Impact of the tri-allelic serotonin transporter polymorphism on the white-matter tract connecting the amygdala and the prefrontal cortex

Journal of Neuroscience

Volumn 29, Issue 34, 2009, Pages 10461-10462

  Jasinska, Agnes J ^a,c   Perkins, Suzanne C ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c 2702 Rachel Upjohn Building   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

ALLELE; AMYGDALOID NUCLEUS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; IN VITRO SELECTION; IN VIVO STUDY; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SHORT SURVEY; SYNAPSE; WHITE MATTER;

ALLELES; AMYGDALA; HUMANS; MAGNETIC RESONANCE IMAGING; NEURAL PATHWAYS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 69449090383     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2774-09.2009     Document Type: Short Survey

References (13)

1. Anand A, Li Y, Wang Y, Lowe MJ, Dzemidzic M (2009) Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res 171:189-198.
2. Andersen SL, Teicher MH (2008) Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci 31:183-191.
3. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386-389. (Pubitemid 36877077)
4. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, WeinbergerDR (2002) Serotonin transporter genetic variation and the response of the human amygdala. Science 297:400-403. (Pubitemid 34790769)
5. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624. (Pubitemid 26159101)
6. Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D, Klein S, Grüsser SM, Flor H, Schumann G, Mann K, Büchel C (2005) Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 8:20-21. (Pubitemid 41236725)
7. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78: 815-826.
8. Mayberg HS (1997) Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci 9:471-481.
9. Pacheco J, Beevers CG, Benavides C, McGeary J, Stice E, Schnyer DM (2009) Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J Neurosci 29: 6229-6233.
10. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8:828-834. (Pubitemid 43085851)
11. Salat DH, Tuch DS, Hevelone ND, Fischl B, Corkin S, Rosas HD, Dale AM (2005) Age-related changes in prefrontal white matter measured by diffusion tensor imaging. Ann N Y Acad Sci 1064:37-49. (Pubitemid 43030947)
12. Snook L, Paulson LA, Roy D, Phillips L, Beaulieu C (2005) Diffusion tensor imaging of neurodevelopment in children and young adults. Neuroimage 26:1164-1173. (Pubitemid 40806495)
13. Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston EE, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP (2009) Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry 66:516-521.