Effect of mass distribution of azithromycin for trachoma control on overall mortality in Ethiopian children: A randomized trial

JAMA

Volumn 302, Issue 9, 2009, Pages 962-968

  Porco, Travis C ^a,b   Gebre, Teshome ^c   Ayele, Berhan ^c   House, Jenafir ^a   Keenan, Jeremy ^a,b   Zhou, Zhaoxia ^a,b   Hong, Kevin Cyrus ^a   Stoller, Nicole ^a   Ray, Kathryn J ^a   Emerson, Paul ^c   Gaynor, Bruce D ^a,b   Lietman, Thomas M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CARTER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; ANTIINFECTIVE AGENT;

ANTIBIOTIC THERAPY; ARTICLE; CHILD; CHILDHOOD MORTALITY; CHLAMYDIASIS; CLINICAL TRIAL; COMMUNITY CARE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CONTROL; ENDEMIC DISEASE; ETHIOPIA; EYE INFECTION; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK MANAGEMENT; RURAL AREA; SCHOOL CHILD; SINGLE DRUG DOSE; THERAPY DELAY; TRACHOMA; ANTIBIOTIC PROPHYLAXIS; INFANT MORTALITY; MORTALITY; RURAL POPULATION; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; AZITHROMYCIN; CHILD; CHILD MORTALITY; CHILD, PRESCHOOL; ETHIOPIA; HUMANS; INFANT; INFANT MORTALITY; RURAL POPULATION; TRACHOMA; TREATMENT OUTCOME;

EID: 69849113646     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2009.1266     Document Type: Article

References (33)

1. Mariotti SP. New steps toward eliminating blinding trachoma. N Engl J Med. 2004;351(19):2004-2007.
2. Bailey RL, Arullendran P, Whittle HC, Mabey DC. Randomised controlled trial of single-dose azithromycin in treatment of trachoma. Lancet. 1993;342 (8869):453-456. (Pubitemid 23240308)
3. Chidambaram JD, Alemayehu W, Melese M, et al. Effect of a single mass antibiotic distribution on the prevalence of infectious trachoma. JAMA. 2006; 295(10):1142-1146. (Pubitemid 43352343)
4. Schachter J, West SK, Mabey D, et al. Azithromycin in control of trachoma. Lancet. 1999;354(9179): 630-635.
5. Melese M, Chidambaram JD, Alemayehu W, et al. Feasibility of eliminating ocular Chlamydia trachomatis with repeat mass antibiotic treatments. JAMA. 2004; 292(6):721-725. (Pubitemid 39062527)
6. Solomon AW, Holland MJ, Alexander ND, et al. Mass treatment with single-dose azithromycin for trachoma. N Engl J Med. 2004;351(19):1962-1971.
7. Gill DA, Lakew T, Alemayehu W, et al. Complete elimination is a difficult goal for trachoma programs in severely affected communities. Clin Infect Dis. 2008; 46(4):564-566. (Pubitemid 351263496)
8. Lietman T, Porco T, Dawson C, Blower S. Global elimination of trachoma: how frequently should we administer mass chemotherapy? Nat Med. 1999; 5(5):572-576. (Pubitemid 29220218)
9. Melese M, Alemayehu W, Lakew T, et al. Comparison of annual and biannual mass antibiotic administration for elimination of infectious trachoma. JAMA. 2008;299(7):778-784. (Pubitemid 351281571)
10. Adegbola RA, Mulholland EK, Bailey R, et al. Effect of azithromycin on pharyngeal microflora. Pediatr Infect Dis J. 1995;14(4):335-337.
11. Atik B, Thanh TT, Luong VQ, Lagree S, Dean D. Impact of annual targeted treatment on infectious trachoma and susceptibility to reinfection. JAMA. 2006; 296(12):1488-1497. (Pubitemid 44465513)
12. Fry AM, Jha HC, Lietman TM, et al. Adverse and beneficial secondary effects of mass treatment with azithromycin to eliminate blindness due to trachoma in Nepal. Clin Infect Dis. 2002;35(4):395-402.
13. Leach AJ, Shelby-James TM, Mayo M, et al. A prospective study of the impact of community-based azithromycin treatment of trachoma on carriage and resistance of Streptococcus pneumoniae. Clin Infect Dis. 1997;24(3):356-362. (Pubitemid 27096788)
14. Solomon AW, Mohammed Z, Massae PA, et al. Impact of mass distribution of azithromycin on the antibiotic susceptibilities of ocular Chlamydia trachomatis. Antimicrob Agents Chemother. 2005;49(11):4804-4806.
15. Guchev IA, Gray GC, Klochkov OI. Two regimens of azithromycin prophylaxis against community-acquired respiratory and skin/soft-tissue infections among military trainees. Clin Infect Dis. 2004; 38(8):1095-1101.
16. House JI, Ayele B, Porco TC, et al. Assessment of herd protection against trachoma due to repeated mass antibiotic distributions: a cluster-randomized trial. Lancet. 2009;373(9669):1111-1118.
17. Eisenberg JN, Lewis BL, Porco TC, Hubbard AH, Colford JM Jr. Bias due to secondary transmission in estimation of attributable risk from intervention trials. Epidemiology. 2003;14(4):442-450.
18. Taye A, Alemayehu W, Melese M, et al. Seasonal and altitudinal variations in fly density and their association with the occurrence of trachoma, in the Gurage zone of central Ethiopia. Ann Trop Med Parasitol. 2007;101(5):441-448. (Pubitemid 47488133)
19. Fleiss JL, Levin B, Paik MC. Statistical Methods for Rates and Proportions. 3rd ed. New York, NY: John Wiley & Sons; 2003.
20. Maher MJ, Summersgill I. A comprehensive methodology for the fitting of predictive accident models. Accid Anal Prev. 1996;28(3):281-296. (Pubitemid 126372950)
21. World Health Organization. Child Health in Ethiopia: Background Document for the National Child Survival Conference, April 22-24, 2004, Addis Ababa, Ethiopia. http://www.afro.who.int/cah/documents /situational-analysis/et-final- cs-situation-analysis .pdf. Accessed August 6, 2009.
22. Mohammed E, Muhe L, Geyid A, et al. Prevalence of bacterial pathogens in children with acute respiratory infection in Addis Ababa. Ethiop Med J. 2000; 38(3):165-174.
23. Thoré n A, Stintzing G, Tufvesson B, Walder M, Habte D. Aetiology and clinical features of severe infantile diarrhoea in Addis Ababa, Ethiopia. J Trop Pediatr. 1982;28(3):127-131.
24. Dunne MW, Singh N, Shukla M, et al. A doubleblind, randomized study of azithromycin compared to chloroquine for the treatment of Plasmodium vivax malaria in India. Am J Trop Med Hyg. 2005;73 (6):1108-1111. (Pubitemid 43038263)
25. Heppner DG Jr, Walsh DS, Uthaimongkol N, et al. Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. Am J Trop Med Hyg. 2005;73(5):842-849. (Pubitemid 41688456)
26. Sadiq ST, Glasgow KW, Drakeley CJ, et al. Effects of azithromycin on malariometric indices in The Gambia. Lancet. 1995;346(8979):881-882.
27. Whitty CJ, Glasgow KW, Sadiq ST, Mabey DC, Bailey R. Impact of community-based mass treatment for trachoma with oral azithromycin on general morbidity in Gambian children. Pediatr Infect Dis J. 1999;18(11):955-958.
28. Snow RW, Armstrong JR, Forster D, et al. Childhood deaths in Africa: uses and limitations of verbal autopsies. Lancet. 1992;340(8815):351-355.
29. Ali M, Asefaw T, Byass P, Beyene H, Pedersen FK. Helping northern Ethiopian communities reduce childhood mortality: population-based intervention trial. Bull World Health Organ. 2005;83(1):27-33.
30. Batt SL, Charalambous BM, Solomon AW, et al. Impact of azithromycin administration for trachoma control on the carriage of antibiotic-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother. 2003;47(9):2765-2769.
31. Geerligs PD, Brabin BJ, Eggelte TA. Analysis of the effects of malaria chemoprophylaxis in children on haematological responses, morbidity and mortality. Bull World Health Organ. 2003;81(3):205-216.
32. Menon A, Snow RW, Byass P, Greenwood BM, Hayes RJ, N'Jie AB. Sustained protection against mortality and morbidity from malaria in rural Gambian children by chemoprophylaxis given by village health workers. Trans R Soc Trop Med Hyg. 1990;84(6): 768-772.
33. Sommer A, Tarwotjo I, Djunaedi E, et al. Impact of vitamin A supplementation on childhood mortality: a randomised controlled community trial. Lancet. 1986;1(8491):1169-1173. (Pubitemid 16122421)