-
1
-
-
0032576752
-
Axonal transection in the lesions of multiple sclerosis
-
DOI 10.1056/NEJM199801293380502
-
Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mörk S, et al: Axonal transaction in the lesions of multiple sclerosis. N Engl J Med 338: 278-285, 1998 (Pubitemid 28065253)
-
(1998)
New England Journal of Medicine
, vol.338
, Issue.5
, pp. 278-285
-
-
Trapp, B.D.1
Peterson, J.2
Ransohoff, R.M.3
Rudick, R.4
Mork, S.5
Bo, L.6
-
2
-
-
17644396349
-
Immunology of multiple sclerosis
-
Sospedra M, Martin R: Immunology of multiple sclerosis. Ann Rev Immunol 23: 683-747, 2005
-
(2005)
Ann Rev Immunol
, vol.23
, pp. 683-747
-
-
Sospedra, M.1
Martin, R.2
-
3
-
-
69549137205
-
Back to the future for multiple sclerosis therapy. Focus on current and emerging disease-modifying strategies
-
Croxford JL, Yamamura T: Back to the future for multiple sclerosis therapy. Focus on current and emerging disease-modifying strategies. Immunotherapy 1: 403-423, 2009
-
(2009)
Immunotherapy
, vol.1
, pp. 403-423
-
-
Croxford, J.L.1
Yamamura, T.2
-
4
-
-
0035957307
-
Mechanisms of action of glatiramer acetate in multiple sclerosis
-
Neuhaus O, Farina C, Wekerle H, Hohlfeld R: Mechanisms of action of glatiramer acetate in multiple sclerosis. Neurology 56: 702-708, 2001 (Pubitemid 32240087)
-
(2001)
Neurology
, vol.56
, Issue.6
, pp. 702-708
-
-
Neuhaus, O.1
Farina, C.2
Wekerle, H.3
Hohlfeld, R.4
-
5
-
-
33646347357
-
Natalizumab effects on immune cell responses in multiple sclerosis
-
DOI 10.1002/ana.20859
-
Niino M, Bodner C, Simard ML, Alatab S, Gano D, et al: Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol 59: 748-754, 2006 (Pubitemid 43673152)
-
(2006)
Annals of Neurology
, vol.59
, Issue.5
, pp. 748-754
-
-
Niino, M.1
Bodner, C.2
Simard, M.-L.3
Alatab, S.4
Gano, D.5
Kim, H.J.6
Trigueiro, M.7
Racicot, D.8
Guerette, C.9
Antel, J.P.10
Fournier, A.11
Grand'Maison, F.12
Bar-Or, A.13
-
6
-
-
54049087015
-
Assessment: The use of natalizumab (Tysabri) for the treatment of multiple sclerosis (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
-
Goodin DS, Cohen BA, O'Connor P, Kappos L, Stevens JC: Assessment: the use of natalizumab (Tysabri) for the treatment of multiple sclerosis (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 71: 766-773, 2008
-
(2008)
Neurology
, vol.71
, pp. 766-773
-
-
Goodin, D.S.1
Cohen, B.A.2
O'Connor, P.3
Kappos, L.4
Stevens, J.C.5
-
7
-
-
57349172905
-
Recombinant T-cell receptor ligands: Immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis
-
Offner H, Sinha S, Wang C, Burrows GG, Vandenbark AA: Recombinant T-cell receptor ligands: Immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis. Rev Neurosci 19: 327-339, 2008
-
(2008)
Rev Neurosci
, vol.19
, pp. 327-339
-
-
Offner, H.1
Sinha, S.2
Wang, C.3
Burrows, G.G.4
Vandenbark, A.A.5
-
8
-
-
54049093695
-
CTLA4Ig treatment in patients with multiple sclerosis. An open-label, phase 1 clinical trial
-
Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, et al: CTLA4Ig treatment in patients with multiple sclerosis. An open-label, phase 1 clinical trial. Neurology 71: 917-924, 2008
-
(2008)
Neurology
, vol.71
, pp. 917-924
-
-
Viglietta, V.1
Bourcier, K.2
Buckle, G.J.3
Healy, B.4
Weiner, H.L.5
-
9
-
-
65249138318
-
Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis
-
Bielekova B, Howard T, Packer AN, Richert N, Blevins G, et al: Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis. Arch Neurol 66: 483-489, 2009
-
(2009)
Arch Neurol
, vol.66
, pp. 483-489
-
-
Bielekova, B.1
Howard, T.2
Packer, A.N.3
Richert, N.4
Blevins, G.5
-
10
-
-
77955799815
-
Oral fingolimod (FTY720) for relapsing multiple sclerosis
-
DOI 10.1056/NEJMoa052643
-
Kappos L, Antel J, Comi G, Montalban X, O'Connor P, et al: Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 355: 1124-1140, 2006 (Pubitemid 44394919)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.11
, pp. 1124-1140
-
-
Kappos, L.1
Antel, J.2
Comi, G.3
Montalban, X.4
O'Connor, P.5
Polman, C.H.6
Haas, T.7
Korn, A.A.8
Karlsson, G.9
Radue, E.W.10
-
11
-
-
54949143968
-
Alemtuzumab vs. interferon β-1a in early multiple sclerosis
-
CAMMS223 Trial Investigators
-
CAMMS223 Trial Investigators, Coles AJ, Compston DA, Selmaj KW, Lake SL, et al: Alemtuzumab vs. interferon β-1a in early multiple sclerosis. N Engl J Med 359: 1786 - 1801, 2008
-
(2008)
N Engl J Med
, vol.359
, pp. 1786-1801
-
-
Coles, A.J.1
Compston, D.A.2
Selmaj, K.W.3
Lake, S.L.4
-
12
-
-
48849087125
-
Repeated subcutaneous injections of IL12/IL23 p40 neutralizing antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: A phase II, double-blind, placebo-controlled, randomized, dose-ranging study
-
Segal BM, Constantinescu CS, Raychaudhuri A, Kim L, Fidelus-Gort R, et al: Repeated subcutaneous injections of IL12/IL23 p40 neutralizing antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomized, dose-ranging study. Lancet Neurol 7: 796-804, 2008
-
(2008)
Lancet Neurol
, vol.7
, pp. 796-804
-
-
Segal, B.M.1
Constantinescu, C.S.2
Raychaudhuri, A.3
Kim, L.4
Fidelus-Gort, R.5
-
13
-
-
39049142995
-
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
-
DOI 10.1056/NEJMoa0706383
-
Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, et al: B-cell depletion with rituximab in relapsing-reitting multiple sclerosis. N Engl J Med 358: 676-688, 2008 (Pubitemid 351240747)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.7
, pp. 676-688
-
-
Hauser, S.L.1
Waubant, E.2
Arnold, D.L.3
Vollmer, T.4
Antel, J.5
Fox, R.J.6
Bar-Or, A.7
Panzara, M.8
Sarkar, N.9
Agarwal, S.10
Langer-Gould, A.11
Smith, C.H.12
-
14
-
-
39049142995
-
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
-
DOI 10.1056/NEJMoa0706383
-
Bar-Or A, Calabresi PA, Arnold D, Markowitz C, Shafer S, et al: Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial. Ann Neurol 63: 395-400, 2008 (Pubitemid 351240747)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.7
, pp. 676-688
-
-
Hauser, S.L.1
Waubant, E.2
Arnold, D.L.3
Vollmer, T.4
Antel, J.5
Fox, R.J.6
Bar-Or, A.7
Panzara, M.8
Sarkar, N.9
Agarwal, S.10
Langer-Gould, A.11
Smith, C.H.12
-
15
-
-
34948888764
-
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
-
DOI 10.1038/nm1664, PII NM1664
-
Mi S, Hu B, Hahm K, Luo Y, Kam Hui ES, et al: LINGO-1 antagonis promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat Med 13: 1228-1233, 2007 (Pubitemid 47530642)
-
(2007)
Nature Medicine
, vol.13
, Issue.10
, pp. 1228-1233
-
-
Mi, S.1
Hu, B.2
Hahm, K.3
Luo, Y.4
Kam Hui, E.S.5
Yuan, Q.6
Wong, W.M.7
Wang, L.8
Su, H.9
Chu, T.-H.10
Guo, J.11
Zhang, W.12
So, K.-F.13
Pepinsky, B.14
Shao, Z.15
Graff, C.16
Garber, E.17
Jung, V.18
Wu, E.X.19
Wu, W.20
more..
-
16
-
-
44849103664
-
Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis
-
Garren H, Robinson WH, Krasulová E, Havrdová E, Nadj C, et 1: Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis. Ann Neurol 63: 611-620, 2008
-
(2008)
Ann Neurol
, vol.63
, pp. 611-620
-
-
Garren, H.1
Robinson, W.H.2
Krasulová, E.3
Havrdová, E.4
Nadj, C.5
-
17
-
-
0026644298
-
Anti-tumor necrosis factorameliorates joint disease in murine collagen-induced arthritis
-
Williams RO, Feldmann M, Maini RN: Anti-tumor necrosis factorameliorates joint disease in murine collagen-induced arthritis. PNAS 89: 9784-9788, 1992
-
(1992)
PNAS
, vol.89
, pp. 9784-9788
-
-
Williams, R.O.1
Feldmann, M.2
Maini, R.N.3
-
18
-
-
0026506799
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against α;4β2 integrin
-
Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, et al: Prevention of experimental autoimmune encephalomyelitis by antibodies against α;4β2 integrin. Nature 356: 63-66, 1992
-
(1992)
Nature
, vol.356
, pp. 63-66
-
-
Yednock, T.A.1
Cannon, C.2
Fritz, L.C.3
Sanchez-Madrid, F.4
Steinman, L.5
-
19
-
-
0033786776
-
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
-
DOI 10.1038/80516
-
Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, et al: Encephalitogenic potential of the myelin basic protein peptide (aino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with and altered peptide ligand. Nat Med 6: 1167-1175, 2000 (Pubitemid 30792198)
-
(2000)
Nature Medicine
, vol.6
, Issue.10
, pp. 1167-1175
-
-
Bielekova, B.1
Goodwin, B.2
Richert, N.3
Cortese, I.4
Kondo, T.5
Afshar, G.6
Gran, B.7
Eaton, J.8
Antel, J.9
Frank, J.A.10
McFarland, H.F.11
Martin, R.12
-
20
-
-
33745291091
-
Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: A randomized trial
-
Kremer JM, Genant HK, Moreland LW, Russell A, Emery P, et al: Effects of Abatacet in patients with methotrexate-esistant active rheumatoid arthritis. A randomized trial. Ann Int Med 144: 865-876, 2006 (Pubitemid 46768126)
-
(2006)
Annals of Internal Medicine
, vol.144
, Issue.12
, pp. 865-876
-
-
Kremer, J.M.1
Genant, H.K.2
Moreland, L.W.3
Russell, A.S.4
Emery, P.5
Abud-Mendoza, C.6
Szechinski, J.7
Li, T.8
Ge, Z.9
Becker, J.-C.10
Westhovens, R.11
-
22
-
-
53349177070
-
Blocking α4-integrins - A small molecule approach to treatment of multiple sclerosis
-
Davenport R, Munday J: Blocking α4-integrins - A small molecule approach to treatment of multiple sclerosis. J Neurol Sci 274: 27-30, 2008
-
(2008)
J Neurol Sci
, vol.274
, pp. 27-30
-
-
Davenport, R.1
Munday, J.2
-
23
-
-
61549130275
-
Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function
-
Khatri BO, Man S, Giovannoni G, Koo AP, Lee JC, et al: Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function. Neurology 72: 402-409, 2009
-
(2009)
Neurology
, vol.72
, pp. 402-409
-
-
Khatri, B.O.1
Man, S.2
Giovannoni, G.3
Koo, A.P.4
Lee, J.C.5
-
24
-
-
33645812129
-
Regulatory CD56 bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis
-
Bielekova B, Catalfamo M, Reichert-Scrivner S, Packer A, Cerna M, et al: Regulatory CD56 bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis. PNAS 103: 5941-5946, 2006
-
(2006)
PNAS
, vol.103
, pp. 5941-5946
-
-
Bielekova, B.1
Catalfamo, M.2
Reichert-Scrivner, S.3
Packer, A.4
Cerna, M.5
-
25
-
-
40649122843
-
FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosohate receptor agonists as immunomodulators based on reverse pharmacology
-
Adachi K, Chiba K: FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosohate receptor agonists as immunomodulators based on reverse pharmacology. Perspectives Med Chem 1: 11-23, 2007
-
(2007)
Perspectives Med Chem
, vol.1
, pp. 11-23
-
-
Adachi, K.1
Chiba, K.2
-
26
-
-
63849147004
-
Oral fingolimod (FTY720) in multiple sclerosis: Two-year results of a phase II extension study
-
O'Connor P, Comi G, Montalban X, Antel J, Radue EW, et al: Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. Neurology 72: 73-79, 2009
-
(2009)
Neurology
, vol.72
, pp. 73-79
-
-
O'Connor, P.1
Comi, G.2
Montalban, X.3
Antel, J.4
Radue, E.W.5
-
27
-
-
54449099880
-
FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis
-
Mehling M, Brinkmann V, Antel J, Bar-Or A, Goebels N, et al: FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology. 71: 1261-1267, 2008
-
(2008)
Neurology.
, vol.71
, pp. 1261-1267
-
-
Mehling, M.1
Brinkmann, V.2
Antel, J.3
Bar-Or, A.4
Goebels, N.5
-
28
-
-
67650032747
-
Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells
-
Kivisäkk P, Healy BC, Viglietta V, Quintana FJ, Hootstein MA, et al: Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology 72: 1922-1930, 2009
-
(2009)
Neurology
, vol.72
, pp. 1922-1930
-
-
Kivisäkk, P.1
Healy, B.C.2
Viglietta, V.3
Quintana, F.J.4
Hootstein, M.A.5
|