Arrhythmogenic effects of anti-Ro/SSA antibodies on the adult heart: More than expected?

Autoimmunity Reviews

Volumn 9, Issue 1, 2009, Pages 40-44

  Lazzerini, Pietro Enea ^a,b   Capecchi, Pier Leopoldo ^a   Acampa, Maurizio ^a   Selvi, Enrico ^a   Guideri, Francesca ^a   Bisogno, Stefania ^a   Rossi, Pier Carlo ^b   Galeazzi, Mauro ^a   Laghi Pasini, Franco ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b Hospital of Carrara   (Italy)

Author keywords

Anti Ro SSA antibodies; Conduction disorders; KCNH2; QTc interval; Ventricular arrhythmias

Indexed keywords

INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; RO ANTIBODY;

ARRHYTHMOGENESIS; AUTOIMMUNITY; CONGENITAL HEART BLOCK; HEART MUSCLE CONDUCTION DISTURBANCE; HEART VENTRICLE ARRHYTHMIA; HUMAN; POTASSIUM CURRENT; QT PROLONGATION; REVIEW; RISK FACTOR; SUDDEN DEATH;

ADULT; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ARRHYTHMIAS, CARDIAC; AUTOANTIBODIES; AUTOANTIGENS; FEMALE; HUMANS; INFANT, NEWBORN; MATERNAL-FETAL EXCHANGE; MYOCARDIAL CONTRACTION; POTASSIUM CHANNELS; PREGNANCY; PROGNOSIS; RIBONUCLEOPROTEINS; RISK FACTORS; RNA, SMALL CYTOPLASMIC; SURVIVAL ANALYSIS;

EID: 69649084206     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2009.03.002     Document Type: Review

References (38)

1. Franceschini F., and Cavazzana I. Anti-Ro/SSA and anti-La/SSB antibodies. Autoimmunity 38 (2005) 55-63
2. Wolin S.L., and Reinisch K.M. The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure. Autoimmun Rev 5 (2006) 367-372
3. Lazzerini PE, Capecchi PL, Laghi Pasini F: Arrhythmogenicity of anti-Ro/SSA antibodies: from the newborn to the adult? In Tarkowicz IR, ed: Progress in cardiac arrhythmias research. New York: Nova Science Publishers, Inc. 2008. p.137-67.
4. Ceribelli A., Cavazzana I., Cattaneo R., et al. Hepatitis C virus infection and primary Sjögren's syndrome: a clinical and serologic description of 9 patients. Autoimmun Rev 8 (2008) 92-94
5. Rovenský J., and Tuchynová A. Systemic lupus erythematosus in the elderly. Autoimmun Rev 7 (2008) 235-239
6. Hayashi N., Koshiba M., Nishimura K., et al. Prevalence of disease-specific antinuclear antibodies in general population: estimates from annual physical examinations of residents of a small town over a 5-year period. Mod Rheumatol 18 (2008) 153-160
7. Lee L.A. Transient autoimmunity related to maternal autoantibodies: neonatal lupus. Autoimmun Rev 4 (2005) 207-213
8. Kobayashi R., Mii S., Nakano T., Harada H., et al. Neonatal lupus erythematosus in Japan: a review of the literature. Autoimmun Rev (Jan 20 2009) 10.1016/j.autrev.2008.12.013 [Electronic publication ahead of print]
9. Brucato A., Jonzon A., Friedman D., et al. Proposal for a new definition of congenital complete atrioventricular block. Lupus 12 (2003) 427-435
10. Buyon J.P. Neonatal lupus syndromes. In: Lahita R. (Ed). Systemic lupus erythematosus. Fourth edition (2004), Elsevier Academic Press, San Diego, CA 449-484
11. Costedoat-Chalumeau N., Amoura Z., et al. Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options. Arthritis Res Ther 7 (2005) 69-73
12. Lazzerini P.E., Capecchi P.L., Guideri F., et al. Autoantibody-mediated cardiac arrhythmias: mechanisms and clinical implications. Basic Res Cardiol 103 (2008) 1-11
13. Motta M., Rodriguez-Perez C., Tincani A., et al. Outcome of infants from mothers with anti-SSA/Ro antibodies. J Perinatol 27 (2007) 278-283
14. Gerosa M., Cimaz R., Stramba-Badiale M., et al. Electrocardiographic abnormalities in infants born from mothers with autoimmune diseases-a multicentre prospective study. Rheumatology 46 (2007) 1285-1289
15. Hu K., Qu Y., and Butjdir M. Functional basis of sinus bradycardia in congenital heart block. Circ Res 94 (2004) e32-e38
16. 1D (Cav 1.3) L-Type calcium channel in autoimmune-associated sinus bradycardia. Circulation 111 (2005) 3034-3041
17. Lazzerini P.E., Capecchi P.L., Guideri F., et al. Connective tissue diseases and cardiac rhythm disorders: an overview. Autoimmun Rev 5 (2006) 306-313
18. Lee L.A., Pickrell M.B., and Reichlin M. Development of complete heart block in an adult patient with Sjogren's syndrome and anti-Ro/SSA autoantibodies. Arthritis Rheum 39 (1996) 1427-1429
19. Brucato A., Frassi M., Franceschini F., et al. Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected with counterimmunoelectrophoresis: a prospective study of 100 women. Arthritis Rheum 44 (2001) 1832-1835
20. Martinez-Costa X., Ordi J., Barbera J., et al. High grade atrioventricular heart block in 2 adults with systemic lupus erythmatosus. J Rheumatol 18 (1991) 1926-1928
21. Mevorach D., Raz E., Shalev O., et al. Complete heart block and seizures in an adult with systemic lupus erythematosus. A possible pathophysiologic role for anti-SS-A/Ro and anti-SS-B/La autoantibodies. Arthritis Rheum 36 (1993) 259-262
22. Fonseca E., Crespo M., and Sobrino J.A. Complete heart block in an adult with systemic lupus erythematosus. Lupus 3 (1994) 129-131
23. Comin-Colet J., Sanchez-Corral M.A., Alegre-Sancho J.J., et al. Complete heart block in an adult with systemic lupus erythematosus and recent onset of hydroxychloroquine therapy. Lupus 10 (2001) 59-62
24. Edwards C.S., Mootoo R., and Bhanji A. High grade heart block in association with SLE. Ann Rheum Dis 63 (2004) 606
25. Behan W.M., Aitchison M., and Behan P.O. Pathogenesis of heart block in a fatal case of dermatomyositis. Br Heart J 56 (1986) 479-482
26. Logar D., Kveder T., Rozman B., et al. Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus eryhematosus. Ann Rheum Dis 9 (1990) 627-629
27. Behan W.M.A., Behan P.O., and Gairns J. Cardiac damage in polymyositis associated with antibodies to tissue ribonucleoproteins. Br Heart J 57 (1987) 176-180
28. O'Neill T.W., Mahmoud A., Tooke A., et al. Is there a relationship between subclinical myocardial abnormalities, conduction defects and Ro/La antibodies in adults with systemic lupus erythematosus?. Clin Exp Rheumatol 11 (1993) 409-412
29. Gordon P.A., Rosenthal E., Khamashta M.A., et al. Absence of conduction defects in the electrocardiograms [correction of echocardiograms] of mothers with children with congenital heart block. J Rheumatol 28 (2001) 366-369
30. Lodde B.M., Sankar V., Kok M.R., et al. Adult heart block is associated with disease activity in primary Sjogren's syndrome. Scand J Rheumatol 34 (2005) 383-386
31. Costa M., Silva M.B., Silva J.A., et al. Anti Ro, anti La, anti RNP antibodies and electrocardiogram's PR interval in adult patients with systemic lupus erythematosus. Acta Reumatol Port 33 (2008) 173-175
32. Lazzerini P.E., Acampa M., Guideri F., et al. Prolongation of the corrected QT interval in adult patients with anti-Ro/SSA-positive connective tissue diseases. Arthritis Rheum 50 (2004) 1248-1252
33. Huikuri H.V., Castellanos A., and Myerburg R.J. Sudden death due to cardiac arrhythmias. N Eng J Med 345 (2001) 1473-1482
34. Costedoat-Chalumeau N., Amoura Z., Hulot J.S., et al. Letter in response to "Prolongation of the corrected QT interval in adult patients with anti-Ro/SSA-positive connective tissue diseases" by Lazzerini et al. in Arthritis Rheum 2004; 50: 1248-52. Arthritis Rheum 52 (2005) 676-677 [author reply 677-678]
35. Pineau CA, Huynh T, Bernatsky S, et al. Prolongation of the corrected QT interval in anti-Ro/SSA positive adults with systemic lupus erithematosus. American College of Rheumatology, San Diego (USA) 12-17 november 2005, program number 1213 [Abstract].
36. Lazzerini P.E., Capecchi P.L., Guideri F., et al. Comparison of frequency of complex ventricular arrhythmias in patients with positive versus negative anti-Ro/SSA and connective tissue disease. Am J Cardiol 100 (2007) 1029-1034
37. Nakamura K., Katayama Y., Kusano K.F., et al. Anti-KCNH2 antibody-induced long QT syndrome: novel acquired form of long QT syndrome. J Am Coll Cardiol 50 (2007) 1808-1809
38. Gupta A., Lawrence A.T., Krishnan K., et al. Current concepts in the mechanisms and management of drug-induced QT prolongation and torsades de pointes. Am Heart J 153 (2007) 891-899