-
1
-
-
74949111223
-
Efficacy and safety of rituximab in patients with moderately to severely active systemic lupus erythematosus (SLE): Results from the randomized, double-blind phase II/III study EXPLORER
-
Abstract L12. This is the first randomized, double-blind trial employing B cell depletion in nonrenal lupus. Despite very encouraging preliminary data, this was a negative trial
-
Merrill J, Neuwelt C, Wallace D, et al. Efficacy and safety of rituximab in patients with moderately to severely active systemic lupus erythematosus (SLE): results from the randomized, double-blind phase II/III study EXPLORER. American College of Rheumatology National Meeting 2008; Abstract L12. This is the first randomized, double-blind trial employing B cell depletion in nonrenal lupus. Despite very encouraging preliminary data, this was a negative trial.
-
American College of Rheumatology National Meeting 2008
-
-
Merrill, J.1
Neuwelt, C.2
Wallace, D.3
-
3
-
-
65249187242
-
A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college London hospital: The first fifty patients
-
This study was a large retrospective analysis of B cell depletion as a rescue agent for patients with non-renal lupus refractory to conventional therapies. Rituximab was used in conjunction with cyclophosphamide, and this combination resulted in a decrease of BILAG score
-
Lu TY, Ng KP, Cambridge G, et al. A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college London hospital: the first fifty patients. Arthritis Rheum 2009; 61:482-487. This study was a large retrospective analysis of B cell depletion as a rescue agent for patients with non-renal lupus refractory to conventional therapies. Rituximab was used in conjunction with cyclophosphamide, and this combination resulted in a decrease of BILAG score.
-
(2009)
Arthritis Rheum
, vol.61
, pp. 482-487
-
-
Lu, T.Y.1
Ng, K.P.2
Cambridge, G.3
-
4
-
-
44349131653
-
Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus
-
Lindholm C, Borjesson-Asp K, Zendjanchi K, et al. Long-term clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus. J Rheumatol 2008; 35:826-833. A small study of refractory lupus, and autoantibody-mediated cytopenias that proved very responsive to B cell depletion therapy. (Pubitemid 351747123)
-
(2008)
Journal of Rheumatology
, vol.35
, Issue.5
, pp. 826-833
-
-
Lindholm, C.1
Borjesson-Asp, K.2
Zendjanchi, K.3
Sundqvist, A.-C.4
Tarkowski, A.5
Bokarewa, M.6
-
5
-
-
66149099305
-
Rituximab in severe lupus nephritis: Early B-cell depletion affects long-term renal outcome
-
A small case series where B cell depletion was effective for a combination of refractory, relapsing and new onset lupus nephritis
-
Melander C, Sallee M, Trolliet P, et al. Rituximab in severe lupus nephritis: early B-cell depletion affects long-term renal outcome. Clin J Am Soc Nephrol 2009; 4:579-587. A small case series where B cell depletion was effective for a combination of refractory, relapsing and new onset lupus nephritis.
-
(2009)
Clin J Am Soc Nephrol
, vol.4
, pp. 579-587
-
-
Melander, C.1
Sallee, M.2
Trolliet, P.3
-
6
-
-
67349230530
-
Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: A long-term prospective study
-
Boletis JN, Marinaki S, Skalioti C, et al. Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: a long-term prospective study. Nephrol Dial Transplant 2009; 24:2157-2160.
-
(2009)
Nephrol Dial Transplant
, vol.24
, pp. 2157-2160
-
-
Boletis, J.N.1
Marinaki, S.2
Skalioti, C.3
-
7
-
-
41749105516
-
Effect of rituximab on clinical and laboratory features of antiphospholipid syndrome: A case report and a review of literature
-
Erre GL, Pardini S, Faedda R, et al. Effect of rituximab on clinical and laboratory features of antiphospholipid syndrome: a case report and a review of literature. Lupus 2008; 17:50-55.
-
(2008)
Lupus
, vol.17
, pp. 50-55
-
-
Erre, G.L.1
Pardini, S.2
Faedda, R.3
-
8
-
-
39549123008
-
B cell depletion therapy for patients with systemic lupus erythaematosus results in a significant drop in anticardiolipin antibody titres
-
DOI 10.1136/ard.2007.078402
-
Ioannou Y, Lambrianides A, Cambridge G, et al. B cell depletion therapy for patients with systemic lupus erythematosus results in a significant drop in anticardiolipin antibody titres. Ann Rheum Dis 2008; 67:425-426. (Pubitemid 351281283)
-
(2008)
Annals of the Rheumatic Diseases
, vol.67
, Issue.3
, pp. 425-426
-
-
Ioannou, Y.1
Lambrianides, A.2
Cambridge, G.3
Leandro, M.J.4
Edwards, J.C.W.5
Isenberg, D.A.6
-
9
-
-
50849110170
-
Prevalence, serological features, response to treatment and outcome of critical peripheral ischaemia in a cohort of lupus patients
-
Oxford
-
Jeffery RC, Narshi CB, Isenberg DA. Prevalence, serological features, response to treatment and outcome of critical peripheral ischaemia in a cohort of lupus patients. Rheumatology (Oxford) 2008; 47:1379-1383.
-
(2008)
Rheumatology
, vol.47
, pp. 1379-1383
-
-
Jeffery, R.C.1
Narshi, C.B.2
Isenberg, D.A.3
-
10
-
-
58749085559
-
Severe acute thrombotic exacerbation in two cases with antiphospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory systemic lupus erythematosus
-
Oxford
-
Suzuki K, Nagasawa H, Kameda H, et al. Severe acute thrombotic exacerbation in two cases with antiphospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory systemic lupus erythematosus. Rheumatology (Oxford) 2009; 48:198-199.
-
(2009)
Rheumatology
, vol.48
, pp. 198-199
-
-
Suzuki, K.1
Nagasawa, H.2
Kameda, H.3
-
11
-
-
34147193717
-
Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system
-
DOI 10.1136/ard.2006.057885
-
Tokunaga M, Saito K, Kawabata D, et al. Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system. Ann Rheum Dis 2007; 66:470-475. (Pubitemid 46580466)
-
(2007)
Annals of the Rheumatic Diseases
, vol.66
, Issue.4
, pp. 470-475
-
-
Tokunaga, M.1
Saito, K.2
Kawabata, D.3
Imura, Y.4
Fujii, T.5
Nakayamada, S.6
Tsujimura, S.7
Nawata, M.8
Iwata, S.9
Azuma, T.10
Mimori, T.11
Tanaka, Y.12
-
12
-
-
59349104779
-
Rituximab levels in cerebrospinal fluid of patients with neurological autoimmune disorders
-
Petereit HF, Rubbert-Roth A. Rituximab levels in cerebrospinal fluid of patients with neurological autoimmune disorders. Mult Scler 2009; 15:189-192.
-
(2009)
Mult Scler
, vol.15
, pp. 189-192
-
-
Petereit, H.F.1
Rubbert-Roth, A.2
-
13
-
-
56749181048
-
Progressive multifocal leucoencephalopathy in the rheumatic diseases: Assessing the risks of biological immunosuppressive therapies
-
Calabrese LH, Molloy ES. Progressive multifocal leucoencephalopathy in the rheumatic diseases: assessing the risks of biological immunosuppressive therapies. Ann Rheum Dis 2008; 67 (Suppl 3):iii64-iii65.
-
(2008)
Ann Rheum Dis
, vol.67
, Issue.SUPPL. 3
-
-
Calabrese, L.H.1
Molloy, E.S.2
-
14
-
-
34547488545
-
Progressive multifocal leukoencephalopathy in rheumatic diseases: Evolving clinical and pathologic patterns of disease
-
DOI 10.1002/art.22657
-
Calabrese LH, Molloy ES, Huang D, et al. Progressive multifocal leukoencephalopathy in rheumatic diseases: evolving clinical and pathologic patterns of disease. Arthritis Rheum 2007; 56:2116-2128. (Pubitemid 47173558)
-
(2007)
Arthritis and Rheumatism
, vol.56
, Issue.7
, pp. 2116-2128
-
-
Calabrese, L.H.1
Molloy, E.S.2
Huang, D.3
Ransohoff, R.M.4
-
15
-
-
39149121144
-
A longitudinal analysis of SLE patients treated with rituximab (anti-CD20): Factors associated with B lymphocyte recovery
-
Sutter JA, Kwan-Morley J, Dunham J, et al. A longitudinal analysis of SLE patients treated with rituximab (anti-CD20): factors associated with B lymphocyte recovery. Clin Immunol 2008; 126:282-290.
-
(2008)
Clin Immunol
, vol.126
, pp. 282-290
-
-
Sutter, J.A.1
Kwan-Morley, J.2
Dunham, J.3
-
16
-
-
33751095383
-
B-cell-targeted therapy for systemic lupus erythematosus
-
DOI 10.2165/00003495-200666150-00004
-
Sabahi R, Anolik JH. B-cell-targeted therapy for systemic lupus erythematosus. Drugs 2006; 66:1933-1948. (Pubitemid 44771932)
-
(2006)
Drugs
, vol.66
, Issue.15
, pp. 1933-1948
-
-
Sabahi, R.1
Anolik, J.H.2
-
17
-
-
4344624041
-
B cells in human and murine systemic lupus erythematosus
-
DOI 10.1097/01.bor.0000133660.52599.f6
-
Anolik J, Sanz I. B cells in human and murine systemic lupus erythematosus. Curr Opin Rheumatol 2004; 16:505-512. (Pubitemid 39128317)
-
(2004)
Current Opinion in Rheumatology
, vol.16
, Issue.5
, pp. 505-512
-
-
Anolik, J.1
Sanz, I.2
-
18
-
-
54949129325
-
Highly sensitive B cell analysis predicts response to rituximab therapy in rheumatoid arthritis
-
Dass S, Rawstron AC, Vital EM, et al. Highly sensitive B cell analysis predicts response to rituximab therapy in rheumatoid arthritis. Arthritis Rheum 2008; 58:2993-2999.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2993-2999
-
-
Dass, S.1
Rawstron, A.C.2
Vital, E.M.3
-
19
-
-
56749153905
-
Variability in the biological response to anti- CD20 B cell depletion in systemic lupus erythaematosus
-
This study illustrates the complexity of immune response that lupus patients mount to the therapeutic monoclonal antibodies, as well as the clinical impact of the resulting HACA
-
Albert D, Dunham J, Khan S, et al. Variability in the biological response to anti- CD20 B cell depletion in systemic lupus erythaematosus. Ann Rheum Dis 2008; 67:1724-1731. This study illustrates the complexity of immune response that lupus patients mount to the therapeutic monoclonal antibodies, as well as the clinical impact of the resulting HACA.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1724-1731
-
-
Albert, D.1
Dunham, J.2
Khan, S.3
-
20
-
-
46849096714
-
B cell depletion therapy in systemic lupus erythaematosus: Relationships among serum B lymphocyte stimulator levels, autoantibody profile and clinical response
-
DOI 10.1136/ard.2007.079418
-
Cambridge G, Isenberg DA, Edwards JC, et al. B cell depletion therapy in systemic lupus erythematosus: relationships among serum B lymphocyte stimulator levels, autoantibody profile and clinical response. Ann Rheum Dis 2008; 67:1011-1016. Variability of BlyS levels during B cell depletion suggests that it could be considered as a potential biomarker and predictor of disease activity. (Pubitemid 351956665)
-
(2008)
Annals of the Rheumatic Diseases
, vol.67
, Issue.7
, pp. 1011-1016
-
-
Cambridge, G.1
Isenberg, D.A.2
Edwards, J.C.W.3
Leandro, M.J.4
Migone, T.-S.5
Teodorescu, M.6
Stohl, W.7
-
21
-
-
66449126945
-
The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
-
Cancro MP, D'Cruz DP, Khamashta MA. The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest 2009; 119:1066-1073.
-
(2009)
J Clin Invest
, vol.119
, pp. 1066-1073
-
-
Cancro, M.P.1
D'Cruz, D.P.2
Khamashta, M.A.3
-
22
-
-
34848912304
-
Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy
-
DOI 10.1002/art.22810
-
Anolik JH, Barnard J, Owen T, et al. Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy. Arthritis Rheum 2007; 56:3044-3056. (Pubitemid 47502752)
-
(2007)
Arthritis and Rheumatism
, vol.56
, Issue.9
, pp. 3044-3056
-
-
Anolik, J.H.1
Barnard, J.2
Owen, T.3
Zheng, B.4
Kemshetti, S.5
Looney, R.J.6
Sanz, I.7
-
23
-
-
44349088168
-
B cell depletion therapy for 19 patients with refractory systemic lupus erythematosus
-
DOI 10.1136/adc.2007.126276
-
Podolskaya A, Stadermann M, Pilkington C, et al. B cell depletion therapy for 19 patients with refractory systemic lupus erythematosus. Arch Dis Child 2008; 93:401-406. A retrospective analysis of B cell depletion in renal and non-renal lupus that demonstrates significant improvement in BILAG score in the pediatric population. (Pubitemid 352025791)
-
(2008)
Archives of Disease in Childhood
, vol.93
, Issue.5
, pp. 401-406
-
-
Podolskaya, A.1
Stadermann, M.2
Pilkington, C.3
Marks, S.D.4
Tullus, K.5
-
24
-
-
59449102225
-
B-cell depletion for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus
-
Kumar S, Benseler SM, Kirby-Allen M, et al. B-cell depletion for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus. Pediatrics 2009; 123:e159-e163.
-
(2009)
Pediatrics
, vol.123
-
-
Kumar, S.1
Benseler, S.M.2
Kirby-Allen, M.3
-
25
-
-
34248512232
-
Will targeting B cells be the answer for Sjogren's syndrome?
-
Looney RJ. Will targeting B cells be the answer for Sjogren's syndrome? Arthritis Rheum 2007; 56:1371-1377.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 1371-1377
-
-
Looney, R.J.1
-
26
-
-
54349116244
-
Reduction of fatigue in Sjogren syndrome with rituximab: Results of a randomised, double-blind, placebo-controlled pilot study
-
This is the first positive double blind trial of B cell depletion in Sjogren's syndrome
-
Dass S, Bowman SJ, Vital EM, et al. Reduction of fatigue in Sjogren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study. Ann Rheum Dis 2008; 67:1541-1544. This is the first positive double blind trial of B cell depletion in Sjogren's syndrome.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1541-1544
-
-
Dass, S.1
Bowman, S.J.2
Vital, E.M.3
-
27
-
-
58849136715
-
Treatment of primary Sjogren syndrome with rituximab: Extended follow-up, safety and efficacy of retreatment
-
Meijer JM, Pijpe J, Vissink A, et al. Treatment of primary Sjogren syndrome with rituximab: extended follow-up, safety and efficacy of retreatment. Ann Rheum Dis 2009; 68:284-285.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 284-285
-
-
Meijer, J.M.1
Pijpe, J.2
Vissink, A.3
-
28
-
-
33749531577
-
Update on the treatment of lupus nephritis
-
Waldman M, Appel GB. Update on the treatment of lupus nephritis. Kidney Int 2006; 70:1403-1412.
-
(2006)
Kidney Int
, vol.70
, pp. 1403-1412
-
-
Waldman, M.1
Appel, G.B.2
-
29
-
-
0742270763
-
Treatment of proliferative lupus nephritis
-
Balow JE, Austin HA 3rd. Treatment of proliferative lupus nephritis. Am J Kidney Dis 2004; 43:383-385.
-
(2004)
Am J Kidney Dis
, vol.43
, pp. 383-385
-
-
Balow, J.E.1
Austin III, H.A.2
-
30
-
-
61549083672
-
New therapies in systemic lupus erythematosus - Trials, troubles and tribulations.... working towards a solution
-
Isenberg D, Gordon C, Merrill J, et al. New therapies in systemic lupus erythematosus - trials, troubles and tribulations.. . . working towards a solution. Lupus 2008; 17:967-970.
-
(2008)
Lupus
, vol.17
, pp. 967-970
-
-
Isenberg, D.1
Gordon, C.2
Merrill, J.3
-
31
-
-
33746864126
-
Clinical trial design in systemic lupus erythematosus
-
DOI 10.1097/01.bor.0000240357.22680.63, PII 0000228120060900000007
-
Dall'Era M, Wofsy D. Clinical trial design in systemic lupus erythematosus. Curr Opin Rheumatol 2006; 18:476-480. (Pubitemid 44200330)
-
(2006)
Current Opinion in Rheumatology
, vol.18
, Issue.5
, pp. 476-480
-
-
Dall'Era, M.1
Wofsy, D.2
-
32
-
-
65349115354
-
New therapies in systemic lupus erythematosus - Trials, troubles and tribulations - working towards a solution: Part 2: The politically incorrect version
-
Wallace DJ. New therapies in systemic lupus erythematosus - trials, troubles and tribulations - working towards a solution: part 2: the politically incorrect version. Lupus 2009; 18:101-103.
-
(2009)
Lupus
, vol.18
, pp. 101-103
-
-
Wallace, D.J.1
-
33
-
-
65249108137
-
EULAR points to consider for conducting clinical trials in systemic lupus erythematosus: Literature based evidence for the selection of endpoints
-
Bertsias GK, Ioannidis JP, Boletis J, et al. EULAR points to consider for conducting clinical trials in systemic lupus erythematosus: literature based evidence for the selection of endpoints. Ann Rheum Dis 2009; 68:477-483.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 477-483
-
-
Bertsias, G.K.1
Ioannidis, J.P.2
Boletis, J.3
-
34
-
-
67349258944
-
Why can't we find a new treatment for SLE?
-
Eisenberg R. Why can't we find a new treatment for SLE? J Autoimmun 2009; 32:223-230.
-
(2009)
J Autoimmun
, vol.32
, pp. 223-230
-
-
Eisenberg, R.1
-
35
-
-
34250631349
-
A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus
-
DOI 10.1007/s10165-007-0565-z
-
Tanaka Y, Yamamoto K, Takeuchi T, et al. A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus. Mod Rheumatol 2007; 17:191-197. (Pubitemid 46929903)
-
(2007)
Modern Rheumatology
, vol.17
, Issue.3
, pp. 191-197
-
-
Tanaka, Y.1
Yamamoto, K.2
Takeuchi, T.3
Nishimoto, N.4
Miyasaka, N.5
Sumida, T.6
Shima, Y.7
Takada, K.8
Matsumoto, I.9
Saito, K.10
Koike, T.11
-
36
-
-
60949101357
-
Use of rituximab in patients with systemic lupus erythematosus: An update
-
Garcia-Carrasco M, Jimenez-Hernandez M, Escarcega RO, et al. Use of rituximab in patients with systemic lupus erythematosus: an update. Autoimmun Rev 2009; 8:343-348.
-
(2009)
Autoimmun Rev
, vol.8
, pp. 343-348
-
-
Garcia-Carrasco, M.1
Jimenez-Hernandez, M.2
Escarcega, R.O.3
-
37
-
-
53149133917
-
Prolonged B-cell depletion following rituximab therapy in systemic lupus erythematosus: A report of two cases
-
Lu TY, Jonsdottir T, van Vollenhoven RF, et al. Prolonged B-cell depletion following rituximab therapy in systemic lupus erythematosus: a report of two cases. Ann Rheum Dis 2008; 67:1493-1494.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1493-1494
-
-
Lu, T.Y.1
Jonsdottir, T.2
Van Vollenhoven, R.F.3
-
38
-
-
33746961890
-
Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
-
DOI 10.1002/art.22025
-
Cohen SB, Emery P, Greenwald MW, et al. Rituximab for rheumatoid arthritis refractory to antitumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006; 54:2793-2806. (Pubitemid 44497758)
-
(2006)
Arthritis and Rheumatism
, vol.54
, Issue.9
, pp. 2793-2806
-
-
Cohen, S.B.1
Emery, P.2
Greenwald, M.W.3
Dougados, M.4
Furie, R.A.5
Genovese, M.C.6
Keystone, E.C.7
Loveless, J.E.8
Burmester, G.-R.9
Cravets, M.W.10
Hessey, E.W.11
Shaw, T.12
Totoritis, M.C.13
-
39
-
-
27544508559
-
Tolerability and safety of rituximab (MabThera)
-
Kimby E. Tolerability and safety of rituximab (MabThera). Cancer Treat Rev 2005; 31:456-473.
-
(2005)
Cancer Treat Rev
, vol.31
, pp. 456-473
-
-
Kimby, E.1
|