Chemokine signaling and the management of neuropathic pain

Molecular Interventions

Volumn 9, Issue 4, 2009, Pages 188-195

  White, Fletcher A ^a   Feldman, Polina ^a   Miller, Richard J ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

CELL MIGRATION; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; DEMYELINATION; DORSAL ROOT; HUMAN; NERVE CELL EXCITABILITY; NERVOUS SYSTEM INFLAMMATION; NEUROPATHIC PAIN; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PERIPHERAL NERVE INJURY; PERIPHERAL NERVOUS SYSTEM; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL; STEM CELL;

ANIMALS; CHEMOKINE CCL2; HUMANS; NERVOUS SYSTEM DISEASES; PAIN; RECEPTORS, CCR2; SIGNAL TRANSDUCTION;

EID: 69749104787     PISSN: 15340384     EISSN: 15432548     Source Type: Journal    
DOI: 10.1124/mi.9.4.7     Document Type: Review

References (34)

1. Devor, M. Sodium channels and mechanisms of neuropathic pain. J. Pain 7, S3-S12 (2006). (Pubitemid 43106683)
2. D'Mello, R. and Dickenson, A.H. Spinal cord mechanisms of pain. Br. J. Anaes. 101, 8-16 (2008).
3. Marchand, F., Perretti, M., and McMahon, S.B. Role of the immune system in chronic pain. Nat. Rev. Neurosci. 6, 521-532 (2005). (Pubitemid 40942819)
4. Thacker, M.A., Clark, A.K., Marchand, F., and McMahon, S.B. Pathophysiology of peripheral neuropathic pain: Immune cells and molecules. Anesth. Analg. 105, 838-847 (2007). (Pubitemid 47300869)
5. Watkins, L.R., Hutchinson, M.R., Ledeboer, A., Wieseler-Frank, J., Milligan, E.D., and Maier, S.F. Norman Cousins Lecture. Glia as the "bad guys": Implications for improving clinical pain control and the clinical utility of opioids. Brain Behav. Immun. 21, 131-146 (2007). (Pubitemid 46038918)
6. DeLeo, J.A., Tanga, F.Y., and Tawfik, V.L. Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia. Neuroscientist 10, 40-52 (2004).
7. Cunha, F.Q., Poole, S., Lorenzetti, B.B., and Ferreira, S.H. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 107, 660-664 (1992). Established that proinflammatory cytokines have an early and crucial role in the development of inflammatory hyperalgesia.
8. Tran, P.B., Banisadr, G., Ren, D., Chenn, A., and Miller, R.J. Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J. Comp. Neurol. 500, 1007-1033 (2007). (Pubitemid 46106463)
9. White, F.A., Bhangoo, S.K., and Miller, R.J. Chemokines: Integrators of pain and inflammation. Nature Rev. 4, 834-844 (2005).
10. Abbadie, C., Lindia, J. A., Cumiskey, A.M., Peterson, L.B., Mudgett, J. S., Bayne, E.K., DeMartino, J.A., MacIntyre, D.E., and Forrest, M.J. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Natl. Acad. Sci. USA 100, 7947-7952 (2003). Showed that genetic deletion of CCR2 diminishes injury-induced neuropathic pain.
11. Oh, S.B., Tran, P.B., Gillard, S.E., Hurley, R.W., Hammond, D.L., and Miller, R.J. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J. Neurosci. 21, 5027-5035 (2001). The first paper describing the expression of diverse chemokine receptors by DRG neurons and their potential role in the generation of pain.
12. Menetski, J., Mistry, S., Lu, M., Mudgett, J.S., Ransohoff, R.M., Demartino, J.A., Macintyre, D.E., and Abbadie, C. Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses. Neuroscience 149, 706-714 (2007). (Pubitemid 47633032)
13. Thacker, M.A., Clark, A.K., Bishop, T., Grist, J., Yip, P. K., Moon, L.D., Thompson, S.W., Marchand, F., and McMahon, S.B. CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur. J. Pain 13, 263-272 (2009).
14. Bhangoo, S., Ripsch, M.S., Buchanan, D., Miller, R.J., and White, F.A. Increased chemokine signaling in a model of HIV-associated peripheral neuropathy. Mol. Pain 5, 48 (2009).
15. Bhangoo, S., Ren, D., Miller, R.J. et al. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: A mechanism for the development of chronic sensitization of peripheral nociceptors. Mol. Pain 3, 38 (2007). (Pubitemid 351234176)
16. Jung, H., Bhangoo, S., Banisadr, G., Freitag, C., Ren, D., White, F.A., and Miller, R.J. Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain. J. Neurosci. 29, 8051-8062 (2009).
17. Toews, A.D., Barrett, C., and Morell, P. Monocyte chemoattractant protein 1 is responsible for macrophage recruitment following injury to sciatic nerve. J. Neurosci. Res. 53, 260-267 (1998). (Pubitemid 28300132)
18. Carroll, S.L. and Frohnert, P.W. Expression of JE (monocyte chemoattractant protein-1) is induced by sciatic axotomy in wild type rodents but not in C57BL/Wld(s) mice. J. Neuropathol. Exp. Neurol. 57, 915-930 (1998).
19. Ramer, M.S., French, G.D., and Bisby, M.A. Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG. Pain 72, 71-78 (1997).
20. Ramer, M.S. and Bisby, M.A. Differences in sympathetic innervation of mouse DRG following proximal or distal nerve lesions. Exp. Neurol. 152, 197-207 (1998).
21. Milligan, E.D. and Watkins, L.R. Pathological and protective roles of glia in chronic pain. Nat. Rev. Neurosci. 10, 23-36 (2009).
22. Tanaka, T., Minami, M., Nakagawa, T., and Satoh, M. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: Possible involvement in the development of neuropathic pain. Neurosci. Res. 48, 463-469 (2004). (Pubitemid 38369344)
23. White, F.A., Sun, J., Waters, S.M. et al. Excitatory monocyte chemoattractant protein-1 signaling is upregulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc. Natl. Acad. Sci. USA 102, 14092-14097 (2005). (Pubitemid 41377708)
24. Flugel, A., Hager, G., Horvat, A., Spitzer, C., Singer, G.M., Graeber, M. B., Kreutzberg, G.W., and Schwaiger, F.W. Neuronal MCP-1 expression in response to remote nerve injury. J. Cereb. Blood Flow Metab. 21, 69-76 (2001). (Pubitemid 32016841)
25. Qin, X., Wan, Y., and Wang, X. CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. J Neurosci. Res. 82, 51-62 (2005). (Pubitemid 41604797)
26. Zhang, J. and De Koninck, Y. Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J. Neurochem. 97, 772-783 (2006).
27. Zhang, J., Shi, X. Q., Echeverry, S., Mogil, J.S., De Koninck, Y., and Rivest, S. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J. Neurosci. 27, 12396-12406 (2007). (Pubitemid 350085465)
28. Gao, Y.J., Zhang, L., Samad, O.A. et al. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J. Neurosci. 29, 4096-4108 (2009).
29. Mahad, D., Callahan, M.K., Williams, K.A. et al. Modulating CCR2 and CCL2 at the blood-brain barrier: Relevance for multiple sclerosis pathogenesis. Brain 129, 212-223 (2006). (Pubitemid 43063772)
30. Gosselin, R.D., Varela, C., Banisadr, G., Mechighel, P., Rostene, W., Kitabgi, P., and Melik-Parsadaniantz, S. Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurons. J. Neurochem. 95, 1023-1034 (2005). (Pubitemid 41713487)
31. Eltayeb, S., Berg, A.L., Lassmann, H., Wallstrom, E., Nilsson, M., Olsson, T., Ericsson-Dahlstrand, A., and Sunnemark, D. Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: Insight into mechanisms of MOG-induced EAE. J. Neuroinflammation 4, 14 (2007). (Pubitemid 46864925)
32. Ransohoff, R.M. Microgliosis: The questions shape the answers. Nat. Neurosci. 10, 1507-1509 (2007).
33. Jung, H., Toth, P.T., White, F.A., and Miller, R.J. Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J. Neurochem. 104, 254-263 (2008). (Pubitemid 350265055)
34. Sun, J.H., Yang, B., Donnelly, D.F., Ma, C., and LaMotte, R.H. MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. J. Neurophysiol. 96, 2189-2199 (2006). (Pubitemid 44785875)