Hypertension genes and retinal vascular calibre: The Cardiovascular Health Study

Journal of Human Hypertension

Volumn 23, Issue 9, 2009, Pages 578-584

  Sun, C ^a   Wang, J J ^a,b   Islam, F M ^a   Heckbert, S R ^c   Klein, R ^d   Siscovick, D S ^c   Klein, B E K ^d   Wong, T Y ^a,e  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADDUCIN; BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT 3; UNCLASSIFIED DRUG;

AFRICAN AMERICAN; AGE DISTRIBUTION; AGED; ALLELE; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; CAUCASIAN; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; RACE DIFFERENCE; RETINA ARTERIOLE; RETINA BLOOD VESSEL; RETINA VEIN; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; ARTERIOLES; CALMODULIN-BINDING PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; HYPERTENSION; LONGITUDINAL STUDIES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-2; RETINAL VESSELS;

EID: 69549122655     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2008.168     Document Type: Article

References (40)

1. Tanira MO, Al Balushi KA. Genetic variations related to hypertension: A review. J Hum Hypertens 2005; 19: 7-19.
2. Harrap SB. Where are all the blood-pressure genes? Lancet 2003; 361: 2149-2151.
3. Tabor HK, Risch NJ, Myers RM. Candidate-gene approaches for studying complex genetic traits: Practical considerations. Nat Rev Genet 2002; 3: 391-397.
4. Agarwal A, Williams GH, Fisher ND. Genetics of human hypertension. Trends Endocrinol Metab 2005; 16: 127-133.
5. Wong TY, Mitchell P. The eye in hypertension. Lancet 2007; 369 425-435.
6. Wong TY, Hubbard LD, Klein R, Marino EK, Kronmal R, Sharrett AR et al. Retinal microvascular abnormalities and blood pressure in older people: The Cardiovascular Health Study. Br J Ophthalmol 2002; 86: 1007-1013.
7. Wong TY, Kamineni A, Klein R, Sharrett AR, Klein BE, Siscovick DS et al. Quantitative retinal venular caliber and risk of cardiovascular disease in older persons: The cardiovascular health study. Arch Intern Med 2006; 166: 2388-2394.
8. Taarnhoj NC, Larsen M, Sander B, Kyvik KO, Kessel L, Hougaard JL et al. Heritability of retinal vessel diameters and blood pressure: A twin study. Invest Ophthalmol Vis Sci 2006; 47: 3539-3544.
9. Wong TY, Klein R, Sharrett AR, Duncan BB, Couper DJ, Klein BE et al. Retinal arteriolar diameter and risk for hypertension. Ann Intern Med 2004; 140: 248-255.
10. Manunta P, Barlassina C, Bianchi G. Adducin in essential hypertension. FEBS Lett 1998; 430: 41-44.
11. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998; 18: 45-48.
12. Tang WH, Devereux RB, Kitzman DW, Province MA, Leppert M, Oberman A et al. The Arg16Gly polymorphism of the beta 2-adrenergic receptor and left ventricular systolic function. Am J Hypertens 2003; 16 945-951.
13. Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997; 349: 1353-1357.
14. Heckbert SR, Hindorff LA, Edwards KL, Psaty BM, Lumley T, Siscovick DS et al. Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly. Circulation 2003; 107: 2021-2024.
15. Kato N, Sugiyama T, Nabika T, Morita H, Kurihara H, Yazaki Y et al. Lack of association between the alpha-adducin locus and essential hypertension in the Japanese population. Hypertension 1998; 31 730-733.
16. Fried LP, Borhani NO, Enright P, Furberg CD, Gardin JM, Kronmal RA et al. The Cardiovascular Health Study: Design and rationale. Ann Epidemiol 1991; 1: 263-276.
17. Tell GS, Fried LP, Hermanson B, Manolio TA, Newman AB, Borhani NO. Recruitment of adults 65 years and older as participants in the Cardiovascular Health Study. Ann Epidemiol 1993; 3: 358-366.
18. Wong TY, Klein R, Sharrett AR, Manolio TA, Hubbard LD, Marino EK et al. The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study. Ophthalmology 2003; 110: 658-666.
19. Hubbard LD, Brothers RJ, King WN, Clegg LX, Klein R, Cooper LS et al. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 1999; 106: 2269-2280.
20. Ranade K, Chang MS, Ting CT, Pei D, Hsiao CF, Olivier M et al. High-throughput genotyping with single nucleotide polymorphisms. Genome Res 2001; 11: 1262-1268.
21. Tell GS, Rutan GH, Kronmal RA, Bild DE, Polak JF, Wong ND et al. Correlates of blood pressure in community-dwelling older adults. The Cardiovascular Health Study. Cardiovascular Health Study (CHS) Collaborative Research Group. Hypertension 1994; 23: 59-67.
22. American Diabetes Association: Clinical practice recommendations 1997. Diabetes Care 1997; 20(Suppl 1): S1-S70.
23. Robbins J, Wahl P, Savage P, Enright P, Powe N, Lyles M. Hematological and biochemical laboratory values in older Cardiovascular Health Study participants. J Am Geriatr Soc 1995; 43: 855-859.
24. Gauderman W, Morrison J. QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies. http://hydra.usc.edu/gxe, 2006.
25. Carter KW, McCaskie PA, Palmer LJ. JLIN: A java based linkage disequilibrium plotter. BMC Bioinformatics 2006; 7: 60.
26. Shioji K, Kokubo Y, Mannami T, Inamoto N, Morisaki H, Mino Y et al. Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study. Hypertens Res 2004; 27: 31-37.
27. Bagos PG, Elefsinioti AL, Nikolopoulos GK, Hamodrakas SJ. The GNB3 C825T polymorphism and essential hypertension: A meta-analysis of 34 studies including 14 094 cases and 17 760 controls. J Hypertens 2007; 25: 487-500.
28. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003; 25: 115-121.
29. Glorioso N, Filigheddu F, Cusi D, Troffa C, Conti M, Natalizio M et al. alpha-Adducin 460Trp allele is associated with erythrocyte Na transport rate in North Sardinian primary hypertensives. Hypertension 2002; 39: 357-362.
30. Beeks E, van der Klauw MM, Kroon AA, Spiering W, Fuss-Lejeune MJ, de Leeuw PW. Alpha-adducin Gly460Trp polymorphism and renal hemodynamics in essential hypertension. Hypertension 2004; 44: 419-423.
31. Guimaraes S, Moura D. Vascular adrenoceptors: An update. Pharmacol Rev 2001; 53: 319-356.
32. Hein TW, Zhang C, Wang W, Kuo L. Heterogeneous beta2-adrenoceptor expression and dilation in coronary arterioles across the left ventricular wall. Circulation 2004; 110: 2708-2712.
33. Morrison AC, Doris PA, Folsom AR, Nieto FJ, Boerwinkle E. G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical stroke. Stroke 2001; 32: 822-829.
34. Siffert W. G protein beta 3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy. Nephrol Dial Transplant 2000; 15: 1298-1306.
35. van Rijn MJE, Bos MJ, Yazdanpanah M, Isaacs A, Arias-Vasquez A, Koudstaal PJ et al. alpha-Adducin polymorphism, atherosclerosis, and cardiovascular and cerebrovascular risk. Stroke 2006; 37 2930-2934.
36. Perticone F, Sciacqua A, Barlassina C, Del Vecchio L, Signorello MC, Dal Fiume C et al. Gly460Trp alpha-adducin gene polymorphism and endothelial function in untreated hypertensive patients. J Hypertens 2007; 25: 2234-2239.
37. Hindorff LA, Heckbert SR, Psaty BM, Lumley T, Siscovick DS, Herrington DM et al. beta(2)-Adrenergic receptor polymorphisms and determinants of cardiovascular risk: The Cardiovascular Health Study. Am J Hypertens 2005; 18: 392-397.
38. Mitchell A, Rushentsova U, Siffert W, Philipp T, Wenzel RR. The angiotensin II receptor antagonist valsartan inhibits endothelin 1-induced vasoconstriction in the skin microcirculation in humans in vivo: Influence of the G-protein beta3 subunit (GNB3) C825T polymorphism. Clin Pharmacol Ther 2006; 79: 274-281.
39. Wong TY, Klein R, Nieto FJ, Klein BE, Sharrett AR, Meuer SM et al. Retinal microvascular abnormalities and 10-year cardiovascular mortality: A population-based case-control study. Ophthalmology 2003; 110: 933-940.
40. van Rijn MJE, Schut AFC, Aulchenko YS, Deinum J, Sayed-Tabatabaei FA, Yazdanpanah M et al. Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes. J Hypertens 2007; 25: 565-570.