Conditional antisense-knockdown of zebrafish cardiac troponin C as a new animal model for dilated cardiomyopathy

Circulation Journal

Volumn 73, Issue 9, 2009, Pages 1691-1697

  Ho, Yi Lwun ^a   Lin, Yen Hung ^a   Tsai, Wei Yuan ^b   Hsieh, Fong Jou ^a   Tsai, Huai Jen ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Antisense RNA; Cardiac troponin C; Dilated cardiomyopathy; Zebrafish

Indexed keywords

CARDIAC MYOSIN; COMPLEMENTARY RNA; DOXYCYCLINE; GREEN FLUORESCENT PROTEIN; MYOSIN LIGHT CHAIN 2; TETRACYCLINE; TROPONIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; EMBRYO; FERTILIZATION; GENE EXPRESSION; HEART EJECTION FRACTION; HEART RATE; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PLASMID; PROMOTER REGION; PROTEIN BINDING; REPORTER GENE; TRANSGENICS; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ATRIAL FUNCTION; BASE SEQUENCE; BLOTTING, WESTERN; CARDIAC MYOSINS; CARDIOMYOPATHY, DILATED; DISEASE MODELS, ANIMAL; GENE KNOCKDOWN TECHNIQUES; GENOTYPE; GREEN FLUORESCENT PROTEINS; HEART RATE; MOLECULAR SEQUENCE DATA; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOSIN LIGHT CHAINS; PHENOTYPE; PROMOTER REGIONS, GENETIC; RNA, ANTISENSE; STROKE VOLUME; TRANSCRIPTION, GENETIC; TROPONIN C; VENTRICULAR FUNCTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 69549127744     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-09-0210     Document Type: Article

References (31)

1. Gomes AV, Potter JD. Molecular and cellular aspects of troponin cardiomyopathies. Ann NY Acad Sci 2004; 1015: 214-224. (Pubitemid 38879492)
2. Mogensen J, Murphy RT, Shaw T, Bahl A, Redwood C, Watkins H, et al. Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2004; 44: 2033-2040. (Pubitemid 39473290)
3. Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science 2002; 298: 2188-2190.
4. Raya AKC, Koth CM, Buscher D, Kawakami Y, Itoh T, Raya RM, et al. Activation of notch signaling pathway precedes heart regeneration in zebrafish. Proc Natl Acad Sci USA 2003; 100:11889-11895. (Pubitemid 37205900)
5. Shu X, Cheng K, Patel N, Chen F, Joseph E, Tsai HJ. Na, K-ATPase is essential for embryonic heart development in the zebrafish. Development 2003; 130: 6165-6173.
6. Fishman MC, Stainier DY. Cardiovascular development: Prospects for a genetic approach. Circ Res 1994; 74: 757-763.
7. Fishman MC, Chien KR. Fashioning the vertebrate heart: Earliest embryonic decisions. Development 1997; 124: 2099-2117.
8. Sehnert AJ, Huq A, Weinstein BM, Walker C, Fishman M, Stainier DY. Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nat Genet 2002; 31: 106-110. (Pubitemid 34887648)
9. Huang CJ, Tu CT, Hsiao CD, Hsieh FJ, Tsai HJ. Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish. Dev Dyn 2003; 228: 30-40.
10. Huang CJ, Jou TS, Ho YL, Lee WH, Jeng YT, Hsieh FJ, et al. Conditional expression of a myocardium-specific transgene in zebrafish transgenic lines. Dev Dyn 2005; 233:1294-1303. (Pubitemid 40995127)
11. Yokoyama K, Imanoto F. Transcriptional control of the endogenous MYC potooncogene by antisense RNA. Proc Natl Acad Sci USA 1987; 84: 7363-7367. (Pubitemid 18035706)
12. McGarry J, Lindquist S. Inhibition of heat shock protein synthesis by heat-inducible antisense RNA. Proc Natl Acad Sci USA 1986; 83: 399-403. (Pubitemid 16080020)
13. Westerfield M. The zebrafish book. Eugene: University of Oregon Press; 1995; 1.1-3.25.
14. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. Stages of embryonic development of the zebrafish. Dev Dyn 1995; 203:253-310.
15. Jowett T. Double in situ hybridization techniques in zebrafish. Methods 2001; 23: 345-358. (Pubitemid 32846454)
16. Huang CJ, Lin JY, Tsai HJ. Two distinct c-ski cDNAs of fish, tilapia (Oreochromis aurea). Mol Reprod Dev 1999; 54: 223-231.
17. Ho YL, Shau YW, Tsai HJ, Lin LC, Huang PJ, Hsieh FJ. Assessment of zebrafish cardiac performance using Doppler echocardiography and power angiography. Ultrasound Med Biol 2002; 28: 1137-1143.
18. Hou PC, Burggren WW. Cardiac output and peripheral resistance during larval development in the anuran amphibian Xenopus laevis. Am J Physiol 1995; 269: R1126-R1132. (Pubitemid 3005999)
19. Yoshikawa T, Baba A, Nagatomo Y. Autoimmune mechanisms underlying dilated cardiomyopathy. Circ J 2009; 73: 602-607.
20. Biesiadecki BJ, Elder BD, Yu ZB, Jin JP. Cardiac troponin T variants produced by aberrant splicing of multiple exons in animals with high instances of dilated cardiomyopathy. J Biol Chem 2002; 277:50275-50285.
21. 2+ sensitizers. Circ J 2008; 72:1915-1925.
22. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992; 89: 5547-5551.
23. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H. Transcriptional activation by tetracycline in mammalian cells. Science 1995;268:1766-1769.
24. Sedmera D, Reckova M, deAlmeida A, Sedmerova M, Biermann M, Volejnik J, et al. Functional and morphological evidence for a ventricular conduction system in zebrafish and Xenopus hearts. Am J Physiol Heart Circ Physiol 2003; 284: H1152-H1160.
25. Raya A, Consiglio A, Kawakami Y, Rodriguez-Esteban C, Izpisua-Belmonte JC. The zebrafish as a model of heart regeneration. Cloning Stem Cells 2004; 6: 345-351.
26. Armstrong EJ, Bischoff J. Heart valve development: endothelial cell signaling and differentiation. Circ Res 2004; 95:459-470. (Pubitemid 39180926)
27. Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, et al. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell 2004; 118: 649-663. (Pubitemid 39179716)
28. Milan DJ, Peterson TA, Ruskin JN, Peterson RT, MacRae CA. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation 2003; 107: 1355-1358.
29. Hsieh DJ, Liao CF. Zebrafish M2 muscarinic acetylcholine receptor: Cloning, pharmacological characterization, expression patterns and roles in embryonic bradycardia. Br J Pharmacol 2002; 137: 782-792.
30. Yamamoto R, Akazawa H, Ito K, Toko H, Sano M, Yasuda N, et al. Angiotensin type la receptor signals are involved in the progression of heart failure in MLP-deficient mice. Circ J 2007; 71: 1958-1964. (Pubitemid 350261424)
31. Toyota E, Kawaguchi Y, Ogasawara Y, Watanabe N, Neishi Y, Kawamoto T, et al. Novel rat model of ischemic cardiomyopathy induced by repetitive myocardial ischemia/reperfusion injury while conscious. Circ J 2007; 71: 788-795. (Pubitemid 46683374)