-
1
-
-
0024268789
-
Human prorenin: Pathophysiology and clinical implications
-
Derkx F, Schalekamp M. Human prorenin: pathophysiology and clinical implications. Clin Exp Hypertens. 1988;A10:1213-1225.
-
(1988)
Clin Exp Hypertens
, vol.A10
, pp. 1213-1225
-
-
Derkx, F.1
Schalekamp, M.2
-
2
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417-1427.
-
(2002)
J Clin Invest
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
Bouzhir, L.4
Giller, T.5
Sraer, J.D.6
-
3
-
-
30944469631
-
Renin increases mesangial cell transforming growth factor-b1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
-
Huang Y, Wongamorntham S, Kasting J, et al. Renin increases mesangial cell transforming growth factor-b1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 2006;69:105-113.
-
(2006)
Kidney Int
, vol.69
, pp. 105-113
-
-
Huang, Y.1
Wongamorntham, S.2
Kasting, J.3
-
4
-
-
34548483245
-
The (pro)renin receptor and the kidney
-
Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Itoh H. The (pro)renin receptor and the kidney. Semin Nephrol. 2007;27:524-528.
-
(2007)
Semin Nephrol
, vol.27
, pp. 524-528
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
Sakoda, M.4
Itoh, H.5
-
5
-
-
33750600468
-
Binding properties of rat prorenin and renin to the recombinant rat renin/ prorenin receptor prepared by a baculovirus expression system
-
Nabi AH, Kageshima A, Uddin M, Nakagawa T, Park E, Suzuki F. Binding properties of rat prorenin and renin to the recombinant rat renin/ prorenin receptor prepared by a baculovirus expression system. Int J Mol Med. 2006;18:483-488.
-
(2006)
Int J Mol Med
, vol.18
, pp. 483-488
-
-
Nabi, A.H.1
Kageshima, A.2
Uddin, M.3
Nakagawa, T.4
Park, E.5
Suzuki, F.6
-
6
-
-
0037591344
-
Human prorenin has "gate and handle" regions for its non-proteolytic activation
-
Suzuki F, Hayakawa M, Nakagawa T, et al. Human prorenin has "gate and handle" regions for its non-proteolytic activation. J Biol Chem. 2003;278:22217-22222.
-
(2003)
J Biol Chem
, vol.278
, pp. 22217-22222
-
-
Suzuki, F.1
Hayakawa, M.2
Nakagawa, T.3
-
7
-
-
37849044605
-
(Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells
-
Sakoda M, Ichihara A, Kaneshiro Y, et al. (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells. Hyper Res. 2007;30:1139-1146.
-
(2007)
Hyper Res
, vol.30
, pp. 1139-1146
-
-
Sakoda, M.1
Ichihara, A.2
Kaneshiro, Y.3
-
8
-
-
34347350179
-
Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells
-
Huang Y, Noble N, Zhang J, Xu C, Border W. Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int. 2007;72:42-52.
-
(2007)
Kidney Int
, vol.72
, pp. 42-52
-
-
Huang, Y.1
Noble, N.2
Zhang, J.3
Xu, C.4
Border, W.5
-
9
-
-
33750266798
-
-
Saris J, 'tHoen P, Garrelds I, et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension. 2006;48:564-571.
-
Saris J, 'tHoen P, Garrelds I, et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension. 2006;48:564-571.
-
-
-
-
10
-
-
34547693066
-
Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor
-
Nabi AH, Uddin M, Nakagawa T, et al. Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci. 2007;12:4810-4817.
-
(2007)
Front Biosci
, vol.12
, pp. 4810-4817
-
-
Nabi, A.H.1
Uddin, M.2
Nakagawa, T.3
-
11
-
-
35848948398
-
Prorenin is the endogenous agonist of the (pro)renin receptor: Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor
-
Batenburg WW, Krop MK, Garrelds IM, et al. Prorenin is the endogenous agonist of the (pro)renin receptor: binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens. 2007;25:2441-2453.
-
(2007)
J Hypertens
, vol.25
, pp. 2441-2453
-
-
Batenburg, W.W.1
Krop, M.K.2
Garrelds, I.M.3
-
12
-
-
39749098706
-
Prorenin and renin-induced extracellular signal regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
-
Feldt S, Batenburg WW, Mazak I, et al. Prorenin and renin-induced extracellular signal regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension. 2008;51:682-688.
-
(2008)
Hypertension
, vol.51
, pp. 682-688
-
-
Feldt, S.1
Batenburg, W.W.2
Mazak, I.3
-
13
-
-
0032787740
-
Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus
-
Deinum J, Ronn B, Mathiesen E, Derkx FH, Hop WCJ, Schalekamp MA. Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus. Diabetologia. 1999;42:1006-1010.
-
(1999)
Diabetologia
, vol.42
, pp. 1006-1010
-
-
Deinum, J.1
Ronn, B.2
Mathiesen, E.3
Derkx, F.H.4
Hop, W.C.J.5
Schalekamp, M.A.6
-
14
-
-
0025089160
-
Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus
-
Wilson D, Leutscher JA. Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. N Engl J Med. 1990;323:1101-1106.
-
(1990)
N Engl J Med
, vol.323
, pp. 1101-1106
-
-
Wilson, D.1
Leutscher, J.A.2
-
15
-
-
9644283069
-
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for non-proteolytic activation of prorenin
-
Ichihara A, Hayashi M, Kaneshiro Y, et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for non-proteolytic activation of prorenin. J Clin Invest. 2004;114:1128-1135.
-
(2004)
J Clin Invest
, vol.114
, pp. 1128-1135
-
-
Ichihara, A.1
Hayashi, M.2
Kaneshiro, Y.3
-
16
-
-
33745824649
-
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice
-
Ichihara A, Suzuki F, Nakagawa T, et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice. J Am Soc Nephrol. 2006;17:1950-1961.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1950-1961
-
-
Ichihara, A.1
Suzuki, F.2
Nakagawa, T.3
-
17
-
-
34447272037
-
Regression of nephropathy developed in diabetes by (pro)renin receptor blockade
-
Takahashi H, Ichihara A, Kaneshiro Y, et al. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol. 2007;18:2054-2061.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 2054-2061
-
-
Takahashi, H.1
Ichihara, A.2
Kaneshiro, Y.3
-
18
-
-
33644983896
-
Elevated blood pressure and heart rate in human renin receptor transgenic rats
-
Burckle CA, Jan Danser AH, Muller DN, et al. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension. 2006;47:552-556.
-
(2006)
Hypertension
, vol.47
, pp. 552-556
-
-
Burckle, C.A.1
Jan Danser, A.H.2
Muller, D.N.3
-
19
-
-
34249881320
-
Slowly progressive, angiotensin II-independent glomerulosclerosis in human-renin/ prorenin-receptor-transgenic rats
-
Kaneshiro Y, Ichihara A, Sakoda M, et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human-renin/ prorenin-receptor-transgenic rats. J Am Soc Nephrol. 2007;18:1789-1795.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1789-1795
-
-
Kaneshiro, Y.1
Ichihara, A.2
Sakoda, M.3
-
20
-
-
33747060126
-
Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats
-
Kaneshiro Y, Ichihara A, Takemitsu T, et al. Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats. Kidney Int. 2006;70:641-646.
-
(2006)
Kidney Int
, vol.70
, pp. 641-646
-
-
Kaneshiro, Y.1
Ichihara, A.2
Takemitsu, T.3
-
21
-
-
33748044643
-
Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage
-
Ichihara A, Kaneshiro Y, Takemitsu T, et al. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol. 2006;17:2495-2503.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2495-2503
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
-
22
-
-
54049106595
-
Cardiovascular effects of prorenin blockade in genetically hypertensive rats on normal and high-salt diet
-
Susic D, Zhou X, Frohlich ED, Lippton H, Knight M. Cardiovascular effects of prorenin blockade in genetically hypertensive rats on normal and high-salt diet. Am J Physiol Heart Circ Physiol. 2008;295:H1117-H1121.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.295
-
-
Susic, D.1
Zhou, X.2
Frohlich, E.D.3
Lippton, H.4
Knight, M.5
-
23
-
-
33646160993
-
Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
-
Ichihara A, Kaneshiro Y, Takemitsu T, et al. Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension. 2006;47:894-900.
-
(2006)
Hypertension
, vol.47
, pp. 894-900
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
-
24
-
-
42249089770
-
The putative (pro)renin receptor blocker HRP fails to prevent (pro) renin signaling
-
Feldt S, Maschke U, Dechend R, Luft FC, Muller DN. The putative (pro)renin receptor blocker HRP fails to prevent (pro) renin signaling. J Am Soc Nephrol. 2008;19:743-748.
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 743-748
-
-
Feldt, S.1
Maschke, U.2
Dechend, R.3
Luft, F.C.4
Muller, D.N.5
-
25
-
-
36849049298
-
Hypoxia and the HIF system in kidney disease
-
Nangaku M, Eckardt KU. Hypoxia and the HIF system in kidney disease. J Mol Med. 2007;85:1325-1330.
-
(2007)
J Mol Med
, vol.85
, pp. 1325-1330
-
-
Nangaku, M.1
Eckardt, K.U.2
-
26
-
-
34548490929
-
Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats
-
Krebs C, Hamming I, Sadaghiani S, et al. Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Kidney Int. 2007;72:725-730.
-
(2007)
Kidney Int
, vol.72
, pp. 725-730
-
-
Krebs, C.1
Hamming, I.2
Sadaghiani, S.3
-
27
-
-
39749088803
-
(Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats
-
Muller DN, Klanke B, Feldt S, et al. (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension. 2008;51:676-681.
-
(2008)
Hypertension
, vol.51
, pp. 676-681
-
-
Muller, D.N.1
Klanke, B.2
Feldt, S.3
|