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Volumn 3, Issue 1, 2007, Pages 28-44

Design and development of oral oil in water ramipril nanoemulsion formulation: In vitro and in vivo assessment

Author keywords

Bioavailability; Nanoemulsion; Phase diagrams; Ramipril; Sefsol 218; SNEDDS; Solubility

Indexed keywords

CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; INTRALIPID; RAMIPRIL; RAMIPRILAT; SURFACTANT; WATER;

EID: 34548763353     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2007.008     Document Type: Conference Paper
Times cited : (113)

References (37)
  • 1
    • 85047692219 scopus 로고
    • Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism
    • J. A. Bruce, Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J. Pharm. Sci. 82, 979 (1993).
    • (1993) J. Pharm. Sci , vol.82 , pp. 979
    • Bruce, J.A.1
  • 2
    • 0002015409 scopus 로고    scopus 로고
    • Introduction: Semi-solid formulations for oral drug delivery
    • J. R. Robinson, Introduction: Semi-solid formulations for oral drug delivery. B. T. Gattefosse. 89, 11 (1996).
    • (1996) B. T. Gattefosse , vol.89 , pp. 11
    • Robinson, J.R.1
  • 4
  • 5
    • 0343909521 scopus 로고
    • Conditions to produce so-called microemulsions: Factors to increase the mutual solubility of oil and water by solubilizer
    • K. Shinoda and H. Kunieda, Conditions to produce so-called microemulsions: Factors to increase the mutual solubility of oil and water by solubilizer. J. Colloid Interf. Sci. 42, 381 (1973).
    • (1973) J. Colloid Interf. Sci , vol.42 , pp. 381
    • Shinoda, K.1    Kunieda, H.2
  • 6
    • 4444359191 scopus 로고    scopus 로고
    • Editorial: Nanotechnology: Challenging the limit of creativity in targeted drug delivery
    • V. H. Lee, Editorial: Nanotechnology: Challenging the limit of creativity in targeted drug delivery. Adv. Drug Deliv. Rev. 56, 1527 (2004).
    • (2004) Adv. Drug Deliv. Rev , vol.56 , pp. 1527
    • Lee, V.H.1
  • 7
    • 3242721638 scopus 로고    scopus 로고
    • Nano-emulsion formulation using spontaneous emulsification: Solvent, oil, and surfactant optimization
    • K. Bouchemal, S, Briancon, E. Perrier, and H. Fessi, Nano-emulsion formulation using spontaneous emulsification: Solvent, oil, and surfactant optimization. Int. J. Pharm. 280, 241 (2004).
    • (2004) Int. J. Pharm , vol.280 , pp. 241
    • Bouchemal, K.1    Briancon, S.2    Perrier, E.3    Fessi, H.4
  • 8
    • 0022561085 scopus 로고
    • The mini-emulsion process - Different of spontaneous emulsification
    • M. El-Aasser, C. D. Lack, J. W. Vanderhoff, and F. M. Fowkes, The mini-emulsion process - Different of spontaneous emulsification. Colloid. Surf. 29, 103 (1988).
    • (1988) Colloid. Surf , vol.29 , pp. 103
    • El-Aasser, M.1    Lack, C.D.2    Vanderhoff, J.W.3    Fowkes, F.M.4
  • 9
    • 0034614208 scopus 로고    scopus 로고
    • Microemulsion-based media as novel drug delivery systems
    • M. J. Lawrence and G. D. Rees, Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 45, 89 (2000).
    • (2000) Adv. Drug Deliv. Rev , vol.45 , pp. 89
    • Lawrence, M.J.1    Rees, G.D.2
  • 10
    • 45849144274 scopus 로고    scopus 로고
    • J. Eccleston, Microemulsions. Encyclopedia of Pharmaceutical Technology, edited by J. Swarbrick and J. C. Boylan. Marcel Dekker, NewYork (1994), 9, pp. 375-421.
    • J. Eccleston, Microemulsions. Encyclopedia of Pharmaceutical Technology, edited by J. Swarbrick and J. C. Boylan. Marcel Dekker, NewYork (1994), Vol. 9, pp. 375-421.
  • 11
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption and biopharmaceutical aspects
    • P. P. Constantinides, Lipid microemulsions for improving drug dissolution and oral absorption and biopharmaceutical aspects. Pharm. Res. 12, 1561 (1995).
    • (1995) Pharm. Res , vol.12 , pp. 1561
    • Constantinides, P.P.1
  • 16
    • 45849149123 scopus 로고    scopus 로고
    • Is ramipril cost-effective as well as clinically useful in reducing cardiovascular risk
    • I. S. Malik, J. Bhatia, and J. S. Kooner, Is ramipril cost-effective as well as clinically useful in reducing cardiovascular risk. JACC, Abstracts-special topics (2001), p. 1247.
    • (2001) JACC, Abstracts-special topics , pp. 1247
    • Malik, I.S.1    Bhatia, J.2    Kooner, J.S.3
  • 17
    • 34247556618 scopus 로고    scopus 로고
    • Antihypenensive efficacy of ramipril in children with chronic renal failure
    • E. Wühl, O. Mehls, and F. Schaefer, Antihypenensive efficacy of ramipril in children with chronic renal failure. Am. J. Hyper. 16, 558 (2003).
    • (2003) Am. J. Hyper , vol.16 , pp. 558
    • Wühl, E.1    Mehls, O.2    Schaefer, F.3
  • 18
    • 45849114282 scopus 로고    scopus 로고
    • Indian Pharmacopeia, Reagents and solutions, Appendix 13 (1996), pp. A144-A145.
    • Indian Pharmacopeia, Reagents and solutions, Appendix 13 (1996), pp. A144-A145.
  • 19
    • 0343487750 scopus 로고    scopus 로고
    • Formulation of self-emulsifying drug delivery systems
    • C. W. Pouton, Formulation of self-emulsifying drug delivery systems. Adv. Drug Deliv. Rev. 25, 47 (1997).
    • (1997) Adv. Drug Deliv. Rev , vol.25 , pp. 47
    • Pouton, C.W.1
  • 20
    • 0032103706 scopus 로고    scopus 로고
    • Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
    • S. M. Khoo, A. J. Humberstone, C. J. H. Potter, G. A. Edwards, and W. N. Charman, Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine. Int. J. Pharm. 167, 155 (1998).
    • (1998) Int. J. Pharm , vol.167 , pp. 155
    • Khoo, S.M.1    Humberstone, A.J.2    Potter, C.J.H.3    Edwards, G.A.4    Charman, W.N.5
  • 21
    • 0026739984 scopus 로고
    • A study on factors influencing the droplet size in nonionic oil-in-water microemulsions
    • D. Attwood, C. Mallon, G. Ktistis, and C. J. Taylor, A study on factors influencing the droplet size in nonionic oil-in-water microemulsions. Int. J. Pharm. 88, 417 (1992).
    • (1992) Int. J. Pharm , vol.88 , pp. 417
    • Attwood, D.1    Mallon, C.2    Ktistis, G.3    Taylor, C.J.4
  • 22
    • 1842609789 scopus 로고    scopus 로고
    • Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs
    • B. K. Kang, J. S. Lee, S. K. Chon, S. Y. Jeong, S. H. Yak, G. Khang, H. B. Lee, and S. H. Cho, Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm. 274, 65 (2004).
    • (2004) Int. J. Pharm , vol.274 , pp. 65
    • Kang, B.K.1    Lee, J.S.2    Chon, S.K.3    Jeong, S.Y.4    Yak, S.H.5    Khang, G.6    Lee, H.B.7    Cho, S.H.8
  • 23
    • 0035146848 scopus 로고    scopus 로고
    • A stability-indicating LC method for the simultaneous determination of ramipril and hydrochloride in dosage forms
    • F. Belal, I. A. AI-Zaagi, M. A. Gadkariem, and M. A. Abounassif, A stability-indicating LC method for the simultaneous determination of ramipril and hydrochloride in dosage forms. J. Pharm. Biomed. Anal. 24, 335 (2001).
    • (2001) J. Pharm. Biomed. Anal , vol.24 , pp. 335
    • Belal, F.1    AI-Zaagi, I.A.2    Gadkariem, M.A.3    Abounassif, M.A.4
  • 25
    • 34247613143 scopus 로고    scopus 로고
    • Self-micro emulsifying drug delivery system (SMEDDS) for improving bioavailability of hydrophobic drugs and its potential to give sustain release dosage form
    • J. Shaji and V. Joshi, Self-micro emulsifying drug delivery system (SMEDDS) for improving bioavailability of hydrophobic drugs and its potential to give sustain release dosage form. Indian J. Pharm. Educ. 39, 130 (2005).
    • (2005) Indian J. Pharm. Educ , vol.39 , pp. 130
    • Shaji, J.1    Joshi, V.2
  • 27
    • 0034284135 scopus 로고    scopus 로고
    • Development and validation of a liquid chromatographic method for the determination of the related substances of ramipril in Altace capsules
    • B. L. Hogan, M. Williams, A. Idiculla, T. Veysoglu, and E. Parente, Development and validation of a liquid chromatographic method for the determination of the related substances of ramipril in Altace capsules. J. Pharm. Bionzed. Anal. 23, 637 (2000).
    • (2000) J. Pharm. Bionzed. Anal , vol.23 , pp. 637
    • Hogan, B.L.1    Williams, M.2    Idiculla, A.3    Veysoglu, T.4    Parente, E.5
  • 28
    • 25444464372 scopus 로고    scopus 로고
    • Bioavailability of Seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats - Effect of medium and long chain triglycerides
    • M. Grove, G. P. Pedersen, J. L. Nielsen, and A. Mullertz, Bioavailability of Seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats - Effect of medium and long chain triglycerides. J. Pharm. Sci. 94, 1830 (2005).
    • (2005) J. Pharm. Sci , vol.94 , pp. 1830
    • Grove, M.1    Pedersen, G.P.2    Nielsen, J.L.3    Mullertz, A.4
  • 29
    • 52849083766 scopus 로고    scopus 로고
    • Light scattering investigations on dilute non-ionic oil-in-water microemulsions
    • W. Warisnoicharoen, A. B. Lansley, and M. J. Lawrence, Light scattering investigations on dilute non-ionic oil-in-water microemulsions. AAPS Pharm. Sci. 2, 429 (2000).
    • (2000) AAPS Pharm. Sci , vol.2 , pp. 429
    • Warisnoicharoen, W.1    Lansley, A.B.2    Lawrence, M.J.3
  • 30
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    • R. N. Gursoy and S. Benita. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed. Pharmacotherapy 58, 173 (2004).
    • (2004) Biomed. Pharmacotherapy , vol.58 , pp. 173
    • Gursoy, R.N.1    Benita, S.2
  • 31
    • 0028949717 scopus 로고
    • An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy
    • D. Q. M. Craig, S. A. Barker, D. Banning, and S. W. Booth, An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int. J. Pharm. 114, 103 (1995).
    • (1995) Int. J. Pharm , vol.114 , pp. 103
    • Craig, D.Q.M.1    Barker, S.A.2    Banning, D.3    Booth, S.W.4
  • 32
    • 10644257823 scopus 로고    scopus 로고
    • Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions
    • L. Ping, A. Ghosh, R. F. Wagner, S. Krill, Y. M. Joshi, and A. T. M. Serajuddin, Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions. Int. J. Pharm. 288, 27 (2005).
    • (2005) Int. J. Pharm , vol.288 , pp. 27
    • Ping, L.1    Ghosh, A.2    Wagner, R.F.3    Krill, S.4    Joshi, Y.M.5    Serajuddin, A.T.M.6
  • 33
    • 30644460910 scopus 로고    scopus 로고
    • ramipril and ramiprilat
    • Human physiologically based pharmacokinetic model for ACE inhibitors
    • D. G. Levitt and R. C. Schoemaker, Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. BMC Clin. Pharmacol. 6, 1 (2006).
    • (2006) BMC Clin. Pharmacol , vol.6 , pp. 1
    • Levitt, D.G.1    Schoemaker, R.C.2
  • 35
    • 0026586447 scopus 로고
    • Self-emulsifying drug delivery systems: Formulation and biopharmaceutic evaluation of an investigational lipophilic compound
    • S. A. Charman, W. N. Charman, M. C. Rogge, T. D. Wilson, F. J. Dutko, and C. W. Pouton. Self-emulsifying drug delivery systems: Formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharm. Res. 9, 87 (1992).
    • (1992) Pharm. Res , vol.9 , pp. 87
    • Charman, S.A.1    Charman, W.N.2    Rogge, M.C.3    Wilson, T.D.4    Dutko, F.J.5    Pouton, C.W.6
  • 36
    • 0028194817 scopus 로고
    • Selfemulsifying drug delivery systems (SEDDS) with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs
    • N. H. Shah, M. T. Carvajal, C. I. Patel, M. H. Infeld, and A. W. Malick, Selfemulsifying drug delivery systems (SEDDS) with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int. J. Pharm. 106, 15 (1994).
    • (1994) Int. J. Pharm , vol.106 , pp. 15
    • Shah, N.H.1    Carvajal, M.T.2    Patel, C.I.3    Infeld, M.H.4    Malick, A.W.5
  • 37
    • 0035966510 scopus 로고    scopus 로고
    • Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery
    • C. K. Kim, Y. J. Cho, and Z. G. Gao, Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery. J. Control. Rel. 70, 149 (2001).
    • (2001) J. Control. Rel , vol.70 , pp. 149
    • Kim, C.K.1    Cho, Y.J.2    Gao, Z.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.