Quantitative spectroscopic imaging with in situ measurements of tissue water T1, T2, and density

Magnetic Resonance in Medicine

Volumn 62, Issue 3, 2009, Pages 583-590

  Gasparovic, Charles ^a,b   Neeb, H ^c   Feis, D L ^c   Damaraju, E ^b   Chen, H ^b   Doty, M J ^b   South, D M ^a,b   Mullins, P G ^b   Bockholt, H J ^b   Shah, N J ^d  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c RheinAhrCampus   (Germany)

^d FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Brain; Magnetic resonance spectroscopy

Indexed keywords

BRAIN; MAGNETIC RESONANCE SPECTROSCOPY; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TISSUE;

HEALTHY SUBJECTS; IN-SITU MEASUREMENT; MEASUREMENTS OF; METABOLITE CONCENTRATIONS; PARTIAL VOLUME EFFECT; PROTON SIGNALS; SPECTROSCOPIC IMAGING; WATER PARAMETERS;

MAGNETIC RESONANCE;

PROTON; WATER;

ADULT; ARTICLE; BRAIN; BRAIN DAMAGE; BRAIN SIZE; CASE REPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENSITY GRADIENT; DIAGNOSTIC VALUE; FEMALE; HUMAN; IN SITU MEASUREMENT; MALE; MEASUREMENT; METABOLITE; MUSCLE RELAXATION; NUCLEAR MAGNETIC RESONANCE SCANNER; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SIGNAL NOISE RATIO; SIGNAL PROCESSING; TISSUE WATER;

EID: 69449093951     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22060     Document Type: Article

References (33)

1. Geurts JJ, Barkhof F, Castelijns JA, Uitdehaag BM, Polman CH, Pouwels PJ. Quantitative 1H-MRS of healthy human cortex, hippocampus, and thalamus: metabolite concentrations, quantification precision, and reproducibility. J Magn Reson Imaging 2004;20:366-371. (Pubitemid 39121932)
2. Tong Z, Yamaki T, Harada K, Houkin K. In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. Magn Reson Imaging 2004;22:1017-1024.
3. Inglese M, Rusinek H, George IC, Babb JS, Grossman RI, Gonen O. Global average gray and white matter N-acetylaspartate concentration in the human brain. Neuroimage 2008;41:270-276.
4. Keevil SF, Barbiroli B, Brooks JC, Cady EB, Canese R, Carlier P, et al. Absolute metabolite quantification by in vivo NMR spectroscopy: II. A multicentre trial of protocols for in vivo localised proton studies of human brain. Magn Reson Imaging 1998;16:1093-1106.
5. Gasparovic C, Song T, Devier D, Bockholt HJ, Caprihan A, Mullins PG, Posse S, Jung RE, Morrison LA. Use of tissue water as a concentration reference for proton spectroscopic imaging. Magn Reson Med 2006;55:1219-1226. (Pubitemid 43856758)
6. Klose U. In vivo proton spectroscopy in presence of eddy currents. Magn Reson Med 1990;14:26-30.
7. Ernst T, Kreis R, Ross BD. Absolute quantitation of water and metabolites in the human brain. I. Compartments and water. J Magn Reson B 1993;102:1-3.
8. Kreis R, Ernst T, Ross BD. Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Reson Med 1993;30:424-437. (Pubitemid 23300070)
9. Kreis R, Ernst T, Ross BD. Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations. J Magn Reson B 1993;102:9-19.
10. Neeb H, Zilles K, Shah NJ. A new method for fast quantitative mapping of absolute water content in vivo. Neuroimage 2006;31:1156-1168. (Pubitemid 43851315)
11. Lin MS. Measurement of spin-lattice relaxation times in double spin-echo imaging. Magn Reson Med 1984;1:361-369.
12. Knight-Scott J, Haley AP, Rossmiller SR, Farace E, Mai VM, Christopher JM, Manning CA, Simnad VI, Siragy HM. Molality as a unit of measure for expressing 1H MRS brain metabolite concentrations in vivo. Magn Reson Imaging 2003;21:787-797. (Pubitemid 37259906)
13. Hetherington HP, Pan JW, Mason GF, Adams D, Vaughn MJ, Twieg DB, Pohost GM. Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation. Magn Reson Med 1996;36:21-29. (Pubitemid 26196527)
14. Ethofer T, Mader I, Seeger U, Helms G, Erb M, Grodd W, Ludolph A, Klose U. Comparison of longitudinal metabolite relaxation times in different regions of the human brain at 1.5 and 3 Tesla. Magn Reson Med 2003;50:1296-1301. (Pubitemid 37494031)
15. Traber F, Block W, Lamerichs R, Gieseke J, Schild HH. 1H metabolite relaxation times at 3.0 tesla: Measurements of T1 and T2 values in normal brain and determination of regional differences in transverse relaxation. J Magn Reson Imaging 2004;19:537-545. (Pubitemid 38619915)
16. Brief EE, Whittall KP, Li DK, MacKay AL. Proton T2 relaxation of cerebral metabolites of normal human brain over large TE range. NMR Biomed 2005;18:14-18.
17. Steinhoff S, Zaitsev M, Zilles K, Shah NJ. Fast T(1) mapping with volume coverage. Magn Reson Med 2001;46:131-140.
18. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679.
19. Pouwels PJ, Frahm J. Differential distribution of NAA and NAAG in human brain as determined by quantitative localized proton MRS. NMR Biomed 1997;10:73-78. (Pubitemid 27332604)
20. Ashburner J, Friston KJ. Unified segmentation. Neuroimage 2005;26:839-851.
21. Rorden C, Brett M. Stereotaxic display of brain lesions. Behav Neurol 2000;12:191-200.
22. Vymazal J, Righini A, Brooks RA, Canesi M, Mariani C, Leonardi M, Pezzoli G. T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation to iron content. Radiology 1999;211:489-495.
23. Rooney WD, Johnson G, Li X, Cohen ER, Kim SG, Ugurbil K, Springer CS Jr. Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. Magn Reson Med 2007;57:308-318. (Pubitemid 46214534)
24. Rutgers DR, van der Grond J. Relaxation times of choline, creatine and N-acetyl aspartate in human cerebral white matter at 1.5 T. NMR Biomed 2002;15:215-221.
25. Deoni SC, Peters TM, Rutt BK. High-resolution T1 and T2 mapping of the brain in a clinically acceptable time with DESPOT1 and DESPOT2. Magn Reson Med 2005;53:237-241.
26. Siemonsen S, Finsterbusch J, Matschke J, Lorenzen A, Ding XQ, Fiehler J. Age-dependent normal values of T2* and T2′ in brain parenchyma. AJNR Am J Neuroradiol 2008;29:950-955. (Pubitemid 351684973)
27. Shah NJ, Zaitsev M, Steinhoff S, Zilles K. A new method for fast multislice T(1) mapping. Neuroimage 2001;14:1175-1185.
28. Neeb H, Ermer V, Stocker T, Shah NJ. Fast quantitative mapping of absolute water content with full brain coverage. Neuroimage 2008;42:1094-1109.
29. Papanikolaou N, Papadaki E, Karampekios S, Spilioti M, Maris T, Prassopoulos P, Gourtsoyiannis N. T2 relaxation time analysis in patients with multiple sclerosis: correlation with magnetization transfer ratio. Eur Radiol 2004;14:115-122. (Pubitemid 38181063)
30. Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PM. White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis. J Neurol 2002;249:1279-1286. (Pubitemid 35025108)
31. Laule C, Vavasour IM, Madler B, Kolind SH, Sirrs SM, Brief EE, Traboulsee AL, Moore GR, Li DK, MacKay AL. MR evidence of long T2 water in pathological white matter. J Magn Reson Imaging 2007;26:1117-1121. (Pubitemid 47548176)
32. Helms G. Volume correction for edema in single-volume proton MR spectroscopy of contrast-enhancing multiple sclerosis lesions. Magn Reson Med 2001;46:256-263.
33. Quirk JD, Bretthorst GL, Duong TQ, Snyder AZ, Springer CS Jr, Ackerman JJ, Neil JJ. Equilibrium water exchange between the intra- and extracellular spaces of mammalian brain. Magn Reson Med 2003;50:493-499.