Extracorporeal photophoresis augments function of CD4+CD25 +FoxP3+ regulatory T cells by triggering adenosine production

Transplantation

Volumn 88, Issue 3, 2009, Pages 411-416

  Schmitt, Sabrina ^a   Johnson, Theron S ^a   Karakhanova, Svetlana ^a   Näher, Helmut ^a   Mahnke, Karsten ^a,b   Enk, Alexander H ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adenosine; Extracorporeal photophoresis; Regulatory T cells

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

ARTICLE; ASSAY; BLOOD SAMPLING; CD4+ CD25+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROPHORESIS; EXTRACORPOREAL PHOTOPHORESIS; FEMALE; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LEUKOCYTE; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ADENOSINE; ANTIGENS, CD; ANTIGENS, CD14; APYRASE; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRAFT VS HOST DISEASE; HUMANS; IMMUNOPHENOTYPING; IMMUNOSUPPRESSION; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MALE; PHOTOPHERESIS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TIME FACTORS;

EID: 69449103953     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181aed927     Document Type: Article

References (21)

1. Aubin F, Mousson C. Ultraviolet light-induced regulatory (suppressor) T cells: An approach for promoting induction of operational allograft tolerance? Transplantation 2004; 77: S29. (Pubitemid 38114416)
2. Marshall SR. Technology insight: ECP for the treatment of GvHD - Can we offer selective immune control without generalized immunosuppression? Nat Clin Pract Oncol 2006; 3: 302.
3. Maeda A, Schwarz A, Kernebeck K, et al. Intravenous infusion of syngeneic apoptotic cells by photophoresis induces antigen-specific regulatory T cells. J Immunol 2005; 174: 5968. (Pubitemid 40663783)
4. Mermet I, Kleinclauss F, Marandin A, et al. Preventive effect of ultraviolet radiation on murine chronic sclerodermatous graft-versus-host disease. Transplantation 2007; 84: 1696.
5. + functional regulatory T-cells in patients with graft-versus- host disease. Transplantation 2007; 8: 31.
6. Bladon J, Taylor P. Extracorporeal photopheresis normalizes some lymphocyte subsets (including T regulatory cells) in chronic graft-versus- host-disease. Ther Apher Dial 2008; 12: 311.
7. Gatza E, Rogers CE, Clouthier SG, et al. Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells. Blood 2008; 112: 1515.
8. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol 2008; 8: 523.
9. Allan SE, Crome SQ, Crellin NK, et al. Activation induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 2007; 19: 345.
10. Deaglio S, Dwyer KM, Gao W, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204: 1257. (Pubitemid 46919862)
11. + Treg cells: Hydrolysis of extracellular ATP and immune suppression. Blood 2007; 110: 1225.
12. Lanzetta PA, Alvarez LJ, Reinach PS, et al. An improved assay for nanomole amounts of inorganic phosphate. Anal Biochem 1979; 100: 95.
13. Di RM, Sbano P, De AG, et al. Extracorporeal photopheresis affects co-stimulatory molecule expression and interleukin-10 production by dendritic cells in graft-versus-host disease patients. Clin Exp Immunol 2008; 151: 407.
14. Jonson CO, Pihl M, Nyholm C, et al. Regulatory T cell-associated activity in photopheresis-induced immune tolerance in recent onset type 1 diabetes children. Clin Exp Immunol 2008; 153: 174. (Pubitemid 351989154)
15. Lamioni A, Carsetti R, Legato A, et al. Induction of regulatory T cells after prophylactic treatment with photopheresis in renal transplant recipients. Transplantation 2007; 83: 1393. (Pubitemid 46800319)
16. Spisek R, Gasova Z, Bartunkova J. Maturation state of dendritic cells during the extracorporeal photophoresis and its relevance for the treatment of chronic graft-versus-host disease. Transfusion 2006; 46: 55. (Pubitemid 43381785)
17. Hasko G, Cronstein BN. Adenosine: An endogenous regulator of innate immunity. Trends Immunol 2004; 25: 33. (Pubitemid 38032805)
18. Eltzschig HK, Faigle M, Knapp S, et al. Endothelial catabolism of extracellular adenosine during hypoxia: The role of surface adenosine deaminase and CD26. Blood 2006; 108: 1602. (Pubitemid 44316128)
19. Bours MJ, Swennen EL, Di VF, et al. Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther 2006; 112: 358.
20. Holtick U, Marshall SR, Wang XN, et al. Impact of psoralen/UVA-treatment on survival, activation, and immunostimulatory capacity of monocyte-derived dendritic cells. Transplantation 2008; 85: 757.
21. + immunoregulatory T cells is antigen nonspecific. J Immunol 2000; 164: 183.