Prevention and treatment of thrombosis in microvascular surgery

Journal of Reconstructive Microsurgery

Volumn 24, Issue 5, 2008, Pages 305-314

  Hanasono, Matthew M ^a   Butler, Charles E ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Anticoagulation; Free flap; Microvascular; Thrombolysis; Thrombosis

Indexed keywords

3 [[4 [4 (AMINOIMINOMETHYL)PHENYL] 2 THIAZOLYL](1 CARBOXYMETHYL 4 PIPERIDINYL)AMINO]PROPIONIC ACID; ACETYLSALICYLIC ACID; ALTEPLASE; ARGATROBAN; DEXTRAN; DEXTRAN 40; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN; HIRUDIN; HIRULOG; LEPIRUDIN; LIDOCAINE; LOW MOLECULAR WEIGHT HEPARIN; PENTOXIFYLLINE; PLACEBO; RECOMBINANT HIRUDIN; STREPTOKINASE; TIROFIBAN; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ALGORITHM; ANAPHYLAXIS; ANASTOMOSIS; BLEEDING; BLEEDING TENDENCY; CLINICAL STUDY; DEEP VEIN THROMBOSIS; EXPERIMENTAL STUDY; FREE TISSUE GRAFT; GASTRITIS; GRAFT FAILURE; HEMATOMA; HUMAN; INFORMATION PROCESSING; KIDNEY FAILURE; LUNG EDEMA; LUNG EMBOLISM; MEDICAL LITERATURE; MICROVASCULAR SURGERY; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; THROMBOCYTOPENIA; THROMBOSIS;

ANTICOAGULANTS; HUMANS; MICROSURGERY; POSTOPERATIVE COMPLICATIONS; SURGICAL FLAPS; THROMBOSIS; VASCULAR SURGICAL PROCEDURES;

EID: 48649090403     PISSN: 0743684X     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1080530     Document Type: Review

References (54)

1. Khouri RK, Cooley BC, Kunselman AR, et al. A prospective study of microvascular free-flap surgery and outcome. Plast Reconstr Surg 1998;102:711-721
2. Yii NW, Evans GR, Miller MJ, et al. Thrombolytic therapy: what is its role in free flap salvage? Ann Plast Surg 2001;46:601-604
3. Nakatsuka T, Harii K, Asato H, et al. Analytic review of 2372 free flap transfers for head and neck reconstruction following cancer resection. J Reconstr Microsurg 2003;19:363-368
4. Bui DT, Cordeiro PG, Hu QY, Disa JJ, Pusic A, Mehrara BJ. Free flap reexploration: indications treatment and outcomes in 1193 free flaps. Plast Reconstr Surg 2007;119:2092-2100
5. Johnson PC. Platelet-mediated thrombosis in microvascular surgery: knowledge and strategies. Plast Reconstr Surg 1990;86:359-367
6. Khouri RK, Cooley BC, Kenna DM, Edstrom LE. Thrombosis of microvascular anastomoses in traumatized vessels: fibrin versus platelets. Plast Reconstr Surg 1990;86:110-117
7. Disa JJ, Cordeiro PG, Hidalgo DA. Efficacy of conventional monitoring techniques in free tissue transfer: an 11-year experience in 750 consecutive cases. Plast Reconstr Surg 1999;104:97-101
8. Jones NF. Intraoperative and postoperative monitoring of microsurgical free tissue transfers. Clin Plast Surg 1992;19:783-797
9. Chen KT, Mardini S, Chuang DCC, et al. Timing of presentation of the first signs of vascular compromise dictates the salvage outcome of free flap transfers. Plast Reconstr Surg 2007;120:187-195
10. Panchapakesan V, Addison P, Beausang E, Lipa JE, Gilbert RW, Neligan PC. Role of thrombolysis in free-flap salvage. J Reconstr Microsurg 2003;19:523-529
11. Hidalgo DA, Jones CS. The role of emergent exploration in free tissue transfer, a review of 150 consecutive cases. Plast Reconstr Surg 1990;86:492-498
12. Kroll SS, Schusterman MA, Reece GP, et al. Timing of pedicle thrombosis and flap loss after free-tissue transfer. Plast Reconstr Surg 1996;98:1230-1233
13. Clarke RJ, Mayo G, Price P, Fitzgerald GA. Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin. N Engl J Med 1991;325:1137-1141
14. Peter FW, Franken RJPM, Wang WZ, et al. Effect of low dose aspirin on thrombus formation at arterial and venous microanastomoses and on the tissue microcirculation. Plast Reconstr Surg 1997;99:1112-1121
15. Ashjian P, Chen CM, Pusic A, Disa JJ, Cordeiro PG, Mehrara BJ. The effect of postoperative anticoagulation on microvascular thrombosis. Ann Plast Surg 2007;59:36-40
16. Chien W, Varvares MA, Hadlock T, Cheney M, Deschler DG. Effects of aspirin and low-dose heparin in head and neck reconstruction using microvascular free flaps. Laryngoscope 2005;115:973-976
17. Taylor DW, Barnett JH, Haynes RB, et al. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomized controlled trial - ASA and Carotid Endarterectomy (ACE) Trial Collaborators. Lancet 1999;353:2179-2184
18. Rothkopf DM, Chu B, Bern S, May JW. The effect of dextran on microvascular thrombosis in an experimental rabbit model. Plast Reconstr Surg 1993;92:511-515
19. Salemark L, Knudsen F, Dougan P. The effect of dextran 40 on patency following severe trauma in small arteries and veins. Br J Plast Surg 1995;48:121-126
20. Kaplan AI, Sabin S. Dextran 40: another cause of drug-induced noncardiogenic pulmonary edema. Chest 1975;68:376-377
21. Hein KD, Wechsler ME, Schwartzstein RM, Morris DJ. The adult respiratory distress syndrome after dextran infusion as an antithrombotic agent in free TRAM flap breast reconstruction. Plast Reconstr Surg 1999;103:1706-1708
22. Conrad MH, Adams WP. Pharmacologic optimization of microsurgery in the new millennium. Plast Reconstr Surg 2001;108:2088-2096
23. Disa JJ, Polvora VP, Pusic AL, Singh B, Cordeiro PG. Dextran-related complications in head and neck microsurgery: do the benefits outweigh the risks? A prospective randomized analysis. Plast Reconstr Surg 2003;112:1534-1539
24. Mahadoo J, Heibert L, Jaques LB. Vascular sequestration of heparin. Thromb Res 1978;12:79-90
25. Kroll SS, Miller MJ, Reece GP, et al. Anticoagulants and hematomas in free flap surgery. Plast Reconstr Surg 1995;96:643-647
26. Johnson PC, Barker JH. Thrombosis and antithrombotic therapy in microvascular surgery. Clin Plast Surg 1992;19:799-807
27. Ritter EF, Cronan JC, Rudner AM, Serafin D, Klitzman B. Improved microsurgical anastomotic patency with low molecular weight heparin. J Reconstr Microsurg 1998;14:331-336
28. Wieslander JB, Dougan P. Washout of vessels with heparin does not improve patency following severe microarterial trauma: an experimental study. Ann Plast Surg 1990;24:216-222
29. Cox GW, Runnels S, Hsu HSH, Das SK. A comparison of heparinized saline irrigation solutions in a model of microvascular thrombosis. Br J Plast Surg 1992;45:345-347
30. Andresen DM, Barker JH, Hjortdal VE. Local heparin is superior to systemic heparin in preventing arterial thrombosis. Microsurgery 2002;22:265-272
31. Schubert W, Hunter DW, Guzman-Stein G, et al. Use of streptokinase for the salvage of a free flap: case report and review of the use of thrombolytic therapy. Microsurgery 1987;8:117-121
32. Esclamado RM, Carroll WR. The pathogenesis of vascular thrombosis and its impact in microvascular surgery. Head Neck 1999;21:355-362
33. Lipton HA, Jupiter JB. Streptokinase salvage of a free tissue transfer: case report and review of the literature. Plast Reconstr Surg 1987;79:977-981
34. Goldberg JA, Pederson WC, Barwick WJ. Salvage of free tissue transfers using thrombolytic agents. J Reconstr Microsurg 1989;5:351-356
35. Serletti JM, Moran SL, Orlando GS, et al. Urokinase protocol for free-flap salvage following prolonged venous thrombosis. Plast Reconstr Surg 1998;102:1947-1953
36. Hergrueter CA, Handren J, Kersh R, May JW. Human recombinant tissue type plasminogen activator and its effect on microvascular thrombosis in the rabbit. Plast Reconstr Surg 1988;81:418-424
37. Fudem GM, Walton RL. Microvascular thrombolysis to salvage a free flap using human recombinant tissue plasminogen activator. J Reconstr Microsurg 1989;5:231-234
38. Atiyeh BS, Hashim HA, Hamdan AM, Musharafieh RS. Local recombinant tissue plasminogen activator (rt-PA) thrombolytic therapy in microvascular surgery. Microsurgery 1999;19:265-271
39. Gore JM, Sloan M, Price TM, et al. Intracerebral hemorrhage, cerebral infarction, and subdural hematoma after acute myocardial infarction and thrombolytic therapy in the Thrombolysis in Myocardial Infarction Study. Thrombolysis in Myocardial Infarction, Phase II pilot and clinical trial. Circulation 1991;83:448-459
40. Rinker BD, Steward DH, Pu LLQ, Vasconez HC. Role of recombinant tissue plasminogen activator in free flap salvage. J Reconstr Microsurg 2007;23:69-74
41. Stein B, Foster V. Antithrombotic therapy in cardiac disease. Circulation 1989;80:1501-1513
42. Hirigoyen MB, Zhang W, Gordon RE, Prabhot A, Urken ML, Weinberg H. Additional benefit of heparin in the thrombolytic salvage of ischemic skin flap. Ann Plast Surg 1995;35:612-619
43. Hubbard T, Olivier T, Bacher P, et al. Use of recombinant hirudin to increase the patency rate of microanastomosis in a rabbit model. Blood Coagul Fibrinolysis 1991;2:101-103
44. Arnljots B, Bergqvist D. Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: a specific thrombin inhibitor. Plast Reconstr Surg 1995;95:894-900
45. Zhang B, Wieslander JB. Comparison of the antithrombotic effect of the new recombinant hirudin HBW 023 and heparin in small arteries and veins. Microsurgery 1996;17:89-96
46. Kronen G, Ferder M, Hunzicker K, Strauch B. The use of pentoxyfilline in microvascular surgery. J Reconstr Microsurg 1994;10:17-20
47. Yates YJ, Farias CL, Kazmier FR, Puckett CL, Concannon MJ. The effect of tirofiban on microvascular thrombosis: crush model. Plast Reconstr Surg 2005;116:205-208
48. Ching S, Thoma A, Monkman S, Kelton JG. Inhibition of microsurgical thrombosis by the platelet glycoprotein IIb/IIIa antagonist SR121566A. Plast Reconstr Surg 2003;112:177-185
49. Glicksman A, Ferder M, Casale P, et al. 1457 years of microsurgical experience. Plast Reconstr Surg 1997;100:355-363
50. Antiplatelet Trialists Collaboration. Collaborative overview of randomised trials of antiplatelet therapy-II: maintenance of vascular graft or arterial patency by antiplatelet therapy. BMJ 1994;308:159-168
51. Wheatley MJ, Meltzer TR. The role of vascular pedicle thrombectomy in the management of compromised free tissue transfers. Ann Plast Surg 1996;36:360-364
52. Gherardini G, Gurlek A, Cromeens D, Joly GA, Wang BG, Evans GR. Drug-induced vasodilation: in vitro and in vivo study on the effects of lidocaine and papaverine on rabbit carotid artery. Microsurgery 1998;18:90-96
53. Harashina T, Fujino T, Watanabe S. The intimai healing of microvascular anastomoses. Plast Reconstr Surg 1976;58:608-613
54. Isogai N, Kamiishi H, Chichibu S. Re-endothelialization stages at the microvascular anastomosis. Microsurgery 1988;9:87-94