The use of antithrombotic agents in microvascular surgery

Clinical Hemorheology and Microcirculation

Volumn 43, Issue 1-2, 2009, Pages 51-56

  Stephan, B ^a   Schenk, J F ^a   Nemeh, A ^a   Pindur, G ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Anticoagulation; Free flaps; Microvascular surgery; Thrombosis

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; CLOPIDOGREL; DEXTRAN; FIBRINOLYTIC AGENT; HEPARIN; ILOPROST; LOW MOLECULAR WEIGHT HEPARIN; PROSTAGLANDIN E1;

ANTICOAGULATION; BLEEDING; BLOOD VESSEL SHUNT; CLINICAL TRIAL; CONSENSUS; CONTROLLED CLINICAL TRIAL; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; FIBRIN FORMATION; FREE TISSUE GRAFT; GASTRITIS; GRAFT FAILURE; HEART INFARCTION; HUMAN; LOW DRUG DOSE; MICROVASCULAR SURGERY; NEPHROTOXICITY; RECOMMENDED DRUG DOSE; REVIEW; SECONDARY PREVENTION; STROKE; THROMBOCYTE FUNCTION; THROMBOSIS;

ANTICOAGULANTS; HUMANS; RECONSTRUCTIVE SURGICAL PROCEDURES; SURGICAL FLAPS; THROMBOSIS; VASCULAR SURGICAL PROCEDURES;

EID: 69449085868     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: 10.3233/CH-2009-1220     Document Type: Review

References (34)

1. W.P. Adams, M.S. Absari and M.T. Hay, Patency of different arterial and venous end-to-side microvascular techniques in a rat model, Plast. Reconstr. Surg. 105 (2000), 156.
2. P. Ashjian, C.M. Chen, A. Pusic, J.J. Disa, P.G. Cordeiro and B.J. Mehrara, The effect of postoperative anticoagulation on microvascular thrombosis, Ann. Plast. Surg. 59 (2007), 36-39.
3. B.S. Atiyeh, H.A. Hashim, A.M. Hamdan and R.S. Musharafieh, Local recombinant tissue plasminogen activator (rt-PA) thrombolytic therapy in microvascular surgery, Microsurgery 19 (1999), 265-271. (Pubitemid 29420258)
4. M. Breuer, A. Schuetz, B. Gansera, W. Eichinger, J. Weingartner and B. Kemkes, Intraoperative local fibrinolysis as emergency therapy after early coronary artery bypass thrombosis, Eur. J. Cardiothorac. Surg. 15 (1999), 266-270.
5. I.C.M. Chen, P. Ashjian, J.J. Disa, P.G. Cordeiro, A.L. Pusic and B.J. Mehrara, Is the use of intraoperative heparin safe?, Plast. Reconstr. Surg. 121 (2008), 49e-53e.
6. W. Chien, M.A. Varvares, T. Hadlock, M. Cheney and D.G. Deschler, Effects of aspirin and low-dose heparin in head and neck reconstruction using microvascular free flaps, Laryngoscope 115 (2005), 973-976. (Pubitemid 40776984)
7. M.H. Conrad and W.P. Adams, Pharmacologic optimization of microsurgery in the new millennium, Plast. Reconstr. Surg. 108 (2001), 2088-2096. (Pubitemid 34000857)
8. D.M. Davies, A world survey of anticoagulation practice in clinical microvascular surgery, Br. J. Plast. Surg. 35 (1982), 96.
9. J.J. Disa, V.P. Polvora, A.L. Pusic, B. Singh and P.G. Cordeiro, Dextran-related complications in head and neck microsurgery: do the benefits outweigh the risks? A prospective randomized analysis, Plast. Reconstr. Surg. 112 (2003), 1534-1539.
10. P. Durnig, M. Meier and B. Reichert, Monitoring of free flaps and replantations. Status quo in German-speaking microsurgery units, Handchir. Mikrochir. Plast. Chir. 40 (2008), 392-399.
11. W.H. Geerts, D. Bergqvist, G.F. Pineo, J.A. Heit, C.M. Samama, M.R. Lassen and C.W. Colwell, Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edn), Chest 133(Suppl. 6) (2008), 381S-453S.
12. M.M. Hanasono and C.E. Butler, Prevention and treatment of thrombosis in microvascular surgery, J. Reconstr. Microsurg. 24 (2008), 305-314.
13. Y. Hataya, K. Matsuo, M. Ishigaki, Y. Imai and K. Taki, Retrograde intra-arterial infusion of prostaglandin E1 and heparin for the no-reflow phenomenon after oromandibular reconstruction with a free fibular flap, Ann. Plast. Surg. 42 (1999), 92-95.
14. M.R. Jackson and G.P. Clagett, Antithrombotic therapy in arterial occlusive disease, Chest 114(Suppl. 5) (1998), 666S-682S.
15. P.C. Johnson and J.H. Barker, Thrombosis and antithrombotic therapy in microvascular surgery, Clin. Plast. Surg. 19 (1992), 799-807.
16. R.K. Khouri, Avoiding free flap failure, Clin. Plast. Surg. 19 (1992), 773-781.
17. R.K. Khouri, B.C. Cooley, A.R. Kunselman et al., A prospective study of microvascular free-flap surgery and outcome, Plast. Reconstr. Surg. 102 (1998), 711.
18. R.K. Khouri, R. Sherman, H.J. Buncke, A.M. Feller, S. Hovius, C.O. Benes, D.M. Ingram, N.N. Natarajan, J.W. Sherman, P.D. Yeramian and B.C. Cooley, A phase II trial of intraluminal irrigation with recombinant human tissue factor pathway inhibitor to prevent thrombosis in free flap surgery, Plast. Reconstr. Surg. 107 (2001), 408-415. (Pubitemid 32125282)
19. S.S. Kroll, M.J. Miller, G.P. Reece, B.J. Baldwin, G.L. Robb, B.P. Bengtson, M.D. Phillips, D. Kim and M.A. Schusterman, Anticoagulants and hematomas in free flap surgery, Plast. Reconstr. Surg. 96 (1995), 643-647.
20. S.S. Kroll, M.A. Schusterman, G.P. Reece et al., Timing of pedicle thrombosis and flap loss after free-tissue transfer, Plast. Reconstr. Surg. 98 (1996), 1230-1233.
21. P. Lamby, L. Prantl, S. Gais, M. Walter, M. Bachthaler, M. Nerlich, S. Feuerbach and E.M. Jung, Evaluation of the vascular integrity of free flaps based on microcirculation imaging techniques, Clin. Hemorheol. Microcirc. 39(1-4) (2008), 253-263.
22. J.P. Lecoq, M. Senard, G.M. Hartstein, M. Lamy and O. Heymans, Thromboprophylaxis in microsurgery, Acta Chir. Belg. 106 (2006), 158-164.
23. K. Matsuo, H. Kushima, M. Noguchi, Y. Sakaguchi and T. Fujiwara, Continuous intraarterial infusion of prostaglandin E1 and heparin to extend and improve the survival of pedicled musculocutaneous flaps through unusual routes: a clinical preliminary report, Ann. Plast. Surg. 29 (1992), 314-320.
24. J.W. May and D.M. Rothkopf, Salvage of a failing microvascular free muscle flap by direct continuous intravascular infusion of heparin: a case report, Plast. Reconstr. Surg. 83 (1989), 1045-1048.
25. D.J. Murray, P.C. Neligan, C.B. Novak, B. Howley, J.S. Wunder and J.E. Lipa, Free tissue transfer and deep vein thrombosis, J. Plast. Reconsr. Aesthet. Surg. 61 (2008), 687-692. (Pubitemid 351680443)
26. J. Pomerance, K. Truppa, Z.J. Bilos, M.I. Vender, J.R. Ruder and S.D. Sagerman, Replantation and revascularization of the digits in a community microsurgical practice, J. Reconstr. Microsurg. 13 (1997), 163-170.
27. L. Prantl, K. Pfister, R. Kubale, S. Schmitt, V. Stockhammer, W. Jung, N. Zorger, T. Herold, M. Nerlich, A. Stehr and E.M. Jung, Value of high resolution ultrasound and contrast enhanced US pulse inversion imaging for the evaluation of the vascular integrity of free-flap grafts, Clin. Hemorheol. Microcirc. 36(3) (2007), 203-216.
28. L. Prantl, S. Schmitt, S. Gais, T.Y. Tsui, P. Lamby, P. Babilas, M. Nerlich, R. Kubale, N. Zorger, T. Herold, S. Feuerbach and E.M. Jung, Contrast harmonic ultrasound and indocyanine-green fluorescence video angiography for evaluation of dermal and subdermal microcirculation in free parascapular flaps, Clin. Hemorheol. Microcirc. 38(1) (2008), 31-44.
29. F. Renaud, E. Succo, M.C. Alessi, R. Legre and I. Juhan-Vague, Iloprost and salvage of a free flap, Br. J. Plast. Surg. 49 (1996), 245-248.
30. B.D. Rinker, D.H. Stewart, L.L. Pu and H.C. Vasconez, Role of recombinant tissue plasminogen activator in free flap salvage, J. Reconstr. Microsurg. 23 (2007), 69-73. (Pubitemid 46418448)
31. E.F. Ritter, J.C. Cronan, A.M. Rudner, D. Serafin and B. Klitzman, Improved microsurgical anastomotic patency with low molecular weight heparin, J. Reconstr. Microsurg. 14 (1998), 331-336. (Pubitemid 28368497)
32. D.M. Tremblay, P.G. Harris, A.R. Gagnon, C. Cordoba, J.P. Brutus and A. Nikolis, Heparin-induced thrombocytopenia syndrome as a cause of flap failure: a report of two cases, J. Plast. Reconsr. Aesthet. Surg. 61 (2008), 78-83.
33. A.P. Trussler, J.P. Watson and C.A. Crisera, Late free-flap salvage with catheter-directed thrombolysis, Microsurgery 28 (2008), 217-222.
34. N.W. Yii, G.R. Evans, M.J. Miller, G.P. Reece, H. Langstein, D. Chang, S.S. Kroll, B. Wang and G.L. Robb, Thrombolytic therapy: what is its role in free flap salvage?, Ann. Plast. Surg. 46 (2001), 601-604.