Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses

Neuropharmacology

Volumn 37, Issue 4-5, 1998, Pages 471-480

  Garcia, Keith S ^a   Mauk, Michael D ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Classical conditioning; Muscimol; Nictitating membrane; Picrotoxin; Plasticity; Reversible lesion

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; MUSCIMOL; PICROTOXIN;

ANIMAL MODEL; CEREBELLUM CORTEX; CONDITIONED REFLEX; CONFERENCE PAPER; CONTROLLED STUDY; EYELID REFLEX; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; BLINKING; CATHETERIZATION; CEREBELLUM; CONDITIONING, CLASSICAL; EYELIDS; GABA AGONISTS; GABA ANTAGONISTS; INFUSIONS, PARENTERAL; MALE; MICROINJECTIONS; MUSCIMOL; NEURONS; PICROTOXIN; RABBITS; TIME FACTORS;

EID: 0031801888     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00055-0     Document Type: Conference Paper

References (47)

1. Aitkin L.M., Boyd J. Acoustic input to the lateral pontine nuclei. Hearing Res. 1:1978;67-77.
2. Bloedel J.R. Functional heterogeneity with structural homogeneity: how does the cerebellum operate? Behav. Brain Sci. 15:1992;666-678.
3. Buonomano D.V., Mauk M.D. Neural network model of the cerebellum: temporal discrimination and the timing of motor responses. Neural Comput. 6:1994;38-55.
4. Chapman P.F., Steinmetz J.E., Sears L.L., Thompson R.F. Effects of lidocaine injection in the interpositus nucleus and red nucleus on conditioned behavioral and neuronal responses. Brain Res. 537:1990;149-156.
5. Chen L., Bao S., Lockard J.M., Kim J.J., Thompson R.F. Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice. J. Neurosci. 16:1996;2829-2838.
6. Clark G.A., McCormick D.A., Lavond D.G., Thompson R.F. Effects of lesions of the cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses. Brain Res. 291:1984;125-136.
7. Clark R.E., Lavond D.G. Reacquisition of eyeblink classical conditioning following large cerebellar cortical lesions in dutch belted rabbits. Behav. Brain Res. 61:1994;101-106.
8. Freeman A.R. Electrophysiological analysis of the actions of strychnine, bicuculline, and picrotoxin on the axonal membrane. J. Neurobiol. 4:1973;567-582.
9. Garcia K.S., Mauk M.D. Cerebellar cortex is necessary for acquisition of Pavlovian eyelid responses. Soc. Neurosci. Abstr. 21:1995;1222.
10. Hardiman M.J., Ramnani N., Yeo C.H. Reversible inactivations of the cerebellum with muscimol prevent the acquisition and extinction of conditioned nictitating membrane responses in the rabbit. Exp. Brain Res. 110:1996;235-247.
11. Hesslow G. Inhibition of classically conditioned eyeblink responses by stimulation of the cerebellar cortex in the decerebrate cat. J. Physiol. 476(2):1994;245-256.
12. Hesslow G., Ivarsson M. Suppression of cerebellar Purkinje cells during conditioned responses in ferrets. Neuroreport. 5(5):1994;649-652.
13. Ivarsson M., Svensson P., Hesslow G. Bilateral disruption of conditioned responses after unilateral blockade of cerebellar output in the decerebrate ferret. J. Physiol. 502:1997;189-201.
14. Krupa D.J., Thompson J.K., Thompson R.F. Localization of a memory trace in the mammalian brain. Science. 260:1993;989-991.
15. Lavond D.G., Hembree T.L., Thompson R.F. Effect of kainic acid lesions of the cerebellar interpositus nucleus on eyelid conditioning in the rabbit. Brain Res. 326:1985;179-182.
16. Lavond D.G., Steinmetz J.E. Acquisition of classical conditioning without cerebellar cortex. Behav. Brain Res. 33:1989;113-164.
17. Lavond D.G., Steinmetz J.E., Yokaitis M.H., Thompson R.F. Reacquisition of classical conditioning after removal of cerebellar cortex. Exper. Brain Res. 67:1987;569-593.
18. Lewis J.L., LoTurco J.J., Solomon P.R. Lesions of the middle cerebellar peduncle disrupt acquisition and retention of the rabbit's classically conditioned nicitating membrane response. Behav. Neurosci. 101:1987;151-157.
19. Llinas R., Lang E.J., Welsh J.P. The cerebellum, LTD and memory: alternative views. Learn. Mem. 3:1997;445-455.
20. Mamounas L.A., Thompson R.F., Madden IV J.M. Cerebellar GABAergic processes: Evidence for critical involvement in a form of simple associative learning in rabbit. Proc. Natl. Acad. Sci. USA. 84:1987;2101-2105.
21. Mauk M.D. Roles of cerebellar cortex and nuclei in motor learning: Contradictions or clues? Neuron. 18(3):1997;343-349.
22. Mauk M.D., Donegan N.H. A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum. Learn. Mem. 3:1997;130-158.
23. Mauk M.D., Ruiz B.P. Learning-dependent timing of Pavlovian eyelid responses: Differential conditioning using multiple interstimulus intervals. Behav. Neurosci. 106:1992;666-681.
24. Mauk M.D., Steele P.M., Medina J.F. Cerebellar involvement in motor learning. The Neuroscientist. 3:1997;303-313.
25. Mauk M.D., Steinmetz J.E., Thompson R.F. Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. Proc. Natl. Acad. Sci. USA. 83:1986;5349-5353.
26. Mauk M.D., Thompson R.F. Retention of classically conditioned eyelid responses following acute decerebration. Brain Res. 403:1987;89-95.
27. McCormick D.A., Steinmetz J.E., Thompson R.F. Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response. Brain Res. 359:1985;120-130.
28. McCormick D.A., Thompson R.F. Cerebellum: Essential involvement in the classically conditioned eyelid response. Science. 223:1984;296-299.
29. McCormick D.A., Thompson R.F. Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. J. Neurosci. 4:1984;2811-2822.
30. Millenson J.R., Kehoe E.J., Gormezano I. Classical conditioning of the rabbit's nictitating membrane response under fixed and mixed CS-US intervals. Learn. Motiv. 8:1977;351-366.
31. Nordholm A.F., Thompson J.K., Dersarkissian C., Thompson R.F. Lidocaine infusion in a critical region of cerebellum completely prevents learning of the conditioned eyeblink response. Behav. Neurosci. 107:1993;882-886.
32. Perrett S.P., Mauk M.D. Extinction of conditioned eyelid responses requires the anterior lobe of the cerebellar cortex. J. Neurosci. 15:1995;2074-2080.
33. Perrett S.P., Ruiz B.P., Mauk M.D. Cerebellar cortex lesions disrupt the learning-dependent timing of conditioned eyelid responses. J. Neurosci. 13:1993;1708-1718.
34. Raymond J.L., Lisberger S.G., Mauk M.D. The cerebellum: a neuronal learning machine? Science. 272:1996;1126-1131.
35. Robinson D.A. Adaptive control of the vestibulo-ocular reflex by the cerebellum. J. Neurophysiol. 39:1976;954-969.
36. Sears L.L., Steinmetz J.E. Dorsal accessory inferior olive activity diminishes during acquisition of the rabbit classically conditioned eyelid response. Brain Res. 545:1991;114-122.
37. Steinmetz J.E. Classical nictitating membrane conditioning in rabbits with varying interstimulus intervals and direct activation of cerebellar mossy fibers as the CS. Behav. Brain Res. 38:1990;97-108.
38. Steinmetz J.E., Lavond D.G., Thompson R.F. Classical conditioning in rabbits using pontine nucleus stimulation as a conditioned stimulus and inferior olive stimulation as an unconditioned stimulus. Synapse. 3:1989;225-233.
39. Steinmetz J.E., Logan C.G., Rosen D.J., Thompson J.K., Lavond D.G., Thompson R.F. Initial localization of the acoustic conditioned stimulus projection system to the cerebellum essential for classical eyelid conditioning. Proc. Natl. Acad. Sci. USA. 84:1987;3531-3535.
40. Steinmetz J.E., Rosen D.J., Chapman P.F., Lavond D.G., Thompson R.F. Classical conditioning of the rabbit eyelid response with a mossy fiber stimulation CS: I. Pontine nuclei and middle cerebellar peduncle stimulation. Behav. Neurosci. 100:1986;878-887.
41. Thompson R.F. The neurobiology of learning and memory. Science. 233:1986;941-947.
42. Welsh J.P., Harvey J.A. Cerebellar lesions and the nictitating membrane reflex: performance deficits of the conditioned and unconditioned response. J. Neurosci. 9:1989;299-311.
43. Welsh J.P., Harvey J.A. Pavlovian conditioning of the rabbit during inactivation of the interposistus nucleus. J. Physiol. 444:1991;459-480.
44. Yeo C.H., Hardiman M.J. Cerebellar cortex and eyeblink conditioning: A re-examination. Exp. Brain Res. 88:1992;623-638.
45. Yeo C.H., Hardiman M.J., Glickstein M. Discrete lesions of the cerebellar cortex abolish the classically conditioned nictitating membrane response of the rabbit. Behav. Brain Res. 13:1984;261-266.
46. Yeo C.H., Hardiman M.J., Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit II. Lesions of the cerebellar cortex. Exp. Brain Res. 60:1985;99-113.
47. Yeo C.H., Hardiman M.J., Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit I. Lesions of the cerebellar nuclei. Exp. Brain Res. 60:1985;87-98.