Investigation of true nanoemulsions for transdermal potential of indomethacin: Characterization, rheological characteristics, and ex vivo skin permeation studies Investigation of true nanoemulsions

Journal of Drug Targeting

Volumn 17, Issue 6, 2009, Pages 435-441

  Shakeel, Faiyaz ^a   Ramadan, Wafa ^a   Ahmed, Musa A ^a  

^a AL ARAB MEDICAL UNIVERSITY   (Libyan Arab Jamahiriya)

Author keywords

Indomethacin; Nanoemulsion gel; Nanoemulsions; Rheological characteristics; Transdermal potential

Indexed keywords

INDOMETACIN; NANOPARTICLE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; EX VIVO STUDY; FLOW KINETICS; MORPHOLOGY; NANOEMULSION; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; THERMODYNAMICS; TRANSMISSION ELECTRON MICROSCOPY; VISCOSITY; ANIMAL; COMPARATIVE STUDY; EMULSION; GEL; IN VITRO STUDY; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; PARTICLE SIZE; PERMEABILITY; SKIN; SKIN ABSORPTION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; EMULSIONS; GELS; INDOMETHACIN; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; PERMEABILITY; RATS; RHEOLOGY; SKIN; SKIN ABSORPTION; THERMODYNAMICS; VISCOSITY;

EID: 69449093984     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860902963021     Document Type: Article

References (22)

1. Ahmed M, Ramadan W, Rambhu D, Shakeel F. (2008). Potential of nanoemulsions for intravenous delivery of rifampicin. Pharmazie, 63, 806-811.
2. Baboota S, Shakeel F, Kohli K. (2006). Development and evaluation of once a day transdermal gel of diclofenacdiethylamine. Method Fin Exp Clin Pharmacol, 28, 109-114.
3. Baboota S, Shakeel F, Ahuja A, Ali J, Shafiq S. (2007a). Design development and evaluation of novel nanoemulsion formulation for transdermal potential of celecoxib. Acta Pharm, 57,315-332.
4. Baboota S, Alazaki A, Kohli K, Ali J, Dixit N, Shakeel F. (2007b). Development and evaluation of a microemulsion formulation for transdermal delivery of terbenafine. PDA J Pharm Sci Tech, 61, 276-285.
5. Badawi AA, El-Laithy HM, El-Qidra RK, El-Mofty H, El-Dally M. (2008). Chitosan based nanocarriers for indomethacin ocular delivery. Arch Pharm Res, 31, 1040-1049.
6. Hart F, Boardman P. (1963). Indomethacin: a new nonsteroidal antiinflammatory agent. Br Med J, 5363, 965-970.
7. Lawrence MJ, Rees GD. (2000). Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev, 45, 89-121.
8. Nandi I, Bari M, Joshi H. (2003). Study of isopropyl myristate microemulsion systems containing cyclodextrins to improve the solubility of 2 hydrophobic drugs. AAPS Pharm Sci Tech, 4, E10.
9. Shafiq S, Shakeel F. (2008). Enhanced stability of ramipril in nanoemulsion containing Cremophor-EL: a technical note. AAPS Pharm Sci Tech, 9, 1097-1101.
10. Shafiq S, Shakeel F, Talegaonkar S, Ali J, Baboota S, Ahuja A, Khar RK, Ali M. (2007a). Formulation development and optimization using nanoemulsion technique: a technical note. AAPS Pharm Sci Tech, 8, E28.
11. Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. (2007b). Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm, 66, 227-243. (Pubitemid 46667230)
12. Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. (2007c). Design and development of ramipril nanoemulsion formulation: in vitro and in vivo assessment. J Biomed Nanotech, 3, 28-44. (Pubitemid 351877125)
13. Shakeel F, Baboota S, Ahuja A, Ali J, Aqil M, Shafiq S. (2007). Nanoemulsions as vehicles for transdermal delivery of aceclofenac. AAPS Pharm Sci Tech, 8, E104.
14. Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. (2008a). Celecoxib nanoemulsion: skin permeation mechanism and bioavailability assessment. J Drug Target, 16, 733-740.
15. Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. (2008b). Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion. J Nanobiotech, 6, E8.
16. Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. (2008c). Skin permeation mechanism of aceclofenac using novel nanoemulsion formulation. Pharmazie, 63, 580-584.
17. Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. (2008d). Accelerated stability testing of celecoxib nanoemulsion containing Cremophor-EL. African J Pharm Pharmacol, 2, 179-183.
18. Shakeel F, Baboota S, Ahuja A, Ali J, Faisal S, Shafiq S. (2008e). Stability evaluation of celecoxib nanoemulsion containing Tween 80. Thai J Pharm Sci, 32, 4-9.
19. Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. (2009a). Enhanced antiinflammatory effects of celecoxib from a transdermally applied nanoemulsion. Pharmazie, 64, 258-259.
20. Shakeel F, Baboota S, Ahuja A, Ali J, Shafiq S. (2009b). Celecoxib nanoemulsion for transdermal drug delivery: characterization and in vitro evaluation. DOI: 10.1080/01932690802644012
21. Trotta M. (1999). Influence of phase transformation on indomethacin release from microemulsions. J Control Release, 60, 399-405.
22. Zabka M, Skoviera F. (2003). Microemulsions as vehicles for transdermal permeation of drugs. Acta Facult Pharm Univ Comenianae, 50, 147-155.