carnosine and related compounds protect the double-chain DNA from oxidative damages. J. Evol. Biochem. Physiol. 42 (2006) 570-574
23. Lenney J.F., Peppers S.C., Kucera-Orallo C.M., and George R.P. Characterization of human tissue carnosinase. Biochem. J. 228 (1985) 653-660
24. Lin M., Katsumura Y., Hata K., Muroya Y., and Nakagawa K. Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). J. Photochem. Photobiol. B. Biol. 89 (2007) 36-43
25. Mathew D., Nair C.K.K., Jacob J.A., Mukherjee T., Kapoor S., and Kagiya T.V. Ascorbic acid monoglucoside as antioxidant and radioprotector. J. Radiat. Res. 48 (2007) 369-376
26. Pavlov A.R., Revina A.A., Dupin A., Boldyrev A., and Yaropolov A.I. The mechanism of interaction of carnosine with superoxide radicals in water solutions. Biochim. Biophys. Acta 1157 (1993) 304-312
27. Rao P.S., Simic M., and Hayon E. Pulse radiolysis study of imidazole and histidine in water. J. Phys. Chem. 79 (1975) 1260-1263
28. Seidler N.W., Yeargans G.S., and Morgan T.G. Carnosine disaggregates glycated alpha-crystallin: an in vitro study. Arch. Biochem. Biophys. 427 (2004) 110-115
29. Skulachev P.V. Membrane-linked energy buffering as the biological function of Na+/K+-gradient. FEBS lett. 87 (1978) 171-176
30. Tamba M., and Torreggiani A. Hydroxyl radical scavenging by carnosine and Cu(II)-carnosine complexes: a pulse-radiolysis and spectroscopic study. Int. J. Radiat. Biol. 75 (1999) 1177-1188
31. Yeargans G.S., and Seidler N.W. Carnosine promotes the heat denaturation of glycated protein. Biochem. Biophys. Res. Commun. 300 (2003) 75-80
32. Yokoya A., Fujii K., Shikazono N., Urushibara A., and Watanabe R. Yields of strand breaks and base lesions induced by soft X-rays in plasmid DNA. Radiat. Prot. Dosimetry 122 (2006) 86-88