Blocking GABAA neurotransmission in the interposed nuclei: Effects on conditioned and unconditioned eyeblinks

Brain Research

Volumn 1292, Issue , 2009, Pages 25-37

  Parker, Krystal L ^a   Zbarska, Svitlana ^a   Carrel, Andrew J ^a   Bracha, Vlastislav ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Classical conditioning; Interposed nuclei; Purkinje cell; Rabbit

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; PICROTOXIN; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; PYRIDAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; CEREBELLUM; CONDITIONED REFLEX; CONTROLLED STUDY; DOSE RESPONSE; EVOKED BRAIN STEM RESPONSE; EYELID CLOSURE; EYELID REFLEX; INTERPOSITUS NUCLEUS; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; ANIMAL; BLINKING; CONDITIONING; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOTOSTIMULATION; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; RABBIT; STIMULATION; SYNAPTIC TRANSMISSION; TIME; TRIGEMINAL NUCLEUS;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

ANIMALS; BLINKING; CEREBELLUM; CONDITIONING, EYELID; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA ANTAGONISTS; MALE; PHOTIC STIMULATION; PHYSICAL STIMULATION; PICROTOXIN; PSYCHOMOTOR PERFORMANCE; PYRIDAZINES; RABBITS; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION; TIME FACTORS; TRIGEMINAL NUCLEI;

EID: 69649105760     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.07.053     Document Type: Article

References (28)

1. Aksenov D., Serdyukova N., Irwin K., and Bracha V. GABA neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity. J. Neurophysiol. 91 (2004) 719-727
2. Attwell P.J., Ivarsson M., Millar L., and Yeo C.H. Cerebellar mechanisms in eyeblink conditioning. Ann. N.Y. Acad. Sci. 978 (2002) 79-92
3. Bao S., Chen L., Kim J.J., and Thompson R.F. Cerebellar cortical inhibition and classical eyeblink conditioning. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 1592-1597
4. Berthier N.E., and Moore J.W. Activity of deep cerebellar nuclear cells during classical conditioning of nictitating membrane extension in rabbits. Exp. Brain Res. 83 (1990) 44-54
5. Bloedel J.R., and Bracha V. On the cerebellum, cutaneomuscular reflexes, movement control and the elusive engrams of memory. Behav. Brain Res. 68 (1995) 1-44
6. Bouairi E., Kamendi H., Wang X., Gorini C., and Mendelowitz D. Multiple types of GABA(A) receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus. J. Neurophysiol. 96 (2006) 3266-3272
7. Bracha V., Webster M.L., Winters N.K., Irwin K.B., and Bloedel J.R. Effects of muscimol inactivation of the cerebellar interposed-dentate nuclear complex on the performance of the nictitating membrane response. Exp. Brain Res. 100 (1994) 453-468
8. Bracha V., Zhao L., Irwin K., and Bloedel J.R. Intermediate cerebellum and conditioned eyeblinks. Parallel involvement in eyeblinks and tonic eyelid closure. Exp. Brain Res. 136 (2001) 41-49
9. Bracha V., Zbarska S., Parker K., Carrel A., Zenitsky G., and Bloedel J.R. The cerebellum and eye-blink conditioning: learning versus network performance hypotheses. Neuroscience (2009) 162 (3), 787-796
10. Chen F.P., and Evinger C. Cerebellar modulation of trigeminal reflex blinks: interpositus neurons. J. Neurosci. 26 (2006) 10569-10576
11. Davis K.D., and Dostrovsky J.O. Modulatory influences of red nucleus stimulation on the somatosensory responses of cat trigeminal subnucleus oralis neurons. Exp. Neurol. 91 (1986) 80-101
12. Delgado-Garcia J.M., and Gruart A. Building new motor responses: eyelid conditioning revisited. Trends Neurosci. 29 (2006) 330-338
13. Desmond J.E., and Moore J.W. Single-unit activity in red nucleus during the classically conditioned rabbit nictitating membrane response. Neurosci. Res. 10 (1991) 260-279
14. Garcia K.S., and Mauk M.D. Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses. Neuropharmacology 37 (1998) 471-480
15. Gerwig M., Hajjar K., Dimitrova A., Maschke M., Kolb F.P., Frings M., Thilmann A.F., Forsting M., Diener H.C., and Timmann D. Timing of conditioned eyeblink responses is impaired in cerebellar patients. J. Neurosci. 25 (2005) 3919-3931
16. Godefroy J.N., Thiesson D., Pollin B., Rokyta R., and Azerad J. Reciprocal connections between the red nucleus and the trigeminal nuclei: a retrograde and anterograde tracing study. Physiol. Res. 47 (1998) 489-500
17. Holstege G., and Tan J. Projections from the red nucleus and surrounding areas to the brainstem and spinal cord in the cat. An HRP and autoradiographical tracing study. Behav. Brain Res. 28 (1988) 33-57
18. Ito M. The Cerebellum and Neural Control (1984), Raven Press, New York
19. Jimenez-Diaz L., Navarro-Lopez J.D., Gruart A., and Delgado-Garcia J.M. Role of cerebellar interpositus nucleus in the genesis and control of reflex and conditioned eyelid responses. J. Neurosci. 24 (2004) 9138-9145
20. Krupa D.J., Thompson J.K., and Thompson R.F. Localization of a memory trace in the mammalian brain. Science 260 (1993) 989-991
21. Mamounas L.A., Thompson R.F., and Madden J. Cerebellar GABAergic processes: evidence for critical involvement in a form of simple associative learning in the rabbit. Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 2101-2105
22. Medina J.F., Garcia K.S., and Mauk M.D. A mechanism for savings in the cerebellum. J. Neurosci. 21 (2001) 4081-4089
23. Ohyama T., Nores W.L., Medina J.F., Riusech F.A., and Mauk M.D. Learning-induced plasticity in deep cerebellar nucleus. J. Neurosci. 26 (2006) 12656-12663
24. Ryan S.B., Detweiler K.L., Holland K.H., Hord M.A., and Bracha V. A long-range, wide field-of-view infrared eyeblink detector. J. Neurosci. Methods 152 (2006) 74-82
25. Thomsen K., Offenhauser N., and Lauritzen M. Principal neuron spiking: neither necessary nor sufficient for cerebral blood flow in rat cerebellum. J. Physiol. 560 (2004) 181-189
26. Welsh J.P. Changes in the motor pattern of learned and unlearned responses following cerebellar lesions: a kinematic analysis of the nictitating membrane reflex. Neuroscience 47 (1992) 1-19
27. Welsh J.P., and Harvey J.A. Cerebellar lesions and the nictitating membrane reflex: performance deficits of the conditioned and unconditioned response. J. Neurosci. 9 (1989) 299-311
28. Zbarska S., Bloedel J.R., and Bracha V. Cerebellar dysfunction explains the extinction-like abolition of conditioned eyeblinks after NBQX injections in the inferior olive. J. Neurosci. 28 (2008) 10-20