Treating sepsis: An update on the latest therapies, part 2

Infections in Medicine

Volumn 26, Issue 6, 2009, Pages

  Cribbs, Sushma K ^a   Martin, Greg S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ARDS; Sepsis; Septic shock

Indexed keywords

DOPAMINE; GLUCOSE; HEPARIN; INSULIN; NORADRENALIN; VASOPRESSIN;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANALGESIA; ARTIFICIAL VENTILATION; CLINICAL TRIAL; DEEP VEIN THROMBOSIS; FLUID RESUSCITATION; HUMAN; HYPOGLYCEMIA; HYPOTENSION; INSULIN TREATMENT; OXYGENATION; REVIEW; SEDATION; SEPSIS; STRESS ULCER; UPPER GASTROINTESTINAL BLEEDING; VENOUS THROMBOEMBOLISM; VENTILATOR ASSOCIATED PNEUMONIA;

EID: 69549131378     PISSN: 07496524     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (58)

1. Martin GS, Bernard GR; International Sepsis Forum. Airway and lung in sepsis. Intensive Care Med. 2001;27(suppl 1):S63-S79.
2. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-1349.
3. Tremblay L, Valenza F, Ribeiro SP, et al. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest. 1997;99:944-952. (Pubitemid 27123631)
4. Tsuno K, Miura K, Takeya M, et al. Histopathologic pulmonary changes from mechanical ventilation at high peak airway pressures. Am Rev Respir Dis. 1991;143(5 pt 1):1115-1120.
5. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301-1308.
6. Bidani A, Tzouanakis AE, Cardenas VJ Jr, Zwischenberger J B. Permissive hypercapnia in acute respiratory failure. JAMA. 1994;272:957-961.
7. Hickling KG, Walsh J, Henderson S, Jackson R. Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study. Crit Care Med. 1994;22:1568-1578. (Pubitemid 24320879)
8. Eisner MD, Thompson T, Hudson LD, et al; Acute Respiratory Distress Syndrome Network. Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001;164:231-236.
9. Yilmaz M, Keegan MT, Iscimen R, et al. Toward the prevention of acute lung injury: protocol-guided limitation of large tidal volume ventilation and inappropriate transfusion. Crit Care Med. 2007;35:1660-1666. (Pubitemid 46985866)
10. Martin GS, Mangialardi RJ, Wheeler AP, et al. Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med. 2002;30:2175-2182. (Pubitemid 35191564)
11. Mitchell JP, Schuller D, Calandrino FS, Schuster DC. Improved outcome based on fluid management in critically ill patients requiring pulmonary artery catheterization. Am Rev Respir Dis. 1992;145:990-998.
12. Schuller D, Mitchell JP, Calandrino FS, Schuster DC. Fluid balance during pulmonary edema. Is fluid gain a marker or a cause of poor outcome? Chest. 1991;100:1068-1075.
13. Martin GS, Eaton S, Mealer M, Moss M. Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit Care. 2005;9:R74-R82.
14. Phillips CR, Chesnutt MS, Smith SM. Extravascular lung water in sepsis-associated acute respiratory distress syndrome: indexing with predicted body weight improves correlation with severity of illness and survival. Crit Care Med. 2008;36:69-73.
15. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network; Wiedemann HP, Wheeler AP, Bernard GR, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354:2564-2575. (Pubitemid 43882352)
16. McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin. 2001;17:107-124.
17. Gelfand RA, Matthews DE, Bier DM, Sherwin RS. Role of counterregulatory hormones in the catabolic response to stress. J Clin Invest. 1984;74:2238-2248. (Pubitemid 15197369)
18. Shamoon H, Hendler R, Sherwin RS. Synergistic interactions among antiinsulin hormones in the pathogenesis of stress hyperglycemia in humans. J Clin Endocrinol Metab. 1981;52:1235-1241. (Pubitemid 13237531)
19. Golden SH, Peart-Vigilance C, Kao WH, Brancati FL. Perioperative glycemic control and the risk of infectious complications in a cohort of adults with diabetes. Diabetes Care. 1999;22:1408-1414.
20. Hirose R, Xu F, Dang K, et al. Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats. Anesthesiology. 2008;108:402-414. (Pubitemid 351304234)
21. Flakoll PJ, Hill JO, Abumrad NN. Acute hyperglycemia enhances proteolysis in normal man. Am J Physiol. 1993;265(5 pt 1):E715-E721. (Pubitemid 23350791)
22. Hansen TK, Thiel S, Wouters PJ, et al. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab. 2003;88:1082-1088. (Pubitemid 36337759)
23. Weckers F, Giulietti AP, Michalaki M, et al. Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology. 2003;144:5329-5338. (Pubitemid 37476061)
24. Dandona P, Aljada A, Mohanty P, et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab. 2001;86:3257-3265. (Pubitemid 32674120)
25. Langouche L, Vanhorebeek I, Vlasselaers D, et al. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest. 2005;115:2277-2286. (Pubitemid 41134169)
26. Vanhorebeek I, De Vos R, Mesotten D, et al. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet. 2005;365:53-59. (Pubitemid 40082146)
27. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359-1367. (Pubitemid 34940724)
28. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449-461. (Pubitemid 43200296)
29. Brunkhorst FM, Engel C, Bloos F, et al; German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358:125-139.
30. ClinicalTrials.gov. Glucontrol Study: Comparing the Effects of Two Glucose Control Regimens by Insulin in Intensive Care Unit Patients. http://www.clinicaltrials.gov. Identifier NCT00107601. Accessed May 2, 2008.
31. Current controlled trials. A multi-centre, open label randomised stratified controlled trial of the effects of blood glucose management on 90-day all-cause mortality in a heterogeneous population of intensive care unit (ICU) patients. http://www.controlled-trials.com/ISRCTN04968275. Accessed April 23, 2008.
32. Preiser JC. Restoring normoglycaemia: not so harmless. Crit Care. 2008;12:116.
33. Dellinger RP, Levy MM, Carlet JM, et al; International Surviving Sepsis Campaign Guidelines Committee, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008 [published correction appears in Crit Care Med. 2008;36:1394-1396]. Crit Care Med 2008;36:296-327.
34. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999;115:462-474. (Pubitemid 29083057)
35. Halpern NA, Bettes L, Greenstein R. Federal and nationwide intensive care units and healthcare costs: 1986-1992. Crit Care Med. 1994;22:2001-2007.
36. Brook AD, Ahrens TS, Schaiff R, et al. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med. 1999;27:2609-2615. (Pubitemid 30027169)
37. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342:1471-1477.
38. Kress JP, Vinayak AG, Levitt J, et al. Daily sedative interruption in mechanically ventilated patients at risk for coronary artery disease. Crit Care Med. 2007;35:365-371. (Pubitemid 46148523)
39. Kress JP, Gehlbach B, Lacy M, et al. The long-term psychological effects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med. 2003;168:1457-1461. (Pubitemid 38037329)
40. Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008;371:126-134.
41. Gardlund B. Randomised, controlled trial of low-dose heparin for prevention of fatal pulmonary embolism in patients with infectious diseases. The Heparin Prophylaxis Study Group. Lancet. 1996;347:1357-1361.
42. Halkin H, Goldberg J, Modan M, Modan B. Reduction of mortality in general medical inpatients by low-dose heparin prophylaxis. Ann Intern Med. 1982;96:561-565.
43. Hirsch DR, Ingenito EP, Goldhaber SZ. Prevalence of deep venous thrombosis among patients in medical intensive care. JAMA. 1995;274:335-337.
44. Pingleton SK, Bone RC, Pingleton WW, Ruth WE. Prevention of pulmonary emboli in a respiratory intensive care unit: efficacy of low-dose heparin. Chest. 1981;79:647-650.
45. Samama MM, Cohen AT, Darmon JY, et al. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in Medical Patients with Enoxaparin Study Group. N Engl J Med. 1999;341:793-800.
46. King CS, Holley AB, Jackson JL, et al. Twice vs three times daily heparin dosing for thromboembolism prophylaxis in the general medical population: a metaanalysis. Chest. 2007;131:507-516.
47. Agu O, Hamilton G, Baker D. Graduated compression stockings in the prevention of venous thromboembolism. Br J Surg. 1999;86:992-1004. (Pubitemid 29387063)
48. Turpie AG, Hirsh J, Gent M, et al. Prevention of deep vein thrombosis in potential neurosurgical patients. A randomized trial comparing graduated compression stockings alone or graduated compression stockings plus intermittent pneumatic compression with control. Arch Intern Med. 1989;149:679-681.
49. Turpie AG, Bauer KA, Caprini JA, et al; Apollo Investigators. Fondaparinux combined with intermittent pneumatic compression vs. intermittent pneumatic compression alone for prevention of venous thromboembolism after abdominal surgery: a randomized, double-blind comparison. J Thromb Haemost. 2007;5:1854-1861.
50. Basso N, Bagarani M, Materia A, et al. Cimetidine and antacid prophylaxis of acute upper gastrointestinal bleeding in high risk patients. Controlled, randomized trial. Am J Surg. 1981;141:339-341. (Pubitemid 11113914)
51. Bresalier RS, Grendell JH, Cello JP, Meyer AA. Sucralfate suspension versus titrated antacid for the prevention of acute stress-related gastrointestinal hemorrhage in critically ill patients. Am J Med. 1987;83:110-116.
52. Poleski MH, Spanier AH. Cimetidine versus antacids in the prevention of stress erosions in critically ill patients. Am J Gastroenterol. 1986;81:107-111.
53. Stothert JC Jr, Simonowitz DA, Dellinger EP, et al. Randomized prospective evaluation of cimetidine and antacid control of gastric pH in the critically ill. Ann Surg. 1980;192:169-174. (Pubitemid 10034335)
54. Friedman CJ, Oblinger MJ, Suratt PM, et al. Prophylaxis of upper gastrointestinal hemorrhage in patients requiring mechanical ventilation. Crit Care Med. 1982;10:316-319.
55. Hastings PR, Skillman JJ, Bushnell LS, Silen W. Antacid titration in the prevention of acute gastrointestinal bleeding: a controlled, randomized trial in 100 critically ill patients. N Engl J Med. 1978;298:1041-1045. (Pubitemid 8362282)
56. Kahn JM, Doctor JN, Rubenfeld GD. Stress ulcer prophylaxis in mechanically ventilated patients: integrating evidence and judgment using a decision analysis. Intensive Care Med. 2006;32:1151-1158.
57. National Institutes of Health. Estimates of funding for various research, condition, and disease categories (RCDC). http://www.nih.gov/news/ fundingresearchareas.htm. Updated January 15, 2009. Accessed May 2, 2008.
58. Centers for Disease Control and Prevention. Ten leading causes of death, 2005: U.S. and all 50 states, listed by age-adjusted death rates. http://www.cdc.gov/nchs/pressroom/data/state-mortality-rank-05.htm. Accessed May 2, 2008.