GABA Neurotransmission in the Cerebellar Interposed Nuclei: Involvement in Classically Conditioned Eyeblinks and Neuronal Activity

Journal of Neurophysiology

Volumn 91, Issue 2, 2004, Pages 719-727

  Aksenov, D ^a   Serdyukova, N ^a   Irwin, K ^a   Bracha, V ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; MUSCIMOL; PICROTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CEREBELLUM CORTEX; CEREBELLUM NUCLEUS; CONDITIONED REFLEX; CONTROLLED STUDY; EYELID CLOSURE; EYELID REFLEX; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; MALE; NERVE CONDUCTION; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RABBIT;

ANIMALS; CEREBELLAR NUCLEI; CONDITIONING, CLASSICAL; CONDITIONING, EYELID; GAMMA-AMINOBUTYRIC ACID; MALE; NEURONS; PICROTOXIN; RABBITS; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION;

EID: 0842284653     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00859.2003     Document Type: Article

References (24)

1. Bao S, Chen L, Kim JJ, and Thompson RF. Cerebellar cortical inhibition and classical eyeblink conditioning. Proc Natl Acad Sci USA 99: 1592-1597, 2002.
2. Berthier NE and Moore JW. Activity of deep cerebellar nuclear cells during classical conditioning of nictitating membrane extension in rabbits. Exp Brain Res 83: 44-54, 1990.
3. Bracha V, Webster ML, Winters NK, Irwin KB, and Bloedel JR. Effects of muscimol inactivation of the cerebellar interposed-dentate nuclear complex on the performance of the nictitating membrane response in the rabbit. Exp Brain Res 100: 453-468, 1994.
4. Bracha V, Zhao L, Irwin K, and Bloedel JR. Intermediate cerebellum and conditioned eyeblinks. Parallel involvement in eyeblinks and tonic eyelid closure. Exp Brain Res 136: 41-49, 2001.
5. Chapman PF, Steinmetz JE, Sears LL, and Thompson RF. Effects of lidocaine injection in the interpositus nucleus and red nucleus on conditioned behavioral and neural responses. Brain Res 537: 149-156, 1990.
6. Freeman AR. Electrophysiological analysis of the actions of strychnine, bicuculline and picrotoxin on the axonal membrane. J Neurobiol 4: 567-582, 1973.
7. Garcia KS and Mauk MD. Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses. Neuropharmacology 37: 471-480, 1998.
8. Gormezano I, Kehoe EJ and Marshall BS. Twenty years of classical conditioning research with the rabbit. Prog Psychobiol Physiol Psychol 10: 197-275, 1983.
9. Ito M. The Cerebellum and Neural Control. New York: Raven Press, 1984.
10. Jimenez-Diaz L, Gruart A, Minano FJ, and Delgado-Garcia JM. An experimental study of posterior interpositus involvement in the genesis and control of conditioned eyelid responses. Ann NY Acad Sci 978: 106-118, 2002.
11. Krupa DJ, Thompson JK, and Thompson RF. Localization of a memory trace in the mammalian brain. Science 260: 989-991, 1993.
12. Krupa DJ and Thompson RF. Reversible inactivation of the cerebellar interpositus nucleus completely prevents acquisition of the classically conditioned eye-blink response. Learn Mem 3: 545-556, 1997.
13. Lincoln JS, McCormick DA, and Thompson RF. Ipsilateral cerebellar lesions prevent learning of the classically conditioned nictitating membrane/eyelid response. Brain Res 242: 190-193, 1982.
14. Mamounas LA, Thompson RF, and Madden J. Cerebellar GABAergic processes: evidence for critical involvement in a form of simple associative learning in the rabbit. Proc Natl Acad Sci USA 84: 2101-2105, 1987.
15. McCormick DA, Clark GA, Lavond DG, and Thompson RF. Initial localization of the memory trace for a basic form of learning. Proc Natl Acad Sci USA 79: 2731-2735, 1982.
16. Medina JF, Garcia KS, and Mauk MD. A mechanism for savings in the cerebellum. J Neurosci 21: 4081-4089, 2001.
17. Medina JF, Nores WL, Ohyama T, and Mauk MD. Mechanisms of cerebellar learning suggested by eyelid conditioning. Curr Opin Neurobiol 10: 717-724, 2000.
18. Mouginot D and Gahwiler BH. Presynaptic GABA-B receptors modulate IPSPs evoked in neurons of deep cerebellar nuclei in vitro. J Neurophysiol 75: 894-901, 1996.
19. Ramnani N and Yeo CH. Reversible inactivations of the cerebellum prevent the extinction of conditioned nictitating membrane responses in rabbits. J Physiol 495: 159-168, 1996.
20. Steinmetz JE. Brain substrates of classical eyeblink conditioning: a highly localized but also distributed system. Behav Brain Res 110: 13-24, 2000.
21. Thompson RF. The neurobiology of learning and memory. Science 233: 941-947, 1986.
22. Thompson RF and Kim JJ. Memory systems in the brain and localization of a memory. Proc Natl Acad Sci USA 93: 13438-13444, 1996.
23. Welsh JP and Harvey JA. Pavlovian conditioning in the rabbit during inactivation of the interpositus nucleus. J Physiol 444: 459-480, 1991.
24. Yeo CH, Hardiman MJ, and Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit. I. Lesions of the cerebellar nuclei. Exp Brain Res 60: 87-98, 1985.