Heparin-induced thrombocytopenia syndrome as a cause of flap failure: A report of two cases

Journal of Plastic, Reconstructive and Aesthetic Surgery

Volumn 61, Issue 1, 2008, Pages 78-83

  Tremblay, Dominique M ^a   Harris, Patrick G ^a   Gagnon, Alain R ^a   Cordoba, Carlos ^a   Brutus, Jean Paul ^a   Nikolis, Andreas ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Flap failure; Heparin; Heparin induced thrombocytopenia; Venous thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTINEOPLASTIC AGENT; DANAPAROID; HEPARIN;

ADULT; AGED; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANTICOAGULANT THERAPY; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; BREAST CANCER; BREAST RECONSTRUCTION; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CASE REPORT; CLINICAL FEATURE; COMORBIDITY; DEEP VEIN THROMBOSIS; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FREE TISSUE GRAFT; GLOSSECTOMY; GRAFT FAILURE; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; LABORATORY TEST; LEECHING; LIP; MALE; MANDIBLE; MASTECTOMY; OSTEOCUTANEOUS FLAP; PLASTIC SURGERY; POSTOPERATIVE COMPLICATION; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROPHYLAXIS; PROTECTIVE CLOTHING; RECURRENT DISEASE; SQUAMOUS CELL CARCINOMA; THROMBOCYTOPENIA; THROMBOEMBOLISM; TOBACCO DEPENDENCE; TRANSVERSE RECTUS ABDOMINIS MUSCULOCUTANEOUS FLAP; VEIN THROMBOSIS; VENOUS CONGESTION;

EID: 36649006452     PISSN: 17486815     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bjps.2006.12.007     Document Type: Article

References (21)

1. Hudson D.A., Engelbrecht G., and Duminy F.J. Another method to prevent venous thrombosis in microsurgery: an in situ venous catheter. Plast Reconstr Surg 105 (2000) 999-1003
2. Khouri R.K., Cooley B., Kunselman A., et al. The International Microvascular Research Group: a prospective study of microvascular free-flap surgery and outcome. Plast Reconstr Surg 102 (1998) 711-721
3. Serletti J.M., Steven L., Orlando G.S., et al. Urokinase protocol for free-flap salvage following prolonged venous thrombosis. Plast Reconstr Surg 102 (1998) 1947-1953
4. Most D., Kozlow J., Heller J., et al. Thromboembolism in plastic surgery. Plast Reconstr Surg 115 (2005) 20e-30e
5. Conrad M.H., and Adams W.P. Pharmacologic optimization of microsurgery in the new millennium. Plast Reconstr Surg 108 (2001) 2088-2097
6. Kirschner R.E., Xu J., Fyfe B., et al. Salvage of free flaps after secondary venous ischemia by local delivery of heparin. Ann Plast Surg 42 (1999) 521-527
7. Spinler S., and Dager W. Overview of heparin-induced thrombocytopenia. Am J Health Syst Pharm 60 Suppl. 5 (2003) S5-S11
8. DeBois W.J., Liu J., Lee L.Y., et al. Diagnosis and treatment of heparin-induced thrombocytopenia. Perfusion 18 (2003) 47-53
9. Mureebe L., and Silver D. Heparin-induced thrombocytopenia: pathophysiology and management. Vasc Endovascular Surg 36 (2002) 163-170
10. Warkentin T.E., Aird W.C., and Rand J.H. Platelet-endothelial interactions: sepsis, HIT and antiphospholipid syndrome. Hematology Am Soc Hematol Educ Program (2003) 497-519
11. Nikolis A., Christopoulos A., Saint-Cyr M., et al. Recurrent venous thrombosis following free flap surgery: The role of heparin-induced thrombocytopenia. Can J Plast Surg 11 (2003) 37-40
12. Utley D.S., Koch R.J., and Goode R.L. The failing flap in facial plastic and reconstructive surgery: role of the medicinal leech. Laryngoscope 108 (1998) 1129-1135
13. Chandawarkar R.Y., Papas N., and Pederson J. Simple methods of preventing microvascular free flap failure. Plast Reconstr Surg 110 (2002) 1188-1190
14. Dager W., and White R. Treatment of heparin-induced thrombocytopenia. Ann Pharmacother 36 (2002) 489-503
15. Warkentin T.E. Platelet count monitoring and laboratory testing for heparin-induced thrombocytopenia. Arch Pathol Lab Med 126 (2002) 1415-1423
16. Warkentin T.E., Levine M.N., Hirsch J., et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 332 (1995) 1330-1335
17. Arepally G., and Cines D.B. Pathogenesis of heparin-induced thrombocytopenia and thrombosis. Autoimmun Rev 1 (2002) 125-132
18. Warkentin T.E., and Kelton J.G. A 14-year study of heparin-induced thrombocytopenia. Am J Med 101 (1996) 502-507
19. Messmore H.L., Jeske W.P., Wehrmacher W.H., et al. Benefit-risk assessment of treatments for heparin-induced thrombocytopenia. Drug Saf 26 (2003) 625-641
20. Davison S.P., Venturi M.L., Attinger C.E., et al. Prevention of venous thromboembolism in the plastic surgery patient. Plast Reconstr Surg 114 (2004) 43e-51e
21. Virchow R.L.K. Gesammelte Abhandlungen zur Wissenschaftlichen Medicin (1856), Meidinger Sohn & Co., Frankfurt