Requirement for the N-Terminal Coiled-Coil Domain for Expression and Function, but not Subunit Interaction of, the ADPR-Activated TRPM2 Channel

Journal of Membrane Biology

Volumn 230, Issue 2, 2009, Pages 93-99

  Mei, Zhu Zhong ^a   Jiang, Lin Hua ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

ADPR evoked current; Coiled coil; Expression; Subunit interaction; TRPM2

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; GLUTAMINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRANSIENT RECEPTOR POTENTIAL MELASTATIN 2 PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION;

ADENOSINE DIPHOSPHATE RIBOSE; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; ION CHANNEL GATING; KIDNEY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 69549095712     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-009-9190-4     Document Type: Article

References (29)

1. DE Clapham 2003 TRP channels as cellular sensors Nature 426 517 524
2. I Erler DM Al-Ansary U Wissenbach TF Wagner V Flockerzi BA Niemeyer 2006 Trafficking and assembly of the cold-sensitive TRPM8 channel J Biol Chem 281 38396 38404
3. A Fleig R Penner 2004 The TRPM ion channel subfamily: molecular, biophysical and functional features Trends Pharmacol Sci 25 633 639
4. E Fonfria IC Marshall I Boyfield SD Skaper JP Hughes DE Owen W Zhang BA Miller CD Benham S [tmp] McNulty 2005 Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures J Neurochem 95 715 723
5. Y Hara M Wakamori M Ishii E Maeno M Nishida T Yoshida H Yamada S Shimizu E Mori J Kudoh N Shimizu H Kurose Y Okada K Imoto Y Mori 2002 LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death Mol Cell 9 163 173
6. 2-induced Ca2+ entry and endothelial hyperpermeability Circ Res 102 347 355
7. K Hill NJ Tigue RE Kelsell CD Benham S [tmp] McNulty M Schaefer AD Randall 2006 Flufenamic acid is a pH-dependent antagonist of TRPM2 channels Neuropharmacology 50 89 97
8. L-H Jiang 2007 Subunit interaction in channel assembly and functional regulation of transient receptor potential melastatin (TRPM) channels Biochem Soc Trans 35 86 88
9. R Kraft C Grimm H Frenzel C Harteneck 2006 Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid Br J Pharmacol 148 264 273
10. P Launay A Fleig AL Perraud AM Scharenberg R Penner JP Kinet 2004 TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization Cell 109 397 407
11. PK Lepage G Boulay 2007 Molecular determinants of TRP channel assembly Biochem Soc Trans 35 81 83
12. A Lupas 1996 Coiled coils: new structures and new functions Trends Biochem Sci 21 375 382
13. ZZ Mei HJ Mao L-H Jiang 2006 Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function Am J Physiol Cell Physiol 291 C1022 C1028
14. ZZ Mei R Xia DJ Beech L-H Jiang 2006 Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2 J Biol Chem 281 38748 38756
15. M Naziroǧlu A Lückhoff 2008 Effects of antioxidants on calcium influx through TRPM2 channels in transfected cells activated by hydrogen peroxide J Neurol Sci 270 152 158
16. M Naziroǧlu A Lückhoff 2008 A calcium influx pathway regulated separately by oxidative stress and ADP-ribose in TRPM2 channels:single channel events Neurochem Res 33 1256 1262
17. B Nilius G Owsianik T Voets JA Peters 2007 Transient receptor potential cation channels in disease Physiol Rev 87 165 217
18. AL Perraud A Fleig CA Dunn LA Bagley P Launay C Schmitz AJ Stokes Q Zhu MJ Bessman R Penner JP Kinet AM Scharenberg 2001 ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology Nature 411 595 599
19. IS Ramsey M Delling DE Clapham 2006 An introduction to TRP channels Annu Rev Physiol 68 619 647
20. Y Sano K Inamura A Miyake S Mochizuki H Yokoi H Matsushime K Furuichi 2001 Immunocyte Ca2+ influx system mediated by LTRPC2 Science 293 1327 1390
21. R Schindl C Romanin 2007 Assembly domains in TRP channels Biochem Soc Trans 35 84 85
22. K Togashi Y Hara T Tominaga T Higashi Y Konishi Y Mori M Tominaga 2006 TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion EMBO J 25 1804 1815
23. PR Tsuruda D Julius DL Minor 2006 Coiled coils direct assembly of a cold-activated TRP channel Neuron 51 201 212
24. K Venkatachalam C Montell 2007 TRP channels Annu Rev Biochem 76 387 417
25. E Wehage J Eisfeld I Heiner E Jüngling C Zitt A Lückhoff 2002 Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose J Biol Chem 277 23150 23156
26. R Xia ZZ Mei HJ Mao W Yang L Dong H Bradley DJ Beech LH Jiang 2008 Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2 J Biol Chem 283 27426 27432
27. S Yamamoto S Shimizu S Kiyonaka N Takahashi T Wajima Y Hara T Negoro T Hiroi Y Kiuchi T Okada S Kaneko I Lange A Fleig R Penner M Nishi H Takeshima Y Mori 2008 TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration Nat Med 14 738 747
28. W Zhang X Chu Q Tong JY Cheung K Conrad K Masker BA Miller 2003 A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death J Biol Chem 278 16222 16229
29. W Zhang I Hirschler-Laszkiewicz Q Tong K Conrad SC Sun L Penn DL Barber R Stahl DJ Carey JY Cheung BA Miller 2006 TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage Am J Physiol Cell Physiol 290 C1146 C1159