메뉴 건너뛰기




Volumn 25, Issue 5, 2009, Pages 466-471

Molecular and cellular regulation of pancreatic acinar cell function

Author keywords

Calcium signaling; Growth; Regeneration; Secretion; Transdifferentiation

Indexed keywords

CALCIUM; CHOLECYSTOKININ; GUANINE NUCLEOTIDE BINDING PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; ION CHANNEL; N ETHYLMALEIMIDE SENSITIVE FACTOR; N ETHYLMALEIMIDE SENSITIVE FACTOR ATTACHMENT PROTEIN RECEPTOR PROTEIN; PANCREAS SPECIFIC TRANSCRIPTION FACTOR 1A; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; ZYMOGEN GRANULE;

EID: 69749125288     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32832ebfac     Document Type: Review
Times cited : (22)

References (26)
  • 1
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver and pancreas
    • This excellent review covers generation and regeneration of cells in both pancreas and liver and discusses the therapeutic implications which arise
    • Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008; 322:1490-1494. This excellent review covers generation and regeneration of cells in both pancreas and liver and discusses the therapeutic implications which arise.
    • (2008) Science , vol.322 , pp. 1490-1494
    • Zaret, K.S.1    Grompe, M.2
  • 2
    • 58049204234 scopus 로고    scopus 로고
    • Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    • Gao N, LeLay J, Vatamaniuk MZ, et al. Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev 2008; 22:3435-3448.
    • (2008) Genes Dev , vol.22 , pp. 3435-3448
    • Gao, N.1    LeLay, J.2    Vatamaniuk, M.Z.3
  • 3
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • DOI 10.1038/ng959
    • Kawaguchi Y, Cooper B, Gannon M, et al. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 2002; 32:128-134. (Pubitemid 34977207)
    • (2002) Nature Genetics , vol.32 , Issue.1 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    MacDonald, R.J.5    Wright, C.V.E.6
  • 4
    • 50249106419 scopus 로고    scopus 로고
    • Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood
    • Masui T, Swift GH, Hale MA, et al. Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. Mol Cell Biol 2008; 28:5458-5468.
    • (2008) Mol Cell Biol , vol.28 , pp. 5458-5468
    • Masui, T.1    Swift, G.H.2    Hale, M.A.3
  • 5
    • 59849105832 scopus 로고    scopus 로고
    • Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice
    • This study shows that activity of the transcription factor c-Myc is required for pancreatic growth and maturation. A second intriguing finding is that pancreatic adipocyte accumulation in these mice is derived from transdifferentiated acinar cells
    • Bonal C, Thorel F, Ait-Lounis A, et al. Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology 2009; 136:309.e9-319.e9. This study shows that activity of the transcription factor c-Myc is required for pancreatic growth and maturation. A second intriguing finding is that pancreatic adipocyte accumulation in these mice is derived from transdifferentiated acinar cells.
    • (2009) Gastroenterology , vol.136
    • Bonal, C.1    Thorel, F.2    Ait-Lounis, A.3
  • 6
    • 58149402376 scopus 로고    scopus 로고
    • Conditional inactivation of Myc impairs development of the exocrine pancreas
    • Nakhai H, Siveke JT, Mendoza-Torres L, Schmid RM. Conditional inactivation of Myc impairs development of the exocrine pancreas. Development 2008; 135:3191-3196.
    • (2008) Development , vol.135 , pp. 3191-3196
    • Nakhai, H.1    Siveke, J.T.2    Mendoza-Torres, L.3    Schmid, R.M.4
  • 7
    • 55249107125 scopus 로고    scopus 로고
    • Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1
    • Jia D, Sun Y, Konieczny SF. Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1. Gastroenterology 2008; 135:1687-1697.
    • (2008) Gastroenterology , vol.135 , pp. 1687-1697
    • Jia, D.1    Sun, Y.2    Konieczny, S.F.3
  • 8
    • 53549088061 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors
    • Haumaitre C, Lenoir O, Scharfmann R. Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol 2008; 28:6373-6383.
    • (2008) Mol Cell Biol , vol.28 , pp. 6373-6383
    • Haumaitre, C.1    Lenoir, O.2    Scharfmann, R.3
  • 10
    • 38649140167 scopus 로고    scopus 로고
    • Notch Signaling Is Required for Exocrine Regeneration after Acute Pancreatitis
    • DOI 10.1053/j.gastro.2007.11.003, PII S0016508507019932
    • Siveke JT, Lubeseder-Martellato C, Lee M, et al. Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology 2008; 134:544-555. The degree to which regeneration of the pancreas occurs after pancreatitis may turn out to be as important in determining the outcome of the disease as the level of inflammation induced by the injury. This study shows that there is reactivation of Notch signaling during pancreatitis, and that inhibition of the Notch pathway impairs acinar cell regeneration. (Pubitemid 351173041)
    • (2008) Gastroenterology , vol.134 , Issue.2
    • Siveke, J.T.1    Lubeseder-Martellato, C.2    Lee, M.3    Mazur, P.K.4    Nakhai, H.5    Radtke, F.6    Schmid, R.M.7
  • 11
    • 48549095907 scopus 로고    scopus 로고
    • Hedgehog signaling is required for effective regeneration of exocrine pancreas
    • In this study, a block in the Hedgehog signaling pathway resulted in an arrest of acinar cell redifferentiation after pancreatitis. The results suggest a link between pancreatitis injury and subsequent pancreatic neoplasia
    • Fendrich V, Esni F, Garay MV, et al. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 2008; 135:621-631. In this study, a block in the Hedgehog signaling pathway resulted in an arrest of acinar cell redifferentiation after pancreatitis. The results suggest a link between pancreatitis injury and subsequent pancreatic neoplasia.
    • (2008) Gastroenterology , vol.135 , pp. 621-631
    • Fendrich, V.1    Esni, F.2    Garay, M.V.3
  • 12
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • This is a fascinating demonstration that mature acinar cells hold the capacity to transdifferentiate to b-cells. A large number of acinar cells transfected in vivo with the transcription factors Pdx1, neurogenin3, and Mafa began to express insulin. The results suggest a potential breakthrough in providing diabetic patients with a source of b-cells from acinar cell pools
    • Zhou Q, Brown J, Kanarek A, et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008; 455:627-632. This is a fascinating demonstration that mature acinar cells hold the capacity to transdifferentiate to b-cells. A large number of acinar cells transfected in vivo with the transcription factors Pdx1, neurogenin3, and Mafa began to express insulin. The results suggest a potential breakthrough in providing diabetic patients with a source of b-cells from acinar cell pools.
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3
  • 13
    • 57749113202 scopus 로고    scopus 로고
    • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    • Habbe N, Shi G, Meguid RA, et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A 2008; 105:18913-18918.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18913-18918
    • Habbe, N.1    Shi, G.2    Meguid, R.A.3
  • 14
    • 57749116315 scopus 로고    scopus 로고
    • Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    • The presence of mutant Kras alone predisposes only a small minority of cells to PanIN formation. This study shows that coexpression of mutant Kras along with Notch in Pdx1 or elastase-expressing cells increases the induction of PanIN lesions by several folds
    • De La OJ, Emerson LL, Goodman JL, et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A 2008; 105:18907-18912. The presence of mutant Kras alone predisposes only a small minority of cells to PanIN formation. This study shows that coexpression of mutant Kras along with Notch in Pdx1 or elastase-expressing cells increases the induction of PanIN lesions by several folds.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18907-18912
    • De La, O.J.1    Emerson, L.L.2    Goodman, J.L.3
  • 15
    • 60449085471 scopus 로고    scopus 로고
    • Regulation of pancreas plasticity and malignant transformation by Akt signaling
    • Elghazi L, Weiss AJ, Barker DJ, et al. Regulation of pancreas plasticity and malignant transformation by Akt signaling. Gastroenterology 2009; 136:1091-1103.
    • (2009) Gastroenterology , vol.136 , pp. 1091-1103
    • Elghazi, L.1    Weiss, A.J.2    Barker, D.J.3
  • 16
    • 84934443211 scopus 로고    scopus 로고
    • Purification and proteomics analysis of pancreatic zymogen granule membranes
    • Chen X, Andrews PC. Purification and proteomics analysis of pancreatic zymogen granule membranes. Methods Mol Biol 2008; 432:275-287.
    • (2008) Methods Mol Biol , vol.432 , pp. 275-287
    • Chen, X.1    Andrews, P.C.2
  • 17
    • 58149287751 scopus 로고    scopus 로고
    • Global topology analysis of pancreatic zymogen granule membrane proteins
    • This study is the first to use an experimentally constrained, comprehensive topology model of identified ZGM proteins. This study may provide a firm foundation for development of a higher order architecture model of the ZGM
    • Chen X, Ulintz PJ, Simon ES, et al. Global topology analysis of pancreatic zymogen granule membrane proteins. Mol Cell Proteomics 2008; 7:2323-2336. This study is the first to use an experimentally constrained, comprehensive topology model of identified ZGM proteins. This study may provide a firm foundation for development of a higher order architecture model of the ZGM.
    • (2008) Mol Cell Proteomics , vol.7 , pp. 2323-2336
    • Chen, X.1    Ulintz, P.J.2    Simon, E.S.3
  • 18
    • 53049084214 scopus 로고    scopus 로고
    • Rap1 activation plays a regulatory role in pancreatic amylase secretion
    • Sabbatini ME, Chen X, Ernst SA, Williams JA. Rap1 activation plays a regulatory role in pancreatic amylase secretion. J Biol Chem 2008; 283:23884-23894.
    • (2008) J Biol Chem , vol.283 , pp. 23884-23894
    • Sabbatini, M.E.1    Chen, X.2    Ernst, S.A.3    Williams, J.A.4
  • 19
    • 44949178276 scopus 로고    scopus 로고
    • Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion
    • Saegusa C, Kanno E, Itohara S, Fukuda M. Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Arch Biochem Biophys 2008; 475:87-92.
    • (2008) Arch Biochem Biophys , vol.475 , pp. 87-92
    • Saegusa, C.1    Kanno, E.2    Itohara, S.3    Fukuda, M.4
  • 20
    • 46749140923 scopus 로고    scopus 로고
    • VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis
    • This study further characterizes the mechanism of exocytosis through specific v-SNAREs and has implications for both pathological and physiological secretion
    • Cosen-Binker LI, Binker MG, Wang CC, et al. VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. J Clin Invest 2008; 118:2535-2551. This study further characterizes the mechanism of exocytosis through specific v-SNAREs and has implications for both pathological and physiological secretion.
    • (2008) J Clin Invest , vol.118 , pp. 2535-2551
    • Cosen-Binker, L.I.1    Binker, M.G.2    Wang, C.C.3
  • 21
    • 58149231024 scopus 로고    scopus 로고
    • Sdmg1 is a component of secretory granules in mouse secretory exocrine tissues
    • Best D, Adams IR. Sdmg1 is a component of secretory granules in mouse secretory exocrine tissues. Dev Dyn 2009; 238:223-231.
    • (2009) Dev Dyn , vol.238 , pp. 223-231
    • Best, D.1    Adams, I.R.2
  • 22
    • 59049087726 scopus 로고    scopus 로고
    • PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion
    • Chen LA, Li J, Silva SR, et al. PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion. J Biol Chem 2009; 284:2459-2471.
    • (2009) J Biol Chem , vol.284 , pp. 2459-2471
    • Chen, L.A.1    Li, J.2    Silva, S.R.3
  • 23
    • 41949114812 scopus 로고    scopus 로고
    • Evidence for KCNQ1 K+ channel expression in rat zymogen granule membranes and involvement in cholecystokinin-induced pancreatic acinar secretion
    • Lee WK, Torchalski B, Roussa E, Thevenod F. Evidence for KCNQ1 K+ channel expression in rat zymogen granule membranes and involvement in cholecystokinin-induced pancreatic acinar secretion. Am J Physiol Cell Physiol 2008; 294:C879-C892.
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Lee, W.K.1    Torchalski, B.2    Roussa, E.3    Thevenod, F.4
  • 24
    • 48549100809 scopus 로고    scopus 로고
    • Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells
    • This elegant study demonstrates, for the first time, a direct effect of the hormone CCK on human pancreatic acinar cells. Prior to this study, CCK was only thought to stimulate human acini indirectly via vagal nerve stimulation
    • Murphy JA, Criddle DN, Sherwood M, et al. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 2008; 135:632-641. This elegant study demonstrates, for the first time, a direct effect of the hormone CCK on human pancreatic acinar cells. Prior to this study, CCK was only thought to stimulate human acini indirectly via vagal nerve stimulation.
    • (2008) Gastroenterology , vol.135 , pp. 632-641
    • Murphy, J.A.1    Criddle, D.N.2    Sherwood, M.3
  • 25
    • 54449089075 scopus 로고    scopus 로고
    • The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells
    • Park HS, Betzenhauser MJ, Won JH, et al. The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells. J Biol Chem 2008; 283:26081-26088.
    • (2008) J Biol Chem , vol.283 , pp. 26081-26088
    • Park, H.S.1    Betzenhauser, M.J.2    Won, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.